Midtown Vacations from $225

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Your Midtown Vacation

Organizing your next getaway just got easier with a vacation package to Midtown. Take in the very best this neighborhood has to offer while making incredible memories you'll treasure. Your trip to Midtown wouldn't be complete without exploring leading attractions nearby such as Busch Stadium, Gateway Arch and Dome at America’s Center. No matter what your dream Midtown vacation looks like, you can make it a reality with Expedia.

The Latest Midtown Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Crowne Plaza St. Louis Airport by IHG
The Wildwood Hotel
The Principal Hotel
Hilton Garden Inn Chesterfield
Aloft St. Louis Cortex

Where to stay in Midtown

Find the best Midtown areas and neighborhoods for the activities you enjoy most. Learn more about Midtown

Midtown Hotel Deals

Element St. Louis Midtown

Element St. Louis Midtown

3 out of 5
3763 Forest Park Avenue, St. Louis, MO
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $158 total per night from Sep 1 to Sep 2
$158 total
Sep 1 - Sep 2
Total includes taxes and fees
9/10 Wonderful! (539 reviews)
"Excellent stay! Samantha surprised me with birthday goody bag! Thank you so much!"

Reviewed on Jul 27, 2025

Element St. Louis Midtown
Residence Inn by Marriott St Louis Downtown

Residence Inn by Marriott St Louis Downtown

3 out of 5
525 S Jefferson Ave, St. Louis, MO
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $136 total per night from Aug 17 to Aug 18
$136 total
Aug 17 - Aug 18
Total includes taxes and fees
7.8/10 Good! (1,000 reviews)
"Location itself was bad"

Reviewed on Jul 8, 2025

Residence Inn by Marriott St Louis Downtown
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St, St. Louis, MO
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $119 total per night from Aug 22 to Aug 23
$119 total
Aug 22 - Aug 23
Total includes taxes and fees
8.4/10 Very Good! (3,893 reviews)
"Everything"

Reviewed on Jul 31, 2025

Hyatt Regency St. Louis at The Arch
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Midtown

Things to do

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.