Title: Top 10 Hotels in Mesopotamia from $32 - Competitive Prices | Expedia.com [Mesopotamia Travel Guide](https://expedia.com/Mesopotamia.dx6208836)[Vacation Rentals in Mesopotamia](https://expedia.com/Mesopotamia-Vacation-Rentals.d6208836.Travel-Guide-VacationRentals)[Flights to Mesopotamia](https://expedia.com/Cheap-Flights-To-Mesopotamia.d6208836.Travel-Guide-Flights)[Car Rentals in Mesopotamia](https://expedia.com/Car-Rentals-In-Mesopotamia.d6208836.Car-Rental-Guide)[Mesopotamia Vacation Packages](https://expedia.com/Mesopotamia.d6208836.Destination-Travel-Guides) ![Iguazu Falls featuring a waterfall](https://images.trvl-media.com/place/6171898/bb162948-b907-405b-9053-fc054127c668.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6171898/bb162948-b907-405b-9053-fc054127c668.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ## Go beyond your typical stay in Mesopotamia Pool [](https://www.expedia.com/Hotel-Search?destination=Mesopotamia%2C+Argentina®ionId=6208836&latLong=-30.337161%2C-58.464548&adults=2&startDate=2026-04-10&d1=2026-04-10&endDate=2026-04-12&d2=2026-04-12&amenities=POOL) Family friendly [](https://www.expedia.com/Hotel-Search?destination=Mesopotamia%2C+Argentina®ionId=6208836&latLong=-30.337161%2C-58.464548&adults=2&startDate=2026-04-10&d1=2026-04-10&endDate=2026-04-12&d2=2026-04-12&travelerType=family_friendly) Cabin [](https://www.expedia.com/Hotel-Search?destination=Mesopotamia%2C+Argentina®ionId=6208836&latLong=-30.337161%2C-58.464548&adults=2&startDate=2026-04-10&d1=2026-04-10&endDate=2026-04-12&d2=2026-04-12&lodging=CABIN) Pet friendly [](https://www.expedia.com/Hotel-Search?destination=Mesopotamia%2C+Argentina®ionId=6208836&latLong=-30.337161%2C-58.464548&adults=2&startDate=2026-04-10&d1=2026-04-10&endDate=2026-04-12&d2=2026-04-12&amenities=PETS) Spa [](https://www.expedia.com/Hotel-Search?destination=Mesopotamia%2C+Argentina®ionId=6208836&latLong=-30.337161%2C-58.464548&adults=2&startDate=2026-04-10&d1=2026-04-10&endDate=2026-04-12&d2=2026-04-12&amenities=SPA_ON_SITE) Apart hotel [](https://www.expedia.com/Hotel-Search?destination=Mesopotamia%2C+Argentina®ionId=6208836&latLong=-30.337161%2C-58.464548&adults=2&startDate=2026-04-10&d1=2026-04-10&endDate=2026-04-12&d2=2026-04-12&lodging=APART_HOTEL) Hot tub [](https://www.expedia.com/Hotel-Search?destination=Mesopotamia%2C+Argentina®ionId=6208836&latLong=-30.337161%2C-58.464548&adults=2&startDate=2026-04-10&d1=2026-04-10&endDate=2026-04-12&d2=2026-04-12&amenities=HOT_TUB) Apart­ment [](https://www.expedia.com/Hotel-Search?destination=Mesopotamia%2C+Argentina®ionId=6208836&latLong=-30.337161%2C-58.464548&adults=2&startDate=2026-04-10&d1=2026-04-10&endDate=2026-04-12&d2=2026-04-12&lodging=APARTMENT) ## Check prices for these dates Tonight [Mar 27 - Mar 28](https://www.expedia.com/Hotel-Search?regionId=6208836&startDate=2026-03-27&endDate=2026-03-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 28 - Mar 29](https://www.expedia.com/Hotel-Search?regionId=6208836&startDate=2026-03-28&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 27 - Mar 29](https://www.expedia.com/Hotel-Search?regionId=6208836&startDate=2026-03-27&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Apr 3 - Apr 5](https://www.expedia.com/Hotel-Search?regionId=6208836&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Mesopotamia hotels ![Outdoor spa tub](https://images.trvl-media.com/lodging/126000000/125980000/125979300/125979202/ec850d29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchen](https://images.trvl-media.com/lodging/126000000/125980000/125979300/125979202/769b8659.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Flat-screen TV](https://images.trvl-media.com/lodging/126000000/125980000/125979300/125979202/3363418d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House, Lake View | Free WiFi](https://images.trvl-media.com/lodging/126000000/125980000/125979300/125979202/a723d686.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pinares del Norte [](https://www.expedia.com/Federacion-Hotels-Pinares-Del-Norte.h125979202.Hotel-Information) Federación $110 nightly $110 total Mar 28 - Mar 29 [](https://www.expedia.com/Federacion-Hotels-Pinares-Del-Norte.h125979202.Hotel-Information) ![Indoor pool, outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/5000000/4670000/4668300/4668235/cc821f0d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/5000000/4670000/4668300/4668235/a0c96e7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/5000000/4670000/4668300/4668235/cf8e0206.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor spa tub](https://images.trvl-media.com/lodging/5000000/4670000/4668300/4668235/138c0f23.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hathor Concordia [](https://www.expedia.com/Concordia-Hotels-Hathor-Concordia.h4668235.Hotel-Information) Concordia 8.6/10 Excellent (372 reviews) "AC did not work well, food was OK. Staff friendly. Good hotel for a stay on the road." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Patrick $65 nightly $65 total Apr 1 - Apr 2 [](https://www.expedia.com/Concordia-Hotels-Hathor-Concordia.h4668235.Hotel-Information) ![2 bedrooms, hypo-allergenic bedding, down comforters, in-room safe](https://images.trvl-media.com/lodging/34000000/33350000/33341500/33341429/8a2a257a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment, 2 Bedrooms | Private kitchen | Full-size fridge, oven, stovetop, rice cooker](https://images.trvl-media.com/lodging/34000000/33350000/33341500/33341429/69bd66ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment | Living area | 32-inch Smart TV with cable channels, TV, Netflix](https://images.trvl-media.com/lodging/34000000/33350000/33341500/33341429/758c5263.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Room, 1 Bedroom | Private kitchen | Full-size fridge, oven, stovetop, rice cooker](https://images.trvl-media.com/lodging/34000000/33350000/33341500/33341429/8309ce06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Totoras Apart Federacion [](https://www.expedia.com/Federacion-Hotels-Totoras-Apart-Federacion.h33341429.Hotel-Information) Federacion 7.4/10 Good (27 reviews) "Todo perfecto!!! " ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) Gabriel $32 nightly $32 total Mar 29 - Mar 30 [](https://www.expedia.com/Federacion-Hotels-Totoras-Apart-Federacion.h33341429.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/121000000/120720000/120713200/120713176/5a0bc70a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Triple Room, Park View | Minibar, in-room safe, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/121000000/120720000/120713200/120713176/5ce32c6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/121000000/120720000/120713200/120713176/3c95eafc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/121000000/120720000/120713200/120713176/8be36161.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Regina Lodge [](https://www.expedia.com/Municipo-De-Itati-Hotels-La-Regina-Lodge.h120713176.Hotel-Information) Municipo de Itati 10/10 Exceptional (1 review) "Excelente pousada, piscina fantástica com visual do rio" ![Brazil](https://a.travel-assets.com/egds/marks/flags/br.svg) Marcos $71 nightly $71 total Apr 24 - Apr 25 [](https://www.expedia.com/Municipo-De-Itati-Hotels-La-Regina-Lodge.h120713176.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/12000000/11880000/11876000/11875903/60e3bf31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/12000000/11880000/11876000/11875903/afd7d710.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Banquet hall](https://images.trvl-media.com/lodging/12000000/11880000/11876000/11875903/7eec541e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/12000000/11880000/11876000/11875903/750a674d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Club Valle Termal Resort [](https://www.expedia.com/Federacion-Hotels-Club-Valle-Termal-Resort.h11875903.Hotel-Information) Federacion 9.2/10 Wonderful (94 reviews) "La habitación estaba impecable, la limpieza de todo el complejo fue excelente, pero quiero destacar la atención de todo su personal, la disponibilidad constante para atender todas nuestras necesidades. Lo recomiendo y espero poder volver pronto." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Fernando $95 nightly $95 total Apr 6 - Apr 7 [](https://www.expedia.com/Federacion-Hotels-Club-Valle-Termal-Resort.h11875903.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/112000000/111550000/111541700/111541690/0e5b5ce6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/112000000/111550000/111541700/111541690/384ea822.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/112000000/111550000/111541700/111541690/9f96608b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/112000000/111550000/111541700/111541690/8d2994c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Mayim Hotel Termal & SPA [](https://www.expedia.com/Concordia-Hotels-Mayim-Hotel-Termal-SPA.h111541690.Hotel-Information) Concordia 9.4/10 Exceptional (8 reviews) "Muy lindo hotel , lástima q se rompió el aire acondicionado y no hay secador de pelo an la habitación " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Catalina $72 nightly $72 total Apr 26 - Apr 27 [](https://www.expedia.com/Concordia-Hotels-Mayim-Hotel-Termal-SPA.h111541690.Hotel-Information) ![BBQ/picnic area](https://images.trvl-media.com/lodging/39000000/38310000/38300200/38300196/5e4aef5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/39000000/38310000/38300200/38300196/a215cbf7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Room | Rollaway beds, bed sheets, wheelchair access](https://images.trvl-media.com/lodging/39000000/38310000/38300200/38300196/8e6becd7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/39000000/38310000/38300200/38300196/cbc5acd9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Posada Che Teindy [](https://www.expedia.com/Colonia-Carlos-Pellegrini-Hotels-Posada-Che-Teindy.h38300196.Hotel-Information) Colonia Carlos Pellegrini $133 nightly $133 total Mar 28 - Mar 29 [](https://www.expedia.com/Colonia-Carlos-Pellegrini-Hotels-Posada-Che-Teindy.h38300196.Hotel-Information) ![Executive Apartment | Private kitchen | Full-size fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/100000000/99270000/99269400/99269311/6427ef82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City Apartment | Living area | 40-inch LED TV with cable channels, Netflix, streaming services](https://images.trvl-media.com/lodging/100000000/99270000/99269400/99269311/f34322b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Duplex | Premium bedding, pillowtop beds, individually decorated](https://images.trvl-media.com/lodging/100000000/99270000/99269400/99269311/960ad1f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/100000000/99270000/99269400/99269311/26003866.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Agustín 1 Apart [](https://www.expedia.com/Parana-Hotels-Agustin-1-Apart.h99269311.Hotel-Information) Parana 8.8/10 Excellent (5 reviews) "Meu problema foi só a garagem, o apartamento é ótimo, limpeza estava impecável." ![Brazil](https://a.travel-assets.com/egds/marks/flags/br.svg) Jose rodrigo kallas $53 nightly $53 total Apr 26 - Apr 27 [](https://www.expedia.com/Parana-Hotels-Agustin-1-Apart.h99269311.Hotel-Information) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/16000000/15370000/15363300/15363214/b3e275d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Room | Premium bedding, blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/16000000/15370000/15363300/15363214/0323f4ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/16000000/15370000/15363300/15363214/216c6bb7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Room (VIP) | Jetted tub](https://images.trvl-media.com/lodging/16000000/15370000/15363300/15363214/ea0ac718.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Bungalows Mexico [](https://www.expedia.com/Concepcion-Del-Uruguay-Hotels-Bungalows-Mexico.h15363214.Hotel-Information) Concepción del Uruguay 8.8/10 Excellent (12 reviews) "Local estava limpo, a cama é ótima, mas o banheiro a água n esquentava. O atendimento foi bom, são atenciosos. " ![Brazil](https://a.travel-assets.com/egds/marks/flags/br.svg) Eduardo $52 nightly $52 total Mar 30 - Mar 31 [](https://www.expedia.com/Concepcion-Del-Uruguay-Hotels-Bungalows-Mexico.h15363214.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/37000000/36910000/36908500/36908421/98d1ea7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/37000000/36910000/36908500/36908421/fe749255.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, individually furnished, desk, blackout drapes](https://images.trvl-media.com/lodging/37000000/36910000/36908500/36908421/7d9efe4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/37000000/36910000/36908500/36908421/a62b286b_edited_cdf8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Rio [](https://www.expedia.com/Chajari-Hotels-Hotel-Rio.h36908421.Hotel-Information) Chajarí 8.8/10 Excellent (11 reviews) "Lindo hotel, moderno, limpio, buena atencion, sumaria opciones saladas en el desayuno, como huevos revueltos." ![Argentina](https://a.travel-assets.com/egds/marks/flags/ar.svg) SANTIAGO $84 nightly $84 total Mar 28 - Mar 29 [](https://www.expedia.com/Chajari-Hotels-Hotel-Rio.h36908421.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/89000000/88090000/88087500/88087470/11027249.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Double Room | Free WiFi, bed sheets](https://images.trvl-media.com/lodging/89000000/88090000/88087500/88087470/f479bf8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![LED TV](https://images.trvl-media.com/lodging/89000000/88090000/88087500/88087470/5adfed6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/89000000/88090000/88087500/88087470/ba4b5c63.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Complejo La Loma [](https://www.expedia.com/Federacion-Hotels-Complejo-La-Loma.h88087470.Hotel-Information) Federacion 8.0/10 Very Good (5 reviews) "Had a very good experience here. Hosts do not speak English, but were very patient with me as I used Google Translate to communicate. Woman at the desk was very kind. I had arrived late and was able to check in without issue. The suite is great - there is a full bathroom, bedroom and kitchen / dining area. There is a communal pool outside in the courtyard as well with lounge chairs. Breakfast was decent as well. Parking on site. I would stay here again for sure, but would be better for multiple... ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Logan $40 nightly $40 total Apr 5 - Apr 6 [](https://www.expedia.com/Federacion-Hotels-Complejo-La-Loma.h88087470.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/3000000/2810000/2803600/2803582/388c5726.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/3000000/2810000/2803600/2803582/ff681a63.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/3000000/2810000/2803600/2803582/c114ee3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/3000000/2810000/2803600/2803582/ce5b95af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Alondra Casa De Huéspedes [](https://www.expedia.com/Corrientes-Hotels-La-Alondra-Casa-De-Huespedes.h2803582.Hotel-Information) Corrientes 9.2/10 Wonderful (68 reviews) "Todo excelente " ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) Arturo Oscar $91 nightly $91 total Mar 29 - Mar 30 [](https://www.expedia.com/Corrientes-Hotels-La-Alondra-Casa-De-Huespedes.h2803582.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/77000000/76460000/76459400/76459363/dbe6098c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/77000000/76460000/76459400/76459363/3ea31922.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Soundproofing, free WiFi, bed sheets](https://images.trvl-media.com/lodging/77000000/76460000/76459400/76459363/86b52c66.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Double Room | Soundproofing, free WiFi, bed sheets](https://images.trvl-media.com/lodging/77000000/76460000/76459400/76459363/7318806c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### O2 Hotel Gualeguaychú [](https://www.expedia.com/Gualeguaychu-Hotels-O2-Gualeguaychu.h76459363.Hotel-Information) Gualeguaychú 7.6/10 Good (80 reviews) "Hotel is very comfortable and clean. There is no breakfast or hotel parking, and the wifi does not work properly in most floors and rooms. Other than that, the staff is very friendly and nice. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Esteban $45 nightly $45 total Mar 29 - Mar 30 [](https://www.expedia.com/Gualeguaychu-Hotels-O2-Gualeguaychu.h76459363.Hotel-Information) ![Living area](https://images.trvl-media.com/lodging/37000000/36660000/36653400/36653372/a1bc361e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/37000000/36660000/36653400/36653372/187f4e02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/37000000/36660000/36653400/36653372/w717h717x3y0-ae142680.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/37000000/36660000/36653400/36653372/19d6d5c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Casa del Árbol Hostel [](https://www.expedia.com/Concepcion-Del-Uruguay-Hotels-Casa-Del-Arbol.h36653372.Hotel-Information) Concepción del Uruguay 7.6/10 Good (9 reviews) "El lugar es divino, la onda de Guadalupe la dueña del lugar" ![Argentina](https://a.travel-assets.com/egds/marks/flags/ar.svg) Sebastián $43 nightly $43 total Mar 28 - Mar 29 [](https://www.expedia.com/Concepcion-Del-Uruguay-Hotels-Casa-Del-Arbol.h36653372.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/5000000/4950000/4947900/4947848/fb045420.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/5000000/4950000/4947900/4947848/e9b4b524.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/5000000/4950000/4947900/4947848/b6d8eda3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Triple Suite + Trundle Bed (4 people) | Premium bedding, down comforters, in-room safe, individually decorated](https://images.trvl-media.com/lodging/5000000/4950000/4947900/4947848/4eedefaa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Donsuites Apart Hotel [](https://www.expedia.com/Corrientes-Hotels-Donsuites-Apart-Hotel.h4947848.Hotel-Information) Corrientes 8.6/10 Excellent (107 reviews) "Loved this place, super clean, and the staff were very nice and helpful😍" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nora $59 nightly $59 total Mar 29 - Mar 30 [](https://www.expedia.com/Corrientes-Hotels-Donsuites-Apart-Hotel.h4947848.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/16000000/15370000/15362200/15362145/a0cc5957.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/16000000/15370000/15362200/15362145/43c3ae01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sauna, steam room, body treatments, hot stone massages, facials](https://images.trvl-media.com/lodging/16000000/15370000/15362200/15362145/ef76fc3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, free WiFi, bed sheets](https://images.trvl-media.com/lodging/16000000/15370000/15362200/15362145/96c73453.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Costarenas Hotel & Spa [](https://www.expedia.com/Colon-Hotels-Costarenas-Hotel-Spa.h15362145.Hotel-Information) Colon 8.6/10 Excellent (60 reviews) "spectacular since we arrived the tstaff was wonderful and kind to us very helpful and nice answering all our questions, the hotel very comfortable!! the river view stunning" ![Argentina](https://a.travel-assets.com/egds/marks/flags/ar.svg) Lisette $117 nightly $117 total Mar 28 - Mar 29 [](https://www.expedia.com/Colon-Hotels-Costarenas-Hotel-Spa.h15362145.Hotel-Information) ![Aerial view](https://images.trvl-media.com/lodging/34000000/33350000/33347000/33346911/e90b77a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive Room | Desk, blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/34000000/33350000/33347000/33346911/a9efae27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/34000000/33350000/33347000/33346911/5cbe2a6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/34000000/33350000/33347000/33346911/dd41bc20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel y Spa Termas del Este [](https://www.expedia.com/Federacion-Hotels-Hotel-Y-Spa-Termas-Del-Este.h33346911.Hotel-Information) Federacion 8.6/10 Excellent (13 reviews) "good for a 1 night stay" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Chase $75 nightly $75 total Apr 6 - Apr 7 [](https://www.expedia.com/Federacion-Hotels-Hotel-Y-Spa-Termas-Del-Este.h33346911.Hotel-Information) ![Seasonal outdoor pool, open noon to 11:00 PM, sun loungers](https://images.trvl-media.com/lodging/5000000/4420000/4411700/4411601/e28dae20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Balcony](https://images.trvl-media.com/lodging/5000000/4420000/4411700/4411601/49faf811.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Minibar, individually decorated, individually furnished, blackout drapes](https://images.trvl-media.com/lodging/5000000/4420000/4411700/4411601/0413fc6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/5000000/4420000/4411700/4411601/714f5749.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Casona de Susana [](https://www.expedia.com/Colon-Hotels-La-Casona-De-Susana.h4411601.Hotel-Information) Colon 7.4/10 Good (26 reviews) "La propietaria respeta el precio acordado. En verano si usás más de 8 horas por día el aire acondicionado te cobran un plus." ![Argentina](https://a.travel-assets.com/egds/marks/flags/ar.svg) Marlene Ruth $48 nightly $48 total Apr 7 - Apr 8 [](https://www.expedia.com/Colon-Hotels-La-Casona-De-Susana.h4411601.Hotel-Information) ![Indoor pool, outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/121000000/120520000/120517600/120517502/a0b30be4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Double Room, River View | In-room safe, free WiFi](https://images.trvl-media.com/lodging/121000000/120520000/120517600/120517502/7faffc8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/121000000/120520000/120517600/120517502/6d2323a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/121000000/120520000/120517600/120517502/w1021h683x3y0-b40ed89a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Turismo Hotel Casino [](https://www.expedia.com/Corrientes-Hotels-Turismo-Hotel-Casino.h120517502.Hotel-Information) Corrientes 8.0/10 Very Good (4 reviews) "Boa infraestrutura, e localização!" ![Brazil](https://a.travel-assets.com/egds/marks/flags/br.svg) D. Omar $112 nightly $112 total Apr 6 - Apr 7 [](https://www.expedia.com/Corrientes-Hotels-Turismo-Hotel-Casino.h120517502.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/37000000/36810000/36801000/36800965/6a6d02f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/37000000/36810000/36801000/36800965/77b70130.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/37000000/36810000/36801000/36800965/f4e90853.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/37000000/36810000/36801000/36800965/908e21a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Maran Suites & Towers - Hotel & Spa [](https://www.expedia.com/Parana-Hotels-Maran-Suites-Towers-Hotel-Spa.h36800965.Hotel-Information) Parana 9.0/10 Wonderful (32 reviews) "Great location and friendly, accommodating staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael $108 nightly $108 total Apr 20 - Apr 21 [](https://www.expedia.com/Parana-Hotels-Maran-Suites-Towers-Hotel-Spa.h36800965.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-10&endDate=2026-04-11®ionId=6208836&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Vacation Rentals in Mesopotamia Cabin ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/16000000/15370000/15363300/15363214/b3e275d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Room | Premium bedding, blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/16000000/15370000/15363300/15363214/0323f4ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/16000000/15370000/15363300/15363214/216c6bb7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Room (VIP) | Jetted tub](https://images.trvl-media.com/lodging/16000000/15370000/15363300/15363214/ea0ac718.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Bungalows Mexico [](https://www.expedia.com/Concepcion-Del-Uruguay-Hotels-Bungalows-Mexico.h15363214.Hotel-Information) Concepción del Uruguay 8.8/10 Excellent (12 reviews) "Local estava limpo, a cama é ótima, mas o banheiro a água n esquentava. O atendimento foi bom, são atenciosos. " [](https://www.expedia.com/Concepcion-Del-Uruguay-Hotels-Bungalows-Mexico.h15363214.Hotel-Information) Aparthotel ![Executive Apartment | Private kitchen | Full-size fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/100000000/99270000/99269400/99269311/6427ef82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City Apartment | Living area | 40-inch LED TV with cable channels, Netflix, streaming services](https://images.trvl-media.com/lodging/100000000/99270000/99269400/99269311/f34322b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Duplex | Premium bedding, pillowtop beds, individually decorated](https://images.trvl-media.com/lodging/100000000/99270000/99269400/99269311/960ad1f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/100000000/99270000/99269400/99269311/26003866.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Agustín 1 Apart [](https://www.expedia.com/Parana-Hotels-Agustin-1-Apart.h99269311.Hotel-Information) Parana 8.8/10 Excellent (5 reviews) "Meu problema foi só a garagem, o apartamento é ótimo, limpeza estava impecável." [](https://www.expedia.com/Parana-Hotels-Agustin-1-Apart.h99269311.Hotel-Information) Cabin ![Exterior](https://images.trvl-media.com/lodging/38000000/37270000/37265200/37265185/ea8d3387.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/38000000/37270000/37265200/37265185/e4309a19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/38000000/37270000/37265200/37265185/87b4104c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/38000000/37270000/37265200/37265185/7084c2b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Verde y Sol en la Colonia [](https://www.expedia.com/Concepcion-Del-Uruguay-Hotels-Verde-Y-Sol-En-La-Colonia.h37265185.Hotel-Information) Concepción del Uruguay 9.0/10 Wonderful (2 reviews) "Einfache Hütte etwas außerhalb gelegen aber mit gutem Pool." [](https://www.expedia.com/Concepcion-Del-Uruguay-Hotels-Verde-Y-Sol-En-La-Colonia.h37265185.Hotel-Information) Aparthotel ![Outdoor pool](https://images.trvl-media.com/lodging/89000000/88090000/88087500/88087470/11027249.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Double Room | Free WiFi, bed sheets](https://images.trvl-media.com/lodging/89000000/88090000/88087500/88087470/f479bf8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![LED TV](https://images.trvl-media.com/lodging/89000000/88090000/88087500/88087470/5adfed6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/89000000/88090000/88087500/88087470/ba4b5c63.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Complejo La Loma [](https://www.expedia.com/Federacion-Hotels-Complejo-La-Loma.h88087470.Hotel-Information) Federacion 8.0/10 Very Good (5 reviews) "Had a very good experience here. Hosts do not speak English, but were very patient with me as I used Google Translate to communicate. Woman at the desk was very kind. I had arrived late and was able to check in without issue. The suite is great - there is a full bathroom, bedroom and kitchen / dining area. There is a communal pool outside in the courtyard as well with lounge chairs. Breakfast was decent as well. Parking on site. I would stay here again for sure, but would be better for multiple... [](https://www.expedia.com/Federacion-Hotels-Complejo-La-Loma.h88087470.Hotel-Information) Aparthotel ![2 bedrooms, hypo-allergenic bedding, down comforters, in-room safe](https://images.trvl-media.com/lodging/34000000/33350000/33341500/33341429/8a2a257a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment, 2 Bedrooms | Private kitchen | Full-size fridge, oven, stovetop, rice cooker](https://images.trvl-media.com/lodging/34000000/33350000/33341500/33341429/69bd66ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment | Living area | 32-inch Smart TV with cable channels, TV, Netflix](https://images.trvl-media.com/lodging/34000000/33350000/33341500/33341429/758c5263.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Room, 1 Bedroom | Private kitchen | Full-size fridge, oven, stovetop, rice cooker](https://images.trvl-media.com/lodging/34000000/33350000/33341500/33341429/8309ce06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Totoras Apart Federacion [](https://www.expedia.com/Federacion-Hotels-Totoras-Apart-Federacion.h33341429.Hotel-Information) Federacion 7.4/10 Good (27 reviews) "Todo perfecto!!! " [](https://www.expedia.com/Federacion-Hotels-Totoras-Apart-Federacion.h33341429.Hotel-Information) Aparthotel ![Outdoor pool](https://images.trvl-media.com/lodging/5000000/4950000/4947900/4947848/fb045420.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/5000000/4950000/4947900/4947848/e9b4b524.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/5000000/4950000/4947900/4947848/b6d8eda3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Triple Suite + Trundle Bed (4 people) | Premium bedding, down comforters, in-room safe, individually decorated](https://images.trvl-media.com/lodging/5000000/4950000/4947900/4947848/4eedefaa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Donsuites Apart Hotel [](https://www.expedia.com/Corrientes-Hotels-Donsuites-Apart-Hotel.h4947848.Hotel-Information) Corrientes 8.6/10 Excellent (107 reviews) "Loved this place, super clean, and the staff were very nice and helpful😍" [](https://www.expedia.com/Corrientes-Hotels-Donsuites-Apart-Hotel.h4947848.Hotel-Information) [See all vacation rentals](https://expedia.com/Hotel-Search?startDate=2026-04-24&endDate=2026-04-27®ionId=6208836&adults=2&sort=RECOMMENDED&stay_options_group=vacation_rentals_option&categorySearch=vacation_rentals_option&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FMesopotamia-Hotels.d6208836.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FMesopotamia-Hotels.d6208836.Travel-Guide-Hotels) ## Stay near popular Mesopotamia attractions ![Parque Nacional El Palmar, Entre Rios, Argentina.](https://images.trvl-media.com/place/6096826/3ac30eef-b699-482d-95ce-e991c872d599.jpg) ### El Palmar National Park Explore the great outdoors at El Palmar National Park, a lovely green space in Ubajay. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6096826) ![Punta San Sebastian, Corrientes, Costanera Corrientes](https://images.trvl-media.com/place/553248621532463961/5eccf4f4-bdb0-4368-8beb-0fffd1c8eab0.jpg) ### Costanera de Corrientes Enjoy an outing to Costanera de Corrientes during your stay in Corrientes. You can enjoy the restaurants while in the area. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532463961) ![Parroquia Nuestra Señora de Itati](https://images.trvl-media.com/place/553248621532463967/dcc3f703-5a3b-46d8-99a7-83b2e87b8ea0.jpg) ### Basilica Nuestra Senora De Itati Learn about the local history of Municipo de Itatí when you take a trip to Basilica Nuestra Senora De Itati. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532463967) ### Termas de Federacion Bring your family to Termas de Federacion and have a fun-filled day at this amusement park in Federacion. Stroll along the beaches or discover the area's waterfalls. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532463682) ### Termas Concepcion Entrerios Bring your family to Termas Concepcion Entrerios and enjoy the excitement of this amusement park in Concepción del Uruguay. Experience the area's art scene and museums. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532463656) ### Termas De Colón Enjoy an outing to Termas De Colón during your stay in Colon. Discover the area's theater scene and spas. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248635939591385) ### Isla Cambacua Beach Why not spend a lazy afternoon at Isla Cambacua Beach during your trip to Concepción del Uruguay? Experience the area's art scene and museums. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248635974793609) ### Portal Carambola You can take time to visit Portal Carambola during your travels to Concepción. While you're in the area, wander around the parks. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248635998020259) ## Learn more about Mesopotamia The awe-inspiring Iguazú Falls is the centerpiece attraction of this northeastern Argentine region, which also hosts the country’s biggest carnival celebration. [See all hotels in Mesopotamia](https://www.expedia.com/Hotel-Search?startDate=2026-04-10&endDate=2026-04-11&adults=2®ionId=6208836) ![](https://images.trvl-media.com/place/6171898/bb162948-b907-405b-9053-fc054127c668.jpg?impolicy=fcrop&w=900&h=506&p=1&q=high) ## Top Mesopotamia Hotel Reviews ![O2 Hotel Gualeguaychú](https://images.trvl-media.com/lodging/77000000/76460000/76459400/76459363/dbe6098c_y.jpg) ### O2 Hotel Gualeguaychú 2/10 Terrible "Las sabanas estaban sucias No andaba la tele para ver No salía agua caliente y el desayuno horrible" [](https://expedia.com/Gualeguaychu-Hotels-O2-Gualeguaychu.h76459363.Hotel-Information) ![Intersur Colon](https://images.trvl-media.com/lodging/115000000/114110000/114109800/114109755/cb01ff56_y.jpg) ### Intersur Colon 2/10 Terrible "Staff as friendly but room was very dirty, toilet had not been flushed, broken lamps and dirty napkins on the floor. " [](https://expedia.com/Colon-Hotels-Intersur-Colon.h114109755.Hotel-Information) ![Holiday Inn Rosario by IHG](https://images.trvl-media.com/lodging/1000000/580000/570400/570357/08f67295_y.jpg) ### Holiday Inn Rosario by IHG 8/10 Good "frienly and competent staff speaking English. room was fine" [](https://expedia.com/Rosario-Hotels-Holiday-Inn-Rosario.h570357.Hotel-Information) ![Casa del Árbol Hostel](https://images.trvl-media.com/lodging/37000000/36660000/36653400/36653372/a1bc361e_y.jpg) ### Casa del Árbol Hostel 2/10 Terrible "La plataforma por.donde contrate te reserva aunque no haya lugar en el hostel Un desastre todo. No tienen verguenza. Poco serio " [](https://expedia.com/Concepcion-Del-Uruguay-Hotels-Casa-Del-Arbol.h36653372.Hotel-Information) ![Club Valle Termal Resort](https://images.trvl-media.com/lodging/12000000/11880000/11876000/11875903/60e3bf31_y.jpg) ### Club Valle Termal Resort 10/10 Excellent "La habitación estaba impecable, la limpieza de todo el complejo fue excelente, pero quiero destacar la atención de todo su personal, la disponibilidad constante para atender todas nuestras necesidades. Lo recomiendo y espero poder volver pronto." [](https://expedia.com/Federacion-Hotels-Club-Valle-Termal-Resort.h11875903.Hotel-Information) ![Costarenas Hotel & Spa](https://images.trvl-media.com/lodging/16000000/15370000/15362200/15362145/a0cc5957_y.jpg) ### Costarenas Hotel & Spa 2/10 Terrible "Short Version See pictures for detailed information) - Rooms and bathrooms are small, shower already tight spaced with doors that don’t close properly. - By day 3, construction noise and chemicals smells from remodeling work became a big issue. - Receptionist did not offer solutions and lied about remodeling hours. Felt uncomfortable when asked for manager’s name, and refused to give any other information. - Same receptionist reached out later to apologize and acknowledged we should have not been placed in those rooms to begin with. Offered to move us to “upgraded” rooms. - “Upgraded” rooms were even worse. One of the rooms was directly under the ones being remodeled and worked on. Noise began at 8 AM - The other two rooms did not have a functioning air conditioner. Staff gave poor excuse and just said to open windows. There’s tons of noise far into the night from motor bikes and people playing music right across the hotel. - Hotel breakfast was motel level at best. You get eggs swimming in water and some cut up ham. Toasters barely worked, and when staff was asked for replacement they appeared completely clueless. - The spa experience was good when it came to the massage. However “quiet” policy is not enforced and hearing toilets go off right next to the spa area don’t help with the experience. - Check out was the final straw. Desk staff was rude and dismissive of concerns, stating that the room “upgrade” was sufficient compensation for the troubles. " [](https://expedia.com/Colon-Hotels-Costarenas-Hotel-Spa.h15362145.Hotel-Information) ![Hotel y Spa Termas del Este](https://images.trvl-media.com/lodging/34000000/33350000/33347000/33346911/e90b77a7_y.jpg) ### Hotel y Spa Termas del Este 8/10 Good "good for a 1 night stay" [](https://expedia.com/Federacion-Hotels-Hotel-Y-Spa-Termas-Del-Este.h33346911.Hotel-Information) ## More cheap stays in Mesopotamia ![Como en casa](https://images.trvl-media.com/lodging/22000000/21480000/21476400/21476350/8ae7da40_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Como en casa San Luis 948 8B Rosario Santa Fe $34 nightly $34 total Mar 31 - Apr 1 8.4/10 Very Good! (7 reviews) [](https://expedia.com/Rosario-Hotels-Como-En-Casa.h21476350.Hotel-Information) ![O2 Hotel Gualeguaychú](https://images.trvl-media.com/lodging/77000000/76460000/76459400/76459363/dbe6098c_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### O2 Hotel Gualeguaychú 115 3 de Febrero Gualeguaychú Entre Ríos $45 nightly $45 total Mar 29 - Mar 30 7.6/10 Good! (80 reviews) [](https://expedia.com/Gualeguaychu-Hotels-O2-Gualeguaychu.h76459363.Hotel-Information) ![Carat Apart Boutique](https://images.trvl-media.com/lodging/24000000/23970000/23963300/23963290/70523b6d_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Carat Apart Boutique Montevideo 1552 Rosario Santa Fe $78 nightly $78 total Apr 4 - Apr 5 9.4/10 Exceptional! (54 reviews) [](https://expedia.com/Rosario-Hotels-Carat-Apart-Boutique.h23963290.Hotel-Information) ![Parador 15](https://images.trvl-media.com/lodging/91000000/90770000/90762900/90762888/38c6417b_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Parador 15 4475 Córdoba Funes Santa Fe $89 nightly $89 total Mar 29 - Mar 30 9.6/10 Exceptional! (4 reviews) [](https://expedia.com/Funes-Hotels-Parador-15.h90762888.Hotel-Information) ![Turismo Hotel Casino](https://images.trvl-media.com/lodging/121000000/120520000/120517600/120517502/a0b30be4_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Turismo Hotel Casino 650 Entre Ríos Corrientes Corrientes $112 nightly $112 total Apr 6 - Apr 7 8/10 Very Good! (4 reviews) [](https://expedia.com/Corrientes-Hotels-Turismo-Hotel-Casino.h120517502.Hotel-Information) ![Hotel Casino Rio Uruguay](https://images.trvl-media.com/lodging/123000000/122660000/122659600/122659562/bb78e4e4_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Casino Rio Uruguay RN117 Paso de los Libres Corrientes [Get rates](https://expedia.com/Hotel-Search?startDate=4%2F10%2F2026&endDate=4%2F11%2F2026&selected=122659562&PinnedHotelID=122659562&HadPinnedHotel=true®ionId=6208836) 10/10 Exceptional! (1 review) [](https://expedia.com/Paso-De-Los-Libres-Hotels-Hotel-Casino-Rio-Uruguay.h122659562.Hotel-Information) ## Hotels in Mesopotamia with star-rating ![5 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/25600/25559/c6e0103a_z.jpg) 5 Star Hotels 1 properties [](https://expedia.com/5Star-Mesopotamia-Hotels.s50-0-d6208836.Travel-Guide-Filter-Hotels) ![4 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/23700/23677/6ae928dd_z.jpg) 4 Star Hotels 18 properties [](https://expedia.com/4Star-Mesopotamia-Hotels.s40-0-d6208836.Travel-Guide-Filter-Hotels) ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 157 properties [](https://expedia.com/3Star-Mesopotamia-Hotels.s30-0-d6208836.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 144 properties [](https://expedia.com/2Star-Mesopotamia-Hotels.s20-0-d6208836.Travel-Guide-Filter-Hotels) ## Find out more about Mesopotamia ### Top reasons to visit Mesopotamia - **Stunning National Parks:** Mesopotamia is home to breathtaking national parks, perfect for hiking and wildlife exploration. - **Outdoor Adventures:** Engage in diverse outdoor activities like birdwatching and yoga sessions amidst scenic beauty. - **Rich Cultural Experiences:** Immerse yourself in local culture through private tours and unique shopping hotspots. - **Romantic Getaways:** The enchanting landscapes make it an ideal destination for a romantic retreat. - **Comfortable Accommodations:** Enjoy a range of hotels catering to all needs, ensuring a memorable stay. ### Find great hotels near Mesopotamia Discover the charm of Mesopotamia, Argentina, where a variety of hotels cater to every traveler's needs. Whether you're seeking family-friendly accommodations or a cozy retreat, you'll find the perfect spot to unwind. From luxurious amenities to convenient locations, the best hotels in Mesopotamia offer exceptional service and comfort for a memorable stay. Explore the diverse options available and make your vacation truly special in this enchanting region. - **[El Tránsito Hotel Boutique: ](https://www.expedia.com/Concepcion-Hotels-Hotel-Boutique-El-Transito.h41507004.Hotel-Information)** El Tránsito Hotel Boutique is a charming 3.5-star hotel with a perfect guest rating of 10.0, located 18 miles from Mesopotamia. This family-friendly accommodation is ideal for those traveling with children, offering amenities such as a dedicated arcade game room, a children’s pool, and complimentary cribs. The hotel combines comfort and fun, ensuring that families can enjoy a memorable vacation experience while providing a welcoming atmosphere for all ages. ### Where to stay near Mesopotamia Mesopotamia, Argentina, offers an enchanting blend of adventure and relaxation, perfect for any traveler. Explore the stunning landscapes, indulge in local culture, and uncover shopping hotspots that showcase the region's charm. Discover breathtaking views that will leave you in awe, whether you’re traveling with family or seeking a romantic getaway. With diverse outdoor activities, Mesopotamia promises an unforgettable experience for all who visit. - **[Mercedes: ](https://www.expedia.com/Mercedes-Hotels.d6338887.Travel-Guide-Hotels)** Located 31 miles from Mesopotamia, Mercedes boasts a charming blend of outdoor adventure and family-friendly experiences. The city is renowned for its vibrant outdoor activities, including golfing and water parks that cater to all ages. Visitors are drawn to the local national state park and theme park, offering a perfect backdrop for exploration and fun. While the travel numbers fluctuate throughout the year, the peak seasons in July and December to January provide a lively atmosphere, making it an ideal time to experience the local culture and community. - **[Concepción: ](https://www.expedia.com/Concepcion-Hotels.d553248635924012399.Travel-Guide-Hotels)** Situated 22 miles from Mesopotamia, Concepción is a scenic city that captivates visitors with its natural beauty and outdoor adventures. Known for its stunning landscapes, the area is perfect for those seeking an adventurous getaway. The local national and natural parks present opportunities for hiking and wildlife observation, making it a haven for nature lovers. With steady visitor numbers throughout the year, peak travel times in April, July, and September ensure a vibrant community atmosphere, inviting travelers to immerse themselves in the local scenery and outdoor pursuits. - **Uguay:** This quaint village lies 17 miles from Mesopotamia and offers a peaceful retreat for those looking to escape the hustle and bustle. Uguay attracts seasonal visitors, particularly peaking in January, March, and November, who come to enjoy the serenity of its natural parks. The village’s proximity to stunning landscapes makes it an excellent base for exploring the surrounding natural beauty. Though quieter compared to its neighboring cities, Uguay provides a unique charm and an authentic experience of rural Argentine life. ### Things to do in Mesopotamia Mesopotamia, Argentina, offers a range of activities for visitors, including birdwatching, hiking, and wildlife exploration. It's an ideal destination for a weekend getaway or a romantic retreat, with opportunities for yoga sessions and private tours. History lovers will also find plenty to appreciate in this captivating region, making it a perfect spot for diverse interests and memorable experiences. **Shopping** In Mesopotamia, Argentina, visit the Shopping del Este for a modern mall experience featuring diverse stores and dining options. For a more local vibe, explore the Feria de Artesanos, a vibrant market offering handmade crafts and unique souvenirs that showcase the region's culture. **Recreation** In Mesopotamia, Argentina, the Termas de Río Hondo offers rejuvenating thermal baths and spa services amidst beautiful landscapes. Enjoy yoga sessions and nature walks at wellness retreats, while savoring local cuisine focused on health and nutrition for a refreshing escape. **Adventure** Explore the Iguazú National Park, where stunning waterfalls and lush rainforest await. Experience thrilling jungle treks and wildlife spotting, or take a boat ride for an exhilarating view of the falls. Don't miss the chance to visit the nearby Jesuit Ruins for a glimpse into the region's history. **Nightlife** In Mesopotamia, Argentina, the nightlife is vibrant with venues like the lively La Casona, known for its upbeat music and dancing. Enjoy local flavors at El Mercado, where you can savor delicious dishes while soaking in the lively atmosphere. Don't miss the cozy bars scattered throughout the area for a relaxed evening. \*Distances are measured in a straight line; actual driving distances may vary depending on the route. ### Booking tips and Expedia advantages for Mesopotamia - **The most and least expensive months on average to stay in a hotel:** The cheapest months to stay around Mesopotamia are October, where the prices are slightly lower. This is in comparison to February and July to August, where prices are slightly higher. - **The best time to book a hotel:** Book your hotel around Mesopotamia about 1 month out to secure some of the cheapest prices. If you're the spontaneous type, Expedia's last minute deals and discounts are indicated via the green label below the price. - **The most and least expensive days on average to stay in a hotel:** The least expensive day to stay around Mesopotamia is Tuesday. The most expensive day to stay around Mesopotamia is Monday. - **Find cheap hotels on Expedia:** Utilize Expedia's search tool to customize your preferences, such as budget, desired location, and hotel type. For instance, selecting the Eco-certified option will show you sustainable and environmentally friendly hotels currently available. To find the best prices and deals, simply sort the price filter from lowest to highest. - **Consider bundling your trip:** You can save money by combining your hotel reservations in Mesopotamia with your flights and activities through an Expedia package deal. ### Find the best attractions near Mesopotamia Mesopotamia, Argentina, offers a variety of attractions for tourists seeking scenic beauty and outdoor adventures. The area is renowned for its national parks, providing ample opportunities for exploration and adventure. Whether you're looking for breathtaking landscapes or thrilling activities, Mesopotamia's local points of interest cater to every traveler's desire for an unforgettable experience. - **[Portal Carambola: ](https://www.expedia.com/Portal-Carambola-Hotels.0-l553248635998020259-0.Travel-Guide-Filter-Hotels)** Located 14 miles from Mesopotamia, this national park offers stunning scenery, thrilling outdoor adventures, and a chance to immerse yourself in nature's beauty, making it a perfect destination for adventure seekers and nature lovers alike. ### Best time to go to Mesopotamia The best time to visit Mesopotamia depends on your weather preferences. The hottest average temperature around Mesopotamia is in January and June. June is mostly sunny. The coolest average temperature around Mesopotamia is in May and July. July is mostly sunny. | **![calendar](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/calendar.png)Calendar Month** | **![temperature](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__hot.png)Temperature** | **![rain](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__rain.png)Precipitation** | **![mostly](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/weather__day_mostly_cloudy.png)Cloudiness** | **![occupation](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/peoplebex.png)Occupancy** | **![price](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/currency_dollar.png)Pricing** | | ---------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------------------------------------------- | ------------------------------------------------------------------------------------------------------------- | | January | 80.1°F (26.7°C) | Light Rain | Sunny | High | Average | | February | 77.7°F (25.4°C) | Light Rain | Mostly Sunny | Average | Slightly High | | March | 72.9°F (22.7°C) | Light Rain | Mostly Sunny | High | Average | | April | 66.7°F (19.3°C) | Light Rain | Mostly Sunny | Average | Average | | May | 59.5°F (15.3°C) | Light Rain | Mostly Sunny | | | | June | 60.1°F (15.6°C) | Light Rain | Mostly Sunny | | | | July | 53.4°F (11.9°C) | Light Rain | Mostly Sunny | Low | Slightly High | | August | 63.7°F (17.6°C) | Light Rain | Mostly Sunny | Average | Slightly High | | September | 60.6°F (15.9°C) | Light Rain | Mostly Sunny | Average | Average | | October | 65.8°F (18.8°C) | Light Rain | Mostly Sunny | Average | Slightly Low | | November | 72.3°F (22.4°C) | Light Rain | Sunny | High | Average | | December | 77.0°F (25.0°C) | Light Rain | Sunny | Average | Average | ### The nearest major airports for your trip to Mesopotamia Traveling to Mesopotamia, Argentina can be accomplished via several major airports. [ASU](https://www.expedia.com/Silvio-Pettirossi-Intl-Airport-Hotels.0-aASU-0.Travel-Guide-Filter-Hotels)ncion (ASU-Silvio Pettirossi Intl.) is 234 miles away, with nearby hotel options like the 4-star [Factoria Hotel](https://www.expedia.com/Asuncion-Hotels-Factoria-Hotel.h15918343.Hotel-Information) and [Gran Bourbon Hotel Asunción](https://www.expedia.com/Asuncion-Hotels-Bourbon-Asuncion-Convention-Hotel.h5013229.Hotel-Information), both offering shuttle services. Posadas ([PSS](https://www.expedia.com/Libertador-General-Jose-De-San-Martin-Airport-Hotels.0-aPSS-0.Travel-Guide-Filter-Hotels)\-Libertador General Jose de San Martin) is located 138 miles from Mesopotamia, with hotels such as [La Mision Posadas Hotel](https://www.expedia.com/Posadas-Hotels-La-Mision-Posadas-Hotel.h4190115.Hotel-Information) providing transportation to the airport. Closer still is [RES](https://www.expedia.com/Resistencia-Intl-Airport-Hotels.0-aRES-0.Travel-Guide-Filter-Hotels)istencia (RES-Resistencia Intl.), just 113 miles away, where you can find the [Amérian Hotel Casino Gala](https://www.expedia.com/Resistencia-Hotels-Amerian-Hotel-Casino-Gala.h1197026.Hotel-Information) and [Gala Hotel y Convenciones](https://www.expedia.com/Resistencia-Hotels-Gala-Hotel-Y-Convenciones.h12370608.Hotel-Information), both conveniently located for airport access. ## Explore a world of travel with Expedia - More ways to book - [Book Hotels in Mesopotamia on Expedia.com.ar ](https://www.expedia.com.ar/Mesopotamia-Hoteles.d6208836.Guia-de-Hoteles)