$358 Cheap Flights from Brussels (BRU) to Panama City (PTY)

View $358 flight on Tue, Oct 14, 2025Opens in a new window

Popular airlines from Brussels Airport (BRU) to Tocumen Intl. Airport (PTY)

Cheap Flights from Brussels to Panama City (BRU-PTY)

Prices were available within the past 7 days and start at $358 for one-way flights and $655 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Air Europa
Tue, Oct 14 - Tue, Nov 18
BRU
Brussels
PTY
Panama City
$655 Roundtrip, found 2 days ago
$655
Roundtrip
found 2 days ago
Select Air Europa flight, departing Tue, Oct 14 from Brussels to Panama City, returning Tue, Nov 18, priced at $655 found 2 days ago
Air Europa
Thu, Nov 13 - Mon, Nov 17
BRU
Brussels
PTY
Panama City
$658 Roundtrip, found 13 hours ago
$658
Roundtrip
found 13 hours ago
Select Air Europa flight, departing Thu, Nov 13 from Brussels to Panama City, returning Mon, Nov 17, priced at $658 found 13 hours ago
Air Europa
Tue, Oct 14 - Tue, Nov 18
BRU
Brussels
PTY
Panama City
$663 Roundtrip, found 2 days ago
$663
Roundtrip
found 2 days ago
Select Air Europa flight, departing Tue, Oct 14 from Brussels to Panama City, returning Tue, Nov 18, priced at $663 found 2 days ago
Air Europa
Thu, Nov 13 - Mon, Nov 17
BRU
Brussels
PTY
Panama City
$666 Roundtrip, found 13 hours ago
$666
Roundtrip
found 13 hours ago
Select Air Europa flight, departing Thu, Nov 13 from Brussels to Panama City, returning Mon, Nov 17, priced at $666 found 13 hours ago
Air Europa
Thu, Nov 13 - Mon, Nov 17
BRU
Brussels
PTY
Panama City
$668 Roundtrip, found 13 hours ago
$668
Roundtrip
found 13 hours ago
Select Air Europa flight, departing Thu, Nov 13 from Brussels to Panama City, returning Mon, Nov 17, priced at $668 found 13 hours ago
Air Europa
Tue, Oct 14 - Tue, Nov 18
BRU
Brussels
PTY
Panama City
$674 Roundtrip, found 2 days ago
$674
Roundtrip
found 2 days ago
Select Air Europa flight, departing Tue, Oct 14 from Brussels to Panama City, returning Tue, Nov 18, priced at $674 found 2 days ago
Brussels Airlines
Sun, Dec 14 - Wed, Dec 31
BRU
Brussels
PTY
Panama City
$678 Roundtrip, found 6 hours ago
$678
Roundtrip
found 6 hours ago
Select Brussels Airlines flight, departing Sun, Dec 14 from Brussels to Panama City, returning Wed, Dec 31, priced at $678 found 6 hours ago
United
Wed, Oct 8 - Sat, Oct 18
BRU
Brussels
PTY
Panama City
$696 Roundtrip, found 22 hours ago
$696
Roundtrip
found 22 hours ago
Select United flight, departing Wed, Oct 8 from Brussels to Panama City, returning Sat, Oct 18, priced at $696 found 22 hours ago
Iberia
Mon, Mar 2 - Mon, Mar 9
BRU
Brussels
PTY
Panama City
$703 Roundtrip, found 2 days ago
$703
Roundtrip
found 2 days ago
Select Iberia flight, departing Mon, Mar 2 from Brussels to Panama City, returning Mon, Mar 9, priced at $703 found 2 days ago
Turkish Airlines
Mon, Mar 2 - Mon, Mar 9
BRU
Brussels
PTY
Panama City
$1,015 Roundtrip, found 2 days ago
$1,015
Roundtrip
found 2 days ago
Select Turkish Airlines flight, departing Mon, Mar 2 from Brussels to Panama City, returning Mon, Mar 9, priced at $1,015 found 2 days ago
Flights from Brussels (BRU) to Panama City (PTY)
Origin airport
Brussels - National
Destination airport
Tocumen Intl.
Airlines serving
Air Europa, American Airlines, British Airways, Delta, Iberia, KLM, Turkish Airlines, United
Roundtrip price
$655
Distance
5466 mi

Brussels to Panama City Flights

The cheapest times to fly from Brussels to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Brussels to Panama City are during the month of October. You can find some of the cheapest flights from Brussels to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Brussels to Panama City

Sunday is one of the best days to book for cheap flights from Brussels to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Brussels to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Brussels to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $358 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Brussels to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Brussels to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Brussels - National Airport (BRU) to Tocumen Intl. Airport (PTY) cost?
Get a cheap one-way flight from $358 or cheap return flight from $655 from Brussels - National Airport (BRU) to Tocumen Intl. Airport (PTY) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Brussels - National Airport (BRU) to Tocumen Intl. Airport (PTY)?
Planning your getaway for October is a great way to save, as it's the cheapest month for flights between BRU and PTY. You'll usually find the lowest fares during the off-season.
What is the cheapest airline that flies from Brussels - National Airport (BRU) to Tocumen Intl. Airport (PTY)?
Expedia's filter tool lets you easily compare travel time, airlines and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest BRU to PTY flight.
How many flights per day from Brussels - National Airport (BRU) to Tocumen Intl. Airport (PTY)?
You'll need to take a flight with a layover if you're traveling from Brussels - National Airport (BRU) to Tocumen Intl. Airport (PTY). Direct flights don't operate daily on this route. However, simply filter your search to include one or more stops to discover an option that works for you.
What day of the week has the most flights from BRU to PTY?
You'll usually find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can vary from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Brussels - National Airport (BRU) to Tocumen Intl. Airport (PTY)?
To avoid possible delays on the Brussels - National Airport (BRU) to Tocumen Intl. Airport (PTY) route, aim to travel before 3 PM. Flights after this time have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Brussels - National Airport (BRU) to Tocumen Intl. Airport (PTY) last-minute?
Last-minute bookings from BRU to PTY are typically more expensive. To lock in the best prices, start looking for flights well ahead of time. That said, if you can play around with your travel dates, it's possible to land a cheap ticket right before your trip.
Is it cheaper to book a BRU to PTY flight and hotel package?
Compared with arranging flights and hotels separately, booking a BRU to PTY flight and hotel package with Expedia could result in significant savings. Better yet, having everything in one convenient place will take the stress out of planning your trip. Just secure your flights and select from our extensive range of stays, then tailor your trip with extras like tours, activities and car rentals.
Can I cancel or change the date of my flight from Brussels - National Airport (BRU) to Tocumen Intl. Airport (PTY)?
It's generally possible to cancel or reschedule your BRU to PTY flight. However, for bookings made more than 24 hours ago, additional charges may apply. Refer to your airline's policies in your itinerary to see what changes are allowed and whether any costs are involved. You'll also find more details on our Customer Service portal.

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*Available to One Key members.