
Midtown Vacations from $225
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Your Midtown Vacation
Organizing your next getaway just got easier with a vacation package to Midtown. Take in the very best this neighborhood has to offer while making incredible memories you'll treasure. Your trip to Midtown wouldn't be complete without exploring leading attractions nearby such as Busch Stadium, Gateway Arch and Dome at America’s Center. No matter what your dream Midtown vacation looks like, you can make it a reality with Expedia.
The Latest Midtown Vacation Packages

Crowne Plaza St. Louis Airport by IHG
Reviewed on Jul 19, 2025

The Wildwood Hotel
Reviewed on Jul 30, 2025

The Principal Hotel
Reviewed on Jul 26, 2025

Hilton Garden Inn Chesterfield
Reviewed on Jul 26, 2025

Aloft St. Louis Cortex
Reviewed on Aug 1, 2025
Where to stay in Midtown

Downtown St. Louis
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.
Midtown Hotel Deals

Element St. Louis Midtown
Reviewed on Jul 27, 2025

Residence Inn by Marriott St Louis Downtown
Reviewed on Jul 8, 2025

Hyatt Regency St. Louis at The Arch
Reviewed on Jul 31, 2025
Discover the most popular places to visit in Midtown

St. Louis University
Explore the campus of St. Louis University as part of your travels around St. Louis. Wander around the area's picturesque gardens or experience its acclaimed theater scene.

Scott Joplin House State Historic Site
Learn about the local history of St. Louis when you spend time at Scott Joplin House State Historic Site. Experience the area's acclaimed theater scene or attend a baseball game.
Chaifetz Arena
Catch an event at Chaifetz Arena during your trip to St. Louis. Amble around the area's picturesque gardens or attend a baseball game.
Things to do

St Louis Ghost Tours: Sinister Sins & Shadows Ghost Tour

Best of St. Louis Small Group Tour w/ Arch & River Cruise
