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Vacation Rentals in Scott County

Top Cities in Scott County

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Vacation RentalsVacation Rentals

Sikeston

Sikeston

Our top choices for Scott County vacation rentals

A cozy room with a wooden table and chairs, a large window, and a door with a sign.

1. Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake
Olive Branch
9.8 out of 10, Exceptional, (43 reviews)
"Super communication! . Accommodating. Nice people"
United States
JASEN
$133 nightly
The price is $140
Oct 15 - Oct 16
Total with taxes and fees
Cozy cabins on beautiful Horseshoe Lake
A small, single-story building with a wooden exterior and large windows.

2. The Rested Duck Mallard Room

The Rested Duck Mallard Room
Olive Branch
9.4 out of 10, Exceptional, (31 reviews)
"This is an excellent place to stay. With a nice lake right across the street. If i. In the are i will stay again for sure"
United States
mike b.
$133 nightly
The price is $140
Oct 15 - Oct 16
Total with taxes and fees
The Rested Duck Mallard Room
A living room with a TV, a fireplace, a sofa, and wall art.

3. Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.4 out of 10, Very good, (59 reviews)
"Great cute place. "
United States
Jeremy W.
$101 nightly
The price is $108
Oct 15 - Oct 16
Total with taxes and fees
Little Blue Cottage on Spanish
A loft-style room with a wooden interior, a sofa, a table with a pumpkin decoration, and a staircase leading to an upper level.

4. Peaceful secluded cabin located near Horseshoe Lake

Peaceful secluded cabin located near Horseshoe Lake
Miller City
9.8 out of 10, Exceptional, (39 reviews)
"Great place in a beautiful location. "
United States
George B.
$190 nightly
The price is $201
Oct 15 - Oct 16
Total with taxes and fees
Peaceful secluded cabin located near Horseshoe Lake
A living room with two sofas, a coffee table, a ceiling fan, and a door.

5. Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals

Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals
Cape Girardeau
$176 nightly
The price is $189
Oct 27 - Oct 28
Total with taxes and fees
Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals
A bedroom with a bed, a bottle of J. Roget champagne, two glasses, and a plate with snacks.

6. The Cottage, Rusted Route Farms

The Cottage, Rusted Route Farms
Jackson
10.0 out of 10, Exceptional, (3 reviews)
"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"
United States
Renee C.
$199 nightly
The price is $199
Oct 19 - Oct 20
Total with taxes and fees
The Cottage, Rusted Route Farms
Exterior

7. Purple Tiny House with Fire pit & Nature

Purple Tiny House with Fire pit & Nature
Cape Girardeau
10.0 out of 10, Exceptional, (1 review)
"First time staying in the purple house, second time staying at the property. 10/10 recommend"
United States
Shawn A.
$193 nightly
The price is $203
Oct 15 - Oct 16
Total with taxes and fees
Purple Tiny House with Fire pit & Nature
A serene outdoor area with a pond, surrounded by trees and a grassy lawn. There are two wooden benches facing the water.

8. Charming cottage overlooking Lake Acre

Charming cottage overlooking Lake Acre
Dongola
10.0 out of 10, Exceptional, (107 reviews)
"Such a beautiful and peaceful place to stay Suzzie is a great host I stay there once or twice a year for the past several years loved every minute can’t wait to go back"
United States
Paul D.
$237 nightly
The price is $251
Oct 15 - Oct 16
Total with taxes and fees
Charming cottage overlooking Lake Acre
A modern living room with a wooden ceiling, a stone fireplace, a TV mounted on the wall, and a bar area with stools.

9. The Twisted Sassafras Treehouse

The Twisted Sassafras Treehouse
Cape Girardeau
10.0 out of 10, Exceptional, (40 reviews)
"Amazing stay! Everything was perfect."
United States
Wayne F.
$366 nightly
The price is $385
Nov 11 - Nov 12
Total with taxes and fees
The Twisted Sassafras Treehouse
Exterior

10. Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly

Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly
Cape Girardeau
10.0 out of 10, Exceptional, (3 reviews)
"The house was very clean and Will kept and the whole property was well maintained. It was very comfortable and nicely decorated. The host was very responsive and helpful! Would definitely stay again and recommend."
United States
Sara C.
$216 nightly
The price is $227
Oct 16 - Oct 17
Total with taxes and fees
Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly
Ground floor of the Euro

11. The Little Château | Woodland Escape

The Little Château | Woodland Escape
Cape Girardeau
$211 nightly
The price is $222
Oct 15 - Oct 16
Total with taxes and fees
The Little Château | Woodland Escape
Private kitchen

12. Enchanted Mermaid A-Frame | Creek + Fire pit | Pet Friendly

Enchanted Mermaid A-Frame | Creek + Fire pit | Pet Friendly
Cape Girardeau
$224 nightly
The price is $235
Oct 18 - Oct 19
Total with taxes and fees
Enchanted Mermaid A-Frame | Creek + Fire pit | Pet Friendly
A two-story house with a front porch, a small garden, and a white picket fence.

13. 3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Cape Girardeau
8.8 out of 10, Excellent, (46 reviews)
"Will definitely book again! Great location, comfortable stay."
United States
Pynktoria !.
$300 nightly
The price is $315
Oct 15 - Oct 16
Total with taxes and fees
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
A room with a pool table, a sofa, and a dining table with chairs.

14. Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge

Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge
Villa Ridge
10.0 out of 10, Exceptional, (4 reviews)
"nice property would stay there again"
United States
Brian F.
$252 nightly
The price is $267
Oct 19 - Oct 20
Total with taxes and fees
Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge
Exterior

15. The Little Cape Lofted Cottage | Creek & Nature

The Little Cape Lofted Cottage | Creek & Nature
Cape Girardeau
9.0 out of 10, Wonderful, (2 reviews)
"It was very clean and had a good feel. It was well stocked. I appreciated the cute little ice tray in the freezer that was full. I also appreciated 4 waters in the fridge. The bed on the loft upstairs was atrocious. You can feel the springs through the mattress. The downstairs bed was good. The pillows were fantastic! I’m a pillow snob. We needed a quick place to land for a church function so I can’t say much about the outside amenities as we weren’t there much. But it was a beautifully tucked...
United States
Trisha S.
$218 nightly
The price is $229
Oct 15 - Oct 16
Total with taxes and fees
The Little Cape Lofted Cottage | Creek & Nature
A log cabin interior with a stone fireplace, leather sofa, and a mounted deer head.

16. Gorgeous 1856 Log Cabin, Completely Renovated

Gorgeous 1856 Log Cabin, Completely Renovated
Jackson
10.0 out of 10, Exceptional, (6 reviews)
"incredible place. I was there for work, but it was a really nice relaxing area to retreat too, and also get some work done in a serene environment. It would be an incredible place for an entire family. And, a good place for friends to get together."
United States
Chandler G.
$313 nightly
The price is $313
Oct 19 - Oct 20
Total with taxes and fees
Gorgeous 1856 Log Cabin, Completely Renovated
A kitchen with wooden cabinets, a black refrigerator, a microwave, a stove, and a ceiling fan. There are three stools at the island.

17. Relax in the country at Countryside Villas! - Villa A

Relax in the country at Countryside Villas! - Villa A
Jackson
10.0 out of 10, Exceptional, (39 reviews)
"Great place to stay, felt like home away from home. "
United States
Brittany
$172 nightly
The price is $181
Oct 22 - Oct 23
Total with taxes and fees
Relax in the country at Countryside Villas! - Villa A
A modern kitchen with a large island, white cabinetry, and a brick accent wall.

18. Beautifully Renovated Farmhouse in Jackson, MO

Beautifully Renovated Farmhouse in Jackson, MO
Jackson
9.4 out of 10, Exceptional, (3 reviews)
" great stay,property landscape nicely manicured, quiet and relaxing inside and outside of the the dwelling."
United States
Sandy S.
$313 nightly
The price is $313
Oct 26 - Oct 27
Total with taxes and fees
Beautifully Renovated Farmhouse in Jackson, MO
A two-story house with a front porch, a covered entryway, and a small garden with white flowers.

19. Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy
Dexter
8.0 out of 10, Very good, (38 reviews)
"Overall, it was a good experience. I would stay again."
United States
Tammy G.
$200 nightly
The price is $215
Oct 15 - Oct 16
Total with taxes and fees
Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy
A compact kitchen with wooden cabinets and a dining area with a table and chairs.

20. Villa B offers peace and quiet with beautiful views of the countryside.

Villa B offers peace and quiet with beautiful views of the countryside.
Jackson
9.8 out of 10, Exceptional, (16 reviews)
"We were only there for 1 night for a business trip but it was perfect for our stay. Very clean and comfortable and the host was onsite to welcome us. She even gave us a tip on the best place nearby for dinner that we will be going to any time we can in the future. I would gladly stay here again for future trips."
United States
Terry H.
$172 nightly
The price is $181
Oct 24 - Oct 25
Total with taxes and fees
Villa B offers peace and quiet with beautiful views of the countryside.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Scott County Hotel Reviews

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

10/10 Excellent
"Wonderful experience. We will return."
Terry 1-night trip
Posted 2 hours ago
Pear Tree Inn Cape Girardeau West

Find out more about Scott County

Discover your perfect Scott County vacation rental with Expedia

How many vacation rentals are available in Scott County?


Expedia has plenty of vacation rentals to choose from in and around  Scott County, so you’re guaranteed to find the right one for you. 


How much is a vacation rental in Scott County?


The selection of Scott County vacation rentals we have selected for you start as low as $108 per night. Entering your travel dates in the search wizard you might find even better deals!


What type of vacation rental can I get in Scott County?


Vacation rentals in Scott County come in all shapes and sizes, and your options depend on your chosen travel dates. You could entertain in a blissful vacation home, chill in a private apartment, or find family fun at a resort. Expedia offers a superb choice of Scott County vacation rentals to suit everyone. 


Why should I choose a vacation rental in Scott County?


Expedia’s vacation rentals provide cozy comforts you can sink into on your own schedule. You’ll enjoy your own space in a property with a kitchen, a pool, a garden etc. Maybe you’ll prefer somewhere with a spa or kids activities. A Scott County vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in. 


How do I find the best deal on a vacation rental in Scott County?


Find vacation rentals in Scott County by viewing Expedia’s latest deals, or enter your travel dates and use the filters to select by amenities, price, or rating. Dive into the reviews to get a true feeling of which is your favorite vacation rental in Scott County.  


What amenities are available in a vacation rental in Scott County?


The choice is yours! Perhaps you love cooking in a well-equipped kitchen. Or maybe a late breakfast and a swimming pool is more your thing. Of course, there’s always the treat of having your own hot tub. Expedia has a vast range of amenities in Scott County vacation rentals designed to suit every budget and trip type.


When is the best time to stay in a vacation rental in Scott County?   


Everytime is a great time to head to Scott County! Staying in a Scott County vacation rentals you will always find lots going on to keep you entertained. 


Why book a vacation rental with Expedia?


Expedia has locked in amazing deals on a huge selection of impressive vacation rentals in Scott County. We give you the information and inspiration you need all in one place. With so many properties to choose from, you know you can book your perfect Scott County vacation rental with confidence. ANd don’t forget, if you bundle with a flight or a car rental in Scott County, you can save even more.


Can I cancel my vacation rental through Expedia?  


Yes, you can cancel or change your Scott County vacation rental by contacting your property manager directly. Contact details are easy to find on your itinerary in Trips. For more information, check out our Customer Service Portal and we’ll help you get everything sorted.