Your Mesopotamia Vacation

When you long for adventure, book a Mesopotamia vacation package. Get set to enjoy culture, nature, festivals, and much more in this vibrant destination. A trip to Mesopotamia wouldn't be complete without getting to some of its leading cities, starting with Corrientes. Two of the top attractions here include Museo de Artesanías Tradicionales Folclóricas and Casinos del Litoral. Concordia is another favorite with Mesopotamia travelers. Visitors to this exciting city love Termas Del Ayui and Concordia Speedway. Whether you're traveling on a shoestring or want to splurge, Expedia are here to help you customize your next Mesopotamia vacation.

The Latest Mesopotamia vacation packages

Price found within the past 48 hours. Click for updated prices.

725 Continental

El Centro

per person

Oct 19 - Oct 26

found 1 day ago

Roundtrip non-stop flight included

Miami (MIA) to Buenos Aires (BUE)

8.6/10 Excellent! (659 reviews)

Excellent location to see Buenos Aires. Room clean and adequate. Meeting room adequate and convenient. Front desk staff helpful. Breakfast buffet unfortunately mediocre especially in comparison to other accommodations on our trip. Offerings were plentiful but not tasty.

Reviewed on Feb 17, 2025

Estancia Villa Maria

Save 100% on your flight

per person

Nov 8 - Nov 15

found 22 hours ago

Roundtrip non-stop flight included

Boston (BOS) to Buenos Aires (BUE)

9.4/10 Exceptional! (94 reviews)

We had an incredible stay. It was very relaxing. The staff is exceptional. The villa itself is very charming. It’s about 45 minutes from the city we had a car and would spend the day in the city and come back in the afternoon for a peaceful break.

Reviewed on Aug 6, 2025

Regal Pacific Buenos Aires

El Centro

Save 100% on your flight

per person

Nov 8 - Nov 15

found 22 hours ago

Roundtrip non-stop flight included

Boston (BOS) to Buenos Aires (BUE)

8.8/10 Excellent! (1,001 reviews)

Bellmen probably treated people base on the race.

Reviewed on Mar 31, 2025

Mio Buenos Aires

Recoleta

Save 100% on your flight

per person

Oct 19 - Oct 26

found 1 day ago

Roundtrip non-stop flight included

Miami (MIA) to Buenos Aires (BUE)

9.4/10 Exceptional! (538 reviews)

Great place to stay!!

Reviewed on Jul 2, 2025

Krista Boutique Hotel

Palermo

per person

Nov 8 - Nov 15

found 22 hours ago

Roundtrip non-stop flight included

Boston (BOS) to Buenos Aires (BUE)

9/10 Wonderful! (280 reviews)

Excelente hotel, desayuno y facilidades. Habitaciones amplias y cómodas. Personal amable y atento.

Reviewed on Jul 6, 2025

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Discover the most popular places to visit in Mesopotamia

El Palmar National Park

Explore the great outdoors at El Palmar National Park, a lovely green space in Ubajay.

Amé las 20 hectáreas de parque y jardines de este Palacio

San José Palace

You can spend an afternoon exploring the galleries in San José Palace in Caseros.

Termas de Federacion

Bring your family to Termas de Federacion and have a fun-filled day at this amusement park in Federacion. Stroll along the beaches or discover the area's waterfalls.

Mesopotamia Hotel Deals

Hathor Concordia

Ruta Nacional 14-km 264.5, Concordia, Entre Rios

Fully refundableReserve now, pay when you stay

$56 nightly

$56 total

Aug 18 - Aug 19

8.6/10 Excellent! (350 reviews)

"Very clean room at affordable price. The dinning is of excellent quality at very reasonable price. The staff are quite friendly and helpful."

Reviewed on Dec 31, 2024

O2 Hotel Gualeguaychú

115 3 de Febrero, Gualeguaychú, Entre Ríos

Fully refundableReserve now, pay when you stay

$38 nightly

$38 total

Aug 19 - Aug 20

7.6/10 Good! (61 reviews)

"Hotel is very comfortable and clean. There is no breakfast or hotel parking, and the wifi does not work properly in most floors and rooms. Other than that, the staff is very friendly and nice."

Reviewed on Jan 2, 2025

La Alondra Casa De Huéspedes

Av. 3 De Abril 827, Corrientes, Corrientes

"Very nice place in the middle of the city to be quiet, eat delicious, sunbathe. They should improve some minor issues to have a more than excellent stay."

Reviewed on Dec 21, 2020

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See all 501 properties in Mesopotamia

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.