Title: Mesopotamia Vacation Packages 2026 from $451 | Expedia.com

[Mesopotamia Travel Guide](https://expedia.com/Mesopotamia.dx6208836)[Hotels in Mesopotamia](https://expedia.com/Mesopotamia-Hotels.d6208836.Travel-Guide-Hotels)[Vacation Rentals in Mesopotamia](https://expedia.com/Mesopotamia-Vacation-Rentals.d6208836.Travel-Guide-VacationRentals)[Flights to Mesopotamia](https://expedia.com/Cheap-Flights-To-Mesopotamia.d6208836.Travel-Guide-Flights)[Car Rentals in Mesopotamia](https://expedia.com/Car-Rentals-In-Mesopotamia.d6208836.Car-Rental-Guide)

![](https://images.trvl-media.com/place/6208836/ca0c6990-9932-4f38-bee6-e89ce7080803.jpg?impolicy=fcrop&w=1200&h=300&q=medium)

# Mesopotamia Vacations from $451

## Book a Hotel + Flight or Car together to unlock savings

- ##  
Plan, book, travel with confidence
- ###  
Better together  
Save up to $1,045 when you book a flight and hotel together\*
- ###  
Find the right fit  
With over 300,000 hotels worldwide, it's easy to create a perfect package
- ###  
Rest easy  
Plan, book, and manage your trip all in one place

### Your Mesopotamia Vacation

When you long for adventure, book a Mesopotamia vacation package. Get set to enjoy culture, nature, festivals, and much more in this vibrant destination. A trip to Mesopotamia wouldn't be complete without getting to some of its leading cities, starting with [Corrientes](https://www.expedia.com/Corrientes.d6054203.Destination-Travel-Guides). Two of the top attractions here include Museo de Artesanías Tradicionales Folclóricas and Casinos del Litoral. [Concordia](https://www.expedia.com/Concordia.d892.Destination-Travel-Guides) is another favorite with Mesopotamia travelers. Visitors to this exciting city love Termas Del Ayui and Concordia Speedway. Whether you're traveling on a shoestring or want to splurge, Expedia are here to help you customize your next Mesopotamia vacation.

## The Latest Mesopotamia vacation packages

Price found within the past 48 hours. Click for updated prices.

![Infinito Hotel](https://images.trvl-media.com/lodging/6000000/5430000/5426800/5426795/a9468ffa_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Infinito Hotel

Palermo

$451

per person

May 7 - May 12

found 1 day ago

Roundtrip flight included

Lima (LIM) to Buenos Aires (EZE)

7.8/10 Good! (222 reviews)

A mi me encanto. Me gusto mucho la area, el staff, y fue comodo.

Reviewed on Oct 3, 2025

![Estancia Villa Maria](https://images.trvl-media.com/lodging/28000000/27600000/27598400/27598318/7a09c91e_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Estancia Villa Maria

$1,245

per person

Jun 7 - Jun 13

found 5 hours ago

Roundtrip flight included

Lima (LIM) to Buenos Aires (EZE)

9.4/10 Exceptional! (107 reviews)

A fairytale place! Beautiful estancia 45 minutes from Ezeiza. Very peacefull, beautifully kept property with wonderful breakfast, lunch Asada!! plus show!) and dining. Perfect service from friendly accomodating staff. Thank you, Luis, for going the extra mile to make our stay comfortable and unforgetable! The carriage ride was very special!

Reviewed on Feb 24, 2026

![Faena Hotel Buenos Aires](https://images.trvl-media.com/lodging/2000000/1060000/1052300/1052252/e0a62399_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Faena Hotel Buenos Aires

Puerto Madero

Save 100% on your flight

$1,098

per person

May 7 - May 12

found 1 day ago

Roundtrip flight included

Lima (LIM) to Buenos Aires (EZE)

9/10 Wonderful! (510 reviews)

Overall pretty good. The room had a few broken items and no coffee machine but they brought one on request . Pool and bar is good .

Reviewed on Mar 4, 2026

![TPYN Palermo](https://images.trvl-media.com/lodging/38000000/37920000/37915600/37915593/47c968c4_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### TPYN Palermo

Palermo

Save 100% on your flight

$542

per person

May 7 - May 12

found 1 day ago

Roundtrip flight included

Lima (LIM) to Buenos Aires (EZE)

8.4/10 Very Good! (25 reviews)

Decent enough but can’t swing a cat in the kitchen area, if you’ve no intention of cooking and you’re on your own ,no problem

Reviewed on Feb 3, 2025

![Casa Umare](https://images.trvl-media.com/lodging/20000000/19070000/19062000/19061954/ea807346_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Casa Umare

Almagro

Save 100% on your flight

$878

per person

Jun 7 - Jun 13

found 5 hours ago

Roundtrip flight included

Lima (LIM) to Buenos Aires (EZE)

9.6/10 Exceptional! (87 reviews)

Casa Umare is beautiful. The

Reviewed on May 8, 2025

Don't see what you're looking for?

See all available trips from Columbus to Mesopotamia

[View all trips](https://expedia.com/go/package/search/FlightHotel/2026-04-22/2026-04-29/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=AOL&NumRoom=1&NumAdult=2&NumChild=0&paandie=true)

### Discover the most popular places to visit in Mesopotamia

![Parque Nacional El Palmar, Entre Rios, Argentina.](https://images.trvl-media.com/place/6096826/3ac30eef-b699-482d-95ce-e991c872d599.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### El Palmar National Park

Explore the great outdoors at El Palmar National Park, a lovely green space in Ubajay. 

[](https://expedia.com/El-Palmar-National-Park-Ubajay.d6096826.Vacation-Attraction)

![Punta San Sebastian, Corrientes, Costanera Corrientes](https://images.trvl-media.com/place/553248621532463961/5eccf4f4-bdb0-4368-8beb-0fffd1c8eab0.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Costanera de Corrientes

Enjoy an outing to Costanera de Corrientes during your stay in Corrientes. You can enjoy the restaurants while in the area. 

[](https://expedia.com/Costanera-De-Corrientes-Corrientes.d553248621532463961.Vacation-Attraction)

![Parroquia Nuestra Señora de Itati](https://images.trvl-media.com/place/553248621532463967/dcc3f703-5a3b-46d8-99a7-83b2e87b8ea0.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Basilica Nuestra Senora De Itati

Learn about the local history of Municipo de Itatí when you take a trip to Basilica Nuestra Senora De Itati. 

[](https://expedia.com/Basilica-Nuestra-Senora-De-Itati-Municipo-de-Itati.d553248621532463967.Vacation-Attraction)

## Mesopotamia Hotel Deals

![O2 Hotel Gualeguaychú](https://images.trvl-media.com/lodging/77000000/76460000/76459400/76459363/dbe6098c_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

O2 Hotel Gualeguaychú

115 3 de Febrero Gualeguaychú Entre Ríos

Fully refundableReserve now, pay when you stay

$46 nightly

$46 total

Mar 23 - Mar 24

7.6/10 Good! (79 reviews)

Las sabanas estaban sucias No andaba la tele para ver No salía agua caliente y el desayuno horrible

Reviewed on Mar 20, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F23%2F2026&endDate=3%2F24%2F2026&selected=76459363&PinnedHotelID=76459363&HadPinnedHotel=true&regionId=6208836)

![Turismo Hotel Casino](https://images.trvl-media.com/lodging/121000000/120520000/120517600/120517502/a0b30be4_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Turismo Hotel Casino

650 Entre Ríos Corrientes Corrientes

Fully refundableReserve now, pay when you stay

$111 nightly

$111 total

Mar 24 - Mar 25

8/10 Very Good! (4 reviews)

Boa infraestrutura, e localização!

Reviewed on Feb 4, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F24%2F2026&endDate=3%2F25%2F2026&selected=120517502&PinnedHotelID=120517502&HadPinnedHotel=true&regionId=6208836)

![Complejo La Loma](https://images.trvl-media.com/lodging/89000000/88090000/88087500/88087470/11027249_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Complejo La Loma

Santa Catalina entre Calle 40 y Tonello Federacion Entre Ríos

Fully refundableReserve now, pay when you stay

$40 nightly

$40 total

Mar 30 - Mar 31

8/10 Very Good! (5 reviews)

Great self-contained suite!

Had a very good experience here. Hosts do not speak English, but were very patient with me as I used Google Translate to communicate. Woman at the desk was very kind. I had arrived late and was able to check in without issue. The suite is great - there is a full bathroom, bedroom and kitchen / dining ...

Reviewed on Sep 9, 2023

[](https://expedia.com/Hotel-Search?startDate=3%2F30%2F2026&endDate=3%2F31%2F2026&selected=88087470&PinnedHotelID=88087470&HadPinnedHotel=true&regionId=6208836)

[See all 511 properties in Mesopotamia](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=3%2F23%2F2026&endDate=3%2F24%2F2026&regionId=6208836)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Find the Best Mesopotamia Vacation Packages

## Mesopotamia Essential Information

| Language        | Spanish                                |
| --------------- | -------------------------------------- |
| Currency        | Argentine pesos                        |
| Local Welcome   | ¡Hola!                                 |
| Local Goodbye   | Adiós                                  |
| Closest Airport | Ministro Pistarini Intl. Airport (EZE) |

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\* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.

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