
Midtown Vacations from $595
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Your Midtown Vacation
Organizing your next getaway just got easier with a vacation package to Midtown. Take in the very best this neighborhood has to offer while making incredible memories you'll treasure. Your trip to Midtown wouldn't be complete without exploring leading attractions nearby such as Busch Stadium, Gateway Arch and Dome at America’s Center. No matter what your dream Midtown vacation looks like, you can make it a reality with Expedia.
The Latest Midtown Vacation Packages

The Knight Center at Washington University
Reviewed on Mar 26, 2026

The Wildwood Hotel
Reviewed on Mar 30, 2026

Hilton Pennywell St. Louis at the Arch
Reviewed on Mar 30, 2026

The Cheshire
Reviewed on Mar 29, 2026

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Reviewed on Mar 22, 2026
Where to stay in Midtown

Downtown St. Louis
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.
Midtown Hotel Deals

Element St. Louis Midtown
For the price I paid, I feel the breakfast selection wasn’t the greatest, however everything served was fresh. Also, I paid an extra 80 plus dollars for parking. If it was mentioned in the listing, it wasn’t plain text that parking was extra. I understand parking space in a big city is a premium, ...
Reviewed on Mar 30, 2026

Residence Inn by Marriott St Louis Downtown
Was not able to use the pool and that was my reasoning for booking the hotel room.
Reviewed on Mar 28, 2026

Drury Plaza Hotel St. Louis at the Arch
The breakfast food was not very good. The breakfast area was kind of dirty. There were probably a couple of hundred people going through there touching the tongs, but there was not a single hand sanitizer to be found. And this was at the height of flu season. Pretty gross.
Reviewed on Mar 28, 2026
Discover the most popular places to visit in Midtown

St. Louis University
Explore the campus of St. Louis University as part of your travels around St. Louis. Wander around the area's picturesque gardens or experience its fascinating museums.

Scott Joplin House State Historic Site
Learn about the local history of St. Louis when you spend time at Scott Joplin House State Historic Site. Experience the area's great live music or attend a baseball game.
Chaifetz Arena
Catch an event at Chaifetz Arena during your trip to St. Louis. Amble around the area's picturesque gardens or attend a baseball game.
Things to do

St. Louis Ghost Tour: Sinister Sins & Shadows

Lemp Haunted Neighborhood Walking Tour























