Find 4 Star Hotels in Mesopotamia from $54

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Check availability on Mesopotamia 4 Star Hotels

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Dec 3 - Dec 4
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Dec 4 - Dec 5
This weekend
Dec 5 - Dec 7
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Dec 12 - Dec 14

Compare Mesopotamia 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Casino
Amérian Hotel Casino Gala

Amérian Hotel Casino Gala

4.0 star property
Resistencia
9.0 out of 10, Wonderful, (165)
"Good check in"
United States
Paul
$58 nightly
The price is $58
Dec 4 - Dec 5
Amérian Hotel Casino Gala
Dining
Esplendor by Wyndham Savoy Rosario

Esplendor by Wyndham Savoy Rosario

4.0 star property
Rosario Centro
8.6 out of 10, Excellent, (443)
"Excellent hotel Everything very comfortable, and convenient"
United States
Cecilia Marina
$84 nightly
The price is $84
Jan 2 - Jan 3, 2026
Esplendor by Wyndham Savoy Rosario
Restaurant
Marriott Corrientes Hotel

Marriott Corrientes Hotel

4.5 star property
Corrientes
10.0 out of 10, Exceptional, (4)
"Very nice hotel"
United States
Jeffrey
$118 nightly
The price is $118
Dec 13 - Dec 14
Marriott Corrientes Hotel
Outdoor pool, sun loungers
Dazzler by Wyndham Rosario

Dazzler by Wyndham Rosario

4.0 star property
Rosario
8.8 out of 10, Excellent, (187)
"Convenient if you like shopping and the hotel very good amenities "
Canada
Daniela
$82 nightly
The price is $82
Dec 4 - Dec 5
Dazzler by Wyndham Rosario
Outdoor pool, sun loungers
InterTower Hotel

InterTower Hotel

4.0 star property
Santa Fe
8.8 out of 10, Excellent, (210)
"Excelent place to stay."
United States
Angel
$93 nightly
The price is $93
Dec 21 - Dec 22
InterTower Hotel
Lobby lounge
Puerto Norte Design Hotel

Puerto Norte Design Hotel

4.0 star property
Rosario
9.2 out of 10, Wonderful, (142)
"Super comfortable and luxurious with amazing view of the river. The staff was courteous enough and parking was easy and right in front of the hotel. "
United States
Katie
$124 nightly
The price is $124
Dec 4 - Dec 5
Puerto Norte Design Hotel
Rooftop terrace
Los Silos Hotel

Los Silos Hotel

4.0 star property
Santa Fe
9.2 out of 10, Wonderful, (27)
"Unique, interesting, and very nice. Staff was outstanding. We will be back soon"
United States
Russell
$116 nightly
The price is $116
Dec 14 - Dec 15
Los Silos Hotel
Aerial view
Pullman Rosario City Center Hotel

Pullman Rosario City Center Hotel

4.0 star property
Rosario
8.6 out of 10, Excellent, (273)
"Nice"
United States
juan
Pullman Rosario City Center Hotel
Outdoor pool
Ros Tower Hotel

Ros Tower Hotel

4.0 star property
Rosario Centro
8.6 out of 10, Excellent, (312)
"The breakfast was excellent, the hotel a bit outdated but still great for Rosario."
United States
Lisa
Ros Tower Hotel
Lobby lounge
La Alondra Casa De Huéspedes

La Alondra Casa De Huéspedes

4.0 star property
Corrientes
9.2 out of 10, Wonderful, (65)
"De lo mejor ! Excelente atención del hotel y restaurante!"
Costa Rica
Maria del Carmen
$138 nightly
The price is $138
Dec 6 - Dec 7
La Alondra Casa De Huéspedes
41-inch TV with satellite channels
Hotel Solans Presidente

Hotel Solans Presidente

4.0 star property
Rosario Centro
8.6 out of 10, Excellent, (146)
"Breakfast was great and staff was great too "
United States
Juan
Hotel Solans Presidente
Standard Room | Soundproofing, free WiFi
Apart Hotel Ribera del Baradero

Apart Hotel Ribera del Baradero

4.0 star property
Baradero
$104 nightly
The price is $104
Dec 11 - Dec 12
Apart Hotel Ribera del Baradero
Premium bedding, pillowtop beds, individually decorated
Agustín 1 Apart

Agustín 1 Apart

4.0 star property
Parana
9.0 out of 10, Wonderful, (4)
"Meu problema foi só a garagem, o apartamento é ótimo, limpeza estava impecável."
Brazil
Jose rodrigo kallas
$54 nightly
The price is $54
Dec 8 - Dec 9
Agustín 1 Apart
City view
Ámbar Suites

Ámbar Suites

4.0 star property
Rosario Centro
Ámbar Suites
Outdoor pool, pool umbrellas, sun loungers
HOTEL TERMAS VICTORIA Wellness Spa

HOTEL TERMAS VICTORIA Wellness Spa

4.0 star property
Victoria
9.0 out of 10, Wonderful, (2)
"El hotel está ubicado en un lugar muy bueno, muy tranquilo, buenas instalaciones y buena disposición de las mismas, la vista es increíble "
Argentina
Mirna
HOTEL TERMAS VICTORIA Wellness Spa
Outdoor dining
Villa Lua

Villa Lua

4.0 star property
Gualeguaychú
Villa Lua
Poolside bar
San Pedro Palace Hotel

San Pedro Palace Hotel

4.5 star property
San Pedro
8.8 out of 10, Excellent, (6)
"EL HOTEL ES MUY LINDO, ACONDICVIONADO PERO CON UN DEJO DE EPOCA QUE TE HACE SENTIR MUY BIEN. LOS EMPLEADOS MUY ATENTOS A TODAS LAS NECESIDADES. LO PASAMOS MUY PERO MUY BIEN"
Argentina
ENRIQUE CARLOS
San Pedro Palace Hotel
3 outdoor pools, pool umbrellas, sun loungers
La Regina Lodge

La Regina Lodge

4.0 star property
Municipo de Itatí
$61 nightly
The price is $61
Dec 4 - Dec 5
La Regina Lodge
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Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Mesopotamia.
Bagú Urbano

Bagú Urbano

Bolivar 2176 Posadas Misiones
Get rates
8.4/10 Very Good! (343 reviews)
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Learn more about Mesopotamia

The awe-inspiring Iguazú Falls is the centerpiece attraction of this northeastern Argentine region, which also hosts the country’s biggest carnival celebration.

See all hotels in Mesopotamia
Mesopotamia showing a river or creek and forest scenes

Top Mesopotamia Hotel Reviews

Amérian Hotel Casino Gala

Amérian Hotel Casino Gala

10/10 Excellent
"Good check in"
Paul 1-night trip
Posted 2 days ago
Amérian Hotel Casino Gala

Find out more about Mesopotamia

Mesopotamia Four Star Hotel Information

When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Mesopotamia, Argentina are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Mesopotamia 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.

Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Mesopotamia. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Mesopotamia, Argentina, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.

Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Mesopotamia hotels offer everything your heart desires.