$524 Cheap Flights from Des Moines (DSM) to Southampton (SOU)

View $524 flight on Sun, Oct 19, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Southampton (SOU)

Cheap Flights from Des Moines to Southampton (DSM-SOU)

Prices were available within the past 7 days and start at $524 for one-way flights and $1,035 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Air France
Wed, May 6 - Sat, May 16
DSM
Des Moines
SOU
Southampton
$1,035 Roundtrip, found 15 hours ago
$1,035
Roundtrip
found 15 hours ago
Select Air France flight, departing Wed, May 6 from Des Moines to Southampton, returning Sat, May 16, priced at $1,035 found 15 hours ago
Air France
Wed, May 6 - Sat, May 16
DSM
Des Moines
SOU
Southampton
$1,061 Roundtrip, found 15 hours ago
$1,061
Roundtrip
found 15 hours ago
Select Air France flight, departing Wed, May 6 from Des Moines to Southampton, returning Sat, May 16, priced at $1,061 found 15 hours ago
Delta
Wed, May 6 - Sat, May 16
DSM
Des Moines
SOU
Southampton
$1,144 Roundtrip, found 15 hours ago
$1,144
Roundtrip
found 15 hours ago
Select Delta flight, departing Wed, May 6 from Des Moines to Southampton, returning Sat, May 16, priced at $1,144 found 15 hours ago
Delta
Wed, May 6 - Sat, May 16
DSM
Des Moines
SOU
Southampton
$1,150 Roundtrip, found 15 hours ago
$1,150
Roundtrip
found 15 hours ago
Select Delta flight, departing Wed, May 6 from Des Moines to Southampton, returning Sat, May 16, priced at $1,150 found 15 hours ago
Air France
Wed, May 6 - Sat, May 16
DSM
Des Moines
SOU
Southampton
$1,153 Roundtrip, found 15 hours ago
$1,153
Roundtrip
found 15 hours ago
Select Air France flight, departing Wed, May 6 from Des Moines to Southampton, returning Sat, May 16, priced at $1,153 found 15 hours ago
Delta
Wed, May 6 - Sat, May 16
DSM
Des Moines
SOU
Southampton
$1,170 Roundtrip, found 15 hours ago
$1,170
Roundtrip
found 15 hours ago
Select Delta flight, departing Wed, May 6 from Des Moines to Southampton, returning Sat, May 16, priced at $1,170 found 15 hours ago
Delta
Wed, May 6 - Sat, May 16
DSM
Des Moines
SOU
Southampton
$1,176 Roundtrip, found 15 hours ago
$1,176
Roundtrip
found 15 hours ago
Select Delta flight, departing Wed, May 6 from Des Moines to Southampton, returning Sat, May 16, priced at $1,176 found 15 hours ago
United
Thu, May 7 - Sun, May 17
DSM
Des Moines
SOU
Southampton
$1,245 Roundtrip, found 15 hours ago
$1,245
Roundtrip
found 15 hours ago
Select United flight, departing Thu, May 7 from Des Moines to Southampton, returning Sun, May 17, priced at $1,245 found 15 hours ago
KLM
Wed, May 6 - Sat, May 16
DSM
Des Moines
SOU
Southampton
$1,450 Roundtrip, found 15 hours ago
$1,450
Roundtrip
found 15 hours ago
Select KLM flight, departing Wed, May 6 from Des Moines to Southampton, returning Sat, May 16, priced at $1,450 found 15 hours ago
Aer Lingus
Wed, May 6 - Sat, May 16
DSM
Des Moines
SOU
Southampton
$1,494 Roundtrip, found 15 hours ago
$1,494
Roundtrip
found 15 hours ago
Select Aer Lingus flight, departing Wed, May 6 from Des Moines to Southampton, returning Sat, May 16, priced at $1,494 found 15 hours ago
Flights from Des Moines (DSM) to Southampton (SOU)
Origin airport
Des Moines Intl.
Destination airport
Southampton
Airlines serving
Aer Lingus, Delta, KLM, Virgin Atlantic
Roundtrip price
$1,034
Distance
4163 mi

Des Moines to Southampton Flights

The cheapest times to fly from Des Moines to Southampton

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Southampton are during the month of May. You can find some of the cheapest flights from Des Moines to Southampton with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Southampton

Sunday is one of the best days to book for cheap flights from Des Moines to Southampton: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Southampton

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Southampton in 2025. You can also book with separate airlines for your outbound and return journeys, from $524 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Southampton flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Southampton airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Southampton Airport (SOU) cost?
Lock in a cheap one-way flight from $524 or cheap return flight from $1,035 from Des Moines Intl. Airport (DSM) to Southampton Airport (SOU) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Southampton Airport (SOU)?
The cheapest month to fly from DSM to SOU is May, when there's less demand. Off-peak months are typically when airlines offer lower prices between these airports.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Southampton Airport (SOU)?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll fly you from DSM to SOU. Then, sort your results by "Price (lowest to highest)" to pick up a good deal.
How many flights per day from Des Moines Intl. Airport (DSM) to Southampton Airport (SOU)?
Direct flights from Des Moines Intl. Airport (DSM) to Southampton Airport (SOU) aren't available daily, so you'll need to take a flight with a layover. Explore your options with our filter tool. Enter your travel details and pick either "1 Stop" or "2+ Stops."
What day of the week has the most flights from DSM to SOU?
You'll usually find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Southampton Airport (SOU)?
Book a flight from Des Moines Intl. Airport (DSM) to Southampton Airport (SOU) that leaves before 3 PM to reduce the risk of delays and cancellations. Departures later than this have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Southampton Airport (SOU) last-minute?
Waiting until just before your departure to book a flight from DSM to SOU often results in higher prices. Although you may find some last-minute discounts, there's no guarantee. Keep your travel schedule open to boost your chances of getting a bargain.
Is it cheaper to book a DSM to SOU flight and hotel package?
Securing a DSM to SOU flight and hotel package is generally cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Pick from our impressive range of accommodations and then add flights, car rentals and activities to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Southampton Airport (SOU)?
In most instances, you can modify or cancel your DSM to SOU flight. However, additional fees may apply, especially if you booked more than 24 hours ago. Double-check your itinerary for the airline's fees and policies on flight changes, or if you need more information, go to our Customer Service portal.

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*Available to One Key members.