Title: Mesopotamia Vacation Packages 2026 from $577 | Expedia.com

[Mesopotamia Travel Guide](https://expedia.com/Mesopotamia.dx6208836)[Hotels in Mesopotamia](https://expedia.com/Mesopotamia-Hotels.d6208836.Travel-Guide-Hotels)[Vacation Rentals in Mesopotamia](https://expedia.com/Mesopotamia-Vacation-Rentals.d6208836.Travel-Guide-VacationRentals)[Flights to Mesopotamia](https://expedia.com/Cheap-Flights-To-Mesopotamia.d6208836.Travel-Guide-Flights)[Car Rentals in Mesopotamia](https://expedia.com/Car-Rentals-In-Mesopotamia.d6208836.Car-Rental-Guide)

![](https://images.trvl-media.com/place/6208836/ca0c6990-9932-4f38-bee6-e89ce7080803.jpg?impolicy=fcrop&w=1200&h=300&q=medium)

# Mesopotamia Vacations from $577

## Book a Hotel + Flight or Car together to unlock savings

- ##  
Plan, book, travel with confidence
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Better together  
Save up to $1,045 when you book a flight and hotel together\*
- ###  
Find the right fit  
With over 300,000 hotels worldwide, it's easy to create a perfect package
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Rest easy  
Plan, book, and manage your trip all in one place

### Your Mesopotamia Vacation

When you long for adventure, book a Mesopotamia vacation package. Get set to enjoy culture, nature, festivals, and much more in this vibrant destination. A trip to Mesopotamia wouldn't be complete without getting to some of its leading cities, starting with [Corrientes](https://www.expedia.com/Corrientes.d6054203.Destination-Travel-Guides). Two of the top attractions here include Museo de Artesanías Tradicionales Folclóricas and Casinos del Litoral. [Concordia](https://www.expedia.com/Concordia.d892.Destination-Travel-Guides) is another favorite with Mesopotamia travelers. Visitors to this exciting city love Termas Del Ayui and Concordia Speedway. Whether you're traveling on a shoestring or want to splurge, Expedia are here to help you customize your next Mesopotamia vacation.

## The Latest Mesopotamia vacation packages

Price found within the past 48 hours. Click for updated prices.

![Infinito Hotel](https://images.trvl-media.com/lodging/6000000/5430000/5426800/5426795/a9468ffa_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Infinito Hotel

Palermo

$577

per person

Jun 7 - Jun 12

found 1 hour ago

Roundtrip non-stop flight included

San José (SJO) to Buenos Aires (EZE)

7.8/10 Good! (222 reviews)

A mi me encanto. Me gusto mucho la area, el staff, y fue comodo.

Reviewed on Oct 3, 2025

![Hotel Bys Palermo](https://images.trvl-media.com/lodging/5000000/4400000/4396500/4396458/a0d3af80_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Hotel Bys Palermo

Palermo

$697

per person

Jun 7 - Jun 12

found 1 hour ago

Roundtrip non-stop flight included

San José (SJO) to Buenos Aires (EZE)

9/10 Wonderful! (402 reviews)

Nice breakfast, swimming pool, friendly staff

Reviewed on Jan 5, 2026

![CasaSur Palermo Hotel](https://images.trvl-media.com/lodging/12000000/11230000/11221800/11221701/3ebd0ae5_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### CasaSur Palermo Hotel

Palermo

$1,465

per person

Apr 30 - May 5

found 1 day ago

Roundtrip non-stop flight included

New York (NYC) to Buenos Aires (EZE)

9/10 Wonderful! (443 reviews)

Great location, very nice and spacious hotel. Highly highly recommend

Reviewed on Mar 12, 2026

![Bulnes Eco Suites](https://images.trvl-media.com/lodging/9000000/8420000/8412000/8411980/2b170537_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Bulnes Eco Suites

Palermo

$1,087

per person

Apr 30 - May 5

found 1 day ago

Roundtrip non-stop flight included

New York (NYC) to Buenos Aires (EZE)

9.4/10 Exceptional! (1,212 reviews)

Amenities excellent.

Reviewed on Mar 21, 2026

![Libertad Hotel Buenos Aires](https://images.trvl-media.com/lodging/5000000/4130000/4122000/4121952/ecea6f01_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Libertad Hotel Buenos Aires

Buenos Aires Central Business District

$1,150

per person

Apr 30 - May 5

found 1 day ago

Roundtrip non-stop flight included

New York (NYC) to Buenos Aires (EZE)

9/10 Wonderful! (550 reviews)

Everything was perfect

Reviewed on Mar 9, 2026

Don't see what you're looking for?

See all available trips from Columbus to Mesopotamia

[View all trips](https://expedia.com/go/package/search/FlightHotel/2026-04-29/2026-05-06/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=AOL&NumRoom=1&NumAdult=2&NumChild=0&paandie=true)

### Discover the most popular places to visit in Mesopotamia

![Parque Nacional El Palmar, Entre Rios, Argentina.](https://images.trvl-media.com/place/6096826/3ac30eef-b699-482d-95ce-e991c872d599.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### El Palmar National Park

Explore the great outdoors at El Palmar National Park, a lovely green space in Ubajay. 

[](https://expedia.com/El-Palmar-National-Park-Ubajay.d6096826.Vacation-Attraction)

![Punta San Sebastian, Corrientes, Costanera Corrientes](https://images.trvl-media.com/place/553248621532463961/5eccf4f4-bdb0-4368-8beb-0fffd1c8eab0.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Costanera de Corrientes

4/5(2 reviews)

Enjoy an outing to Costanera de Corrientes during your stay in Corrientes. You can enjoy the restaurants while in the area. 

[](https://expedia.com/Costanera-De-Corrientes-Corrientes.d553248621532463961.Vacation-Attraction)

![Parroquia Nuestra Señora de Itati](https://images.trvl-media.com/place/553248621532463967/dcc3f703-5a3b-46d8-99a7-83b2e87b8ea0.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Basilica Nuestra Senora De Itati

Learn about the local history of Municipo de Itatí when you take a trip to Basilica Nuestra Senora De Itati. 

[](https://expedia.com/Basilica-Nuestra-Senora-De-Itati-Municipo-de-Itati.d553248621532463967.Vacation-Attraction)

## Mesopotamia Hotel Deals

![O2 Hotel Gualeguaychú](https://images.trvl-media.com/lodging/77000000/76460000/76459400/76459363/dbe6098c_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

O2 Hotel Gualeguaychú

115 3 de Febrero Gualeguaychú Entre Ríos

Fully refundableReserve now, pay when you stay

$46 nightly

$46 total

Mar 30 - Mar 31

7.6/10 Good! (80 reviews)

Las sabanas estaban sucias No andaba la tele para ver No salía agua caliente y el desayuno horrible

Reviewed on Mar 20, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F30%2F2026&endDate=3%2F31%2F2026&selected=76459363&PinnedHotelID=76459363&HadPinnedHotel=true&regionId=6208836)

![Turismo Hotel Casino](https://images.trvl-media.com/lodging/121000000/120520000/120517600/120517502/a0b30be4_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Turismo Hotel Casino

650 Entre Ríos Corrientes Corrientes

Fully refundableReserve now, pay when you stay

$112 nightly

$112 total

Apr 6 - Apr 7

8/10 Very Good! (4 reviews)

Boa infraestrutura, e localização!

Reviewed on Feb 4, 2026

[](https://expedia.com/Hotel-Search?startDate=4%2F6%2F2026&endDate=4%2F7%2F2026&selected=120517502&PinnedHotelID=120517502&HadPinnedHotel=true&regionId=6208836)

![Intersur Colon](https://images.trvl-media.com/lodging/115000000/114110000/114109800/114109755/cb01ff56_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Intersur Colon

Av. Gdor. Quiros 185 Colón Entre Ríos

$77 nightly

$77 total

Apr 27 - Apr 28

8/10 Very Good! (8 reviews)

Staff as friendly but room was very dirty, toilet had not been flushed, broken lamps and dirty napkins on the floor.

Reviewed on Mar 9, 2026

[](https://expedia.com/Hotel-Search?startDate=4%2F27%2F2026&endDate=4%2F28%2F2026&selected=114109755&PinnedHotelID=114109755&HadPinnedHotel=true&regionId=6208836)

[See all 510 properties in Mesopotamia](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=3%2F30%2F2026&endDate=3%2F31%2F2026&regionId=6208836)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Find the Best Mesopotamia Vacation Packages

## Mesopotamia Essential Information

| Language        | Spanish                                |
| --------------- | -------------------------------------- |
| Currency        | Argentine pesos                        |
| Local Welcome   | ¡Hola!                                 |
| Local Goodbye   | Adiós                                  |
| Closest Airport | Ministro Pistarini Intl. Airport (EZE) |

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\* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.