Title: Visit Puxico: 2026 Travel Guide for Puxico, Missouri | Expedia.com [Hotels in Puxico](https://expedia.com/Puxico-Hotels.d553248634983343452.Travel-Guide-Hotels)[Vacation Rentals in Puxico](https://expedia.com/Puxico-Vacation-Rentals.d553248634983343452.Travel-Guide-VacationRentals)[Car Rentals in Puxico](https://expedia.com/Car-Rentals-In-Puxico.d553248634983343452.Car-Rental-Guide)[Puxico Vacation Packages](https://expedia.com/Puxico.d553248634983343452.Destination-Travel-Guides) # Puxico, MO ## Travel Guide ![Puxico](https://images.trvl-media.com/place/553248634983343452/de6c5278-53d4-4238-882c-19c2c1cec581.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit Puxico - Puxico Hotel Deals - Vacation Rentals in Puxico ![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/22960908_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Motel 6 Poplar Bluff, MO 4101 Highway 67 N Poplar Bluff MO $65 nightly $69 total Apr 12 - Apr 13 Total with taxes and fees Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ... 8/10 Very Good! (1,000 reviews) I stay here quite often in my travels. My room is almost always pretty clean - it is still a motel 6\. Sheets and towels are always clean. I usually order food and just stay in my room once it’s dark out because I’m not sure about the area - it’s outside of town. Reviewed on Apr 5, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F12%2F2026&endDate=4%2F13%2F2026&selected=15689127&PinnedHotelID=15689127&HadPinnedHotel=true®ionId=553248634983343452) ![Drury Inn & Suites Poplar Bluff](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/b034b164_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Inn & Suites Poplar Bluff 2220 N Westwood Blvd Poplar Bluff MO $94 nightly $106 total Apr 19 - Apr 20 Total with taxes and fees Book a stay at this business-friendly hotel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ... 9.2/10 Wonderful! (1,001 reviews) Clean Reviewed on Apr 5, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F19%2F2026&endDate=4%2F20%2F2026&selected=41515&PinnedHotelID=41515&HadPinnedHotel=true®ionId=553248634983343452) ![Fairfield Inn & Suites by Marriott Poplar Bluff](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Fairfield Inn & Suites by Marriott Poplar Bluff 3109 Oak Grove Poplar Bluff MO $110 nightly $124 total Apr 11 - Apr 12 Total with taxes and fees Book a stay at this business-friendly hotel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ... 9.4/10 Exceptional! (885 reviews) Breakfast was really good and fresh. Room was clen Reviewed on Apr 4, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F11%2F2026&endDate=4%2F12%2F2026&selected=28807257&PinnedHotelID=28807257&HadPinnedHotel=true®ionId=553248634983343452) [See all 55 properties in Puxico](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=4%2F9%2F2026&endDate=4%2F10%2F2026®ionId=553248634983343452) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![Private lake, beach & hot tub, romantic getaway or family vaca](https://images.trvl-media.com/lodging/90000000/89720000/89711400/89711320/9da4f272_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Private lake, beach & hot tub, romantic getaway or family vaca Wappapello MO Stay at this vacation home in Wappapello. Enjoy laundry facilities, air conditioning, and a hot tub. Popular attractions Eagle Point Recreation Area and Lake ... 9.8/10 Exceptional! (42 reviews) This is a nice peaceful property enjoyed our family stay Reviewed on Mar 23, 2026 [](https://expedia.com/Wappapello-Hotels-Private-Lake.h89711320.Hotel-Information) ![Warm, Cozy and Historic](https://images.trvl-media.com/lodging/123000000/122470000/122467400/122467371/8fefc68b_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Warm, Cozy and Historic Poplar Bluff MO Stay at this vacation home in Poplar Bluff. Enjoy laundry facilities, in-room fireplaces, and air conditioning. Popular attractions Margaret Harwell Art Museum ... 10/10 Exceptional! (3 reviews) The kitchen was fully equipped and the home was per friendly. Reviewed on Mar 28, 2026 [](https://expedia.com/Poplar-Bluff-Hotels-Warm.h122467371.Hotel-Information) ![Camp Minnow Beach House](https://images.trvl-media.com/lodging/97000000/96480000/96471100/96471085/3a131419_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Camp Minnow Beach House Wappapello MO Book a stay at this family-friendly cabin in Wappapello. Enjoy a garden, patios, and cable/satellite TV service. Popular attractions Eagle Point Recreation Area ... 9.4/10 Exceptional! (16 reviews) The cabin was excellent! From the moment we walked in, the kids got to playing with all the games around. The cabin fit the description and was everything we were hoping for. It's a close distance to parks and trails, and the fire pit and hot tub are great to have. Communication with the owner is ... Reviewed on Nov 11, 2025 [](https://expedia.com/Camp-Minnow.h96471085.Hotel-Information) [See all properties in Puxico](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=553248634983343452&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Puxico hotel availability [Tonight ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634983343452&startDate=2026-04-08&endDate=2026-04-09)[Apr 8 - Apr 9](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634983343452&startDate=2026-04-08&endDate=2026-04-09) [Tomorrow night ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634983343452&startDate=2026-04-09&endDate=2026-04-10)[Apr 9 - Apr 10](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634983343452&startDate=2026-04-09&endDate=2026-04-10) [This weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634983343452&startDate=4%2F10%2F2026&endDate=4%2F12%2F2026)[Apr 10 - Apr 12](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634983343452&startDate=4%2F10%2F2026&endDate=4%2F12%2F2026) [Next weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634983343452&startDate=4%2F17%2F2026&endDate=4%2F19%2F2026)[Apr 17 - Apr 19](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634983343452&startDate=4%2F17%2F2026&endDate=4%2F19%2F2026) ## Cities near Puxico ![Small Cove at Sunset Peoples Creek Recreation Area Lake Wappapello Wayne County Missouri on November 19, 2021 The setting sun illuminates the shoreline of a small cove ](https://images.trvl-media.com/place/183505/e604cc88-0ab4-411b-96cd-381b2eda6337.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Wappapello - Cities near Puxico - Places of interest [Wappapello](https://expedia.com/Wappapello.dx183505)[Sturdivant](https://expedia.com/Sturdivant.dx3000349555) - [Mark Twain National Forest ](https://expedia.com/Mark-Twain-National-Forest-Missouri.d553248635976468503.Vacation-Attraction) - [Lake Wappapello ](https://expedia.com/Lake-Wappapello-Wappapello.d553248621532648460.Vacation-Attraction) - [Ozark Ridge Golf Course ](https://expedia.com/Ozark-Ridge-Golf-Course-Poplar-Bluff.d553248621554123001.Vacation-Attraction) - [Black River Coliseum ](https://expedia.com/Black-River-Coliseum-Poplar-Bluff.d553248635997959425.Vacation-Attraction) - [Margaret Harwell Art Museum ](https://expedia.com/Margaret-Harwell-Art-Museum-Poplar-Bluff.d553248621554123003.Vacation-Attraction) - [Dexter Welcome Center Depot and Museum ](https://expedia.com/Dexter-Welcome-Center-Depot-And-Museum-Dexter.d553248621592342445.Vacation-Attraction) - [Mo-Ark Regional Railroad Museum ](https://expedia.com/Mo-Ark-Regional-Railroad-Museum-Poplar-Bluff.d553248621554123004.Vacation-Attraction) - [Stoddard County Civil War Memorial Cemetery ](https://expedia.com/Stoddard-County-Civil-War-Memorial-Cemetery-Dexter.d553248621532655747.Vacation-Attraction) - [The Heritage House ](https://expedia.com/The-Heritage-House-Dexter.d553248621592342444.Vacation-Attraction) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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