$276 Cheap Flights from Guayaquil (GYE) to Santiago (STI)

View $276 flight on Thu, Feb 5, 2026Opens in a new window

Popular airlines from Jose Joaquin de Olmedo Intl. Airport (GYE) to Cibao Intl. Airport (STI)

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Cheap Flights from Guayaquil to Santiago (GYE-STI)

Prices were available within the past 7 days and start at $276 for one-way flights and $473 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Mon, Feb 9 - Sat, Feb 14
GYE
Guayaquil
STI
Santiago de los Caballeros
$473 Roundtrip, found 2 days ago
$473
Roundtrip
found 2 days ago
Select Copa flight, departing Mon, Feb 9 from Guayaquil to Santiago de los Caballeros, returning Sat, Feb 14, priced at $473 found 2 days ago
Copa
Thu, Jan 29 - Sat, Feb 14
GYE
Guayaquil
STI
Santiago de los Caballeros
$485 Roundtrip, found 5 days ago
$485
Roundtrip
found 5 days ago
Select Copa flight, departing Thu, Jan 29 from Guayaquil to Santiago de los Caballeros, returning Sat, Feb 14, priced at $485 found 5 days ago
Copa
Wed, Jan 28 - Sat, Feb 14
GYE
Guayaquil
STI
Santiago de los Caballeros
$507 Roundtrip, found 5 days ago
$507
Roundtrip
found 5 days ago
Select Copa flight, departing Wed, Jan 28 from Guayaquil to Santiago de los Caballeros, returning Sat, Feb 14, priced at $507 found 5 days ago
JetBlue Airways
Mon, Jan 26 - Tue, Feb 10
GYE
Guayaquil
STI
Santiago de los Caballeros
$516 Roundtrip, found 5 days ago
$516
Roundtrip
found 5 days ago
Select JetBlue Airways flight, departing Mon, Jan 26 from Guayaquil to Santiago de los Caballeros, returning Tue, Feb 10, priced at $516 found 5 days ago
Copa
Mon, Feb 9 - Thu, Feb 19
GYE
Guayaquil
STI
Santiago de los Caballeros
$519 Roundtrip, found 2 days ago
$519
Roundtrip
found 2 days ago
Select Copa flight, departing Mon, Feb 9 from Guayaquil to Santiago de los Caballeros, returning Thu, Feb 19, priced at $519 found 2 days ago
JetBlue Airways
Tue, Jan 20 - Fri, Feb 6
GYE
Guayaquil
STI
Santiago de los Caballeros
$529 Roundtrip, found 5 days ago
$529
Roundtrip
found 5 days ago
Select JetBlue Airways flight, departing Tue, Jan 20 from Guayaquil to Santiago de los Caballeros, returning Fri, Feb 6, priced at $529 found 5 days ago
Copa
Thu, Feb 5 - Sat, Feb 14
GYE
Guayaquil
STI
Santiago de los Caballeros
$531 Roundtrip, found 4 days ago
$531
Roundtrip
found 4 days ago
Select Copa flight, departing Thu, Feb 5 from Guayaquil to Santiago de los Caballeros, returning Sat, Feb 14, priced at $531 found 4 days ago
Copa
Fri, Jan 16 - Mon, Feb 2
GYE
Guayaquil
STI
Santiago de los Caballeros
$537 Roundtrip, found 5 days ago
$537
Roundtrip
found 5 days ago
Select Copa flight, departing Fri, Jan 16 from Guayaquil to Santiago de los Caballeros, returning Mon, Feb 2, priced at $537 found 5 days ago
Copa
Sun, Mar 22 - Thu, Mar 26
GYE
Guayaquil
STI
Santiago de los Caballeros
$541 Roundtrip, found 3 days ago
$541
Roundtrip
found 3 days ago
Select Copa flight, departing Sun, Mar 22 from Guayaquil to Santiago de los Caballeros, returning Thu, Mar 26, priced at $541 found 3 days ago
American Airlines
Wed, Mar 18 - Sat, Apr 4
GYE
Guayaquil
STI
Santiago de los Caballeros
$1,154 Roundtrip, found 7 hours ago
$1,154
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Wed, Mar 18 from Guayaquil to Santiago de los Caballeros, returning Sat, Apr 4, priced at $1,154 found 7 hours ago

Find the cheapest month to fly from Guayaquil (GYE) to Santiago de los Caballeros (STI)

November is typically the cheapest month to fly

From $450 - $1,392 per traveler.

Alternative airports near Santiago de los Caballeros

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Gregorio Luperon Intl. POP. Average driving time to city center is 59 minutes. Flights from $1,041
POP
Gregorio Luperon Intl.
Average driving time to city center59 min
Flights from $1,041

Frequently asked questions

How much does a flight from Jose Joaquin de Olmedo Intl. Airport (GYE) to Cibao Intl. Airport (STI) cost?
Lock in a cheap one-way flight from $276 or cheap return flight from $473 from Jose Joaquin de Olmedo Intl. Airport (GYE) to Cibao Intl. Airport (STI) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Jose Joaquin de Olmedo Intl. Airport (GYE) to Cibao Intl. Airport (STI)?
February is the most affordable month to fly from GYE to STI. Traveling during an off-peak travel window is often the key to scoring lower fares.
What is the cheapest airline that flies from Jose Joaquin de Olmedo Intl. Airport (GYE) to Cibao Intl. Airport (STI)?
To find the cheapest airline flying from GYE to STI, use Expedia's filter tool. Tailor your search based on what's important to you, such as preferred carriers and flight duration. You can then sort your results by "Price (lowest to highest)" to see the most affordable options first.
How many flights per day from Jose Joaquin de Olmedo Intl. Airport (GYE) to Cibao Intl. Airport (STI)?
Direct flights from Jose Joaquin de Olmedo Intl. Airport (GYE) to Cibao Intl. Airport (STI) aren't available daily, so you'll have to take a flight with a layover. Explore your options with Expedia's filters. Enter your travel details and pick either "1 Stop" or "2+ Stops."
What day of the week has the most flights from GYE to STI?
You'll typically find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can change from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Jose Joaquin de Olmedo Intl. Airport (GYE) to Cibao Intl. Airport (STI)?
To land at Cibao Intl. Airport (STI) on time, book a flight that takes off from Jose Joaquin de Olmedo Intl. Airport (GYE) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Jose Joaquin de Olmedo Intl. Airport (GYE) to Cibao Intl. Airport (STI) last-minute?
Holding off until just before your trip to book a ticket from GYE to STI often results in higher prices. Although you may find some last-minute deals, they're not always guaranteed. Allow some flexibility in your schedule to maximize your chances of getting a bargain.
Is it cheaper to book a GYE to STI flight and hotel package?
Compared with arranging flights and hotels separately, booking a GYE to STI flight and hotel package with Expedia could result in significant savings. What's more, having everything in one place will take the stress out of travel planning. Just pick your flights and choose from our wide range of hotels, then personalize your trip with other add-ons like activities and car rentals.
Can I cancel or change the date of my flight from Jose Joaquin de Olmedo Intl. Airport (GYE) to Cibao Intl. Airport (STI)?
If you reserved your GYE to STI flight in the last 24 hours, you may be able to cancel or modify it at no cost. Depending on the airline and the ticket type you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for further details.

Travel information

Origin airport
Jose Joaquin de Olmedo Intl.
Destination airport
Cibao Intl.
Airlines serving
American Airlines, Copa, JetBlue Airways
Roundtrip price
$473
Distance
1616 mi

Book with confidence

Guayaquil to Santiago Flights

The cheapest times to fly from Guayaquil to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Guayaquil to Santiago are during the month of February. You can find some of the cheapest flights from Guayaquil to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Guayaquil to Santiago

Sunday is one of the best days to book for cheap flights from Guayaquil to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Guayaquil to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Guayaquil to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $276 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Guayaquil to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Guayaquil to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Guayaquil to Santiago Flights

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*Available to One Key members.