Title: Cape Girardeau Vacation Rentals from $101: Search Short-Term Rentals | Expedia.com

[Cape Girardeau Travel Guide](https://expedia.com/Cape-Girardeau.dx820)[Hotels in Cape Girardeau](https://expedia.com/Cape-Girardeau-Hotels.d820.Travel-Guide-Hotels)[Flights to Cape Girardeau](https://expedia.com/Cheap-Flights-To-Cape-Girardeau.d820.Travel-Guide-Flights)[Car Rentals in Cape Girardeau](https://expedia.com/Car-Rentals-In-Cape-Girardeau.d820.Car-Rental-Guide)[Cape Girardeau Vacation Packages](https://expedia.com/Cape-Girardeau.d820.Destination-Travel-Guides)

![Beautiful city by the Mississippi River](https://images.trvl-media.com/place/820/c000ed90-c592-47c7-a850-3eeb29bbc936.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

Photo by Alice Burghart

![](https://images.trvl-media.com/place/820/c000ed90-c592-47c7-a850-3eeb29bbc936.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check prices for these dates

In two weeks

[Feb 27 - Mar 1](https://www.expedia.com/Hotel-Search?regionId=820&startDate=2026-02-27&endDate=2026-03-01&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[Apr 10 - Apr 12](https://www.expedia.com/Hotel-Search?regionId=820&startDate=2026-04-10&endDate=2026-04-12&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[May 8 - May 10](https://www.expedia.com/Hotel-Search?regionId=820&startDate=2026-05-08&endDate=2026-05-10&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jun 5 - Jun 7](https://www.expedia.com/Hotel-Search?regionId=820&startDate=2026-06-05&endDate=2026-06-07&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Cape Girardeau vacation rentals

![1 bedroom, desk, iron/ironing board, WiFi](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/add99418.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, fireplace](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/b0435fb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/1862bab6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/2aecac3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Cottage, Rusted Route Farms

[](https://www.expedia.com/Cape-Girardeau-Hotels-The-Cottage.h112868647.Hotel-Information)

Jackson

10/10

Exceptional

(2 reviews)

"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Renee C.

$195 nightly

$195 total

Feb 11 - Feb 12

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-The-Cottage.h112868647.Hotel-Information)

![Living area](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/143b0eab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/9ff1a808.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/ad11073b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/3867ac72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Little Blue Cottage on Spanish

[](https://www.expedia.com/Cape-Girardeau-Hotels-Little-Blue-Cottage-On-Spanish.h45712431.Hotel-Information)

Cape Girardeau

8.4/10

Very Good

(50 reviews)

"Cozy and perfect for a couple. Great communication with the host"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Beth G.

$101 nightly

$101 total

Feb 11 - Feb 12

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-Little-Blue-Cottage-On-Spanish.h45712431.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/1c1368ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/c5155680.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/f4fbd89f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/0b3aaea0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Twisted Sassafras Treehouse 

[](https://www.expedia.com/Cape-Girardeau-Hotels-The-Twisted-Sassafras-Treehouse.h95879160.Hotel-Information)

Cape Girardeau

10/10

Exceptional

(30 reviews)

"This is the perfect private romantic getaway! We had such a blast here. Definitely recommend!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Eric S.

$329 nightly

$343 total

Mar 9 - Mar 10

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-The-Twisted-Sassafras-Treehouse.h95879160.Hotel-Information)

![Living area](https://images.trvl-media.com/lodging/113000000/112630000/112624300/112624271/599e7a95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchen](https://images.trvl-media.com/lodging/113000000/112630000/112624300/112624271/02b08ccf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/113000000/112630000/112624300/112624271/403251a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/113000000/112630000/112624300/112624271/a7405e78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy upstairs unit in Cape Girardeau

[](https://www.expedia.com/Cape-Girardeau-Hotels-Cozy-Upstairs-Unit-In-Cape-Girardeau.h112624271.Hotel-Information)

Cape Girardeau

$128 nightly

$128 total

Feb 11 - Feb 12

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-Cozy-Upstairs-Unit-In-Cape-Girardeau.h112624271.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/469a5901.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/211494f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/a97a55c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/6a739ba8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

[](https://www.expedia.com/Cape-Girardeau-Hotels-Colorful-Oasis-5mins-To-DownTown-Lush-Yard-W-Summer-PoolVENUE-Now-Open.h71745619.Hotel-Information)

Cape Girardeau

8.8/10

Excellent

(38 reviews)

"Very nice house. The pool and hot tub were perfect for a short getaway. Tons of activities and games to keep the fanily entertained. Will definitely come back! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Emily D.

$207 nightly

$215 total

Feb 15 - Feb 16

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-Colorful-Oasis-5mins-To-DownTown-Lush-Yard-W-Summer-PoolVENUE-Now-Open.h71745619.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/0c802aa2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/60c56f2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/860b4de6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/0622af9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming Secluded Getaway Cabin within minutes of amenities 

[](https://www.expedia.com/Cape-Girardeau-Hotels-Charming-Getaway-Cabin.h75891457.Hotel-Information)

Cape girardeau

10/10

Exceptional

(18 reviews)

"We had a great time at Blair and her family's property. The cabin was very comfortable and as advertised. I would be happy to recommend it to others "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tammy M.

$292 nightly

$292 total

Feb 11 - Feb 12

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-Charming-Getaway-Cabin.h75891457.Hotel-Information)

![TV, fireplace](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/2c8cc497.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/673b3050.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/bb974ed1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, fireplace](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/8932b23e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Gorgeous 1856 Log Cabin, Completely Renovated

[](https://www.expedia.com/Cape-Girardeau-Hotels-Gorgeous-1856-Log-Cabin.h112868642.Hotel-Information)

Jackson

10/10

Exceptional

(3 reviews)

"incredible place. I was there for work, but it was a really nice relaxing area to retreat too, and also get some work done in a serene environment. It would be an incredible place for an entire family. And, a good place for friends to get together."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Chandler G.

$310 nightly

$310 total

Feb 11 - Feb 12

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-Gorgeous-1856-Log-Cabin.h112868642.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/f432dafb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, fireplace, DVD player, books](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/6d0c8b74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/564d6e43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/a340bc3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Serenity South -- Gardens, River-Views, and Refreshing Space

[](https://www.expedia.com/Sikeston-Hotels-Serenity-Gardens.h38940154.Hotel-Information)

Cape Girardeau

10/10

Exceptional

(150 reviews)

"Such a great place and location"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tracy H.

$229 nightly

$245 total

Feb 11 - Feb 12

Total with taxes and fees

[](https://www.expedia.com/Sikeston-Hotels-Serenity-Gardens.h38940154.Hotel-Information)

![Pool](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/w1440h810x0y3-bf19009e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace, video games, foosball](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/a7fa16a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace, video games, foosball](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/62582c8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Game room](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/f1c736a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

[](https://www.expedia.com/Cape-Girardeau-Hotels-4-Bedroom-Home-2-King-Beds.h111971489.Hotel-Information)

Cape Girardeau

9.6/10

Exceptional

(8 reviews)

"Nice place, great times"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jace W.

$416 nightly

$432 total

Feb 15 - Feb 16

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-4-Bedroom-Home-2-King-Beds.h111971489.Hotel-Information)

![2 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/126000000/125640000/125633400/125633310/aa034afc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/126000000/125640000/125633400/125633310/009833c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/126000000/125640000/125633400/125633310/36ff87fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/126000000/125640000/125633400/125633310/099c1c0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Pleasant 2-bedroom mobile home with AC /heat in Friedheim 2 Queen beds 1 Bath.

[](https://www.expedia.com/Friedheim-Hotels-Pleasant-2-Bedroom-Mobile-Home-With-AC-Heat-In-Friedheim-2-Queen-Beds-1-Bath.h125633310.Hotel-Information)

Friedheim

$192 nightly

$202 total

Feb 11 - Feb 12

Total with taxes and fees

[](https://www.expedia.com/Friedheim-Hotels-Pleasant-2-Bedroom-Mobile-Home-With-AC-Heat-In-Friedheim-2-Queen-Beds-1-Bath.h125633310.Hotel-Information)

![Exterior detail](https://images.trvl-media.com/lodging/89000000/88870000/88869200/88869111/3d5ec048.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/89000000/88870000/88869200/88869111/853dbdda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/89000000/88870000/88869200/88869111/48434221.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/89000000/88870000/88869200/88869111/6e1fe8fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!

[](https://www.expedia.com/Makanda-Hotels-3-Minutes-To-Giant-City-6-Minutes-To-SIU-4-Minutes-To-Shawnee-Winetrail.h88869111.Hotel-Information)

Makanda

9.8/10

Exceptional

(60 reviews)

"Stephen very friendly and accomadations excellent!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Walter H.

$164 nightly

$181 total

Feb 11 - Feb 12

Total with taxes and fees

[](https://www.expedia.com/Makanda-Hotels-3-Minutes-To-Giant-City-6-Minutes-To-SIU-4-Minutes-To-Shawnee-Winetrail.h88869111.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/f8286145.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/63184534.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/8a8ad86a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/4f18c4a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!

[](https://www.expedia.com/Makanda-Hotels-Winetrail-Cabin-SIU.h88928399.Hotel-Information)

Makanda

9.6/10

Exceptional

(41 reviews)

"Everything was very nice. We enjoyed our stay! The cabin had everything we needed."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Cheri U.

$191 nightly

$211 total

Feb 11 - Feb 12

Total with taxes and fees

[](https://www.expedia.com/Makanda-Hotels-Winetrail-Cabin-SIU.h88928399.Hotel-Information)

![TV](https://images.trvl-media.com/lodging/124000000/123540000/123531800/123531709/c6da1d27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/124000000/123540000/123531800/123531709/580fe6cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/124000000/123540000/123531800/123531709/b657209e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/124000000/123540000/123531800/123531709/3096adbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fantastic 1-bedroom Cabin in peaceful Makanda, Pet-Friendly!

[](https://www.expedia.com/Makanda-Hotels-Camos-Hideout-Fantastic-1-Bedroom-Cabin-In-Peaceful-Makanda.h123531709.Hotel-Information)

Makanda

10/10

Exceptional

(2 reviews)

"Great host, amenities, and location!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kevin W.

$95 nightly

$101 total

Feb 11 - Feb 12

Total with taxes and fees

[](https://www.expedia.com/Makanda-Hotels-Camos-Hideout-Fantastic-1-Bedroom-Cabin-In-Peaceful-Makanda.h123531709.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/d22aee4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace, DVD player](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/ded6701c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/2c1a0ed0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/b0f0a7b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Rest, Relax and Renew. Our log cabin experience awaits your arrival. 

[](https://www.expedia.com/Anna-Hotels-Rest.h31189922.Hotel-Information)

Anna

10/10

Exceptional

(405 reviews)

"Nice cabin and beautiful scenery! We enjoyed our stay."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Hannah G.

$189 nightly

$200 total

Feb 12 - Feb 13

Total with taxes and fees

[](https://www.expedia.com/Anna-Hotels-Rest.h31189922.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/09707f79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/30627e31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/7bfe8087.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, DVD player](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/c221a56c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming cottage overlooking Lake Acre

[](https://www.expedia.com/Charming-Cabin-Overlooking-5-Acre-Lake.h39671140.Hotel-Information)

Dongola

10/10

Exceptional

(102 reviews)

"Great place so peaceful and relaxing "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Paul D.

$265 nightly

$281 total

Feb 11 - Feb 12

Total with taxes and fees

[](https://www.expedia.com/Charming-Cabin-Overlooking-5-Acre-Lake.h39671140.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/124000000/123430000/123422100/123422053/1d4ebdb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/124000000/123430000/123422100/123422053/d050ba1a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/124000000/123430000/123422100/123422053/d46d2628.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/124000000/123430000/123422100/123422053/249a50ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy and Updated Farmhouse with King Suite

[](https://www.expedia.com/Anna-Hotels-Cozy-And-Updated-Farmhouse-With-King-Suite.h123422053.Hotel-Information)

Anna

10/10

Exceptional

(1 review)

"Older farmhouse but comfy and had everything we needed for our stay. I would recommend without hesitation "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Marla K.

$139 nightly

$148 total

Feb 11 - Feb 12

Total with taxes and fees

[](https://www.expedia.com/Anna-Hotels-Cozy-And-Updated-Farmhouse-With-King-Suite.h123422053.Hotel-Information)

![Outdoor dining](https://images.trvl-media.com/lodging/104000000/103090000/103080200/103080140/38c121bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/104000000/103090000/103080200/103080140/b89da9ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace](https://images.trvl-media.com/lodging/104000000/103090000/103080200/103080140/e63a4931.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/104000000/103090000/103080200/103080140/b5194a9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Beautiful location in the secluded woods 

[](https://www.expedia.com/Pomona-Hotels-Beautiful-Location-In-The-Secluded-Woods.h103080140.Hotel-Information)

Pomona

10/10

Exceptional

(64 reviews)

"It was very nice and clean. We really enjoyed staying there. We would love to rent this place again. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

susan B.

$158 nightly

$168 total

Feb 24 - Feb 25

Total with taxes and fees

[](https://www.expedia.com/Pomona-Hotels-Beautiful-Location-In-The-Secluded-Woods.h103080140.Hotel-Information)

![Smart TV](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/1be40475.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/d47379a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/13ed0134.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, bed sheets](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/d4f180ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Peaceful secluded cabin located near Horseshoe Lake 

[](https://www.expedia.com/Peaceful-Secluded-Cabin-Located-Near-Horseshoe-Lake.h109730068.Hotel-Information)

Miller City

10/10

Exceptional

(21 reviews)

"The cabin is perfect for a quiet getaway. Location is great close to Dollar General, gas station and restaurants"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Marsha G.

$173 nightly

$183 total

Feb 11 - Feb 12

Total with taxes and fees

[](https://www.expedia.com/Peaceful-Secluded-Cabin-Located-Near-Horseshoe-Lake.h109730068.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/53db6388.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, desk, bed sheets](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/3bc4c831.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/52fdc4c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Shower, towels, soap, shampoo](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/23c71fcc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy cabins on beautiful Horseshoe Lake

[](https://www.expedia.com/Cozy-Cabins-On-Beautiful-Horseshoe-Lake.h90331191.Hotel-Information)

Olive Branch

9.8/10

Exceptional

(35 reviews)

"Beautiful place, host was kind and and quick to respond to messages "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Melissa W.

$133 nightly

$140 total

Feb 11 - Feb 12

Total with taxes and fees

[](https://www.expedia.com/Cozy-Cabins-On-Beautiful-Horseshoe-Lake.h90331191.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/119000000/118740000/118735000/118734902/b3197e50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/119000000/118740000/118735000/118734902/1c7b520a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/119000000/118740000/118735000/118734902/w1320h1474x0y0-c28d188d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/119000000/118740000/118735000/118734902/w1320h1756x0y0-48d6becd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming 2-bedroom with AC, WiFi in lovely Jonesboro

[](https://www.expedia.com/Jonesboro-Hotels-Charming-2-Bedroom-With-AC.h118734902.Hotel-Information)

Jonesboro

10/10

Exceptional

(5 reviews)

"great place. wonderful host."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Carla m.

$244 nightly

$259 total

Feb 20 - Feb 21

Total with taxes and fees

[](https://www.expedia.com/Jonesboro-Hotels-Charming-2-Bedroom-With-AC.h118734902.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-02-24&endDate=2026-02-25&regionId=820&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

## Find vacation rentals that suit your style

Cabins

[](https://www.expedia.com/Hotel-Search?destination=Cape+Girardeau%2C+Missouri%2C+United+States+of+America&regionId=820&latLong=37.305884%2C-89.518148&adults=2&startDate=2026-05-10&d1=2026-05-10&endDate=2026-05-13&d2=2026-05-13&lodging=CABIN)

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=Cape+Girardeau%2C+Missouri%2C+United+States+of+America&regionId=820&latLong=37.305884%2C-89.518148&adults=2&startDate=2026-05-10&d1=2026-05-10&endDate=2026-05-13&d2=2026-05-13&lodging=VACATION_HOME)

Apartments

[](https://www.expedia.com/Hotel-Search?destination=Cape+Girardeau%2C+Missouri%2C+United+States+of+America&regionId=820&latLong=37.305884%2C-89.518148&adults=2&startDate=2026-05-10&d1=2026-05-10&endDate=2026-05-13&d2=2026-05-13&lodging=APARTMENT)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=Cape+Girardeau%2C+Missouri%2C+United+States+of+America&regionId=820&latLong=37.305884%2C-89.518148&adults=2&startDate=2026-05-10&d1=2026-05-10&endDate=2026-05-13&d2=2026-05-13&lodging=COTTAGE)

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## Top Cape Girardeau Hotel Reviews

![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/4b521966_y.jpg)

### Drury Inn & Suites Cape Girardeau

10/10 Excellent

"From our room, to food; this was one of the best experiences that we’ve had with hotel travel. The breakfast rivaled a restaurant, the evening snacks and beverages were above board. The staff was friendly, the rooms were clean. The location is fantastic with Outback right beside the hotel and shopping and conveniences very close. I would recommend this establishment, we will be staying here again"

[](https://expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information)

![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89_y.jpg)

### Pear Tree Inn Cape Girardeau West

10/10 Excellent

"Great "

[](https://expedia.com/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information)

![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg)

### Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"The room was great. The facility was excellent. The people were excellent. Definitely going back."

[](https://expedia.com/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

![Courtyard by Marriott Cape Girardeau Downtown](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/ae49c8da_y.jpg)

### Courtyard by Marriott Cape Girardeau Downtown

10/10 Excellent

"Convenient location, clean room, and easy check in/out process. Really cool little downtown."

[](https://expedia.com/Sikeston-Hotels-Courtyard-By-Marriott-Cape-Girardeau-Downtown.h24322039.Hotel-Information)

![The Riverview](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg)

### The Riverview

10/10 Excellent

"The hotel was so nice! We planned this trip for my husbands 40th birthday, and I called ahead to see if they did anything for birthdays and they gave us a complementary upgrade on our room. I was taken back on that and thought it was so kind and generous. I wasn’t expecting that - I would have been fine with some cookies and a sign that said happy birthday! We really appreciate everyone and their generosity for us. We definitely will be staying again!!"

[](https://expedia.com/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information)

![Hampton Inn Cape Girardeau I 55 East](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/540ce58d_y.jpg)

### Hampton Inn Cape Girardeau I 55 East

10/10 Excellent

"Nice staff. Clean room. Good cookies. And breakfast adequate. "

[](https://expedia.com/Sikeston-Hotels-Hampton-Inn-Cape-Girardeau-I-55-East.h12786627.Hotel-Information)

![Quality Inn](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/d2a0e781_y.jpg)

### Quality Inn

10/10 Excellent

"The lady at the front desk was an amazing person and treated me with the upmost respect "

[](https://expedia.com/Sikeston-Hotels-Quality-Inn.h855988.Hotel-Information)

![Tru By Hilton Cape Girardeau](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/w3837h2560x3y0-1bbb6bc9_y.jpg)

### Tru By Hilton Cape Girardeau

10/10 Excellent

"Very nice room!"

[](https://expedia.com/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information)

![Fairfield Inn & Suites by Marriott Cape Girardeau](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/347bcd98_y.jpg)

### Fairfield Inn & Suites by Marriott Cape Girardeau

10/10 Excellent

"Clean rooms and friendly staff"

[](https://expedia.com/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information)

## Find out more about Cape Girardeau

**Everything you need to know about Cape Girardeau vacation rentals**

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Cape Girardeau vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Cape Girardeau vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

**Cape Girardeau vacation rentals: An excellent choice for every season**

Whenever you want to travel, a warm welcome awaits you in Cape Girardeau. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Cape Girardeau in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $101 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

**How to find incredible deals on Cape Girardeau rentals**

At Expedia, we put the best Cape Girardeau vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Cape Girardeau rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Cape Girardeau vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Cape Girardeau. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

## Explore a world of travel with Expedia

- Trending destinations on Expedia.com
- All accommodation types in Cape Girardeau

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- [Lake of the Ozarks Vacation Rentals ](https://www.expedia.com/Lake-Ozark-Vacation-Rentals.d177772.Travel-Guide-VacationRentals)
- [Florida Vacation Rentals ](https://www.expedia.com/Destinations-In-Florida.d211.Vacation-Rental-Destinations)
- [Hawaii Vacation Rentals ](https://www.expedia.com/Destinations-In-Hawaii.d213.Vacation-Rental-Destinations)
- [Michigan Vacation Rentals ](https://www.expedia.com/Destinations-In-Michigan.d224.Vacation-Rental-Destinations)

- [Vacation Homes in Cape Girardeau ](https://expedia.com/Cape-Girardeau-Private-Vacation-Homes.d820-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Cabin Rentals in Cape Girardeau ](https://expedia.com/Cape-Girardeau-Cabins.d820-aaCabins.Travel-Guide-Accommodation)
- [Apartments in Cape Girardeau ](https://expedia.com/Cape-Girardeau-Apartments.d820-aaApartments.Travel-Guide-Accommodation)
- [Farmstay in Cape Girardeau ](https://expedia.com/Cape-Girardeau-Agritourism.d820-aaAgritourism.Travel-Guide-Accommodation)
- [B&B in Cape Girardeau ](https://expedia.com/Cape-Girardeau-Bed-And-Breakfast.d820-aaBedAndBreakfast.Travel-Guide-Accommodation)
- [Lodges in Cape Girardeau ](https://expedia.com/Cape-Girardeau-Lodges.d820-aaLodges.Travel-Guide-Accommodation)
- [Cottages in Cape Girardeau ](https://expedia.com/Cape-Girardeau-Cottages.d820-aaCottages.Travel-Guide-Accommodation)
- [Motels in Cape Girardeau ](https://expedia.com/Cape-Girardeau-Motels.d820-aaMotels.Travel-Guide-Accommodation)
- [RV Parks in Cape Girardeau ](https://expedia.com/Cape-Girardeau-RV-Parks.d820-aaRVParks.Travel-Guide-Accommodation)

## Frequently asked questions

### Can I find vacation rentals in Cape Girardeau?

### What are some of the best vacation home rentals in Cape Girardeau?

### How many vacation rentals will I find in Cape Girardeau?

### What can I see and do in Cape Girardeau?

### What are vacation rentals like in Cape Girardeau?

### Expedia's Latest Trends

Hotels

- [Hotels in Columbia](https://expedia.com/Columbia-Hotels.d901.Travel-Guide-Hotels)
- [Hotels in St. Joseph](https://expedia.com/St-Joseph-Hotels.d9934.Travel-Guide-Hotels)
- [Hotels in Hermann](https://expedia.com/Hermann-Hotels.d183475.Travel-Guide-Hotels)
- [Hotels in Branson](https://expedia.com/Branson-Hotels.d6058734.Travel-Guide-Hotels)
- [Cheap Hotels in Branson](https://expedia.com/Branson-Hotels-Cheap-Hotels.0-0-d6058734-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Hotels in Poplar Bluff](https://expedia.com/Poplar-Bluff-Hotels.d9449.Travel-Guide-Hotels)
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- [Hotels in Lake Ozark](https://expedia.com/Lake-Ozark-Hotels.d177772.Travel-Guide-Hotels)
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- [Cheap Hotels in Springfield](https://expedia.com/Springfield-Hotels-Cheap-Hotels.0-0-d602962-tCheapHotels.Travel-Guide-Filter-Hotels)
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Flights

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Cars

- [Car rentals in Columbia](https://expedia.com/Car-Rentals-In-Columbia.d901.Car-Rental-Guide)
- [Car rentals in Springfield](https://expedia.com/Car-Rentals-In-Springfield.d602962.Car-Rental-Guide)

Activities

- [Things to do in Branson](https://expedia.com/Things-To-Do-In-Branson.d6058734.Travel-Guide-Activities)

Packages

- [Branson Vacation](https://expedia.com/Branson.d6058734.Destination-Travel-Guides)

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- [Branson Vacation Rentals](https://expedia.com/Branson-Vacation-Rentals.d6058734.Travel-Guide-VacationRentals)

General

- [Visit Osage Beach](https://expedia.com/Osage-Beach.dx6058781)

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