$756 Cheap Flights from Panama City (PTY) to Santander (SDR)

View $756 flight on Thu, Nov 27, 2025Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to Santander (SDR)

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Cheap Flights from Panama City to Santander (PTY-SDR)

Prices were available within the past 7 days and start at $756 for one-way flights and for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Flights from Panama City (PTY) to Santander (SDR)
Origin airport
Tocumen Intl.
Destination airport
Santander
Distance
5065 mi

Panama City to Santander Flights

The cheapest times to fly from Panama City to Santander

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to Santander are during the month of . You can find some of the cheapest flights from Panama City to Santander with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Panama City to Santander

Sunday is one of the best days to book for cheap flights from Panama City to Santander: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Panama City to Santander

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to Santander in 2025. You can also book with separate airlines for your outbound and return journeys, from $756 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to Santander flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to Santander airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Tocumen Intl. Airport (PTY) to Santander Airport (SDR) cost?
Grab a cheap one-way flight from $756 or cheap return flight from Tocumen Intl. Airport (PTY) to Santander Airport (SDR) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Tocumen Intl. Airport (PTY) to Santander Airport (SDR)?
is the most affordable month to fly from PTY to SDR. Planning your trip for the off-season is often the key to landing a great deal.
What is the cheapest airline that flies from Tocumen Intl. Airport (PTY) to Santander Airport (SDR)?
To find the cheapest airline that'll fly you from PTY to SDR, use Expedia's filter tool. Customize your search based on what matters most to you, such as preferred carriers and seat class. You can then sort your results by "Price (lowest to highest)" to list the most affordable options first.
How many flights per day from Tocumen Intl. Airport (PTY) to Santander Airport (SDR)?
Direct flights from Tocumen Intl. Airport (PTY) to Santander Airport (SDR) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filter tool. Enter your dates and pick either "1 Stop" or "2+ Stops."
What day of the week has the most flights from PTY to SDR?
Friday is generally the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can change based on a number of factors, such as the airline and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Tocumen Intl. Airport (PTY) to Santander Airport (SDR)?
Book a flight from Tocumen Intl. Airport (PTY) to Santander Airport (SDR) that takes off before 3 PM to reduce the risk of delays and cancellations. Later departures are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Tocumen Intl. Airport (PTY) to Santander Airport (SDR) last-minute?
Holding off until just before your departure to book your flight from PTY to SDR often results in higher prices. While you may come across some last-minute deals, they're not always guaranteed. Keep your travel plans flexible to maximize your chances of getting a bargain.
Is it cheaper to book a PTY to SDR flight and hotel package?
You can save money by securing a PTY to SDR flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's simple to manage it all in one place. After selecting your ideal flights and accommodations, consider other add-ons like tours, car rentals and activities.
Can I cancel or change the date of my flight from Tocumen Intl. Airport (PTY) to Santander Airport (SDR)?
You can usually reschedule or cancel your PTY to SDR flight. However, for bookings made more than 24 hours ago, additional fees may apply. Refer to your airline's policies in your itinerary to see what changes are possible and whether any costs are involved. You'll also find more information on our Customer Service portal.

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*Available to One Key members.