Title: Visit Midtown: 2026 Midtown, St. Louis Travel Guide | Expedia.com [Hotels in Midtown](https://expedia.com/Midtown-St-Louis-Hotels.0-n553248635976008329-0.Travel-Guide-Filter-Hotels)[Flights to St. Louis](https://expedia.com/Cheap-Flights-To-St-Louis.d178309.Travel-Guide-Flights)[Things to do in St. Louis](https://expedia.com/Things-To-Do-In-St-Louis.d178309.Travel-Guide-Activities)[Car Rentals in Midtown](https://expedia.com/Car-Rentals-In-Midtown.d553248635976008329.Car-Rental-Guide)[Midtown Vacations](https://expedia.com/Midtown.d553248635976008329.Destination-Travel-Guides) # Midtown, MO ## St. Louis ![St. Louis, Missouri - 08.22.2021 - Brookings Hall on the Danforth Campus of Washington University in St. Louis.](https://images.trvl-media.com/place/502875/5ca38745-4153-4e94-ab7e-09c532468b9f.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![St. Louis, Missouri - 08.22.2021 - Brookings Hall on the Danforth Campus of Washington University in St. Louis.](https://images.trvl-media.com/place/502875/5ca38745-4153-4e94-ab7e-09c532468b9f.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Midtown](https://images.trvl-media.com/place/3284/d55b436c-a6f6-420f-818f-aa3ccdc0a7fa.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Midtown](https://images.trvl-media.com/place/3284/72436d55-6453-454a-932d-0eb0c75005e5.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Midtown](https://images.trvl-media.com/place/3284/d64474b6-ef59-4458-b07b-0c0eda260efa.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit Midtown Hotels Where to stay [St. Louis Travel Guide](https://expedia.com/St-Louis.dx178309) --- --- ## Midtown Hotel Deals ![Element St. Louis Midtown](https://images.trvl-media.com/lodging/58000000/57060000/57057200/57057177/3e830499_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Element St. Louis Midtown 3763 Forest Park Avenue St. Louis MO $135 nightly $158 total Mar 29 - Mar 30 Total with taxes and fees Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ... 9/10 Wonderful! (690 reviews) The pool was too cold, but the hotel was clean and spacious! Reviewed on Mar 11, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F29%2F2026&endDate=3%2F30%2F2026&selected=57057177&PinnedHotelID=57057177&HadPinnedHotel=true®ionId=553248635976008329) ![Residence Inn by Marriott St Louis Downtown](https://images.trvl-media.com/lodging/2000000/1280000/1273600/1273566/a7e6efee_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Residence Inn by Marriott St Louis Downtown 525 S Jefferson Ave St. Louis MO $101 nightly $120 total Apr 1 - Apr 2 Total with taxes and fees Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, a 24-hour fitness center, and parking (surcharge). Our guests praise the breakfast ... 7.8/10 Good! (1,002 reviews) Pulled out the sofa bed and stains all over. Third person (that I paid for was not able to sleep on the mattress). Took pictures showed to front desk and they took the pictures from my phone and said “ok” . Absolutely disgusting. Reviewed on Mar 9, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F1%2F2026&endDate=4%2F2%2F2026&selected=1273566&PinnedHotelID=1273566&HadPinnedHotel=true®ionId=553248635976008329) ![Clayton Plaza Hotel & Extended Stay](https://images.trvl-media.com/lodging/1000000/20000/18200/18144/5c61cbf8_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Clayton Plaza Hotel & Extended Stay 7750 Carondelet Avenue St. Louis MO $100 nightly $116 total Apr 12 - Apr 13 Total with taxes and fees Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ... 8.8/10 Excellent! (3,103 reviews) This is an older property, but very clean, comfortable, spacious and convenient to downtown Clayton. Parking was convenient and free on the weekend. Breakfast was better than average, with chef-made omelets and waffles. Reviewed on Mar 11, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F12%2F2026&endDate=4%2F13%2F2026&selected=18144&PinnedHotelID=18144&HadPinnedHotel=true®ionId=553248635976008329) ![21C Museum Hotel St Louis ](https://images.trvl-media.com/lodging/90000000/89170000/89164600/89164592/bd7064dc_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### 21C Museum Hotel St Louis 1528 Locust street St. Louis MO $131 nightly $153 total Apr 5 - Apr 6 Total with taxes and fees Book a stay at this luxury hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the restaurant in our ... 9/10 Wonderful! (1,648 reviews) Such a cool hotel I love the museum on the second floor so interesting and all the penguins food is great restaurants great everything just what a great stay very unique but very quiet very cozy love everything about it. Can’t wait to stay at the other ones. Reviewed on Mar 11, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&selected=89164592&PinnedHotelID=89164592&HadPinnedHotel=true®ionId=553248635976008329) ![Drury Plaza Hotel St. Louis at the Arch](https://images.trvl-media.com/lodging/1000000/550000/546300/546271/e43b9580_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Plaza Hotel St. Louis at the Arch 2 South 4th Street St. Louis MO $135 nightly $158 total Mar 16 - Mar 17 Total with taxes and fees Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and 2 hot tubs. Our guests praise the breakfast and the pool in our ... 9.4/10 Exceptional! (3,362 reviews) Very nice staff and great atmosphere. Quietest hotel room i have ever stayed in Reviewed on Mar 10, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F16%2F2026&endDate=3%2F17%2F2026&selected=546271&PinnedHotelID=546271&HadPinnedHotel=true®ionId=553248635976008329) ![Hyatt Regency St. Louis at The Arch](https://images.trvl-media.com/lodging/1000000/20000/14900/14877/ad35f056_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hyatt Regency St. Louis at The Arch 315 Chestnut St St. Louis MO Fully refundableReserve now, pay when you stay $169 nightly $199 total Mar 23 - Mar 24 Total with taxes and fees Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ... 8.4/10 Very Good! (3,989 reviews) Very clean, bar staff was great, amazing restaurants-will be back! Reviewed on Mar 11, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F23%2F2026&endDate=3%2F24%2F2026&selected=14877&PinnedHotelID=14877&HadPinnedHotel=true®ionId=553248635976008329) [See all 1,898 properties in Midtown](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=3%2F13%2F2026&endDate=3%2F14%2F2026®ionId=553248635976008329) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=DX-NH_SPRING_PROMO_553248635976008329) ## Check Midtown hotel availability [Tonight ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976008329&startDate=2026-03-12&endDate=2026-03-13)[Mar 12 - Mar 13](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976008329&startDate=2026-03-12&endDate=2026-03-13) [Tomorrow night ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976008329&startDate=2026-03-13&endDate=2026-03-14)[Mar 13 - Mar 14](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976008329&startDate=2026-03-13&endDate=2026-03-14) [This weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976008329&startDate=3%2F13%2F2026&endDate=3%2F15%2F2026)[Mar 13 - Mar 15](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976008329&startDate=3%2F13%2F2026&endDate=3%2F15%2F2026) [Next weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976008329&startDate=3%2F20%2F2026&endDate=3%2F22%2F2026)[Mar 20 - Mar 22](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976008329&startDate=3%2F20%2F2026&endDate=3%2F22%2F2026) --- ### Other neighborhoods around Midtown ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### The Gate While there might not be top attractions in The Gate, you can explore the larger area and discover places like St. Louis Union Station and Busch Stadium. [](https://expedia.com/St-Louis-The-Gate.dx553248635976474004) ![Love this hotel.](https://images.trvl-media.com/place/3284/7d953ffd-a093-422e-8101-35af3b9eb6fc.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Downtown West If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing. [](https://expedia.com/St-Louis-Downtown-West.dx553248635976473134) ![Lafayette Square which includes a house and a garden](https://images.trvl-media.com/place/6292381/f746e8db-cb81-4d52-a7d7-3ec56595e9b0.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Lafayette Square The restaurants and shopping are a few reasons travelers visit Lafayette Square. Though there aren't many top sights in the neighborhood, you can visit St. Louis Union Station and Busch Stadium, a few notable attractions nearby. [](https://expedia.com/St-Louis-Lafayette-Square.dx6292381) ![Not just bars but also loft apartments are lit in rainbow lights for Pride weekend in the Grove neighborhood in St. Louis! #LifeAtExpedia](https://images.trvl-media.com/place/3284/4b636840-fa59-4f14-a526-b5e40380bb6b.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### The Grove The Grove might not have many top sights, but St. Louis Science Center and Missouri Botanical Gardens and Arboretum are two attractions nearby that you can check out. [](https://expedia.com/St-Louis-The-Grove.dx808797266555363328) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Shaw 4.5/5(3 area reviews) While there might not be top attractions in Shaw, you can explore the larger area and discover places like Missouri Botanical Gardens and Arboretum and St. Louis Science Center. [](https://expedia.com/St-Louis-Shaw.dx553248635976473555) ![Central West End](https://images.trvl-media.com/place/6175135/a1a4060c-5623-4543-941c-91e3f85f02cc.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Central West End 4.5/5(450 area reviews) Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis. [](https://expedia.com/St-Louis-Central-West-End.dx6175135) [See our Where To Stay guide](https://expedia.com/St-Louis.dx178309.Where-To-Stay?rfrr=TG.LP.Dest.Neigh.Neighborhoods) --- --- - [Stays](?pwaLob=wizard-hotel-pwa-v2) - [Packages](?pwaLob=wizard-package-pwa) - [Flights](?pwaLob=wizard-flight-pwa) - [Things to do](?pwaLob=wizard-lx-pwa) - [Cruises](?pwaLob=wizard-cruise-pwa) - [Cars](?pwaLob=wizard-car-pwa) # Midtown, MO ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app