$249 Cheap Flights from Medellín (MDE) to Santiago (STI)

View $249 flight on Sat, Jan 31, 2026Opens in a new window

Popular airlines from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI)

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Cheap Flights from Medellín to Santiago (MDE-STI)

Prices were available within the past 7 days and start at $249 for one-way flights and $408 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Sat, Jan 31 - Sat, Feb 7
MDE
Medellin
STI
Santiago de los Caballeros
$408 Roundtrip, found 2 hours ago
$408
Roundtrip
found 2 hours ago
Select Copa flight, departing Sat, Jan 31 from Medellin to Santiago de los Caballeros, returning Sat, Feb 7, priced at $408 found 2 hours ago
Copa
Sat, Jan 31 - Sat, Feb 7
MDE
Medellin
STI
Santiago de los Caballeros
$434 Roundtrip, found 2 hours ago
$434
Roundtrip
found 2 hours ago
Select Copa flight, departing Sat, Jan 31 from Medellin to Santiago de los Caballeros, returning Sat, Feb 7, priced at $434 found 2 hours ago
Copa
Sat, Jan 31 - Sat, Feb 7
MDE
Medellin
STI
Santiago de los Caballeros
$496 Roundtrip, found 2 hours ago
$496
Roundtrip
found 2 hours ago
Select Copa flight, departing Sat, Jan 31 from Medellin to Santiago de los Caballeros, returning Sat, Feb 7, priced at $496 found 2 hours ago
Copa
Sat, Jan 31 - Sat, Feb 7
MDE
Medellin
STI
Santiago de los Caballeros
$522 Roundtrip, found 2 hours ago
$522
Roundtrip
found 2 hours ago
Select Copa flight, departing Sat, Jan 31 from Medellin to Santiago de los Caballeros, returning Sat, Feb 7, priced at $522 found 2 hours ago
Copa
Sat, Jan 31 - Sat, Feb 7
MDE
Medellin
STI
Santiago de los Caballeros
$542 Roundtrip, found 2 hours ago
$542
Roundtrip
found 2 hours ago
Select Copa flight, departing Sat, Jan 31 from Medellin to Santiago de los Caballeros, returning Sat, Feb 7, priced at $542 found 2 hours ago
Copa
Fri, Jan 30 - Sat, Feb 7
MDE
Medellin
STI
Santiago de los Caballeros
$553 Roundtrip, found 2 hours ago
$553
Roundtrip
found 2 hours ago
Select Copa flight, departing Fri, Jan 30 from Medellin to Santiago de los Caballeros, returning Sat, Feb 7, priced at $553 found 2 hours ago
avianca
Mon, Oct 20 - Mon, Jan 19
MDE
Medellin
STI
Santiago de los Caballeros
$599 Roundtrip, found 10 hours ago
$599
Roundtrip
found 10 hours ago
Select avianca flight, departing Mon, Oct 20 from Medellin to Santiago de los Caballeros, returning Mon, Jan 19, priced at $599 found 10 hours ago
United
Mon, Oct 20 - Mon, Jan 19
MDE
Medellin
STI
Santiago de los Caballeros
$647 Roundtrip, found 10 hours ago
$647
Roundtrip
found 10 hours ago
Select United flight, departing Mon, Oct 20 from Medellin to Santiago de los Caballeros, returning Mon, Jan 19, priced at $647 found 10 hours ago
JetBlue Airways
Sat, Jan 31 - Sat, Feb 7
MDE
Medellin
STI
Santiago de los Caballeros
$703 Roundtrip, found 2 hours ago
$703
Roundtrip
found 2 hours ago
Select JetBlue Airways flight, departing Sat, Jan 31 from Medellin to Santiago de los Caballeros, returning Sat, Feb 7, priced at $703 found 2 hours ago
American Airlines
Wed, Mar 4 - Tue, Mar 17
MDE
Medellin
STI
Santiago de los Caballeros
$1,103 Roundtrip, found 9 hours ago
$1,103
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Wed, Mar 4 from Medellin to Santiago de los Caballeros, returning Tue, Mar 17, priced at $1,103 found 9 hours ago

Find the cheapest month to fly from Medellín (MDE) to Santiago de los Caballeros (STI)

February is typically the cheapest month to fly

From $234 - $1,075 per traveler.

Graph displaying average flight prices per month

Alternative airports near Santiago de los Caballeros

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Gregorio Luperon Intl. POP. Average driving time to city center is 59 minutes. Flights from $1,267
POP
Gregorio Luperon Intl.
Average driving time to city center59 min
Flights from $1,267
Flights from Medellín (MDE) to Santiago (STI)
Origin airport
José María Córdova Intl.
Destination airport
Cibao Intl.
Airlines serving
American Airlines, Copa, JetBlue Airways, United
Roundtrip price
$408
Distance
969 mi

Medellín to Santiago Flights

The cheapest times to fly from Medellín to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medellín to Santiago are during the month of January. You can find some of the cheapest flights from Medellín to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medellín to Santiago

Sunday is one of the best days to book for cheap flights from Medellín to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medellín to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medellín to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $249 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medellín to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medellín to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI) cost?
Discover the latest flight deals from MDE to STI by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from MDE to STI?
The cheapest flights from MDE to STI are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI)?
When heading out of Jose Maria Cordova Intl. Airport (MDE), you can take a direct flight to Cibao Intl. Airport (STI) with Arajet.
What is the cheapest airline that flies from MDE to STI?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from MDE to STI. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI)?
On average, you can pick from 2 direct flights each week from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI). To broaden your travel options, consider a flight with a layover. Simply enter your details on Expedia and then filter your search to show one or more stops.
What are the most popular departure times for flights from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI)?
More people fly between MDE and STI at 10 AM than at any other time. Prefer a quieter experience? Consider flying outside peak hours and you could save on your ticket as well.
What day of the week has the most flights from MDE to STI?
Thursday has the most flights from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI). Consider leaving on this day and you'll have the best chance of finding a departure that fits your plans.
What is the earliest flight from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI)?
The first flight of the day leaving Jose Maria Cordova Intl. Airport (MDE) is at around 10:50AM UTC-5. Board this plane and you'll reach Cibao Intl. Airport (STI) at approximately 2:30PM UTC-4. The total flight duration is 2h 40m.
How long does it take to fly from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI)?
The average flight time from MDE to STI is 2 hours and 40 minutes, covering a distance of 970 mi.
What is the best time to fly from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI)?
Book a flight from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI) that leaves before 3 PM to reduce the risk of cancellations and delays. Departures after this hour have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Santiago de los Caballeros from Jose Maria Cordova Intl. Airport (MDE)?
If you're flying on a direct flight from Jose Maria Cordova Intl. Airport (MDE) to Santiago de los Caballeros, Cibao Intl. Airport (STI) is the only airport you can land at.
Is it cheaper to buy a plane ticket from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI) last-minute?
Holding off until just before your departure to book your flight from MDE to STI generally means paying more. While you may come across some last-minute deals, they aren't always guaranteed. Keep your travel plans flexible to boost your chances of scoring a bargain.
Is it cheaper to book a MDE to STI flight and hotel package?
Compared with arranging flights and hotels separately, booking a MDE to STI flight and hotel package with Expedia could result in significant savings. What's more, managing everything in one place will take the stress out of planning your trip. Just secure your flights and select from our wide range of stays, then tailor your trip with extras like car rentals and activities.
Can I cancel or change the date of my flight from Jose Maria Cordova Intl. Airport (MDE) to Cibao Intl. Airport (STI)?
Typically, you're able to cancel or reschedule your MDE to STI flight. However, additional fees may apply, especially if your booking was made more than 24 hours ago. Double-check your itinerary for the airline's fees and policies on flight changes, or if you need more information, head to our Customer Service portal.

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*Available to One Key members.