Midtown Vacation Packages 2026 from $309

Your Midtown Vacation

Organizing your next getaway just got easier with a vacation package to Midtown. Take in the very best this neighborhood has to offer while making incredible memories you'll treasure. Your trip to Midtown wouldn't be complete without exploring leading attractions nearby such as Busch Stadium, Gateway Arch and Dome at America’s Center. No matter what your dream Midtown vacation looks like, you can make it a reality with Expedia.

The Latest Midtown Vacation Packages

Price found within the past 48 hours. Click for updated prices.

The Wildwood Hotel

Save 100% on your flight

$309

per person

Dec 29 - Jan 1

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

9.2/10 Wonderful! (1,679 reviews)

StayAtlas Retreat w/ Pool, Gym, Games, BBQ

Mount Pleasant

Save 100% on your flight

$3,011

per person

Dec 23 - Dec 30

found 4 hours ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to St. Louis (STL)

10/10 Exceptional! (1 review)

The property was such a fun surprise- the neighborhood was a little sketchy, but it was great on the inside and the backyard... Great experience, fun complimentary toiletries, etc

Reviewed on Sep 25, 2026

Hermann Grain Bins BNB

$1,938

per person

Dec 23 - Dec 30

found 5 hours ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to St. Louis (STL)

6/10 (2 reviews)

It was so comfortable and uniquely and beautifully decorated! There was so many awesome areas to explore inside and outside of the Grain Bins. Food provided for breakfast was fresh and hot. There was perfectly cooked bacon, scrambled eggs and really moist corn muffins with homemade mango preservers! We were welcomed with fresh, homemade plum bread. Instructions for everything available to utilize and operate were easy to understand. I can’t wait to go back and I will tell all my friends and family about this unique and relaxing place.

Reviewed on May 22, 2026

The Westin St. Louis

Downtown St. Louis

$372

per person

Dec 29 - Jan 1

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.6/10 Excellent! (1,012 reviews)

DoubleTree by Hilton Hotel St. Louis - Chesterfield

$346

per person

Dec 29 - Jan 1

found 24 hours ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.8/10 Excellent! (1,002 reviews)

Where to stay in Midtown

Find the best Midtown areas and neighborhoods for the activities you enjoy most. Learn more about Midtown

A public park with a fountain featuring bronze sculptures of mythological figures, surrounded by trees and a large building in the background.

Downtown St. Louis

4 out of top 10 points of interest in this area

Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.

The illuminated Gateway Arch at night with a city skyline in the background.

Clayton

1 out of top 10 points of interest in this area

Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

A street with parked cars, a building with a sign reading "Brennan's", and a tree in front.

Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.

A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

Midtown Hotel Deals

Clayton Plaza Hotel & Extended Stay

7750 Carondelet Avenue St. Louis MO

Fully refundableReserve now, pay when you stay

$92 nightly

$108 total

Nov 1 - Nov 2

Total with taxes and fees

Pear Tree Inn St. Louis Airport

10810 Pear Tree Ln St. Ann MO

Fully refundableReserve now, pay when you stay

$88 nightly

$104 total

Oct 22 - Oct 23

Total with taxes and fees

Drury Plaza Hotel St. Louis at the Arch

2 South 4th Street St. Louis MO

Fully refundableReserve now, pay when you stay

$135 nightly

$158 total

Oct 25 - Oct 26

Total with taxes and fees

See all 1,969 properties in Midtown

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Midtown attractions

A historic building with a large lawn, a flagpole with flags, and a clear blue sky.

St. Louis University

8.6/10 (526 reviews)

Explore the campus of St. Louis University as part of your travels around St. Louis. Wander around the area's picturesque gardens or experience its acclaimed theater scene.

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A room with a grand piano, a white door, and a framed picture on the wall.

Scott Joplin House State Historic Site

Learn about the local history of St. Louis when you spend time at Scott Joplin House State Historic Site. Experience the area's fascinating museums or attend a baseball game.

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Chaifetz Arena

8.8/10 (59 reviews)

Catch an event at Chaifetz Arena during your trip to St. Louis. Amble around the area's picturesque gardens or attend a baseball game.

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Harris-Stowe State University

Explore the campus of Harris-Stowe State University during your visit to St. Louis.

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Fubar

Fubar is just one of the places to see in St. Louis, so why not enjoy the other things to explore during your travels?

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Samuel Cupples House

You can learn about the history of St. Louis with a stop at Samuel Cupples House. Experience the area's acclaimed theater scene or attend a sporting event.

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Red Flag

You can enjoy a show at Red Flag on your trip to St. Louis.

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City Foundry STL

City Foundry STL is just one of the places to see in St. Louis, so why not enjoy the other things to explore during your travels?

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Things to do

StL's Signature "Sights and Bites" - Private Tour in St. Louis

$175

per adult

St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

$24

per adult

100% of travellers recommend

Self Guided Walking & Driving Audio Tour St. Louis

Self Guided Walk & Drive Audio Tour St. Louis & Gateway Arch NP

$15

per traveler

See all activities in St. Louis

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.

Midtown Vacations from $309

Book a Hotel + Flight or Car together to unlock savings

Room 1

Your Midtown Vacation

The Latest Midtown Vacation Packages

The Wildwood Hotel

StayAtlas Retreat w/ Pool, Gym, Games, BBQ

Hermann Grain Bins BNB

The Westin St. Louis

DoubleTree by Hilton Hotel St. Louis - Chesterfield

Where to stay in Midtown

Downtown St. Louis

Clayton

Central West End

St. Charles Historic District

Creve Coeur

Midtown Hotel Deals

Clayton Plaza Hotel & Extended Stay

Pear Tree Inn St. Louis Airport

Drury Plaza Hotel St. Louis at the Arch

Stay near popular Midtown attractions

St. Louis University

Scott Joplin House State Historic Site

Chaifetz Arena

Harris-Stowe State University

Fubar

Samuel Cupples House

Red Flag

City Foundry STL

Things to do

StL's Signature "Sights and Bites" - Private Tour in St. Louis

St. Louis Ghost Tour: Sinister Sins & Shadows

Self Guided Walk & Drive Audio Tour St. Louis & Gateway Arch NP