Title: Mesopotamia Vacation Packages 2026 from $666 | Expedia.com

[Mesopotamia Travel Guide](https://expedia.com/Mesopotamia.dx6208836)[Hotels in Mesopotamia](https://expedia.com/Mesopotamia-Hotels.d6208836.Travel-Guide-Hotels)[Vacation Rentals in Mesopotamia](https://expedia.com/Mesopotamia-Vacation-Rentals.d6208836.Travel-Guide-VacationRentals)[Flights to Mesopotamia](https://expedia.com/Cheap-Flights-To-Mesopotamia.d6208836.Travel-Guide-Flights)[Car Rentals in Mesopotamia](https://expedia.com/Car-Rentals-In-Mesopotamia.d6208836.Car-Rental-Guide)

![](https://images.trvl-media.com/place/6208836/ca0c6990-9932-4f38-bee6-e89ce7080803.jpg?impolicy=fcrop&w=1200&h=300&q=medium)

# Mesopotamia Vacations from $666

## Book a Hotel + Flight or Car together to unlock savings

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### Your Mesopotamia Vacation

When you long for adventure, book a Mesopotamia vacation package. Get set to enjoy culture, nature, festivals, and much more in this vibrant destination. A trip to Mesopotamia wouldn't be complete without getting to some of its leading cities, starting with [Corrientes](https://www.expedia.com/Corrientes.d6054203.Destination-Travel-Guides). Two of the top attractions here include Museo de Artesanías Tradicionales Folclóricas and Casinos del Litoral. [Concordia](https://www.expedia.com/Concordia.d892.Destination-Travel-Guides) is another favorite with Mesopotamia travelers. Visitors to this exciting city love Termas Del Ayui and Concordia Speedway. Whether you're traveling on a shoestring or want to splurge, Expedia are here to help you customize your next Mesopotamia vacation.

## The Latest Mesopotamia vacation packages

Price found within the past 48 hours. Click for updated prices.

![Casa Umare](https://images.trvl-media.com/lodging/20000000/19070000/19062000/19061954/ea807346_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Casa Umare

Almagro

$666

per person

Jun 11 - Jun 14

found 1 day ago

Roundtrip flight included

Lima (LIM) to Buenos Aires (EZE)

9.6/10 Exceptional! (87 reviews)

Casa Umare is beautiful. The

Reviewed on May 8, 2025

![Estancia Villa Maria](https://images.trvl-media.com/lodging/28000000/27600000/27598400/27598318/7a09c91e_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Estancia Villa Maria

Save 100% on your flight

$714

per person

Jun 11 - Jun 14

found 1 day ago

Roundtrip flight included

Lima (LIM) to Buenos Aires (EZE)

9.4/10 Exceptional! (107 reviews)

A fairytale place! Beautiful estancia 45 minutes from Ezeiza. Very peacefull, beautifully kept property with wonderful breakfast, lunch Asada!! plus show!) and dining. Perfect service from friendly accomodating staff. Thank you, Luis, for going the extra mile to make our stay comfortable and unforgetable! The carriage ride was very special!

Reviewed on Feb 24, 2026

![Algodon Mansion](https://images.trvl-media.com/lodging/5000000/4420000/4417500/4417480/766afb7c_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Algodon Mansion

Buenos Aires Central Business District

$1,413

per person

Jun 8 - Jun 12

found 21 hours ago

Roundtrip non-stop flight included

New York (NYC) to Buenos Aires (EZE)

9.6/10 Exceptional! (111 reviews)

What a fabulous hotel to stay in. We had a wonderful vacation. Our suite was very quiet, spacious and well appointed. The concierge team stood out and coordinated day trips and dinners. These experiences made our trip to Buenos Aires extra special. Highly recommend staying at the Algodon Mansion.

Reviewed on Feb 15, 2026

![Mio Buenos Aires](https://images.trvl-media.com/lodging/5000000/4270000/4260900/4260897/ab1143f6_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Mio Buenos Aires

Recoleta

$1,165

per person

Jun 8 - Jun 12

found 21 hours ago

Roundtrip non-stop flight included

New York (NYC) to Buenos Aires (EZE)

9.4/10 Exceptional! (605 reviews)

Fantastic stay! Great in the veryway

Reviewed on Mar 22, 2026

Don't see what you're looking for?

See all available trips from Columbus to Mesopotamia

[View all trips](https://expedia.com/go/package/search/FlightHotel/2026-04-30/2026-05-07/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=AOL&NumRoom=1&NumAdult=2&NumChild=0&paandie=true)

### Discover the most popular places to visit in Mesopotamia

![Parque Nacional El Palmar, Entre Rios, Argentina.](https://images.trvl-media.com/place/6096826/3ac30eef-b699-482d-95ce-e991c872d599.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### El Palmar National Park

Explore the great outdoors at El Palmar National Park, a lovely green space in Ubajay. 

[](https://expedia.com/El-Palmar-National-Park-Ubajay.d6096826.Vacation-Attraction)

![Punta San Sebastian, Corrientes, Costanera Corrientes](https://images.trvl-media.com/place/553248621532463961/5eccf4f4-bdb0-4368-8beb-0fffd1c8eab0.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Costanera de Corrientes

4/5(2 reviews)

Enjoy an outing to Costanera de Corrientes during your stay in Corrientes. You can enjoy the restaurants while in the area. 

[](https://expedia.com/Costanera-De-Corrientes-Corrientes.d553248621532463961.Vacation-Attraction)

![Parroquia Nuestra Señora de Itati](https://images.trvl-media.com/place/553248621532463967/dcc3f703-5a3b-46d8-99a7-83b2e87b8ea0.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Basilica Nuestra Senora De Itati

Learn about the local history of Municipo de Itatí when you take a trip to Basilica Nuestra Senora De Itati. 

[](https://expedia.com/Basilica-Nuestra-Senora-De-Itati-Municipo-de-Itati.d553248621532463967.Vacation-Attraction)

## Mesopotamia Hotel Deals

![O2 Hotel Gualeguaychú](https://images.trvl-media.com/lodging/77000000/76460000/76459400/76459363/dbe6098c_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

O2 Hotel Gualeguaychú

115 3 de Febrero Gualeguaychú Entre Ríos

Fully refundableReserve now, pay when you stay

$46 nightly

$46 total

Mar 31 - Apr 1

7.6/10 Good! (80 reviews)

Las sabanas estaban sucias No andaba la tele para ver No salía agua caliente y el desayuno horrible

Reviewed on Mar 20, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F31%2F2026&endDate=4%2F1%2F2026&selected=76459363&PinnedHotelID=76459363&HadPinnedHotel=true&regionId=6208836)

![Turismo Hotel Casino](https://images.trvl-media.com/lodging/121000000/120520000/120517600/120517502/a0b30be4_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Turismo Hotel Casino

650 Entre Ríos Corrientes Corrientes

$112 nightly

$112 total

Apr 6 - Apr 7

8/10 Very Good! (4 reviews)

Boa infraestrutura, e localização!

Reviewed on Feb 4, 2026

[](https://expedia.com/Hotel-Search?startDate=4%2F6%2F2026&endDate=4%2F7%2F2026&selected=120517502&PinnedHotelID=120517502&HadPinnedHotel=true&regionId=6208836)

![Intersur Colon](https://images.trvl-media.com/lodging/115000000/114110000/114109800/114109755/cb01ff56_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Intersur Colon

Av. Gdor. Quiros 185 Colón Entre Ríos

$77 nightly

$77 total

Apr 30 - May 1

8/10 Very Good! (8 reviews)

Staff as friendly but room was very dirty, toilet had not been flushed, broken lamps and dirty napkins on the floor.

Reviewed on Mar 9, 2026

[](https://expedia.com/Hotel-Search?startDate=4%2F30%2F2026&endDate=5%2F1%2F2026&selected=114109755&PinnedHotelID=114109755&HadPinnedHotel=true&regionId=6208836)

[See all 510 properties in Mesopotamia](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=3%2F31%2F2026&endDate=4%2F1%2F2026&regionId=6208836)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Find the Best Mesopotamia Vacation Packages

## Mesopotamia Essential Information

| Language        | Spanish                                |
| --------------- | -------------------------------------- |
| Currency        | Argentine pesos                        |
| Local Welcome   | ¡Hola!                                 |
| Local Goodbye   | Adiós                                  |
| Closest Airport | Ministro Pistarini Intl. Airport (EZE) |

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