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Find hotels in Santee, NE from $126

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Sep 30 - Oct 1
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Oct 1 - Oct 2
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Oct 2 - Oct 4
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Our top choices for Santee hotels

A spacious kitchen with a large island, modern pendant lights, and a ceiling fan.
A modern kitchen with stainless steel appliances, dark wood cabinets, and a tiled floor.
A modern kitchen with dark cabinets, stainless steel appliances, and a large window.
Two people sitting on Adirondack chairs facing a lake, with picnic tables and benches in the background.

1. Lewis and Clark Resort

Lewis and Clark Resort
Yankton
United States
Jeff
$119 nightly
$126 total
Oct 1 - Oct 2
Total with taxes and fees
Lewis and Clark Resort
A hotel lobby with a reception desk, seating area, and a large window with a view of a building.
A hotel reception area with a long counter, coffee machines, and a television screen displaying a program.
A spa area with a hot tub, seating, and a view of the parking lot.
A hotel room with two beds, a desk, a chair, and a framed picture on the wall.

2. Comfort Inn Yankton SD

Comfort Inn Yankton SD
Yankton
United States
Vanessa
$95 nightly
$105 total
Oct 25 - Oct 26
Total with taxes and fees
Comfort Inn Yankton SD
A wooden cabin interior with a spiral staircase, a dining area, a living room with a sofa, and a kitchen.
A wooden cabin with a loft bedroom, a staircase, and a view of the outside.
A wooden interior with a hallway leading to a bedroom, a chevron-patterned wall art, and a ceiling light.
A building with a green roof, a sign reading 'Northwood Nest,' outdoor seating with wooden chairs, and a picnic table.

3. Family-friendly log cabin style house by Lewis & Clark Lake at DJ's Resort

Family-friendly log cabin style house by Lewis & Clark Lake at DJ's Resort
Yankton
United States
Linda
Family-friendly log cabin style house by Lewis & Clark Lake at DJ's Resort
A grand staircase with wooden railings and a red flag, leading to a room with a patterned ceiling and string lights.
A bedroom with a bed, bedside table, lamp, and a window with blinds.
A neatly made bed with a patterned bedspread and pillows, a bedside lamp, and a window with closed blinds.
A bed with a metal headboard, two pillows, a bedside table with a lamp, and a window with curtains.

4. The Historic Argo Hotel

The Historic Argo Hotel
Crofton
United States
Deborah
$168 nightly
$188 total
Oct 30 - Oct 31
Total with taxes and fees
The Historic Argo Hotel
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Stay near popular attractions around Santee

Nestled in the heart of nature, Santee offers a perfect escape for outdoor enthusiasts and romance seekers alike. With stunning parks, serene lakes, and breathtaking scenery, you'll find countless opportunities for family adventures and eco-friendly experiences that create lasting memories.

Niobrara State Park

10.0/10 (3 reviews)
Ideal for outdoor enthusiasts, Niobrara State Park offers breathtaking scenery and adventure in a serene setting. Located about 12 miles from Santee, this park is perfect for exploring nature while providing easy access to nearby attractions, making it a convenient base for your vacation.
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Lewis and Clark Lake

9.2/10 (57 reviews)
Experience the best of outdoor adventure at Lewis and Clark Lake, a scenic destination perfect for couples and families alike. Enjoy the romantic atmosphere, breathtaking views, and beach vibes that make this lake a must-visit. Located about 7 miles from Santee, it offers convenient access for a memorable getaway.
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Bloomfield Recreation Area

Ideal for families seeking outdoor adventures, Bloomfield Recreation Area offers a serene setting with eco-friendly vibes. Located about 11 miles from Santee, this park features lush landscapes and recreational opportunities. Staying nearby provides easy access to a peaceful retreat for nature lovers.
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Pebble Beach

No trip is complete without a visit to Pebble Beach, a perfect spot for families seeking a relaxing day by the water. With its inviting beach vibes, this destination offers a unique experience for those looking to unwind. Located about 13 miles from Santee, it’s an easy excursion that enhances your stay in the area.
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Sioux Council Boy Scout Reservation

Discover the appeal of this family-friendly park, the Sioux Council Boy Scout Reservation, located in Tabor, South Dakota. Known for its outdoor and eco-friendly vibes, it offers a perfect setting for nature lovers. Situated about 13 miles from Santee, it's a convenient stop for a refreshing getaway.
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Lesterville Recreation Area

For families seeking outdoor adventures, Lesterville Recreation Area offers a picturesque escape with its eco-friendly vibes and ample recreational opportunities. Situated about 14 miles from Santee, this park is perfect for enjoying nature and creating lasting memories, making it a convenient choice for your getaway.
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Top Santee Hotel Reviews

Lewis and Clark Resort

Lewis and Clark Resort

8/10 Good
"Facilities are nothing special, paint over spray on shower, trim. Towels must be 10 yrs old or older, but clean. Just not anything special."
Douglas 3-night trip
Posted 3 days ago
Lewis and Clark Resort
Haven by the Lake

Haven by the Lake

10/10 Excellent
"My children and grandchildren enjoyed the stay. Grandchildren wanted to know when they could come back to stay again. They especially loved watching the turkeys and even got close enough to get a picture of a young buck deer."
Ann K. 2-night trip
Posted 3 days ago
Haven by the Lake
Newly Remodeled Creekside Bungalow on 3 acres with Private Beach Beside Creek

Newly Remodeled Creekside Bungalow on 3 acres with Private Beach Beside Creek

10/10 Excellent
"Very nice and very clean house. Everything is just as it's described. Would highly recommend!"
Chad W. 2-night trip
Posted 10 days ago
Newly Remodeled Creekside Bungalow on 3 acres with Private Beach Beside Creek
Charming Lake House within Walking Distance from Lake

Charming Lake House within Walking Distance from Lake

10/10 Excellent
"It was a great place to stay , it was nice the kids had their own area to hang out"
Eugenia D. 3-night trip
Posted 3 weeks ago
Charming Lake House within Walking Distance from Lake
Hunters & outdoor lovers charming 4-bedrm house - best Lewis & Clark lake view!

Hunters & outdoor lovers charming 4-bedrm house - best Lewis & Clark lake view!

10/10 Excellent
"The location was perfect and absolutely beautiful. The floor plan is great having the two living rooms and kitchens. We had trucks with trailers and plenty of room to turn around and park. It did seem like they were in the middle of some remodel projects. It was not a big deal but somewhat strange. We did get two different answers regarding having extra family coming to the property but not staying the night, we were also unsure on how many were going to be joining. We will definitely return to this home. It has a welcome home feeling. To be expected the bugs and spiders, we did a quick clean around the doors and wipe down when we got there. The outside cameras were no big deal for us and extra security for our toys."
patricia f. 4-night trip
Posted 3 weeks ago
Hunters & outdoor lovers charming 4-bedrm house - best Lewis & Clark lake view!
Modern Lewis and Clark lake home with lake views and 3 min drive to the beach!

Modern Lewis and Clark lake home with lake views and 3 min drive to the beach!

10/10 Excellent
"Everything was great!"
Brenna J. 3-night trip
Posted 3 weeks ago
Modern Lewis and Clark lake home with lake views and 3 min drive to the beach!
Fully furnished lake house with cozy spaces, full kitchen, and lake views.

Fully furnished lake house with cozy spaces, full kitchen, and lake views.

10/10 Excellent
"Great location to host our company retreat! The house was spacious and offered plenty of room. Appreciated all the outdoor chairs available to use. We enjoyed sitting around the outdoor firepit at night."
Katie K. 3-night trip
Posted 3 weeks ago
Fully furnished lake house with cozy spaces, full kitchen, and lake views.
Retreat near the Lake and State Parks of Yankton

Retreat near the Lake and State Parks of Yankton

10/10 Excellent
"."
Andrea S. 3-night trip
Posted 3 weeks ago
Retreat near the Lake and State Parks of Yankton
Lewis and Clark Lake Home/Loft for Rent/Lake View Property and Lake Access

Lewis and Clark Lake Home/Loft for Rent/Lake View Property and Lake Access

10/10 Excellent
"The view is worth it alone. The space great for all to be together. Well equipped. The location for us worked great! We hope to be back."
karla s. 3-night trip
Posted 3 weeks ago
Lewis and Clark Lake Home/Loft for Rent/Lake View Property and Lake Access

More cheap stays in Santee

Lewis and Clark Resort

Lewis and Clark Resort

43496 Shore Drive Yankton SD
$119 nightly
$126 total
Oct 1 - Oct 2
Total with taxes and fees
8.8/10 Excellent! (348 reviews)
Lewis and Clark Resort

Hotels in Santee with star-rating

Frequently asked questions

What is the best area to stay in Santee?
The best area to stay in Santee is within the main part of the village, particularly near the Santee Sioux Nation's Ohiya Casino & Resort. This area serves as the primary hub for visitor amenities and activities.The Ohiya Casino & Resort is the focal point of the village, offering lodging, dining, and entertainment options. It's located just off Highway 12, making it easily accessible. This area is convenient for solo travelers and couples looking for entertainment and comfortable accommodations in a central location.For visitors interested in the cultural aspects of the Santee Sioux Nation, staying near the casino and resort allows easy access to tribal events and community gatherings that are often held in the vicinity.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Santee.
How much is the nightly rate at a Santee hotel?
Prices for hotels in Santee often vary, but you can find a great deal from $126 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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