$558 Cheap Flights from Des Moines (DSM) to São Paulo (GRU)

View $558 flight on Mon, Dec 29, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to São Paulo/Guarulhos Intl. Airport

Cheap Flights from Des Moines to São Paulo (DSM-GRU)

Prices were available within the past 7 days and start at $558 for one-way flights and $1,044 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Mon, Dec 29 - Wed, Jan 21
DSM
Des Moines
GRU
Sao Paulo
$1,044 Roundtrip, found 11 hours ago
$1,044
Roundtrip
found 11 hours ago
Select American Airlines flight, departing Mon, Dec 29 from Des Moines to Sao Paulo, returning Wed, Jan 21, priced at $1,044 found 11 hours ago
United
Mon, Dec 29 - Wed, Jan 21
DSM
Des Moines
GRU
Sao Paulo
$1,044 Roundtrip, found 11 hours ago
$1,044
Roundtrip
found 11 hours ago
Select United flight, departing Mon, Dec 29 from Des Moines to Sao Paulo, returning Wed, Jan 21, priced at $1,044 found 11 hours ago
United
Sun, Jan 25 - Tue, Feb 3
DSM
Des Moines
GRU
Sao Paulo
$1,047 Roundtrip, found 6 days ago
$1,047
Roundtrip
found 6 days ago
Select United flight, departing Sun, Jan 25 from Des Moines to Sao Paulo, returning Tue, Feb 3, priced at $1,047 found 6 days ago
Delta
Sun, Jan 11 - Tue, Jan 20
DSM
Des Moines
GRU
Sao Paulo
$1,050 Roundtrip, found 6 days ago
$1,050
Roundtrip
found 6 days ago
Select Delta flight, departing Sun, Jan 11 from Des Moines to Sao Paulo, returning Tue, Jan 20, priced at $1,050 found 6 days ago
Delta
Wed, Dec 24 - Wed, Jan 14
DSM
Des Moines
GRU
Sao Paulo
$1,054 Roundtrip, found 6 days ago
$1,054
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, Dec 24 from Des Moines to Sao Paulo, returning Wed, Jan 14, priced at $1,054 found 6 days ago
LATAM Airlines Group
Mon, Dec 29 - Wed, Jan 21
DSM
Des Moines
GRU
Sao Paulo
$1,065 Roundtrip, found 11 hours ago
$1,065
Roundtrip
found 11 hours ago
Select LATAM Airlines Group flight, departing Mon, Dec 29 from Des Moines to Sao Paulo, returning Wed, Jan 21, priced at $1,065 found 11 hours ago
United
Mon, Dec 29 - Wed, Jan 21
DSM
Des Moines
GRU
Sao Paulo
$1,070 Roundtrip, found 11 hours ago
$1,070
Roundtrip
found 11 hours ago
Select United flight, departing Mon, Dec 29 from Des Moines to Sao Paulo, returning Wed, Jan 21, priced at $1,070 found 11 hours ago
LATAM Airlines Group
Thu, Dec 25 - Mon, Jan 12
DSM
Des Moines
GRU
Sao Paulo
$1,071 Roundtrip, found 5 days ago
$1,071
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Thu, Dec 25 from Des Moines to Sao Paulo, returning Mon, Jan 12, priced at $1,071 found 5 days ago
American Airlines
Mon, Dec 29 - Wed, Jan 21
DSM
Des Moines
GRU
Sao Paulo
$1,074 Roundtrip, found 11 hours ago
$1,074
Roundtrip
found 11 hours ago
Select American Airlines flight, departing Mon, Dec 29 from Des Moines to Sao Paulo, returning Wed, Jan 21, priced at $1,074 found 11 hours ago
Copa
Fri, Oct 3 - Wed, Oct 29
DSM
Des Moines
GRU
Sao Paulo
$1,154 Roundtrip, found 2 days ago
$1,154
Roundtrip
found 2 days ago
Select Copa flight, departing Fri, Oct 3 from Des Moines to Sao Paulo, returning Wed, Oct 29, priced at $1,154 found 2 days ago

Alternative airports near São Paulo

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Guarulhos - Governor Andre Franco Montoro Intl. GRU. Cheapest option available. Average driving time to city center is 22 minutes. Flights from $1,403
GRU
Guarulhos - Governor Andre Franco Montoro Intl.
Cheapest
Average driving time to city center22 min
Flights from $1,403
Flights from Des Moines (DSM) to São Paulo (GRU)
Origin airport
Des Moines Intl.
Destination airport
Guarulhos - Governor André Franco Montoro Intl.
Airlines serving
Air Canada, LATAM Airlines Group
Roundtrip price
$1,044
Distance
5407 mi

Des Moines to São Paulo Flights

The cheapest times to fly from Des Moines to São Paulo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to São Paulo are during the month of December. You can find some of the cheapest flights from Des Moines to São Paulo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to São Paulo

Sunday is one of the best days to book for cheap flights from Des Moines to São Paulo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to São Paulo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to São Paulo in 2025. You can also book with separate airlines for your outbound and return journeys, from $558 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to São Paulo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to São Paulo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Guarulhos - Governor Andre Franco Montoro Intl. Airport (GRU) cost?
Get a cheap one-way flight from $558 or cheap return flight from $1,044 from Des Moines Intl. Airport (DSM) to Guarulhos - Governor Andre Franco Montoro Intl. Airport (GRU) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Guarulhos - Governor Andre Franco Montoro Intl. Airport (GRU)?
December is the cheapest month to fly from DSM to GRU. Timing your trip outside of the busy season is often the key to better flight prices.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Guarulhos - Governor Andre Franco Montoro Intl. Airport (GRU)?
To find the cheapest airline that'll fly you from DSM to GRU, use Expedia's filter tool. Tailor your search based on your travel needs, such as preferred carriers and ideal departure window. You can then sort your results by "Price (lowest to highest)" to discover the cheapest flight right away.
How many flights per day from Des Moines Intl. Airport (DSM) to Guarulhos - Governor Andre Franco Montoro Intl. Airport (GRU)?
There are no daily direct flights departing from Des Moines Intl. Airport (DSM) to Guarulhos - Governor Andre Franco Montoro Intl. Airport (GRU). But you can choose flights with layovers. Filter your search results on Expedia to include one or more stops, and you'll be on your way before you know it.
What day of the week has the most flights from DSM to GRU?
Friday is typically the busiest day for flights, while Tuesday is often the quietest.* Keep in mind that flight schedules can change depending on various factors, such as the airline and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Guarulhos - Governor Andre Franco Montoro Intl. Airport (GRU)?
To reach Guarulhos - Governor Andre Franco Montoro Intl. Airport (GRU) without delays, opt for a flight that leaves Des Moines Intl. Airport (DSM) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Guarulhos - Governor Andre Franco Montoro Intl. Airport (GRU) last-minute?
Waiting until right before your break to book a ticket from DSM to GRU often results in higher prices. While you might find some last-minute deals, they're not always guaranteed. Be flexible with your itinerary to maximize your chances of scoring a bargain.
Is it cheaper to book a DSM to GRU flight and hotel package?
You can save money by securing a DSM to GRU flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage it all in one place. After selecting your preferred accommodations and flights, you can add extras such as car rentals, tours and activities.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Guarulhos - Governor Andre Franco Montoro Intl. Airport (GRU)?
Typically, you're able to cancel or reschedule your DSM to GRU flight. However, there may be additional charges, especially if your booking was made over 24 hours ago. Double-check your itinerary for the airline's guidelines and fees on flight changes, or if you want more details, go to our Customer Service portal.

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*Available to One Key members.