Doniphan Vacations from $357

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The Latest Doniphan vacation packages

Price found within the past 48 hours. Click for updated prices.
EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel

3 out of 5
Price was $369, price is now $357 per person
$357
per person
Sep 17 - Sep 19
found 23 hours ago
Roundtrip flight included
Orlando (MCO) to Cape Girardeau (CGI)
9.6/10 Exceptional! (103 reviews)

The Mediterranean House 1858

The Mediterranean House 1858

2 out of 5
Price was $1,020, price is now $957 per person
$957
per person
Sep 17 - Sep 19
found 23 hours ago
Roundtrip flight included
Orlando (MCO) to Cape Girardeau (CGI)
No reviews

Urban Lofts

Urban Lofts

3 out of 5
Price was $553, price is now $525 per person
$525
per person
Sep 17 - Sep 19
found 23 hours ago
Roundtrip flight included
Orlando (MCO) to Cape Girardeau (CGI)
9.4/10 Exceptional! (22 reviews)
Beautiful, clean property in the heart of city center. Many options for food and shopping within short walking distance.

Reviewed on Jun 11, 2026

Makanda Inn

Makanda Inn

3.5 out of 5
Price was $485, price is now $465 per person
$465
per person
Sep 17 - Sep 19
found 23 hours ago
Roundtrip flight included
Orlando (MCO) to Cape Girardeau (CGI)
10/10 Exceptional! (38 reviews)
I travel to So. Illinois annually to visit but this is my first stay at the Makanda Inn. It will not be my last. I had a very peaceful stay- after long days of family visit and running around with the grands, it was so nice to stay here where it was quiet and relaxing. Breakfast every morning was top notch and just the right portions.

Reviewed on Jul 22, 2026

The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel

2 out of 5
Price was $410, price is now $397 per person
$397
per person
Sep 17 - Sep 19
found 23 hours ago
Roundtrip flight included
Orlando (MCO) to Cape Girardeau (CGI)
9.6/10 Exceptional! (4 reviews)
What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway.

Reviewed on Jun 13, 2026

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Stay near popular Doniphan attractions

Deer Leap Recreation Area

Tucked along the Current River, Deer Leap offers tranquil campsites beneath towering pines. Launch your canoe from the non-motorized ramp for a peaceful float through Missouri's scenic waterways.
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Doniphan Hotel Deals

Romantic couples retreat 100 feet from Current River, Doniphan, MO

Romantic couples retreat 100 feet from Current River, Doniphan, MO

Doniphan MO
10/10 Exceptional! (21 reviews)
"The house was immaculate and very comfortable with everything you’ll need. The deck and fire pit outside are great and awesome places to spend an evening while overlooking the river. The river is a short walk behind the house with a private beach that can be used by guests. The hosts couldn’t have ..."

Reviewed on Jul 28, 2026

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Romantic couples retreat 100 feet from Current River, Doniphan, MO
Current River Cottage

Current River Cottage

Doniphan MO
9.4/10 Exceptional! (44 reviews)
"The TV didn’t work in the queen bedroom"

Reviewed on Jul 5, 2026

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Current River Cottage
Cabin Right on Current River, conveniently located close to town.

Cabin Right on Current River, conveniently located close to town.

Doniphan MO
9.6/10 Exceptional! (45 reviews)
"I have stayed here multiple times. The house is great and the gravel bar in front of the house is amazing. My friends and I just didn’t want to get out of the river. I love this house and you will too!"

Reviewed on Jul 11, 2026

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Cabin Right on Current River, conveniently located close to town.
See all 154 properties in Doniphan
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Doniphan Vacation Packages

Doniphan Essential Information

Language
English
Currency
U.S dollars
Population
2,000
Max Temp Winter
45ºF
Max Temp Summer
90ºF

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Frequently asked questions

How much does a Doniphan vacation package cost?
You'll find cheap prices from $357 on Expedia for your Doniphan escape. However, a range of factors like your choice of hotel, the season and length of stay will determine how much your vacation to Doniphan costs.
What are the cheapest months to go to Doniphan?
February, November and December are the best times to look for cheap Doniphan vacation packages. Opting to travel in quieter months means you can typically find lower prices on flights and hotels.
How many days is enough for Doniphan?
The ideal duration of your Doniphan vacation depends on what you'd like to see. Typically, a few days to a week will give you enough time to hit all the top attractions and explore some hidden gems along the way.
How to find the best Doniphan package deals?
Begin your search for a Doniphan package deal by entering your destination and preferred travel dates under our "Packages" tab. Then add a few filters, like "Property type" and "Popular locations," to tailor the results to your exact needs. You can also sort by "Package discount" and browse offers that come with big savings. If you don't find the perfect Doniphan package deal straight away, simply play around with your dates and search again. Bear in mind that deals are only available for a limited time, so book early and get your Doniphan getaway off to a flying start.
Is it cheaper to book a Doniphan vacation as a package?
Expedia vacation packages are designed to help you keep more cash in your pocket. Bundle your car rental, hotel and flight into one great-value price and you could save hundreds of dollars. You'll generally score a better deal than booking each component individually. And you'll still get the flexibility to create a personalized Doniphan vacation by choosing your favorite type of stay, airline and car class.
When to book a vacation package to Doniphan?
If you're considering an impromptu Doniphan vacation, check out our last-minute deals that can be booked up to a week before you take off. Don't want to leave things to the last minute? You can find incredible deals on your hotels and flights by booking ahead.
Does Expedia offer Book Now, Pay Later Doniphan vacation packages?
Jet off on your dream trip to Doniphan with Expedia's Book Now, Pay Later vacations. There's no need to save up or hold off until payday — we've teamed up with online lender Affirm to give you flexibility with your finances. Our vacation packages with payment plans let you spread the cost over 3, 6 or 12 months. With no hidden or late payment fees, it's a breeze to budget for your trip and snap up bargains before they disappear.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.