Midtown Vacations from $377

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Your Midtown Vacation

Organizing your next getaway just got easier with a vacation package to Midtown. Take in the very best this neighborhood has to offer while making incredible memories you'll treasure. Your trip to Midtown wouldn't be complete without exploring leading attractions nearby such as Busch Stadium, Gateway Arch and Dome at America’s Center. No matter what your dream Midtown vacation looks like, you can make it a reality with Expedia.

The Latest Midtown Vacation Packages

Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel

The Wildwood Hotel

$377
per person
Sep 30 - Oct 5
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.2/10 Wonderful! (1,665 reviews)
The Cheshire

The Cheshire

Save 100% on your flight
$485
per person
Sep 30 - Oct 5
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,005 reviews)
HoteLumiere at the Arch Hotel & Casino - A Caesars Rewards Destination

HoteLumiere at the Arch Hotel & Casino - A Caesars Rewards Destination

Downtown St. Louis
Save 100% on your flight
$405
per person
Sep 30 - Oct 5
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
6.8/10 (1,004 reviews)
Crowne Plaza St. Louis Airport by IHG

Crowne Plaza St. Louis Airport by IHG

Save 100% on your flight
$437
per person
Nov 2 - Nov 7
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8/10 Very Good! (1,003 reviews)
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

Save 100% on your flight
$571
per person
Nov 2 - Nov 7
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.6/10 Excellent! (1,043 reviews)

Where to stay in Midtown

Find the best Midtown areas and neighborhoods for the activities you enjoy most. Learn more about Midtown
A public park with a fountain featuring bronze sculptures of mythological figures, surrounded by trees and a large building in the background.

Downtown St. Louis

3 out of top 10 points of interest in this area

Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.

Find hotels in Downtown St. Louis
The illuminated Gateway Arch at night with a city skyline in the background.

Clayton

1 out of top 10 points of interest in this area

Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

Find hotels in Clayton
A street with parked cars, a building with a sign reading "Brennan's", and a tree in front.

Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

Find hotels in Central West End
A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

Find hotels in Creve Coeur
An ornate hall with arched ceilings and intricate patterns.

Downtown West

2 out of top 10 points of interest in this area

If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.

Find hotels in Downtown West

Midtown Hotel Deals

Element by Marriott St. Louis Midtown

Element by Marriott St. Louis Midtown

3763 Forest Park Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$135 nightly
$158 total
Sep 27 - Sep 28
Total with taxes and fees
9/10 Wonderful! (814 reviews)
"Everytjing"

Reviewed on Aug 27, 2026

Element by Marriott St. Louis Midtown
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$93 nightly
$109 total
Aug 30 - Aug 31
Total with taxes and fees
9/10 Wonderful! (3,353 reviews)
"Front desk rude. Room smelled funny. Bed had a stain. In a nice part of town but don’t let the outside food you it’s worse inside. I would have rather stayed at red room inn"

Reviewed on Aug 29, 2026

Clayton Plaza Hotel & Extended Stay
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

315 Chestnut St St. Louis MO
Fully refundableReserve now, pay when you stay
$134 nightly
$158 total
Sep 4 - Sep 5
Total with taxes and fees
Hyatt Regency St. Louis at The Arch
See all 1,982 properties in Midtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
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Beach Vacations
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Where to go when
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Honeymoon Vacations
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Mountain Vacations
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Solo Vacations

Stay near popular Midtown attractions

A historic building with a large lawn, a flagpole with flags, and a clear blue sky.

St. Louis University

8.6/10 (526 reviews)
Explore the campus of St. Louis University as part of your travels around St. Louis. Wander around the area's picturesque gardens or experience its fascinating museums.
See properties
A room with a grand piano, a white door, and a framed picture on the wall.
Photo by Wanderlustfemale

Scott Joplin House State Historic Site

Learn about the local history of St. Louis when you spend time at Scott Joplin House State Historic Site. Experience the area's fascinating museums or attend a baseball game.
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Chaifetz Arena

8.8/10 (59 reviews)
Catch an event at Chaifetz Arena during your trip to St. Louis. Amble around the area's picturesque gardens or attend a baseball game.
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Harris-Stowe State University

Explore the campus of Harris-Stowe State University during your visit to St. Louis.
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City Foundry STL

City Foundry STL is just one of the places to see in St. Louis, so why not enjoy the other things to explore during your travels?
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Topgolf

You can take time to visit Topgolf during your travels to St. Louis.
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Red Flag

You can enjoy a show at Red Flag on your trip to St. Louis.
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Museum of Contemporary Religious Art

You can spend an afternoon exploring the galleries in Museum of Contemporary Religious Art during your trip to St. Louis. Experience the area's acclaimed theater scene or attend a sporting event.
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Things to do

St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

$24
per adult
100% of travellers recommend
St. Louis Ghost Tour: Sinister Sins & Shadows
The Gateway Arch National Park & Museum

StL's Signature "Sights and Bites" - Private Tour in St. Louis

$175
per adult
StL's Signature "Sights and Bites" - Private Tour in St. Louis
Lemp Haunted Neighborhood Walking Tour

Lemp Haunted Neighborhood Walking Tour

$25
per adult
84% of travellers recommend
Lemp Haunted Neighborhood Walking Tour
See all activities in St. Louis
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.