Mesopotamia

Travel Guide

Mesopotamia showing a river or creek and forest scenes
Mesopotamia showing a river or creek and forest scenes
Mesopotamia featuring forest scenes
Foz do Iguaçu which includes bird life
Mesopotamia featuring forest scenes and a river or creek

The awe-inspiring Iguazú Falls is the centerpiece attraction of this northeastern Argentine region, which also hosts the country’s biggest carnival celebration.

A heady mix of ancient history, natural beauty and flamboyant festivals features in Argentina’s hot and humid Mesopotamia region. Be inspired by thundering waterfalls, spot exotic wildlife, experience indigenous traditions and relax at sleepy riverside resorts. Mesopotamia sits sandwiched between two mighty rivers, the Río Paraná and Rió Uruguay, and is covered with subtropical rainforests and wetlands. It includes the provinces of Misiones, Corrientes and Entre Ríos.

Straddling the Río Iguazú in Misiones province, and shared between Argentina and Brazil, is the UNESCO-protected Iguazú National Park. Come here to admire the 275 individual waterfalls that make up the Iguazú Falls. Follow trails to panoramic lookouts, ride on a speedboat beneath a cascade and see wildlife such as toucans and monkeys. Access the Brazilian side of the park via a short drive from the town of Puerto Iguazú.

Tour the towns of Misiones to appreciate the province’s diversity. Find a gemstone mine in Wanda, flower-filled gardens in Montecarlo and colonial architecture in Oberá. Visit 17th-century Jesuit ruins at San Ignacio. Saltos del Moconá, in Parque Provincial Moconá, is another waterfall worth visiting.

Discover a breezy esplanade, graceful architecture and artisan markets, which showcase Guarani culture, in Corrientes city. Spend some time at easy-going river towns, including Itati and Ituzaingó. Be amazed by the craggy, granite ravine of Barrancas del Empedrado and hike amid thick forest in Mburucuya National Park. Go in search of some 350 bird species and the rare maned wolf at Esteros del Iberá wetlands reserve.

Hot springs, fishing trips, pristine reserves and boisterous carnival parties await in Entre Ríos province. Gualeguaychú explodes into color in February with arguably Argentina’s most famous carnival. The powdery, white sand at nearby Ñandubaysal evokes images of a tropical island paradise. Fish for huge dorado in Santa Elena and enjoy the charm of riverfront Colón. Don’t miss the enormous yatay palm trees in El Palmar National Park.

The southern area of Mesopotamia is just a short bus ride from Buenos Aires. You can also fly to Corrientes and Puerto Iguazú and then get around the region via public buses and organized tours.

O2 Hotel Gualeguaychú

O2 Hotel Gualeguaychú

2.5 out of 5
115 3 de Febrero Gualeguaychú Entre Ríos
$43 nightly
The price is $43 total per night from Feb 1 to Feb 2
$43 total
Feb 1 - Feb 2
Stay at this hotel in Gualeguaychú. Enjoy free WiFi, a 24-hour front desk, and a business center. Popular attractions Gualeguaychú Cathedral and San Martin Square ...
7.6/10 Good! (69 reviews)
La limpieza de los cuartos necesita mejorar. También agregar servicios básicos como TV y teléfono en los cuartos

Reviewed on Mar 12, 2025

O2 Hotel Gualeguaychú
Marriott Corrientes Hotel

Marriott Corrientes Hotel

4.5 out of 5
Av Costanera Juan Pablo II y Lavalle Corrientes
$134 nightly
The price is $134 total per night from Feb 4 to Feb 5
$134 total
Feb 4 - Feb 5
Book a stay at this luxury hotel in Corrientes. Popular attractions Costanera de Corrientes and Cumba Cua Park are located nearby.
9.8/10 Exceptional! (20 reviews)
Excelente

Reviewed on Jan 21, 2026

Marriott Corrientes Hotel
Hathor Concordia

Hathor Concordia

3 out of 5
Ruta Nacional 14-km 264.5 Concordia Entre Rios
$68 nightly
The price is $68 total per night from Feb 5 to Feb 6
$68 total
Feb 5 - Feb 6
Book a stay at this business-friendly hotel in Concordia. Enjoy free breakfast, free WiFi, and room service. Popular attractions Concordia Golf Course and Castillo ...
8.6/10 Excellent! (364 reviews)
The hotel staff is very polite Service: "Friendly and efficient," "helpful," "attentive," "welcoming smile," "professional".

Reviewed on Dec 5, 2025

Hathor Concordia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Complejo La Loma

Complejo La Loma

3 out of 5
Santa Catalina entre Calle 40 y Tonello Federacion Entre Ríos
Stay at this aparthotel in Federacion. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Termas Federacion Water Park and Termas de Federacion ...
7.6/10 Good! (4 reviews)
Great self-contained suite!
Had a very good experience here. Hosts do not speak English, but were very patient with me as I used Google Translate to communicate. Woman at the desk was very kind. I had arrived late and was able to check in without issue. The suite is great - there is a full bathroom, bedroom and kitchen / dining ...

Reviewed on Sep 9, 2023

Complejo La Loma
Agustín 1 Apart

Agustín 1 Apart

4 out of 5
130 Gral. Pedro Ferré Parana Entre Ríos
Stay at this aparthotel in Parana. Enjoy free WiFi, parking (surcharge), and onsite spa services. Popular attractions Plaza de Mayo and Museu De Sitio are located ...
9/10 Wonderful! (4 reviews)
Indico
Meu problema foi só a garagem, o apartamento é ótimo, limpeza estava impecável.

Reviewed on Jan 25, 2025

Agustín 1 Apart
Totoras Apart Federacion

Totoras Apart Federacion

2.5 out of 5
Ñandubay (ex Hermanas Betancourt) 2610 Federacion Entre Rios
Stay at this aparthotel in Federacion. Enjoy free WiFi, free parking, and room service. Popular attractions Termas de Federacion and Termas Federacion Water ...
7.4/10 Good! (27 reviews)
Nada en particular, es buena la relación precio prestación.

Reviewed on Jan 3, 2026

Totoras Apart Federacion
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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