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Vacation Rentals in Cape Girardeau County

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Top Cities in Cape Girardeau County

Top Vacation Rentals in Cape Girardeau County

Serenity South -- Gardens, River-Views, and Refreshing Space

10.0 out of 10, Exceptional, (142)
"Beautiful house. Great stay. Would definitely stay again!"
$229 nightly
The price is $245
Oct 12 - Oct 13
Total with taxes and fees
Serenity South -- Gardens, River-Views, and Refreshing Space

The Twisted Sassafras Treehouse

10.0 out of 10, Exceptional, (24)
"Charming little treehouse. We wanted a private little getaway that was still semi close and it was perfect. The hot tub, the outdoor set up, the two person shower. Would highly recommend. "
$291 nightly
The price is $303
Nov 10 - Nov 11
Total with taxes and fees
The Twisted Sassafras Treehouse

Little Blue Cottage on Spanish

8.6 out of 10, Excellent, (43)
"We enjoy every time we stay here . We have stayed her many times. There is some repairs that need to be done . Also I think there needs to be a better way to cook besides a microwave. "
$101 nightly
The price is $101
Oct 12 - Oct 13
Total with taxes and fees
Little Blue Cottage on Spanish

Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO

9.6 out of 10, Exceptional, (40)
"Nice place to stay! Clean, able to walk to everything!"
$132 nightly
The price is $138
Oct 19 - Oct 20
Total with taxes and fees
Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO

Charming Secluded Getaway Cabin within minutes of amenities

10.0 out of 10, Exceptional, (16)
"Nice little Cabin in a beautiful area. Blair and her family were wonderful!"
Charming Secluded Getaway Cabin within minutes of amenities

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

8.8 out of 10, Excellent, (34)
"Abbie was an amazing hostess. She was great with communicating with our group and made our stay awesome. She was very accommodating and made sure we had everything we needed to make our trip perfect. The house and pool were great. We were very pleased. "
$205 nightly
The price is $213
Oct 14 - Oct 15
Total with taxes and fees
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

Rest, Relax and Renew. Our log cabin experience awaits your arrival.

10.0 out of 10, Exceptional, (396)
"Clean comfortable cabin in a beautiful relaxing setting. Would definitely stay again."
$187 nightly
The price is $198
Oct 12 - Oct 13
Total with taxes and fees
Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Peaceful secluded cabin located near Horseshoe Lake

9.8 out of 10, Exceptional, (18)
"Wasent long enough!"
$180 nightly
The price is $191
Oct 13 - Oct 14
Total with taxes and fees
Peaceful secluded cabin located near Horseshoe Lake

New cabin in the woods with private hot tub

10.0 out of 10, Exceptional, (128)
"Beautiful cabin. Great location - so close to Starview Vineyard (also visited Feather Hill, Blue Sky, and Owl Creek). Also really enjoyed the hot tub! We’d definitely stay here again! "
New cabin in the woods with private hot tub

Notting Hill Cottage

9.6 out of 10, Exceptional, (325)
"It was the perfect stay. Great location right by the wine trail. It was secluded and the hot Tub was heavenly. Would recommend to anyone that needs a getaway. "
Notting Hill Cottage

Minutes from Giant City - SIU - Shawnee Winetrail - Cedar Lake - Shawnee Forest!

9.6 out of 10, Exceptional, (42)
"I was very happy with the cleanliness and amenities including Internet access, snacks, bathing, and comfortable sleeping."
Minutes from Giant City - SIU - Shawnee Winetrail - Cedar Lake - Shawnee Forest!

Hot Tub - Minutes from Winetrail, SIU, Giant City, Cedar Lake, Shawnee Forest!

10.0 out of 10, Exceptional, (55)
"Had a great stay"
Hot Tub - Minutes from Winetrail, SIU, Giant City, Cedar Lake, Shawnee Forest!

Brand new cabin in the woods with hot tub 1/2 mile from Starview Winery

10.0 out of 10, Exceptional, (144)
"The cabin was perfect for our weekend getaway to celebrate my fiancés birthday. "
Brand new cabin in the woods with hot tub 1/2 mile from Starview Winery

Stones Throw from Giant City Park, Wineries, Hiking, Biking, Hunting and more.

9.8 out of 10, Exceptional, (62)
"Nice place!"
Stones Throw from Giant City Park, Wineries, Hiking, Biking, Hunting and more.

* On the Wine Trail * Hot Tub * Wi-Fi *

9.8 out of 10, Exceptional, (237)
"The place was just as described. Great location. We could walk to Havisham Bourbon Bar. We will definitely be staying there again. "
* On the Wine Trail * Hot Tub * Wi-Fi *

Minutes to Giant City - SIU - Shawnee Winetrail - Shawnee Forest - Wi-Fi

9.4 out of 10, Exceptional, (40)
"The place was great for our needs and as advertised. Very near to beautiful hiking and some nice wineries.The bed was not very comfortable, but everything was great. "
Minutes to Giant City - SIU - Shawnee Winetrail - Shawnee Forest - Wi-Fi

Winetrail Cabin - Giant City SP, SIU, Cedar Lake, & Shawnee Forest minutes away!

9.8 out of 10, Exceptional, (40)
"Great location off of route 51 that gets you to all the fun on the wine trail and allows you get to a bunch of different stuff to do outdoor. Enjoyed our stay 4th of July Weekend 2025!"
Winetrail Cabin - Giant City SP, SIU, Cedar Lake, & Shawnee Forest minutes away!

Beautiful location in the secluded woods

10.0 out of 10, Exceptional, (52)
"Our trip was to attend my son's graduation from SIU. The cabin was in an accessible spot to Carbondale and was great for the 5 of us. We enjoyed our stay!"
$169 nightly
The price is $179
Oct 20 - Oct 21
Total with taxes and fees
Beautiful location in the secluded woods

Cabin in Southern Illinois - Hot Tub - Romantic Getaway -Shawnee National Forest

10.0 out of 10, Exceptional, (259)
"Had an amazing stay!"
Cabin in Southern Illinois - Hot Tub - Romantic Getaway -Shawnee National Forest

Feels like your in a Tree House! On the Wine 🍷Trail! Private Location

9.6 out of 10, Exceptional, (219)
"This stay was so peaceful & relaxing! Perfect for a couples getaway or for some family fun. The bonfire area and other outdoor spaces were perfect. Would definitely book again in the future!"
Feels like your in a Tree House! On the Wine 🍷Trail! Private Location
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Cape Girardeau County Hotel Reviews

Find out more about Cape Girardeau County

Discover your perfect Cape Girardeau County vacation rental with Expedia

How many vacation rentals are available in Cape Girardeau County?


Expedia has plenty of vacation rentals to choose from in and around  Cape Girardeau County, so you’re guaranteed to find the right one for you. 


How much is a vacation rental in Cape Girardeau County?


The selection of Cape Girardeau County vacation rentals we have selected for you start as low as $101 per night. Entering your travel dates in the search wizard you might find even better deals!


What type of vacation rental can I get in Cape Girardeau County?


Vacation rentals in Cape Girardeau County come in all shapes and sizes, and your options depend on your chosen travel dates. You could entertain in a blissful vacation home, chill in a private apartment, or find family fun at a resort. Expedia offers a superb choice of Cape Girardeau County vacation rentals to suit everyone. 


Why should I choose a vacation rental in Cape Girardeau County?


Expedia’s vacation rentals provide cozy comforts you can sink into on your own schedule. You’ll enjoy your own space in a property with a kitchen, a pool, a garden etc. Maybe you’ll prefer somewhere with a spa or kids activities. A Cape Girardeau County vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in. 


How do I find the best deal on a vacation rental in Cape Girardeau County?


Find vacation rentals in Cape Girardeau County by viewing Expedia’s latest deals, or enter your travel dates and use the filters to select by amenities, price, or rating. Dive into the reviews to get a true feeling of which is your favorite vacation rental in Cape Girardeau County.  


What amenities are available in a vacation rental in Cape Girardeau County?


The choice is yours! Perhaps you love cooking in a well-equipped kitchen. Or maybe a late breakfast and a swimming pool is more your thing. Of course, there’s always the treat of having your own hot tub. Expedia has a vast range of amenities in Cape Girardeau County vacation rentals designed to suit every budget and trip type.


When is the best time to stay in a vacation rental in Cape Girardeau County?   


Everytime is a great time to head to Cape Girardeau County! Staying in a Cape Girardeau County vacation rentals you will always find lots going on to keep you entertained. 


Why book a vacation rental with Expedia?


Expedia has locked in amazing deals on a huge selection of impressive vacation rentals in Cape Girardeau County. We give you the information and inspiration you need all in one place. With so many properties to choose from, you know you can book your perfect Cape Girardeau County vacation rental with confidence. ANd don’t forget, if you bundle with a flight or a car rental in Cape Girardeau County, you can save even more.


Can I cancel my vacation rental through Expedia?  


Yes, you can cancel or change your Cape Girardeau County vacation rental by contacting your property manager directly. Contact details are easy to find on your itinerary in Trips. For more information, check out our Customer Service Portal and we’ll help you get everything sorted.