Title: Mesopotamia Vacation Packages 2026 from $518 | Expedia.com

[Mesopotamia Travel Guide](https://expedia.com/Mesopotamia.dx6208836)[Hotels in Mesopotamia](https://expedia.com/Mesopotamia-Hotels.d6208836.Travel-Guide-Hotels)[Vacation Rentals in Mesopotamia](https://expedia.com/Mesopotamia-Vacation-Rentals.d6208836.Travel-Guide-VacationRentals)[Flights to Mesopotamia](https://expedia.com/Cheap-Flights-To-Mesopotamia.d6208836.Travel-Guide-Flights)[Car Rentals in Mesopotamia](https://expedia.com/Car-Rentals-In-Mesopotamia.d6208836.Car-Rental-Guide)

![](https://images.trvl-media.com/place/6208836/ca0c6990-9932-4f38-bee6-e89ce7080803.jpg?impolicy=fcrop&w=1200&h=300&q=medium)

# Mesopotamia Vacations from $518

## Book a Hotel + Flight or Car together to unlock savings

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### Your Mesopotamia Vacation

When you long for adventure, book a Mesopotamia vacation package. Get set to enjoy culture, nature, festivals, and much more in this vibrant destination. A trip to Mesopotamia wouldn't be complete without getting to some of its leading cities, starting with [Corrientes](https://www.expedia.com/Corrientes.d6054203.Destination-Travel-Guides). Two of the top attractions here include Museo de Artesanías Tradicionales Folclóricas and Casinos del Litoral. [Concordia](https://www.expedia.com/Concordia.d892.Destination-Travel-Guides) is another favorite with Mesopotamia travelers. Visitors to this exciting city love Termas Del Ayui and Concordia Speedway. Whether you're traveling on a shoestring or want to splurge, Expedia are here to help you customize your next Mesopotamia vacation.

## The Latest Mesopotamia vacation packages

Price found within the past 48 hours. Click for updated prices.

![Duque Hotel Boutique & Spa](https://images.trvl-media.com/lodging/4000000/3440000/3439500/3439490/f0993a71_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Duque Hotel Boutique & Spa

Palermo

$518

per person

May 7 - May 11

found 1 day ago

Roundtrip flight included

Lima (LIM) to Buenos Aires (EZE)

9.4/10 Exceptional! (897 reviews)

Great customer service in Español and English. Beautiful building and central in Buenos Aires. Nice morning breakfast as well. Clean.

Reviewed on Mar 6, 2026

![Estancia Villa Maria](https://images.trvl-media.com/lodging/28000000/27600000/27598400/27598318/7a09c91e_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Estancia Villa Maria

$1,593

per person

May 29 - Jun 5

found 1 day ago

Roundtrip non-stop flight included

Miami (MIA) to Buenos Aires (EZE)

9.4/10 Exceptional! (107 reviews)

A fairytale place! Beautiful estancia 45 minutes from Ezeiza. Very peacefull, beautifully kept property with wonderful breakfast, lunch Asada!! plus show!) and dining. Perfect service from friendly accomodating staff. Thank you, Luis, for going the extra mile to make our stay comfortable and unforgetable! The carriage ride was very special!

Reviewed on Feb 24, 2026

![Palacio Duhau - Park Hyatt Buenos Aires](https://images.trvl-media.com/lodging/2000000/1340000/1339900/1339890/14e60a20_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Palacio Duhau - Park Hyatt Buenos Aires

Recoleta

Save 100% on your flight

$1,376

per person

May 4 - May 9

found 9 hours ago

Roundtrip flight included

Lima (LIM) to Buenos Aires (EZE)

9.4/10 Exceptional! (481 reviews)

Unbelievable customer service. The concierge team are the best I’ve ever experienced. Spectacular hotel

Reviewed on Feb 20, 2026

![Design cE - Hotel Boutique de Diseño](https://images.trvl-media.com/lodging/2000000/1480000/1472900/1472885/6cb33cd7_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Design cE - Hotel Boutique de Diseño

Recoleta

Save 100% on your flight

$1,206

per person

May 29 - Jun 5

found 1 day ago

Roundtrip non-stop flight included

Miami (MIA) to Buenos Aires (EZE)

8.6/10 Excellent! (454 reviews)

The staff was fantastic

Reviewed on Feb 27, 2026

Don't see what you're looking for?

See all available trips from Columbus to Mesopotamia

[View all trips](https://expedia.com/go/package/search/FlightHotel/2026-04-11/2026-04-18/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=AOL&NumRoom=1&NumAdult=2&NumChild=0&paandie=true)

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## 

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.

[Book now](https://expedia.com/deals?rfrr=PKG_SPRING_PROMO_6208836)

### Discover the most popular places to visit in Mesopotamia

![Punta San Sebastian, Corrientes, Costanera Corrientes](https://images.trvl-media.com/place/553248621532463961/5eccf4f4-bdb0-4368-8beb-0fffd1c8eab0.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Costanera de Corrientes

Enjoy an outing to Costanera de Corrientes during your stay in Corrientes. You can enjoy the restaurants while in the area. 

[](https://expedia.com/Costanera-De-Corrientes-Corrientes.d553248621532463961.Vacation-Attraction)

![Parque Nacional El Palmar, Entre Rios, Argentina.](https://images.trvl-media.com/place/6096826/3ac30eef-b699-482d-95ce-e991c872d599.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### El Palmar National Park

Explore the great outdoors at El Palmar National Park, a lovely green space in Ubajay. 

[](https://expedia.com/El-Palmar-National-Park-Ubajay.d6096826.Vacation-Attraction)

![Parroquia Nuestra Señora de Itati](https://images.trvl-media.com/place/553248621532463967/dcc3f703-5a3b-46d8-99a7-83b2e87b8ea0.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Basilica Nuestra Senora De Itati

Learn about the local history of Municipo de Itatí when you take a trip to Basilica Nuestra Senora De Itati. 

[](https://expedia.com/Basilica-Nuestra-Senora-De-Itati-Municipo-de-Itati.d553248621532463967.Vacation-Attraction)

## Mesopotamia Hotel Deals

![O2 Hotel Gualeguaychú](https://images.trvl-media.com/lodging/77000000/76460000/76459400/76459363/dbe6098c_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

O2 Hotel Gualeguaychú

115 3 de Febrero Gualeguaychú Entre Ríos

Fully refundableReserve now, pay when you stay

$46 nightly

$46 total

Mar 23 - Mar 24

7.8/10 Good! (77 reviews)

Si un huesped pregunta si se olvida algo en la habitacion tener la deliquicadesa de contestar por eso la calificaccion no me volveria a quedar

Reviewed on Dec 23, 2025

[](https://expedia.com/Hotel-Search?startDate=3%2F23%2F2026&endDate=3%2F24%2F2026&selected=76459363&PinnedHotelID=76459363&HadPinnedHotel=true&regionId=6208836)

![Marriott Corrientes Hotel](https://images.trvl-media.com/lodging/118000000/117160000/117154200/117154160/45830686_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Marriott Corrientes Hotel

Av Costanera Juan Pablo II y Lavalle Corrientes 

Fully refundableReserve now, pay when you stay

$134 nightly

$134 total

Apr 10 - Apr 11

10/10 Exceptional! (22 reviews)

Fantastic stay. Room was immaculate and hotel staff were very friendly and helpful. Great pool and beds were super comfortable.

Reviewed on Feb 6, 2026

[](https://expedia.com/Hotel-Search?startDate=4%2F10%2F2026&endDate=4%2F11%2F2026&selected=117154160&PinnedHotelID=117154160&HadPinnedHotel=true&regionId=6208836)

![Hathor Concordia](https://images.trvl-media.com/lodging/5000000/4670000/4668300/4668235/cc821f0d_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Hathor Concordia

Ruta Nacional 14-km 264.5 Concordia Entre Rios

8.6/10 Excellent! (369 reviews)

AC did not work well, food was OK. Staff friendly. Good hotel for a stay on the road.

Reviewed on Dec 22, 2025

[Get rates](https://expedia.com/Hotel-Search?startDate=3%2F25%2F2026&endDate=3%2F26%2F2026&selected=4668235&PinnedHotelID=4668235&HadPinnedHotel=true&regionId=6208836)

[](https://expedia.com/Hotel-Search?startDate=3%2F25%2F2026&endDate=3%2F26%2F2026&selected=4668235&PinnedHotelID=4668235&HadPinnedHotel=true&regionId=6208836)

[See all 513 properties in Mesopotamia](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=3%2F12%2F2026&endDate=3%2F13%2F2026&regionId=6208836)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Find the Best Mesopotamia Vacation Packages

## Mesopotamia Essential Information

| Language        | Spanish                                |
| --------------- | -------------------------------------- |
| Currency        | Argentine pesos                        |
| Local Welcome   | ¡Hola!                                 |
| Local Goodbye   | Adiós                                  |
| Closest Airport | Ministro Pistarini Intl. Airport (EZE) |

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\* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.

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