Isla del Rey Luxury Vacations

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Top Luxury vacation packages in Isla del Rey

Price found within the past 48 hours. Click for updated prices.

Riande Aeropuerto Hotel & Casino

Tocumen Airport

$889

per person

Dec 3 - Dec 7

found 2 days ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

8.6/10 Excellent! (1,811 reviews)

Yes was good everything excellent breakfast and the worker muy tradable.I will comback.

Reviewed on Sep 26, 2026

Central Hotel Panama Casco Viejo

Casco Viejo

Save 100% on your flight

$1,615

per person

Nov 7 - Nov 14

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

9/10 Wonderful! (1,012 reviews)

Great location in Casco Viejo Breakfast buffet was good !!

Reviewed on Sep 25, 2026

Megapolis Hotel Panamá

San Francisco

$939

per person

Dec 3 - Dec 7

found 2 days ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

8.4/10 Very Good! (1,693 reviews)

Excelente el desayuno buffet

Reviewed on Sep 26, 2026

Yoo by Wynwood House

Calidonia

$1,014

per person

Nov 3 - Nov 8

found 2 days ago

Roundtrip flight included

Georgetown (GEO) to Panama City (PTY)

9.4/10 Exceptional! (6 reviews)

Unfortunately the name of the property was not Yoo by Wynwood. It is P. H. Yoo Panama & Arts Tower. This detail that was incorrect cost us time, money and stress at the beginning of our trip. We weren't able to get in touch with anyone at the property or at expedia and we ended up having to cross reference google photos to figure out the correct name and address of the location. This took us about an hour to do in a Country that we had never been to. We are very displeased with Expedia about this. We still have not been contacted by anyone.

Reviewed on Jul 26, 2025

Hotel Riu Plaza Panama

Bella Vista

$895

per person

Dec 3 - Dec 7

found 2 days ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

9/10 Wonderful! (5,977 reviews)

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5* Luxury vacations in Isla del Rey

Price found within the past 48 hours. Click for updated prices.

Renaissance Panama City Hotel

Bella Vista

$872

per person

Dec 3 - Dec 7

found 2 days ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

8.8/10 Excellent! (292 reviews)

Beautiful property. I enjoyed the courteous nature of the staff.

Reviewed on Sep 24, 2026

Hotel Riu Plaza Panama

Bella Vista

$895

per person

Dec 3 - Dec 7

found 2 days ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

9/10 Wonderful! (5,977 reviews)

Hyatt Regency Panama City

Bella Vista

$959

per person

Dec 3 - Dec 7

found 2 days ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

9.6/10 Exceptional! (438 reviews)

Don't see what you're looking for?

See all available trips from Columbus to Isla del Rey

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3 Night Luxury vacations in Isla del Rey

Price found within the past 48 hours. Click for updated prices.

Riande Aeropuerto Hotel & Casino

Tocumen Airport

$853

per person

Oct 29 - Nov 1

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

8.6/10 Excellent! (1,811 reviews)

Yes was good everything excellent breakfast and the worker muy tradable.I will comback.

Reviewed on Sep 26, 2026

Megapolis Hotel Panamá

San Francisco

$887

per person

Oct 29 - Nov 1

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

8.4/10 Very Good! (1,693 reviews)

Excelente el desayuno buffet

Reviewed on Sep 26, 2026

Central Hotel Panama Casco Viejo

Casco Viejo

$997

per person

Oct 29 - Nov 1

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

9/10 Wonderful! (1,012 reviews)

Great location in Casco Viejo Breakfast buffet was good !!

Reviewed on Sep 25, 2026

Don't see what you're looking for?

See all available trips from Columbus to Isla del Rey

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4 Night Luxury vacations in Isla del Rey

Price found within the past 48 hours. Click for updated prices.

Riande Aeropuerto Hotel & Casino

Tocumen Airport

$889

per person

Dec 3 - Dec 7

found 2 days ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

8.6/10 Excellent! (1,811 reviews)

Yes was good everything excellent breakfast and the worker muy tradable.I will comback.

Reviewed on Sep 26, 2026

Megapolis Hotel Panamá

San Francisco

$939

per person

Dec 3 - Dec 7

found 2 days ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

8.4/10 Very Good! (1,693 reviews)

Excelente el desayuno buffet

Reviewed on Sep 26, 2026

Central Hotel Panama Casco Viejo

Casco Viejo

Save 100% on your flight

$1,052

per person

Dec 3 - Dec 7

found 2 days ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

9/10 Wonderful! (1,012 reviews)

Great location in Casco Viejo Breakfast buffet was good !!

Reviewed on Sep 25, 2026

Don't see what you're looking for?

See all available trips from Columbus to Isla del Rey

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What can I expect from a luxury Isla del Rey vacation?

Luxury means the very finest of the things you enjoy most. Indulge your every waking moment—and restful night—with a luxury Isla del Rey vacation. Sip handcrafted cocktails by an infinity pool, sink into bliss at a full-service spa with a massage cabana on the beach, and chat, cheers, and laugh through exquisite breakfasts, lunches, and dinners with spectacular views. 

How can I find all-inclusive luxury vacation packages in Isla del Rey?

By refining your filters, the most opulent all-inclusive vacation packages will appear before your eyes. Check the 5* filter to find truly sensational stays. You barely need to lift a finger. 

Can I book a cheap Isla del Rey luxury vacation?

Affordable luxury is only ever a few clicks away. Enter your travel dates and sort the grandiose getaways on offer by price to see the most fiscally friendly retreats first. Filter by budget, too, to find your perfect balance of luxury. Right now, luxury vacations start at $853. Prices and availability are subject to change. Additional terms may apply.

How can I book a luxury family vacation in Isla del Rey?

Tailor your luxury family escape by checking the filters that set the whole family’s hearts a-flutter. Whether that’s wet and wild water parks, heavenly hot tubs, or the kid-quieting magic of free Wi-Fi. 

Can I book a package in Isla del Rey with a luxury vacation home?

A private paradise is true luxury! Filter by property type for houses, villas, and apartments. For an amazingly affordable all-in-one luxury experience, book your accommodation, airfare, and car rental as a package.   

How can I find the best luxury vacation deals in Isla del Rey?

Find absolute delight in the dropdown! Simply sort your tempting search results by deals to find that lean-budget luxury. For a budget conscious stay, consider booking a stay away from big cities or outside the peak months.

Can I book a luxury holiday in Isla del Rey with free cancellation and/or flexible dates?

Freedom and flexibility are the greatest luxuries of all. Get both when you filter by payment option and book a trip with free cancellation or on a buy now, pay later plan. 

Why should I book my luxury trip to Isla del Rey with Expedia?

A luxurious trip follows a stress-free booking experience. Find, build, and book the most glorious of getaways in seconds—with ATOL protection for added peace of mind.