Find luxury hotels in East Main Street, Grand Junction

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Check availability on East Main Street Luxury Hotels

Our top choices for East Main Street luxury hotels

Terrace/patio
Hotel Maverick

Hotel Maverick

Hotel Maverick
4.0 star property
Capitol Hill
9.6 out of 10, Exceptional, (1000)
"Excellent place to stay in Grand Junction. "
United States
Steve
$168 nightly
The price is $192
Jan 4 - Jan 5, 2026
Total with taxes and fees
Hotel Maverick
Lobby
Doubletree Hotel Grand Junction

Doubletree Hotel Grand Junction

Doubletree Hotel Grand Junction
4.0 star property
Horizon Drive District
8.0 out of 10, Very Good, (1000)
"Good value, nice big room, convenient"
United States
Kathy
$87 nightly
The price is $99
Jan 8 - Jan 9, 2026
Total with taxes and fees
Doubletree Hotel Grand Junction
Land view from property
The Homestead

The Homestead

The Homestead
4.5 star property
Palisade
10.0 out of 10, Exceptional, (63)
"Very beautiful setting in a cute town famed for its Palisade Peaches!"
United States
Ronald
$179 nightly
The price is $188
Dec 14 - Dec 15
Total with taxes and fees
The Homestead
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top East Main Street Hotel Reviews

Wine Country Inn Palisade

Wine Country Inn Palisade

10/10 Excellent
"This place was amazing from check in to check out. The breakfast was great and the wine was amazing. Definitely will return, especially in the spring or summer "
Dalesk 1-night trip
Posted 1 day ago
Wine Country Inn Palisade

Frequently asked questions

Are you looking for a luxury hotel for your East Main Street vacation?
Use Expedia to arrange your flight to Grand Junction Regional Airport (GJT) airport, and then select from a variety of places to stay that will deliver the luxury you want. Amenities are an important consideration when you plan a trip, so we make it easy to find what you'd like to make your stay special. If you want a posh hotel with a spa, an indoor pool, or luxury bedding, Expedia can help you find the best luxury hotel experience that East Main Street offers.
What's there to see and do in East Main Street?
Enjoy all that East Main Street has to offer when you visit Western Colorado Botanical Gardens, Mesa County Fairgrounds, and Bananas Fun Park. If you have extra time while you're in the area, you might want to see Redlands Mesa Golf Club and Grand Junction Motor Speedway.

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