Vacation Rentals in Pike County

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Our top choices for Pike County vacation rentals

9.8 out of 10, Exceptional, (32)
"I enjoyed my stay, the place when very clean and just how it was advertised. "
United States
Doug S.
"Exclusive" River Cabin on Stilts

Vacation Home in Louisiana

The Yellow Rose Historic Home
9.8 out of 10, Exceptional, (12)
"We are 7 sisters aged 50-76. We had a wonderful stay at the Yellow Rose. This beautiful old home had rooms and beds for all of us. Would definitely stay here again"
United States
Ellen B.
$306 nightly
The price is $314
Dec 17 - Dec 18
Total with taxes and fees
The Yellow Rose Historic Home

Aparthotel in Hannibal

Lighthouse Inn & Suites
4.0 star property
8.8 out of 10, Excellent, (23)
"Very nice room, close enough to walk to riverfront attractions. "
United States
Robert
$188 nightly
The price is $215
Dec 17 - Dec 18
Total with taxes and fees
Lighthouse Inn & Suites
9.6 out of 10, Exceptional, (31)
"Wonderful historic property. Beautiful and well kept. Absolutely loved this place "
United States
Randy F.
$155 nightly
The price is $155
Dec 17 - Dec 18
Total with taxes and fees
Historic brick 2-bedroom house in downtown Hannibal with off street parking WiFi
9.6 out of 10, Exceptional, (37)
"Great hosts, great stay, always enjoy my time"
United States
Anonymous traveler
$195 nightly
The price is $208
Dec 18 - Dec 19
Total with taxes and fees
Owl house was built for unplugging, relaxing & connecting with friends/family
9.4 out of 10, Exceptional, (40)
"It was very clean and manageable was nice. I stayed in the Bird house. "
United States
Connie T.
$195 nightly
The price is $208
Dec 18 - Dec 19
Total with taxes and fees
The Nest, reconnect with that special someone in our charming birdhouse!

Cabin in Perry

Cannon Dam Cabins
3.0 star property
9.2 out of 10, Wonderful, (13)
"Love this place! Great location to the launch ramp and Dog friendly. Management is amazing and kind and knowledgeable of the area. "
United States
stacy
$103 nightly
The price is $109
Dec 17 - Dec 18
Total with taxes and fees
Cannon Dam Cabins

Vacation Home in Monroe City

“Peaceful Retreat” @ MTL
10.0 out of 10, Exceptional, (103)
"Beautiful property with gracious hosts. As close to Indian creek marina as you can be. "
United States
Kevin S.
“Peaceful Retreat” @ MTL
10.0 out of 10, Exceptional, (210)
"Clean and airy secluded except for semis on road but very nice"
United States
Curt M.
$232 nightly
The price is $246
Dec 18 - Dec 19
Total with taxes and fees
Peaceful, Country Cottage with Open Floor Plan
8.4 out of 10, Very Good, (47)
"It was so close to everything. We greatly enjoyed our stay."
United States
Karla R.
Hannibal House ~ Walking Distance From Historic District
9.8 out of 10, Exceptional, (147)
"This was a great place to stay. Clean, quiet and very welcoming! I would definitely stay again and recommend!"
United States
johnna T.
Spacious Riverfront Perch/Easy Access to St.Charles less than 1 Hr to St. Louis
10.0 out of 10, Exceptional, (9)
"It was very cozy and well stocked and organized as well! Neat experience to stay in a historic home like this! "
United States
Ashley S.
$343 nightly
The price is $388
Dec 17 - Dec 18
Total with taxes and fees
Gorgeous Victorian with Seasonal Pool , sleeps 8, pet friendly close to downtown

Vacation Home in Troy

The Chicken Coop on Highway H
10.0 out of 10, Exceptional, (17)
"Great place to stay. Beautiful decor. Peaceful, relaxing, great set up, welcoming. Loved the decor. "
United States
Paul G.
The Chicken Coop on Highway H
9.6 out of 10, Exceptional, (10)
"The house was great and clean and very nice. The host very responsive. "
United States
Natalie M.
$251 nightly
The price is $283
Jan 12 - Jan 13, 2026
Total with taxes and fees
Vibey home a few blocks from downtown Hannibal

Vacation Home in Monroe City

Mark Twain lake getaway at Blue Lagoon!
10.0 out of 10, Exceptional, (33)
"Excellent property! "
United States
Nick B.
Mark Twain lake getaway at Blue Lagoon!
9.2 out of 10, Wonderful, (9)
"Beautiful, tastefully decorated and well stocked historic home within walking distance of tourist sites and restaurants. We were in town for a wedding and we truly enjoyed our stay. Great front porch and back patio."
United States
Susan C.
$207 nightly
The price is $227
Dec 17 - Dec 18
Total with taxes and fees
The John Sydney House - Family and Pet Friendly Historic Home Downtown
10.0 out of 10, Exceptional, (1)
"Very nice and clean! So cozy and was perfect for our weekend at the lake! "
United States
Cristin H.
$189 nightly
The price is $200
Jan 5 - Jan 6, 2026
Total with taxes and fees
MTL HUNTING LAYAWAY & OUTDOOR HANGOUT
10.0 out of 10, Exceptional, (21)
"It was such a clean and cute little place to stay. We enjoyed staying there. The back patio was a wonderful place to sit with coffee and read in the morning."
United States
MaryY
Modern and comfy home five minutes from downtown
9.8 out of 10, Exceptional, (27)
"Me and my family had a wonderful time for the weekend. The house was clean, spacious and had very easy walking access to the downtown shopping of Hannibal, MO. Will absolutely stay here again."
United States
Cody
Guest House with a River View, located downtown Hannibal, MO—- No Cleaning Fee
9.0 out of 10, Wonderful, (2)
"Beautiful location and rustic feel was what we were looking for. Cabin was clean and easily accessible. "
United States
Rich E.
Family Cabin by a private fishing lake
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Pike County Hotel Reviews

Find out more about Pike County

Discover your perfect Pike County vacation rental with Expedia

How many vacation rentals are available in Pike County?


Expedia has plenty of vacation rentals to choose from in and around  Pike County, so you’re guaranteed to find the right one for you. 


How much is a vacation rental in Pike County?


The selection of Pike County vacation rentals we have selected for you start as low as $109 per night. Entering your travel dates in the search wizard you might find even better deals!


What type of vacation rental can I get in Pike County?


Vacation rentals in Pike County come in all shapes and sizes, and your options depend on your chosen travel dates. You could entertain in a blissful vacation home, chill in a private apartment, or find family fun at a resort. Expedia offers a superb choice of Pike County vacation rentals to suit everyone. 


Why should I choose a vacation rental in Pike County?


Expedia’s vacation rentals provide cozy comforts you can sink into on your own schedule. You’ll enjoy your own space in a property with a kitchen, a pool, a garden etc. Maybe you’ll prefer somewhere with a spa or kids activities. A Pike County vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in. 


How do I find the best deal on a vacation rental in Pike County?


Find vacation rentals in Pike County by viewing Expedia’s latest deals, or enter your travel dates and use the filters to select by amenities, price, or rating. Dive into the reviews to get a true feeling of which is your favorite vacation rental in Pike County.  


What amenities are available in a vacation rental in Pike County?


The choice is yours! Perhaps you love cooking in a well-equipped kitchen. Or maybe a late breakfast and a swimming pool is more your thing. Of course, there’s always the treat of having your own hot tub. Expedia has a vast range of amenities in Pike County vacation rentals designed to suit every budget and trip type.


When is the best time to stay in a vacation rental in Pike County?   


Everytime is a great time to head to Pike County! Staying in a Pike County vacation rentals you will always find lots going on to keep you entertained. 


Why book a vacation rental with Expedia?


Expedia has locked in amazing deals on a huge selection of impressive vacation rentals in Pike County. We give you the information and inspiration you need all in one place. With so many properties to choose from, you know you can book your perfect Pike County vacation rental with confidence. ANd don’t forget, if you bundle with a flight or a car rental in Pike County, you can save even more.


Can I cancel my vacation rental through Expedia?  


Yes, you can cancel or change your Pike County vacation rental by contacting your property manager directly. Contact details are easy to find on your itinerary in Trips. For more information, check out our Customer Service Portal and we’ll help you get everything sorted.