Title: Mesopotamia Vacation Packages 2026 from $1,162 | Expedia.com

[Mesopotamia Travel Guide](https://expedia.com/Mesopotamia.dx6208836)[Hotels in Mesopotamia](https://expedia.com/Mesopotamia-Hotels.d6208836.Travel-Guide-Hotels)[Vacation Rentals in Mesopotamia](https://expedia.com/Mesopotamia-Vacation-Rentals.d6208836.Travel-Guide-VacationRentals)[Flights to Mesopotamia](https://expedia.com/Cheap-Flights-To-Mesopotamia.d6208836.Travel-Guide-Flights)[Car Rentals in Mesopotamia](https://expedia.com/Car-Rentals-In-Mesopotamia.d6208836.Car-Rental-Guide)

![](https://images.trvl-media.com/place/6208836/ca0c6990-9932-4f38-bee6-e89ce7080803.jpg?impolicy=fcrop&w=1200&h=300&q=medium)

# Mesopotamia Vacations from $1,162

## Book a Hotel + Flight or Car together to unlock savings

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### Your Mesopotamia Vacation

When you long for adventure, book a Mesopotamia vacation package. Get set to enjoy culture, nature, festivals, and much more in this vibrant destination. A trip to Mesopotamia wouldn't be complete without getting to some of its leading cities, starting with [Corrientes](https://www.expedia.com/Corrientes.d6054203.Destination-Travel-Guides). Two of the top attractions here include Museo de Artesanías Tradicionales Folclóricas and Casinos del Litoral. [Concordia](https://www.expedia.com/Concordia.d892.Destination-Travel-Guides) is another favorite with Mesopotamia travelers. Visitors to this exciting city love Termas Del Ayui and Concordia Speedway. Whether you're traveling on a shoestring or want to splurge, Expedia are here to help you customize your next Mesopotamia vacation.

## The Latest Mesopotamia vacation packages

Price found within the past 48 hours. Click for updated prices.

![Apassionata Tango Hotel](https://images.trvl-media.com/lodging/16000000/15030000/15025400/15025387/d71e3b32_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Apassionata Tango Hotel

Balvanera

$1,162

per person

May 22 - May 25

found 1 day ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Buenos Aires (EZE)

8.2/10 Very Good! (39 reviews)

Our stay at Apassionata was amazing. Fabian is incredibly attentive and kind and made us feel very welcome. He was always unavailable for questions and concerns and was quick to resolve any problems. Initially we had some issues with the heating in our room and when it couldn't be fixed, we were quickly moved to a much better room. The small size of the hotel allowed so that we got to know the other guests that were staying there. Overall our stay at Apassionata was fabulous.

Reviewed on Sep 26, 2019

![Krista Boutique Hotel](https://images.trvl-media.com/lodging/40000000/39640000/39637500/39637443/5a201def_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Krista Boutique Hotel

Palermo

$1,178

per person

Jun 8 - Jun 10

found 1 day ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Buenos Aires (EZE)

9.2/10 Wonderful! (331 reviews)

Beautiful hotel in a perfect location, right in between Palermo Soho & Recoleta. Staff was very friendly and helpful. Delicious breakfast! Would definitely stay again.

Reviewed on Mar 22, 2026

![Cassa Lepage Art Hotel Buenos Aires](https://images.trvl-media.com/lodging/27000000/26670000/26662200/26662155/w2996h2033x0y0-5041f74c_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Cassa Lepage Art Hotel Buenos Aires

Monserrat

$1,200

per person

Apr 30 - May 5

found 13 hours ago

Roundtrip non-stop flight included

New York (NYC) to Buenos Aires (EZE)

9.8/10 Exceptional! (162 reviews)

Gorgeous boutique hotel with huge rooms and windows that open onto a courtyard. The free breakfast was amazing. The hotel itself is a museum and is stunning!

Reviewed on Mar 27, 2026

![Howard Johnson by Wyndham Ezeiza Convention Center](https://images.trvl-media.com/lodging/7000000/6780000/6771300/6771293/e8d58ca2_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Howard Johnson by Wyndham Ezeiza Convention Center

$1,246

per person

May 22 - May 25

found 1 day ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Buenos Aires (EZE)

7.2/10 Good! (282 reviews)

Easy check 9n nice clean room. Roads from airport to hotel is very rough and bumpy

Reviewed on Feb 22, 2026

![Casa Umare](https://images.trvl-media.com/lodging/20000000/19070000/19062000/19061954/ea807346_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Casa Umare

Almagro

$1,272

per person

May 22 - May 25

found 1 day ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Buenos Aires (EZE)

9.6/10 Exceptional! (87 reviews)

Casa Umare is beautiful. The

Reviewed on May 8, 2025

Don't see what you're looking for?

See all available trips from Columbus to Mesopotamia

[View all trips](https://expedia.com/go/package/search/FlightHotel/2026-04-28/2026-05-05/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=AOL&NumRoom=1&NumAdult=2&NumChild=0&paandie=true)

### Discover the most popular places to visit in Mesopotamia

![Parque Nacional El Palmar, Entre Rios, Argentina.](https://images.trvl-media.com/place/6096826/3ac30eef-b699-482d-95ce-e991c872d599.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### El Palmar National Park

Explore the great outdoors at El Palmar National Park, a lovely green space in Ubajay. 

[](https://expedia.com/El-Palmar-National-Park-Ubajay.d6096826.Vacation-Attraction)

![Punta San Sebastian, Corrientes, Costanera Corrientes](https://images.trvl-media.com/place/553248621532463961/5eccf4f4-bdb0-4368-8beb-0fffd1c8eab0.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Costanera de Corrientes

4/5(2 reviews)

Enjoy an outing to Costanera de Corrientes during your stay in Corrientes. You can enjoy the restaurants while in the area. 

[](https://expedia.com/Costanera-De-Corrientes-Corrientes.d553248621532463961.Vacation-Attraction)

![Parroquia Nuestra Señora de Itati](https://images.trvl-media.com/place/553248621532463967/dcc3f703-5a3b-46d8-99a7-83b2e87b8ea0.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Basilica Nuestra Senora De Itati

Learn about the local history of Municipo de Itatí when you take a trip to Basilica Nuestra Senora De Itati. 

[](https://expedia.com/Basilica-Nuestra-Senora-De-Itati-Municipo-de-Itati.d553248621532463967.Vacation-Attraction)

## Mesopotamia Hotel Deals

![O2 Hotel Gualeguaychú](https://images.trvl-media.com/lodging/77000000/76460000/76459400/76459363/dbe6098c_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

O2 Hotel Gualeguaychú

115 3 de Febrero Gualeguaychú Entre Ríos

Fully refundableReserve now, pay when you stay

$46 nightly

$46 total

Mar 29 - Mar 30

7.6/10 Good! (80 reviews)

Las sabanas estaban sucias No andaba la tele para ver No salía agua caliente y el desayuno horrible

Reviewed on Mar 20, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F29%2F2026&endDate=3%2F30%2F2026&selected=76459363&PinnedHotelID=76459363&HadPinnedHotel=true&regionId=6208836)

![Turismo Hotel Casino](https://images.trvl-media.com/lodging/121000000/120520000/120517600/120517502/a0b30be4_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Turismo Hotel Casino

650 Entre Ríos Corrientes Corrientes

$103 nightly

$103 total

Mar 30 - Mar 31

8/10 Very Good! (4 reviews)

Boa infraestrutura, e localização!

Reviewed on Feb 4, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F30%2F2026&endDate=3%2F31%2F2026&selected=120517502&PinnedHotelID=120517502&HadPinnedHotel=true&regionId=6208836)

![Complejo La Loma](https://images.trvl-media.com/lodging/89000000/88090000/88087500/88087470/11027249_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Complejo La Loma

Santa Catalina entre Calle 40 y Tonello Federacion Entre Ríos

Fully refundableReserve now, pay when you stay

$40 nightly

$40 total

Apr 5 - Apr 6

8/10 Very Good! (5 reviews)

Great self-contained suite!

Had a very good experience here. Hosts do not speak English, but were very patient with me as I used Google Translate to communicate. Woman at the desk was very kind. I had arrived late and was able to check in without issue. The suite is great - there is a full bathroom, bedroom and kitchen / dining ...

Reviewed on Sep 9, 2023

[](https://expedia.com/Hotel-Search?startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&selected=88087470&PinnedHotelID=88087470&HadPinnedHotel=true&regionId=6208836)

[See all 511 properties in Mesopotamia](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=3%2F29%2F2026&endDate=3%2F30%2F2026&regionId=6208836)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Find the Best Mesopotamia Vacation Packages

## Mesopotamia Essential Information

| Language        | Spanish                                |
| --------------- | -------------------------------------- |
| Currency        | Argentine pesos                        |
| Local Welcome   | ¡Hola!                                 |
| Local Goodbye   | Adiós                                  |
| Closest Airport | Ministro Pistarini Intl. Airport (EZE) |

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