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Our top choices for Santa Isabel hotels

Hotel Lucerna Mexicali

Hotel Lucerna Mexicali
4.0 star property
Mexicali
9.2 out of 10, Wonderful, (1,706 reviews)
"Such kind staff. The pools are pretty nice."
United States
Susana
6 days ago
$112 nightly
The price is $126
Jul 17 - Jul 18
Total with taxes and fees
Hotel Lucerna Mexicali

Hotel Araiza Mexicali

Hotel Araiza Mexicali
4.0 star property
Mexicali
8.8 out of 10, Excellent, (1,863 reviews)
"Traveled for a family event. Great place, my parents enjoyed the place and their room."
United States
Cristina A
1 day ago
$113 nightly
The price is $128
Jul 15 - Jul 16
Total with taxes and fees
Hotel Araiza Mexicali

Real Inn Mexicali

Real Inn Mexicali
4.0 star property
Civic Center
8.4 out of 10, Very Good, (1,716 reviews)
"Place was nice, and clean even tho , they are under construction!"
United States
Nelly
May 23rd, 2026
Real Inn Mexicali

Extended Suites Mexicali Cataviña

Extended Suites Mexicali Cataviña
3.0 star property
Mexicali
8.0 out of 10, Very Good, (2,448 reviews)
"Friendly staff, clean and good communication."
United States
Estela
9 days ago
$55 nightly
The price is $67
Jul 19 - Jul 20
Total with taxes and fees
Extended Suites Mexicali Cataviña

Calafia Hotel

Calafia Hotel
3.5 star property
Mexicali
8.4 out of 10, Very Good, (1,012 reviews)
"The restaurant was great the waiter was great we had the best service thank you."
United States
Maricela
2 days ago
$68 nightly
The price is $78
Jul 19 - Jul 20
Total with taxes and fees
Calafia Hotel

Hotel Colonial Mexicali

Hotel Colonial Mexicali
3.5 star property
Civic Center
8.0 out of 10, Very Good, (1,018 reviews)
"So safe and fun! Loved the location."
United States
Silvia
7 days ago
$96 nightly
The price is $108
Jul 18 - Jul 19
Total with taxes and fees
Hotel Colonial Mexicali

City Express Plus by Marriott Mexicali

City Express Plus by Marriott Mexicali
3.5 star property
Mexicali
8.6 out of 10, Excellent, (1,031 reviews)
"The parking lot looks very safe."
United States
Bryan
7 days ago
$73 nightly
The price is $83
Jul 19 - Jul 20
Total with taxes and fees
City Express Plus by Marriott Mexicali

Fairfield Inn & Suites by Marriott Mexicali

Fairfield Inn & Suites by Marriott Mexicali
3.0 star property
Mexicali
9.6 out of 10, Exceptional, (1,011 reviews)
"Nice clean rooms, breakfast was great, staff was real helpful."
United States
saul
1 day ago
$110 nightly
The price is $124
Jul 24 - Jul 25
Total with taxes and fees
Fairfield Inn & Suites by Marriott Mexicali

Fiesta Inn Mexicali

Fiesta Inn Mexicali
3.5 star property
Civic Center
8.4 out of 10, Very Good, (1,002 reviews)
"Excellent location, very good for the price, safe and nice pool."
United States
jose
29 days ago
$74 nightly
The price is $85
Aug 7 - Aug 8
Total with taxes and fees
Fiesta Inn Mexicali

City Express by Marriott Mexicali

City Express by Marriott Mexicali
3.0 star property
Mexicali
8.4 out of 10, Very Good, (1,015 reviews)
"10 out of 10 for this stay."
United States
Maria
14 days ago
$68 nightly
The price is $77
Jul 19 - Jul 20
Total with taxes and fees
City Express by Marriott Mexicali

Sleep Inn Mexicali

Sleep Inn Mexicali
3.0 star property
Mexicali
8.4 out of 10, Very Good, (1,016 reviews)
"Air conditioner was out in our room told the staff."
United States
Esteban
11 days ago
$70 nightly
The price is $85
Aug 1 - Aug 2
Total with taxes and fees
Sleep Inn Mexicali

One Mexicali

One Mexicali
3.0 star property
Mexicali
8.0 out of 10, Very Good, (1,007 reviews)
"We always stay there good Hotel food prices."
United States
Maria Luisa
June 5th, 2026
$61 nightly
The price is $70
Jul 26 - Jul 27
Total with taxes and fees
One Mexicali

Hotel del Norte

Hotel del Norte
3.0 star property
Mexicali Historic Center
8.4 out of 10, Very Good, (1,005 reviews)
"The free breakfast was amazing. I really enjoyed our stay."
United States
Gregory
June 2nd, 2026
$52 nightly
The price is $63
Jul 26 - Jul 27
Total with taxes and fees
Hotel del Norte

Hotel Siesta Real

Hotel Siesta Real
3.0 star property
Mexicali
8.2 out of 10, Very Good, (1,013 reviews)
"Is good and private parking."
United States
Martin
23 days ago
$83 nightly
The price is $94
Jul 15 - Jul 16
Total with taxes and fees
Hotel Siesta Real

Holiday Inn Express & Suites Mexicali by IHG

Holiday Inn Express & Suites Mexicali by IHG
3.0 star property
Mexicali
9.4 out of 10, Exceptional, (1,000 reviews)
"Nice facility. Very clean. Staff helpful. Otherwise stay was nice."
United States
Julie
2 days ago
$129 nightly
The price is $145
Aug 7 - Aug 8
Total with taxes and fees
Holiday Inn Express & Suites Mexicali by IHG

City Express Junior by Marriott Mexicali

City Express Junior by Marriott Mexicali
3.0 star property
Mexicali
8.0 out of 10, Very Good, (1,013 reviews)
"Staff was good. There was hair on bed and floor."
United States
Efrain
6 days ago
$56 nightly
The price is $63
Jul 19 - Jul 20
Total with taxes and fees
City Express Junior by Marriott Mexicali

Motel Virreyes

Motel Virreyes
3.0 star property
Mexicali
8.6 out of 10, Excellent, (10 reviews)
"Comfortable the staff was very good. I was good everything was nice."
United States
Estefani
April 20th, 2026
$42 nightly
The price is $48
Jul 15 - Jul 16
Total with taxes and fees
Motel Virreyes

Azteca de Oro Mexicali

Azteca de Oro Mexicali
3.0 star property
Mexicali
7.8 out of 10, Good, (518 reviews)
"Convenient good restaurant on site."
United States
gilbert
$46 nightly
The price is $52
Jul 22 - Jul 23
Total with taxes and fees
Azteca de Oro Mexicali

Courtyard by Marriott Mexicali

Courtyard by Marriott Mexicali
3.0 star property
Mexicali
9.4 out of 10, Exceptional, (987 reviews)
"Staff were excellent and nice quiet room."
Canada
David
June 11th, 2026
$90 nightly
The price is $102
Aug 1 - Aug 2
Total with taxes and fees
Courtyard by Marriott Mexicali

Hotel Cosmos Don Carlos

Hotel Cosmos Don Carlos
3.0 star property
Mexicali
8.0 out of 10, Very Good, (546 reviews)
"Room was very clean no complaints at all. Good place to stay."
United States
gerardo
March 21st, 2026
$47 nightly
The price is $53
Jul 15 - Jul 16
Total with taxes and fees
Hotel Cosmos Don Carlos
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Stay near popular attractions around Santa Isabel

Nestled in the heart of Baja California, Santa Isabel offers a charming blend of outdoor adventures and cultural experiences. Explore vibrant civic centers, immerse yourself in local arts, and enjoy family-friendly activities, making it the perfect base for your Mexican getaway.

Top Santa Isabel Hotel Reviews

More cheap stays in Santa Isabel

Find out more about Santa Isabel

Top reasons to visit Santa Isabel

  • Outdoor Adventures: Enjoy nature walks and hiking in the picturesque landscapes surrounding Santa Isabel.
  • Family-Friendly Activities: The recreational area and recreation center offer fun for visitors of all ages.
  • Rich Cultural Experience: Explore local museums and historic buildings that highlight the region's vibrant culture.
  • Charming Neighborhoods: Experience the warmth and friendliness of local culture in vibrant neighborhoods.
  • Relaxing Beaches: Unwind on beautiful beaches, soaking up the sun and enjoying the serene atmosphere.

Find great hotels near Santa Isabel

Experience the charm of Santa Isabel in Mexicali, Baja California, with a variety of hotel accommodations designed for every traveler. From eco-certified resorts to business-friendly hotels, you’ll find options that cater to your needs. Whether you're looking for the best hotels like Hotel Santa Isabel, Hotel Las Vegas, or Habaguanex, you’re sure to enjoy a warm, welcoming atmosphere, including LGBTQIA-friendly options for a memorable stay.

  • Real Inn Mexicali: Real Inn Mexicali is a 3.5-star hotel, boasting a solid guest rating of 8.2, making it an excellent choice for eco-conscious travelers. Located 6 miles from Santa Isabel, this property is eco-certified, ensuring that your stay is not only comfortable but also environmentally friendly. The hotel features well-appointed rooms suited for business travelers, complete with modern amenities, a business center, and meeting facilities. Guests appreciate the focus on sustainability, along with friendly service and a relaxing atmosphere, perfect for unwinding after a busy day.
  • Fiesta Inn Mexicali: With a guest rating of 8.4, Fiesta Inn Mexicali is a 3.5-star hotel that caters primarily to business travelers, located 6 miles from Santa Isabel. This hotel offers a sleek, modern design paired with essential amenities such as high-speed internet, a business center, and comfortable meeting spaces. Guests enjoy the on-site restaurant that serves a variety of delicious meals, along with a fitness center for those looking to maintain their workout routine. The welcoming atmosphere and attentive staff make it an ideal base for both work and leisure.
  • Hotel del Norte: Hotel del Norte is a 3-star hotel with a guest rating of 8.2, situated 5 miles from Santa Isabel in the heart of the city. This property features a vibrant city theme, making it perfect for travelers eager to explore the urban landscape. With its convenient location, guests have easy access to local attractions, dining, and shopping. The hotel offers comfortable accommodations alongside essential amenities that cater to business travelers, including Wi-Fi and meeting facilities. Its friendly environment and city-centric vibe make it a great choice for both work and play.

Where to stay in Santa Isabel

Santa Isabel offers a charming blend of family-friendly activities and outdoor adventures. Explore the picturesque landscapes surrounding the village, perfect for hiking and enjoying nature. Nearby, discover vibrant neighborhoods that showcase the warmth of local culture and friendly people. Don't miss the chance to relax on the beautiful beaches of the region, where you can soak up the sun and unwind. Whether you're seeking recreation or a taste of local life, Santa Isabel has something for everyone.

  • Mexicali: As the capital city of Baja California, Mexicali offers a vibrant atmosphere that beautifully blends urban life with cultural experiences. Located in the heart of the region, Santa Isabel is nestled within this bustling city. Visitors flock to Mexicali for family-friendly activities, business ventures, and city-themed exploration. Key highlights include expansive shopping malls and lively entertainment arenas, perfect for an afternoon of fun. Sports enthusiasts will appreciate the local stadiums and convention centers, which host a variety of events throughout the year. With a peak in visitor numbers from March to July, Mexicali is an inviting destination year-round.
  • Mexicali Historic Center: Just 5 miles from Santa Isabel, the Mexicali Historic Center offers a glimpse into the city's rich cultural past. This neighborhood is a treasure trove of museums and symbolic landmarks that reflect the heritage of the region. While visitor numbers are highest from October to December, the Historic Center remains an engaging destination at any time of the year. Travelers seeking a deep dive into local culture will find this area irresistible, as it combines historical charm with modern conveniences.
  • Civic Center: Located 6 miles from Santa Isabel, the Civic Center is a bustling neighborhood that caters to families, business travelers, and city explorers alike. The area is known for its shopping centers and entertainment venues, making it an ideal spot for a day out. Visitors can enjoy the local stadium and convention center, as well as historic buildings that add character to the landscape. With peak tourist activity from October to December, the Civic Center offers a lively atmosphere filled with opportunities for enjoyment and discovery.

Things to do in Santa Isabel

Santa Isabel offers a delightful mix of family-friendly activities and outdoor adventures, making it an ideal vacation spot. Visitors can enjoy the recreational area and recreation center, perfect for leisure and fun. Nature walks provide a chance to explore the beautiful surroundings, while the former mansion adds a touch of history to your visit. Experience the charm and local culture as you explore this vibrant community in Mexicali, Baja California.

Shopping

In Santa Isabel, enjoy local shops and markets for unique souvenirs and gifts. If you're up for a drive, visit Plaza Cachanilla, located 10 miles away, featuring a mix of retail stores, dining options, and entertainment. It's a great spot for shopping and experiencing local culture.

Recreation

In Santa Isabel, indulge in rejuvenating therapies at local wellness retreats, where holistic treatments blend with serene desert landscapes. Enjoy yoga sessions and guided meditations that connect you with nature, while nearby hiking trails offer invigorating outdoor activities for a refreshing escape from daily routines.

Adventure

Explore the stunning landscapes of Sierra de los Cucapah, perfect for hiking and mountain biking. Experience thrilling off-road adventures in the surrounding desert, or try your hand at rock climbing for a breathtaking view of the area. Don't miss the rich local culture and delicious cuisine.

Nightlife

In Santa Isabel, the vibrant nightlife offers lively bars and local music venues, perfect for soaking up the atmosphere. Grab a drink at a local cantina, enjoy live mariachi performances, or dance the night away at a nearby club, immersing yourself in the unique culture of Mexicali.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Santa Isabel

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Santa Isabel are July to September, where the prices are slightly lower. This is in comparison to February to March and May, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Santa Isabel is Sunday. The most expensive day to stay in Santa Isabel is Saturday.
  • Find cheap hotels on Expedia: Utilize Expedia’s search tool to narrow down your options based on your budget, preferred location, and desired hotel type. To find the best prices and deals, simply arrange the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your Santa Isabel hotel reservation with your flights and activities when you book an Expedia package.

Find the best attractions near Santa Isabel

Santa Isabel offers a delightful blend of family-friendly activities and outdoor adventures, making it perfect for a memorable vacation. Visitors can explore a variety of civic and historic buildings, as well as local museums that showcase the region's rich culture and history. Whether you're seeking a cultural experience or outdoor fun, Santa Isabel has something for everyone to enjoy.

  • Mexicali Border Port I: Experience the bustling atmosphere of Mexicali Border Port I, located a mere 5 miles from Santa Isabel. This civic site serves as a significant gateway between the U.S. and Mexico, showcasing the vibrant exchange of cultures and commerce.
  • Vicente Guerrero Park: Enjoy a family-friendly atmosphere at Vicente Guerrero Park, 6 miles away from Santa Isabel. This urban park is perfect for outdoor activities, offering lush landscapes and recreational facilities that invite relaxation and fun for all ages.
  • State Center for the Arts (CEART): Immerse yourself in the rich culture at the State Center for the Arts (CEART), located 5 miles from Santa Isabel. This arts center hosts various exhibitions and performances, celebrating local and international artistry in a stunning architectural setting.

The nearest major airports for your trip to Santa Isabel

Traveling to Santa Isabel, Mexicali, Baja California, offers multIPLe airport options. TIJuana International Airport (TIJ) is 82 miles away, with hotels like Real Inn Tijuana and Quartz Hotel & SPA, both just 3 miles from the airport. Mexicali International Airport (MXL) is much closer, located 19 miles from Santa Isabel, with nearby accommodations such as Courtyard by Marriott and Holiday Inn Express & Suites, approximately 9 to 10 miles away. Additionally, YUMa International Airport (YUM) is 57 miles away, featuring hotels like Radisson Hotel Yuma, located 3 miles from the airport. Each hotel provides various transportation services to facilitate your travel to these airports.

Frequently asked questions

What is the best area to stay in Santa Isabel?
The best area to stay in Santa Isabel is the city center, particularly around Avenida Reforma and Boulevard Benito Juárez.

This area is the commercial and administrative heart of Santa Isabel, offering a concentrated selection of hotels, restaurants, and shops. It's well-connected and provides easy access to the city's main public buildings and services. While not a tourist destination in itself, it's a practical base for travelers passing through or conducting business.

For solo travelers, staying in the city center provides convenience for dining and accessing transportation. You'll find a variety of local eateries and coffee shops within walking distance, making it easy to grab a meal or a quick coffee before heading out.

Business travelers will find the city center particularly suitable due to its proximity to government offices and corporate spaces.
When is the best time to go to Santa Isabel?
The best time to visit Santa Isabel is during the spring (March to May) and fall (September to November) months.

These seasons offer pleasant weather with comfortable temperatures and less humidity, making it ideal for exploring the area's natural beauty and enjoying outdoor activities. You'll find the climate just right for relaxing on the beaches or engaging in water sports without the intense heat of summer or the cooler temperatures of winter.

For couples looking for a tranquil getaway, these shoulder seasons provide a more relaxed experience with fewer crowds. You can enjoy quiet walks along the coastline, explore local eateries, and take in the scenic views without feeling rushed. It's an excellent time for those who appreciate a calm and unhurried vacation pace.

Travelers interested in outdoor adventures will also find these times perfect. The conditions are favorable for activities like fishing, kayaking, or simply enjoying the ocean breeze.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Santa Isabel.
How can I save on a Santa Isabel hotel booking with Expedia?
With Expedia, you earn OneKeyCash™* on eligible Santa Isabel hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Santa Isabel hotel?
Prices for hotels in Santa Isabel often vary, but you can find a great deal from $40 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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