Midtown Vacations from $595
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Your Midtown Vacation
Organizing your next getaway just got easier with a vacation package to Midtown. Take in the very best this neighborhood has to offer while making incredible memories you'll treasure. Your trip to Midtown wouldn't be complete without exploring leading attractions nearby such as Busch Stadium, Gateway Arch and Dome at America’s Center. No matter what your dream Midtown vacation looks like, you can make it a reality with Expedia.
The Latest Midtown Vacation Packages
Price found within the past 48 hours. Click for updated prices.
The Knight Center at Washington University
Price was $791, price is now $595 per person
$595
per person
Jun 22 - Jun 26
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.4/10 Exceptional! (496 reviews)
Great, simple breakfast options. Clean fitness room. Terrific location steps from main campus and a short walk to town and restaurants.
Reviewed on Mar 26, 2026
The Wildwood Hotel
Save 100% on your flight
Price was $948, price is now $596 per person
$596
per person
May 21 - May 25
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.2/10 Wonderful! (1,620 reviews)
The breakfaat was average, thou fresh. There was enough street parking nearby, safe.
Reviewed on Mar 30, 2026
Hilton Pennywell St. Louis at the Arch
Downtown St. Louis
Price was $953, price is now $710 per person
$710
per person
Jun 22 - Jun 26
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,029 reviews)
Our stay at the Pennywell was great! We arrived before checkout but we were able to leave our bags at the front desk so we could explore. We were in town for Opening Day and the hotel was very close to the stadium, which was great. It is also super close to the Arch as well. Lots of food options around the hotel to check out. Room was clean and well kept. Although, our view was less than desirable as our window faced a brick wall but, we spent most of our time in St. Louis out and about. But, if thats important to you, you might want to request a specific room. Overall, great stay and I'd stay again if we went back to St. Louis!
Reviewed on Mar 30, 2026
The Cheshire
Price was $833, price is now $628 per person
$628
per person
May 21 - May 25
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.6/10 Excellent! (1,009 reviews)
The room was comfortable and we had the amenities we needed. It offered a generous breakfast every morning. Coffee and water were available at all times. The gym was clean and easily accessible. The pool was closed during our stay due to the season we traveled in. There was ample parking downstairs. The bar on site was really cute and the drinks were great. We were driving distance to a lot of things and it made it a great homebase. We would definitely stay here again.
Reviewed on Mar 29, 2026
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Grand Center
Price was $792, price is now $610 per person
$610
per person
Jun 22 - Jun 26
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,065 reviews)
Cleaning needs help in the rooms and bathrooms. Room 511 hopefully is the smallest of all the rooms. You couldn’t use the chair fully with the desk and had to take turns in areas it was so tight. The staff was wrong about times for the Terrance bar and restaurant causing us to wait for that and then miss the downstairs restaurant being open so we waited a few more hours to find a place to eat. Simple mistake but that’s their job.
Reviewed on Mar 22, 2026
Where to stay in Midtown
Find the best Midtown areas and neighborhoods for the activities you enjoy most. Learn more about Midtown
Downtown St. Louis
3 out of top 10 points of interest in this area
4/5(4,044 area reviews)
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.
Midtown Hotel Deals
Element St. Louis Midtown
3763 Forest Park Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $158 total per night from Apr 8 to Apr 9
$158 total
Apr 8 - Apr 9
Total with taxes and fees
9/10 Wonderful! (702 reviews)
For the price I paid, I feel the breakfast selection wasn’t the greatest, however everything served was fresh. Also, I paid an extra 80 plus dollars for parking. If it was mentioned in the listing, it wasn’t plain text that parking was extra. I understand parking space in a big city is a premium, ...
Reviewed on Mar 30, 2026
Residence Inn by Marriott St Louis Downtown
525 S Jefferson Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$118 nightly
The price is $140 total per night from Apr 6 to Apr 7
$140 total
Apr 6 - Apr 7
Total with taxes and fees
7.8/10 Good! (1,001 reviews)
Was not able to use the pool and that was my reasoning for booking the hotel room.
Reviewed on Mar 28, 2026
Drury Plaza Hotel St. Louis at the Arch
2 South 4th Street St. Louis MO
Fully refundableReserve now, pay when you stay
$162 nightly
The price is $189 total per night from Apr 5 to Apr 6
$189 total
Apr 5 - Apr 6
Total with taxes and fees
9.4/10 Exceptional! (3,355 reviews)
The breakfast food was not very good. The breakfast area was kind of dirty. There were probably a couple of hundred people going through there touching the tongs, but there was not a single hand sanitizer to be found. And this was at the height of flu season. Pretty gross.
Reviewed on Mar 28, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Midtown
St. Louis University
Explore the campus of St. Louis University as part of your travels around St. Louis. Wander around the area's picturesque gardens or experience its fascinating museums.
Scott Joplin House State Historic Site
Learn about the local history of St. Louis when you spend time at Scott Joplin House State Historic Site. Experience the area's great live music or attend a baseball game.
Chaifetz Arena
Catch an event at Chaifetz Arena during your trip to St. Louis. Amble around the area's picturesque gardens or attend a baseball game.
Things to do
St. Louis Ghost Tour: Sinister Sins & Shadows
$24
per adult
Lemp Haunted Neighborhood Walking Tour
$30
per adult
84% of travellers recommend
St. Louis Premium Driving Tour with Boat Ride & Arch
$174
per adult
100% of travellers recommend
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.