Title: Isla del Rey Luxury Vacations 2026 | Expedia.com ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_packages.jpeg?impolicy=fcrop&w=1200&h=300&q=medium) # Isla del Rey Luxury Vacations ## Book a Luxury Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to $1,045 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ## Top Luxury vacation packages in Isla del Rey Price found within the past 48 hours. Click for updated prices. ![Casa Blanca](https://images.trvl-media.com/lodging/106000000/105820000/105811400/105811314/5298e308_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Casa Blanca $499 per person May 4 - May 11 found 1 day ago Roundtrip flight included Miami (MIA) to Panama City (PTY) 4/10 (1 review) ![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/3165768f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Central Hotel Panama Casco Viejo Casco Viejo Save 100% on your flight $1,207 per person Apr 29 - May 5 found 1 day ago Roundtrip flight included Newark Liberty Intl. Airport (EWR) to Panama City (PTY) 9/10 Wonderful! (1,002 reviews) Room was amazing, beautiful hotel in the center of town. Service also very good and attentive. Amazing breakfast. Reviewed on Feb 24, 2026 ![Yoo by Wynwood House](https://images.trvl-media.com/lodging/104000000/103610000/103606300/103606257/f526e4da_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Yoo by Wynwood House Calidonia $1,225 per person Apr 29 - May 5 found 1 day ago Roundtrip flight included Newark Liberty Intl. Airport (EWR) to Panama City (PTY) 9.2/10 Wonderful! (5 reviews) Unfortunately the name of the property was not Yoo by Wynwood. It is P. H. Yoo Panama & Arts Tower. This detail that was incorrect cost us time, money and stress at the beginning of our trip. We weren't able to get in touch with anyone at the property or at expedia and we ended up having to cross reference google photos to figure out the correct name and address of the location. This took us about an hour to do in a Country that we had never been to. We are very displeased with Expedia about this. We still have not been contacted by anyone. Reviewed on Jul 26, 2025 ![Megapolis Hotel Panamá](https://images.trvl-media.com/lodging/92000000/92000000/91995600/91995575/4aee4896_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Megapolis Hotel Panamá San Francisco $1,149 per person May 8 - May 13 found 1 day ago Roundtrip flight included Newark Liberty Intl. Airport (EWR) to Panama City (PTY) 8.4/10 Very Good! (1,204 reviews) The room was excellent served was excellent. Everything was 100% service breakfast pool rooms view 10+ I strongly recommend this hotel. They grows in the breakfast, Melissa. Magella list Daniela Monica, the pool, amazing amazing girls. They were so helpful and caring all the way. The courtesy was amazing. Reviewed on Feb 24, 2026 Don't see what you're looking for? See all available trips from Columbus to Isla del Rey [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-03-25/2026-04-01/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 5\* Luxury vacations in Isla del Rey Price found within the past 48 hours. Click for updated prices. ![Hotel Riu Plaza Panama](https://images.trvl-media.com/lodging/4000000/3910000/3900400/3900395/1eaf88f5_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Riu Plaza Panama Bella Vista $844 per person May 8 - May 13 found 1 day ago Roundtrip flight included Newark Liberty Intl. Airport (EWR) to Panama City (PTY) 9/10 Wonderful! (4,515 reviews) 3rd time there. Love it Reviewed on Feb 24, 2026 ![Waldorf Astoria Panama](https://images.trvl-media.com/lodging/5000000/4960000/4952100/4952056/e7e98c5e_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Waldorf Astoria Panama Bella Vista $1,263 per person Apr 29 - May 6 found 1 day ago Roundtrip flight included New York (JFK) to Panama City (PTY) 9/10 Wonderful! (1,001 reviews) The hotel was wonderful. The entire hotel was clean, staff welcoming especially security employee Flash. The breakfast buffet was great and it was so nice that Divney the receptionist remembered our names each day. My overall stay was great and I would highly recommend this hotel to anyone visiting Panama. Reviewed on Feb 23, 2026 ![Hotel La Compania Del Valle](https://images.trvl-media.com/lodging/112000000/111210000/111207500/111207482/bd071da6_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel La Compania Del Valle $1,229 per person Apr 21 - Apr 27 found 1 day ago Roundtrip flight included New York (JFK) to Panama City (PTY) 9.8/10 Exceptional! (54 reviews) Modern beautiful property, complimentary handmade cocktails from 5pm to 7pm Reviewed on Feb 19, 2026 Don't see what you're looking for? See all available trips from Columbus to Isla del Rey [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-03-25/2026-04-01/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 3 Night Luxury vacations in Isla del Rey Price found within the past 48 hours. Click for updated prices. ![Megapolis Hotel Panamá](https://images.trvl-media.com/lodging/92000000/92000000/91995600/91995575/4aee4896_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Megapolis Hotel Panamá San Francisco $863 per person May 1 - May 4 found 1 day ago Roundtrip flight included Newark Liberty Intl. Airport (EWR) to Panama City (PTY) 8.4/10 Very Good! (1,204 reviews) The room was excellent served was excellent. Everything was 100% service breakfast pool rooms view 10+ I strongly recommend this hotel. They grows in the breakfast, Melissa. Magella list Daniela Monica, the pool, amazing amazing girls. They were so helpful and caring all the way. The courtesy was amazing. Reviewed on Feb 24, 2026 ![Casa Mallet by Wynwood House](https://images.trvl-media.com/lodging/100000000/99780000/99778900/99778891/dfb3f761_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Casa Mallet by Wynwood House Casco Viejo Save 100% on your flight $1,384 per person Apr 2 - Apr 5 found 1 day ago Roundtrip flight included Miami (MIA) to Panama City (PTY) 9.8/10 Exceptional! (24 reviews) Beautiful apartment definitely recommend staying here if you are coming to Panama Reviewed on Nov 29, 2025 ![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/3165768f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Central Hotel Panama Casco Viejo Casco Viejo $874 per person May 1 - May 4 found 18 hours ago Roundtrip flight included New York (JFK) to Panama City (PTY) 9/10 Wonderful! (1,002 reviews) Room was amazing, beautiful hotel in the center of town. Service also very good and attentive. Amazing breakfast. Reviewed on Feb 24, 2026 Don't see what you're looking for? See all available trips from Columbus to Isla del Rey [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-03-25/2026-04-01/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 4 Night Luxury vacations in Isla del Rey Price found within the past 48 hours. Click for updated prices. ![Villa Botero By Casa Mojito B&B](https://images.trvl-media.com/lodging/12000000/11930000/11927200/11927153/393d35f8_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Villa Botero By Casa Mojito B&B $562 per person Apr 1 - Apr 5 found 1 day ago Roundtrip flight included Miami (MIA) to Panama City (PTY) 9.8/10 Exceptional! (60 reviews) We stayed one night and it exceeded our expectations. The owners were incredibly friendly and easy to contact, making us feel right at home. Everything was spotless, and the atmosphere was warm and inviting. The homemade breakfast was a highlight—absolutely delicious and full of flavor. We will stay again longer next time. Reviewed on Jan 22, 2026 ![Mahogany Suites](https://images.trvl-media.com/lodging/119000000/118410000/118402400/118402387/179ad971_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Mahogany Suites $712 per person Mar 31 - Apr 4 found 1 day ago Roundtrip flight included Newark Liberty Intl. Airport (EWR) to Panama City (PTY) 10/10 Exceptional! (1 review) Excellent apartment on a golf resort. 5 Star. Reviewed on Jan 28, 2026 ![Casa Mallet by Wynwood House](https://images.trvl-media.com/lodging/100000000/99780000/99778900/99778891/dfb3f761_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Casa Mallet by Wynwood House Casco Viejo Save 100% on your flight $2,056 per person Apr 2 - Apr 6 found 1 day ago Roundtrip flight included New York (JFK) to Panama City (PTY) 9.8/10 Exceptional! (24 reviews) Beautiful apartment definitely recommend staying here if you are coming to Panama Reviewed on Nov 29, 2025 Don't see what you're looking for? See all available trips from Columbus to Isla del Rey [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-03-25/2026-04-01/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## All you need to know about luxury vacations in Isla del Rey #### What can I expect from a luxury Isla del Rey vacation? Luxury means the very finest of the things you enjoy most. Indulge your every waking moment—and restful night—with a luxury Isla del Rey vacation. Sip handcrafted cocktails by an infinity pool, sink into bliss at a full-service spa with a massage cabana on the beach, and chat, cheers, and laugh through exquisite breakfasts, lunches, and dinners with spectacular views. #### How can I find all-inclusive luxury vacation packages in Isla del Rey? By refining your filters, the most opulent all-inclusive vacation packages will appear before your eyes. Check the 5\* filter to find truly sensational stays. You barely need to lift a finger. #### Can I book a cheap Isla del Rey luxury vacation? Affordable luxury is only ever a few clicks away. Enter your travel dates and sort the grandiose getaways on offer by price to see the most fiscally friendly retreats first. Filter by budget, too, to find your perfect balance of luxury. Right now, luxury vacations start at $499\. Prices and availability are subject to change. Additional terms may apply. #### How can I book a luxury family vacation in Isla del Rey? Tailor your luxury family escape by checking the filters that set the whole family’s hearts a-flutter. Whether that’s wet and wild water parks, heavenly hot tubs, or the kid-quieting magic of free Wi-Fi. #### Can I book a package in Isla del Rey with a luxury vacation home? A private paradise is true luxury! Filter by property type for houses, villas, and apartments. For an amazingly affordable all-in-one luxury experience, book your accommodation, airfare, and car rental as a package. #### How can I find the best luxury vacation deals in Isla del Rey? Find absolute delight in the dropdown! Simply sort your tempting search results by deals to find that lean-budget luxury. For a budget conscious stay, consider booking a stay away from big cities or outside the peak months. #### Can I book a luxury holiday in Isla del Rey with free cancellation and/or flexible dates? Freedom and flexibility are the greatest luxuries of all. Get both when you filter by payment option and book a trip with free cancellation or on a buy now, pay later plan. #### Why should I book my luxury trip to Isla del Rey with Expedia? A luxurious trip follows a stress-free booking experience. Find, build, and book the most glorious of getaways in seconds—with ATOL protection for added peace of mind. ## More vacations you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Kid Friendly Vacations [](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click) 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](https://expedia.com/Isla-Del-Rey-Vacation-Rentals.d6336628.Travel-Guide-VacationRentals)[ Car Rentals in Isla del Rey ](https://expedia.com/Car-Rentals-In-Isla-Del-Rey.d6336628.Car-Rental-Guide)[ Isla del Rey Vacations ](https://expedia.com/Isla-Del-Rey.d6336628.Destination-Travel-Guides) \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app