Mesopotamia Vacations from $1,045

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Your Mesopotamia Vacation

When you long for adventure, book a Mesopotamia vacation package. Get set to enjoy culture, nature, festivals, and much more in this vibrant destination. A trip to Mesopotamia wouldn't be complete without getting to some of its leading cities, starting with Corrientes. Two of the top attractions here include Museo de Artesanías Tradicionales Folclóricas and Casinos del Litoral. Concordia is another favorite with Mesopotamia travelers. Visitors to this exciting city love Termas Del Ayui and Concordia Speedway. Whether you're traveling on a shoestring or want to splurge, Expedia are here to help you customize your next Mesopotamia vacation.

The Latest Mesopotamia vacation packages

Price found within the past 48 hours. Click for updated prices.
Bulnes Eco Suites
Argentina Tango Hotel
Estancia Villa Maria
Byblos Palermo Soho
Algodon Mansion
Don't see what you're looking for?
See all available trips from Columbus to Mesopotamia
View all trips

Discover the most popular places to visit in Mesopotamia

Mesopotamia Hotel Deals

Marriott Corrientes Hotel

Marriott Corrientes Hotel

4.5 out of 5
Av Costanera Juan Pablo II y Lavalle Corrientes
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $134 total per night from Jan 9 to Jan 10
$134 total
Jan 9 - Jan 10
9.6/10 Exceptional! (10 reviews)
Welcoming and accommodating staff. Good location and views of river. Clean and comfortable rooms. Newly opened hotel, the best in the city. Good breakfast buffet.

Reviewed on Dec 22, 2025

Marriott Corrientes Hotel
O2 Hotel Gualeguaychú

O2 Hotel Gualeguaychú

2.5 out of 5
115 3 de Febrero Gualeguaychú Entre Ríos
Fully refundableReserve now, pay when you stay
$39 nightly
The price is $39 total per night from Jan 5 to Jan 6
$39 total
Jan 5 - Jan 6
7.6/10 Good! (67 reviews)
Hotel is very comfortable and clean. There is no breakfast or hotel parking, and the wifi does not work properly in most floors and rooms. Other than that, the staff is very friendly and nice.

Reviewed on Jan 2, 2025

O2 Hotel Gualeguaychú
Hathor Concordia

Hathor Concordia

3 out of 5
Ruta Nacional 14-km 264.5 Concordia Entre Rios
Fully refundableReserve now, pay when you stay
$74 nightly
The price is $74 total per night from Jan 4 to Jan 5
$74 total
Jan 4 - Jan 5
8.6/10 Excellent! (357 reviews)
The hotel staff is very polite Service: "Friendly and efficient," "helpful," "attentive," "welcoming smile," "professional".

Reviewed on Dec 5, 2025

Hathor Concordia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Mesopotamia Vacation Packages

Mesopotamia Essential Information

Language
Spanish
Currency
Argentine pesos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Ministro Pistarini Intl. Airport (EZE)

More vacations you might like

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.