$627 Cheap Brussels Airlines flights Boston (BOS) to Samos (SMI)

Scoring cheap one-way Brussels Airlines flights from BOS to SMI from $627 on Expedia couldn't be easier --- just filter by "Price (lowest to highest)." Alternatively, check out our affordable return fares from $849 for your next break.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

To find affordable flights from BOS to SMI with Brussels Airlines, begin searching about one month before your planned departure. You can save 17% when you lock in your international tickets 18 to 29 days ahead instead of booking four to five months in advance. Another good tip? Booking on Sunday offers average savings of 17% compared to Friday (the most expensive day).**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Sort your results by "Early Morning" and "Morning" to see the earliest flights from BOS to SMI. Leaving early means you're less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.

With a rewarding loyalty program, Brussels Airlines is a top pick for many passengers journeying from BOS to SMI. Plus, if you're a Miles and More and One Key™ member booking through Expedia, you can earn OneKeyCash™* on eligible flights on top of your airline miles.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.