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Our top choices for Mesopotamia hotels

Hotel Crespo

Hotel Crespo
3.0 star property
Crespo
10.0 out of 10, Exceptional, (1)
$15 nightly
The price is $15
Dec 27 - Dec 28
Hotel Crespo

Marriott Corrientes Hotel

Marriott Corrientes Hotel
4.5 star property
Corrientes
9.6 out of 10, Exceptional, (8)
"Very nice hotel"
United States
Jeffrey
$134 nightly
The price is $134
Jan 2 - Jan 3, 2026
Marriott Corrientes Hotel

Casa del Árbol

Casa del Árbol
3.0 star property
Concepción del Uruguay
8.4 out of 10, Very Good, (8)
"La primera vez que venga a Concepcion del Uruguay, quiero alquilar en" la casa del arbol" Me sentí muy bienvenida y en buena compañía, los anfitriones son maravillosos "
Mexico
Olga Beatriz
$39 nightly
The price is $39
Dec 27 - Dec 28
Casa del Árbol

Mayim Hotel Termal & SPA

Mayim Hotel Termal & SPA
3.0 star property
Concordia
8.8 out of 10, Excellent, (5)
"Muy lindo hotel , lástima q se rompió el aire acondicionado y no hay secador de pelo an la habitación "
United States
Catalina
$103 nightly
The price is $103
Dec 28 - Dec 29
Mayim Hotel Termal & SPA

Hotel Rio

Hotel Rio
3.0 star property
Chajarí
8.8 out of 10, Excellent, (11)
"Lindo hotel, moderno, limpio, buena atencion, sumaria opciones saladas en el desayuno, como huevos revueltos."
Argentina
SANTIAGO
$78 nightly
The price is $78
Dec 27 - Dec 28
Hotel Rio

Estancia Iberá

Estancia Iberá
3.0 star property
Mercedes
10.0 out of 10, Exceptional, (1)
"we had a wonderful experience the staff was very friendly and helpful and took us out on lots of activities and we saw an amazing amount of wildlife in a very short period of time. The place is very beautiful and tranquil. I would highly recommend it and give it five stars. "
Canada
orit
$119 nightly
The price is $119
Jan 21 - Jan 22, 2026
Estancia Iberá

Costarenas Hotel & Spa

Costarenas Hotel & Spa
3.5 star property
Colon
8.6 out of 10, Excellent, (58)
"spectacular since we arrived the tstaff was wonderful and kind to us very helpful and nice answering all our questions, the hotel very comfortable!! the river view stunning"
Argentina
Lisette
$112 nightly
The price is $112
Dec 27 - Dec 28
Costarenas Hotel & Spa

Hathor Concordia

Hathor Concordia
3.0 star property
Concordia
8.6 out of 10, Excellent, (358)
"AC did not work well, food was OK. Staff friendly. Good hotel for a stay on the road."
United States
Patrick
Hathor Concordia

Don Pedro Apart Hotel

Don Pedro Apart Hotel
2.0 star property
Federacion
10.0 out of 10, Exceptional, (1)
"Estuvo muy bien, la atención fue muy buena. "
Costa Rica
Marianela
$30 nightly
The price is $30
Dec 27 - Dec 28
Don Pedro Apart Hotel

Rio Arriba Suites Apartments y Resto

Rio Arriba Suites Apartments y Resto
3.5 star property
Bella Vista
8.6 out of 10, Excellent, (4)
"Pessoal da recepção excelente acolhimento. Hotel bonito, falta manutenção em certos lugares. Quarto ótimo, cama com colchão selado e barulho nos ares condicionados. Café da manhã deixa a desejar. Restaurante muito bonito. "
Brazil
Anonymous traveler
Rio Arriba Suites Apartments y Resto

Donsuites Apart Hotel

Donsuites Apart Hotel
3.0 star property
Corrientes
8.6 out of 10, Excellent, (105)
"Loved this place, super clean, and the staff were very nice and helpful😍"
United States
Nora
$61 nightly
The price is $61
Dec 30 - Dec 31
Donsuites Apart Hotel

Rincón del Socorro

Rincón del Socorro
3.0 star property
Mercedes
10.0 out of 10, Exceptional, (6)
"People could not be nicer. It is a jewel that needs to be protected and cherished"
United States
Anonymous traveler
$600 nightly
The price is $600
Jan 2 - Jan 3, 2026
Rincón del Socorro

O2 Hotel Gualeguaychú

O2 Hotel Gualeguaychú
2.5 star property
Gualeguaychú
7.6 out of 10, Good, (67)
"Hotel is very comfortable and clean. There is no breakfast or hotel parking, and the wifi does not work properly in most floors and rooms. Other than that, the staff is very friendly and nice. "
United States
Esteban
$30 nightly
The price is $30
Dec 28 - Dec 29
O2 Hotel Gualeguaychú

Agustín 1 Apart

Agustín 1 Apart
4.0 star property
Parana
9.0 out of 10, Wonderful, (4)
"Meu problema foi só a garagem, o apartamento é ótimo, limpeza estava impecável."
Brazil
Jose rodrigo kallas
$53 nightly
The price is $53
Dec 27 - Dec 28
Agustín 1 Apart

Estancia La Violeta

Estancia La Violeta
2.5 star property
Chajarí
8.8 out of 10, Excellent, (3)
"Best place to spend a few days resting espero under by natural beauty and Argentinian estancia history. The staff is amazing. We will be back"
United States
Orestes
$237 nightly
The price is $237
Jan 6 - Jan 7, 2026
Estancia La Violeta

Totoras Apart Federacion

Totoras Apart Federacion
2.5 star property
Federacion
7.4 out of 10, Good, (26)
"Todo perfecto!!! "
Mexico
Gabriel
Totoras Apart Federacion

Maran Suites & Towers - Hotel & Spa

Maran Suites & Towers - Hotel & Spa
3.5 star property
Parana
9.2 out of 10, Wonderful, (31)
"Great location and friendly, accommodating staff. "
United States
Michael
$85 nightly
The price is $85
Dec 29 - Dec 30
Maran Suites & Towers - Hotel & Spa

COSTA NORTE HOSTERIA

COSTA NORTE HOSTERIA
3.0 star property
Colón
8.0 out of 10, Very Good, (1)
"O quarto e banheiro estavam impecaveis. A equipe de recepção foi muito reativa, quiseram me cobrar o quarto a pesar que mostrei o recibo de pagamento no site da Hoteis.com, e também achamos que o horario do cafe da manhã é muito tarde (a partir das 8.30), como a nossa partida foi mais cedo, pela nossa insistencia nos serviram apenas um cafe mais simples."
Brazil
Antonio
$55 nightly
The price is $55
Dec 27 - Dec 28
COSTA NORTE HOSTERIA

Hotel y Spa Termas del Este

Hotel y Spa Termas del Este
3.0 star property
Federacion
8.4 out of 10, Very Good, (12)
"good for a 1 night stay"
Canada
Chase
Hotel y Spa Termas del Este

La Alondra Casa De Huéspedes

La Alondra Casa De Huéspedes
4.0 star property
Corrientes
9.2 out of 10, Wonderful, (65)
"De lo mejor ! Excelente atención del hotel y restaurante!"
Costa Rica
Maria del Carmen
$129 nightly
The price is $129
Jan 18 - Jan 19, 2026
La Alondra Casa De Huéspedes
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Mesopotamia attractions

Learn more about Mesopotamia

The awe-inspiring Iguazú Falls is the centerpiece attraction of this northeastern Argentine region, which also hosts the country’s biggest carnival celebration.

Mesopotamia showing a river or creek and forest scenes

Top Mesopotamia Hotel Reviews

More cheap stays in Mesopotamia

Hotels in Mesopotamia with star-rating

Find out more about Mesopotamia

Top reasons to visit Mesopotamia

  • Adventure and Outdoor Activities: Mesopotamia is perfect for outdoor enthusiasts, featuring scenic hikes and thrilling adventures in stunning national parks.
  • Family-Friendly Attractions: The region offers a variety of activities suitable for families, including water parks and engaging nature experiences.
  • Beautiful Landscapes: Enjoy picturesque landscapes ideal for picnics and relaxation, providing breathtaking views and a romantic atmosphere.
  • Diverse Accommodations: Find cozy hotels with family-friendly amenities and budget-friendly options, ensuring a comfortable stay.
  • Vibrant Nature: Experience birdwatching and explore vibrant surroundings, making it a nature lover's paradise.

Find great hotels near Mesopotamia

Experience the charm of Mesopotamia, Argentina, with a variety of hotel accommodations designed to provide a memorable family vacation. From cozy hotels with family-friendly amenities to well-reviewed options that suit every budget, you’ll find the perfect place to unwind. Explore the best hotels in the area, compare room rates, and read guest reviews to ensure a delightful stay in this enchanting destination.

  • El Tránsito Hotel Boutique: Nestled 18 miles from Mesopotamia, El Tránsito Hotel Boutique offers a charming family-friendly atmosphere perfect for vacationing families. This 3.5-star hotel features a variety of child-focused amenities, including a dedicated children's pool, an exciting arcade game room, and complimentary cribs for younger guests. With its inviting ambiance and thoughtful facilities, this hotel ensures a memorable stay for both parents and children, making it an ideal choice for your family getaway in the heart of Argentina.

Where to stay near Mesopotamia

Mesopotamia, Argentina, offers a captivating blend of outdoor adventures and family-friendly activities. Explore its picturesque landscapes, ideal for picnics and scenic views, while enjoying a romantic or relaxing atmosphere. Discover popular destinations that showcase the region's beautiful properties and vibrant city views, ensuring a memorable vacation experience for all types of travelers seeking adventure and family fun.

  • Mercedes: Located 31 miles from Mesopotamia, Mercedes is a vibrant city that offers an exciting mix of outdoor adventures and family-friendly experiences. With visitor numbers peaking in July and December to January, this city is perfect for those looking to enjoy activities such as golf, water parks, and nearby national and theme parks. The scenic beauty surrounding Mercedes makes it an ideal spot for outdoor enthusiasts, ensuring a fun-filled vacation for all ages.
  • Concepción: Just 22 miles away from Mesopotamia, Concepción is a charming city known for its stunning scenery and adventurous spirit. Visitors flock here during April, July, and September, drawn by the allure of outdoor activities and natural parks. The city’s proximity to national parks allows for immersive experiences in nature, making it a perfect destination for those seeking breathtaking landscapes and thrilling adventures.
  • Uguay: A quaint village located 17 miles from Mesopotamia, Uguay captivates visitors with its natural parks and serene environment. While traveler arrivals peak in January, March, and November, Uguay offers a seasonal charm that is hard to resist. This village is an excellent choice for those looking to escape the hustle and bustle of city life and immerse themselves in peaceful natural settings, perfect for relaxation and exploration.

Things to do in Mesopotamia

Mesopotamia, Argentina, offers a delightful mix of entertainment, adventure, and family-friendly activities. Visitors can enjoy the excitement of a water park, explore nature through birdwatching, and embark on scenic hikes. Outdoor seating is available for those looking to relax and soak in the vibrant surroundings. Whether you're seeking adventure or a leisurely experience, Mesopotamia has something for everyone.

Shopping

In Mesopotamia, Argentina, visit the Plaza Shopping Center, a vibrant hub featuring a variety of shops, cafes, and entertainment options. Don't miss the local markets like the Mercado de Posadas, where you can find unique handmade crafts and delicious regional delicacies perfect for souvenirs.

Recreation

Experience tranquility at the Termas de Copahue, where you can soak in natural hot springs and indulge in therapeutic mud treatments. Engage in yoga sessions surrounded by lush landscapes, and enjoy guided nature walks that promote relaxation and rejuvenation in the serene environment of Mesopotamia.

Adventure

Explore the stunning Iguazu Falls, where you can hike trails and take boat rides that get you up close to the thundering waterfalls. Experience the diverse wildlife at the Iberá Wetlands, perfect for kayaking and birdwatching in a breathtaking natural setting.

Nightlife

Experience the vibrant nightlife in Mesopotamia, Argentina, with a visit to La Ronda for live music and dancing. For a relaxed vibe, check out El Patio, where you can enjoy local brews and delicious tapas while mingling with friendly locals.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Mesopotamia

To save money during your visit to Mesopotamia, Argentina, consider traveling during the off-peak months when prices are lower, avoiding July, August, and December. Book your hotel about a month in advance for better rates, and check Expedia for last-minute deals. Stay on a Tuesday for the best hotel prices and use Expedia's search tool to find budget-friendly accommodations. Consider booking a package deal that includes flights and activities, and join the One Key membership program for exclusive discounts. Lastly, explore free local attractions to maximize your savings.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around Mesopotamia are , where the prices are slightly lower. This is in comparison to July to August and December, where prices are slightly higher.
  • The best time to book a hotel: The cheapest time to book a hotel around Mesopotamia is usually 1 month out from when you are planning to stay, though if you're late to the party, have a look at Expedia's last minute deals - the green banner below the hotel's price indicates a discounted rate.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around Mesopotamia is Tuesday. The most expensive day to stay around Mesopotamia is Monday.
  • Find cheap hotels on Expedia: Utilize Expedia's search tool to customize your options based on your budget, desired location, and preferred type of accommodation. For instance, selecting the Eco-certified option will showcase hotels that prioritize sustainability and eco-friendliness. To find the best prices and deals, simply sort the results by price from lowest to highest.
  • Consider bundling your trip: You can save money by booking an Expedia package that combines your Mesopotamia hotel stay with your flights and activities.
  • Become a One Key member: Join Expedia's One Key membership program for exclusive discounts and deals on hotel bookings. You can also earn OneKeyCash to use on future selected hotels.

Find the best attractions near Mesopotamia

Mesopotamia, Argentina, is perfect for family-friendly, adventure-filled vacations. Visitors can explore stunning national parks and other attractions that cater to those seeking outdoor experiences and breathtaking scenery. Whether you're looking for thrilling adventures or relaxing moments in nature, Mesopotamia offers a variety of points of interest that will make your trip memorable.

  • Portal Carambola: Located 14 miles from Mesopotamia, this national park offers thrilling adventures and stunning scenery, perfect for outdoor enthusiasts looking to immerse themselves in nature's beauty.

Best time to go to Mesopotamia

The best time to visit Mesopotamia depends on your weather preferences. The hottest average temperature around Mesopotamia is in January and February. February is mostly sunny. The coolest average temperature around Mesopotamia is in May and July. July is mostly sunny.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January80.1°F (26.700000000000003°C)Light RainSunnyModerately HighAverage
February77.7°F (25.4°C)Light RainMostly Sunny
March72.9°F (22.700000000000003°C)Light RainMostly SunnyModerately HighAverage
April66.7°F (19.3°C)Light RainMostly SunnyAverageAverage
May59.5°F (15.3°C)Light RainMostly Sunny
June60.1°F (15.6°C)Light RainMostly Sunny
July53.4°F (11.9°C)Light RainMostly SunnyAverageSlightly High
August63.7°F (17.6°C)Light RainMostly SunnyAverageSlightly High
September60.6°F (15.9°C)Light RainMostly SunnyAverageAverage
October65.8°F (18.8°C)Light RainMostly SunnyAverageAverage
November72.3°F (22.4°C)Light RainSunnyModerately HighAverage
December77.0°F (25.0°C)Light RainSunnyAverageSlightly High

The nearest major airports for your trip to Mesopotamia

For travelers heading to Mesopotamia, Argentina, there are three major airports to consider. Posadas Airport (PSS) is 138 miles away, with nearby accommodations such as La Mision Posadas Hotel, Continental Posadas Hotel, and Hotel Batista, all rated 3.5 stars. Resistencia Airport (RES) is 113 miles from Mesopotamia, offering options like Gala Hotel y Convenciones and Amérian Hotel Casino Gala, both rated 3.5 stars as well. The closest is Uruguaiana Airport (URG), located 91 miles away, with Hotel Monte Carlo and River Hotel as lodging options. Each airport provides various transportation services to facilitate easy access to these hotels.