$159 Cheap Flights from Mayagüez (MAZ) to Santo Domingo (SDQ)

View $159 flight on Thu, Dec 4, 2025Opens in a new window

Popular airlines from Mayagüez (MAZ-Eugenio María de Hostos) to Las Americas Intl. Airport (SDQ)

Cheap Flights from Mayagüez to Santo Domingo (MAZ-SDQ)

Prices were available within the past 7 days and start at $159 for one-way flights and $326 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Cape Air
Sat, Nov 8 - Wed, Nov 12
MAZ
Mayagüez
SDQ
Santo Domingo
$326 Roundtrip, found 5 days ago
$326
Roundtrip
found 5 days ago
Select Cape Air flight, departing Sat, Nov 8 from Mayagüez to Santo Domingo, returning Wed, Nov 12, priced at $326 found 5 days ago
Cape Air
Sat, Nov 8 - Sat, Nov 15
MAZ
Mayagüez
SDQ
Santo Domingo
$336 Roundtrip, found 5 days ago
$336
Roundtrip
found 5 days ago
Select Cape Air flight, departing Sat, Nov 8 from Mayagüez to Santo Domingo, returning Sat, Nov 15, priced at $336 found 5 days ago
Cape Air
Sat, Nov 8 - Mon, Nov 10
MAZ
Mayagüez
SDQ
Santo Domingo
$346 Roundtrip, found 5 days ago
$346
Roundtrip
found 5 days ago
Select Cape Air flight, departing Sat, Nov 8 from Mayagüez to Santo Domingo, returning Mon, Nov 10, priced at $346 found 5 days ago
JetBlue Airways
Mon, Nov 10 - Thu, Nov 13
MAZ
Mayagüez
SDQ
Santo Domingo
$352 Roundtrip, found 5 days ago
$352
Roundtrip
found 5 days ago
Select JetBlue Airways flight, departing Mon, Nov 10 from Mayagüez to Santo Domingo, returning Thu, Nov 13, priced at $352 found 5 days ago
JetBlue Airways
Sun, Nov 9 - Tue, Nov 11
MAZ
Mayagüez
SDQ
Santo Domingo
$372 Roundtrip, found 5 days ago
$372
Roundtrip
found 5 days ago
Select JetBlue Airways flight, departing Sun, Nov 9 from Mayagüez to Santo Domingo, returning Tue, Nov 11, priced at $372 found 5 days ago
Cape Air
Fri, Nov 7 - Sat, Nov 15
MAZ
Mayagüez
SDQ
Santo Domingo
$401 Roundtrip, found 5 days ago
$401
Roundtrip
found 5 days ago
Select Cape Air flight, departing Fri, Nov 7 from Mayagüez to Santo Domingo, returning Sat, Nov 15, priced at $401 found 5 days ago
JetBlue Airways
Fri, Nov 7 - Mon, Nov 10
MAZ
Mayagüez
SDQ
Santo Domingo
$415 Roundtrip, found 5 days ago
$415
Roundtrip
found 5 days ago
Select JetBlue Airways flight, departing Fri, Nov 7 from Mayagüez to Santo Domingo, returning Mon, Nov 10, priced at $415 found 5 days ago
Cape Air
Fri, Nov 7 - Mon, Nov 17
MAZ
Mayagüez
SDQ
Santo Domingo
$421 Roundtrip, found 5 days ago
$421
Roundtrip
found 5 days ago
Select Cape Air flight, departing Fri, Nov 7 from Mayagüez to Santo Domingo, returning Mon, Nov 17, priced at $421 found 5 days ago
Cape Air
Fri, Nov 28 - Mon, Dec 1
MAZ
Mayagüez
SDQ
Santo Domingo
$431 Roundtrip, found 3 days ago
$431
Roundtrip
found 3 days ago
Select Cape Air flight, departing Fri, Nov 28 from Mayagüez to Santo Domingo, returning Mon, Dec 1, priced at $431 found 3 days ago
Cape Air
Fri, Nov 28 - Mon, Dec 1
MAZ
Mayagüez
SDQ
Santo Domingo
$441 Roundtrip, found 3 days ago
$441
Roundtrip
found 3 days ago
Select Cape Air flight, departing Fri, Nov 28 from Mayagüez to Santo Domingo, returning Mon, Dec 1, priced at $441 found 3 days ago

Frequently asked questions

How much does a flight from Eugenio Maria de Hostos Airport (MAZ) to Las Americas Intl. Airport (SDQ) cost?
Lock in a cheap one-way flight from $159 or cheap return flight from $326 from Eugenio Maria de Hostos Airport (MAZ) to Las Americas Intl. Airport (SDQ) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Eugenio Maria de Hostos Airport (MAZ) to Las Americas Intl. Airport (SDQ)?
Planning your trip for November is a great way to save, as it's the cheapest month for flights between MAZ and SDQ. You'll usually find the lowest fares during off-peak months.
What is the cheapest airline that flies from Eugenio Maria de Hostos Airport (MAZ) to Las Americas Intl. Airport (SDQ)?
To find the cheapest airline that'll fly you from MAZ to SDQ, use Expedia's filter tool. Tailor your search based on your travel style, such as preferred carriers and number of stops. You can then sort your results by "Price (lowest to highest)" to list the most affordable options first.
How many flights per day from Eugenio Maria de Hostos Airport (MAZ) to Las Americas Intl. Airport (SDQ)?
There are no daily direct flights departing from Eugenio Maria de Hostos Airport (MAZ) to Las Americas Intl. Airport (SDQ). But you can opt for flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be cruising above the clouds in no time.
What day of the week has the most flights from MAZ to SDQ?
Friday is typically the busiest day for flights, while Tuesday is often the quietest.* Just remember that flight schedules can change depending on various factors, such as the time of year and carrier.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Eugenio Maria de Hostos Airport (MAZ) to Las Americas Intl. Airport (SDQ)?
Opt for a flight from Eugenio Maria de Hostos Airport (MAZ) to Las Americas Intl. Airport (SDQ) that leaves before 3 PM to reduce the risk of cancellations. Later departures have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Eugenio Maria de Hostos Airport (MAZ) to Las Americas Intl. Airport (SDQ) last-minute?
Last-minute bookings from MAZ to SDQ are typically more expensive. For the best prices, start searching for flights as soon as possible. That said, if you can play around with your travel dates, you may land a cheap fare just before your departure.
Is it cheaper to book a MAZ to SDQ flight and hotel package?
Opting for a MAZ to SDQ flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Choose from our extensive range of accommodations and then add car rentals, flights and activities to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Eugenio Maria de Hostos Airport (MAZ) to Las Americas Intl. Airport (SDQ)?
If you booked your MAZ to SDQ flight in the last 24 hours, you may be able to cancel or modify it at no cost. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Eugenio María de Hostos
Destination airport
Las Americas Intl.
Roundtrip price
$325
Distance
166 mi

Book with confidence

Mayagüez to Santo Domingo Flights

The cheapest times to fly from Mayagüez to Santo Domingo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Mayagüez to Santo Domingo are during the month of November. You can find some of the cheapest flights from Mayagüez to Santo Domingo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Mayagüez to Santo Domingo

Sunday is one of the best days to book for cheap flights from Mayagüez to Santo Domingo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Mayagüez to Santo Domingo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Mayagüez to Santo Domingo in 2025. You can also book with separate airlines for your outbound and return journeys, from $159 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Mayagüez to Santo Domingo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Mayagüez to Santo Domingo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Mayagüez to Santo Domingo Flights

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*Available to One Key members.