Punta Paitilla Vacations from $928

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Your Punta Paitilla Vacation

The easiest way to experience this exciting city is with a tailor-made Punta Paitilla vacation package. Base yourself in the neighborhood of Marbella, which is good for cafes, walking and dining or go someplace else — our package deals are all about you. Every trip to Punta Paitilla needs a well-planned itinerary. Fill yours with attractions like Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama. Expedia will help you escape your daily routine. Tailor your vacation to Punta Paitilla to suit your travel style, whatever that may be.

The Latest Punta Paitilla Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Decapolis Hotel Panama City

Decapolis Hotel Panama City

San Francisco
$928
per person
Nov 3 - Nov 8
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.6/10 Excellent! (1,708 reviews)
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

Casco Viejo
Save 100% on your flight
$1,356
per person
Nov 28 - Dec 4
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9/10 Wonderful! (1,012 reviews)
Megapolis Hotel Panamá

Megapolis Hotel Panamá

San Francisco
$1,110
per person
Dec 13 - Dec 17
found 23 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.4/10 Very Good! (1,693 reviews)
loved my family suite !!! very spacious and cute ! awesome views… the pool was such a vibe even on the days it did rain the bar was still open. great location in the city

Reviewed on Sep 27, 2026

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

Tocumen Airport
$949
per person
Nov 3 - Nov 8
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.6/10 Excellent! (1,811 reviews)
Casa Mallet by Wynwood House

Casa Mallet by Wynwood House

Casco Viejo
$1,596
per person
Nov 4 - Nov 8
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.8/10 Exceptional! (29 reviews)
I would highly recommend, the service I received was impeccable and just a wonderful experience! I was a bit hesitant regarding the location but once I got there, it turned out to be perfect. The concierge staff was such a pleasure to work with especially ‘Jerry’, who provided recommendations and information. This was such a blessing to us. I would stay here again in a heart beat. It’s a must stay!

Reviewed on Sep 16, 2026

Where to stay in Punta Paitilla

Find the best Punta Paitilla areas and neighborhoods for the activities you enjoy most. Learn more about Punta Paitilla
A waterfront cityscape with historic buildings and a prominent clock tower.

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

A cityscape with modern skyscrapers, including a distinctive twisting tower.

Bella Vista

1 out of top 10 points of interest in this area

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station.

A city skyline with modern high-rise buildings and a river in the foreground.

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

A bridge over a body of water with several boats.

San Francisco

1 out of top 10 points of interest in this area

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

A building with three arched windows, a balcony with wrought iron railings, and a tiled roof.

San Felipe

If you're spending some time in San Felipe, Independence Square and Interoceanic Canal Museum are top sights worth seeing.

Punta Paitilla Hotel Deals

Megapolis Hotel Panamá

Megapolis Hotel Panamá

Avenida Balboa Panama City
Fully refundableReserve now, pay when you stay
$139 nightly
$139 total
Oct 13 - Oct 14
Total with taxes and fees
8.6/10 Excellent! (1,762 reviews)
"loved my family suite !!! very spacious and cute ! awesome views… the pool was such a vibe even on the days it did rain the bar was still open. great location in the city"

Reviewed on Sep 27, 2026

Megapolis Hotel Panamá
Decapolis Hotel Panama City

Decapolis Hotel Panama City

Avenida Balboa Con Multicentro Panama City Panama
Fully refundableReserve now, pay when you stay
$101 nightly
$111 total
Oct 10 - Oct 11
Total with taxes and fees
Decapolis Hotel Panama City
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
$147 nightly
$161 total
Sep 29 - Sep 30
Total with taxes and fees
Las Americas Golden Tower Panama
See all 1,806 properties in Punta Paitilla
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Punta Paitilla attractions

Pacific Center

You can enjoy retail therapy at Pacific Center during your visit to Panama City. You can enjoy the restaurants while in the area.
See properties

Things to do

Panama Canal: The Most Complete Monkey Island Experience

Panama Canal: The Most Complete Wildlife Experience

$48
per adult
98% of travellers recommend
Panama Canal: The Most Complete Wildlife Experience
Picture 3 for Activity Panama City: All-Inclusive Catamaran Cruise to Taboga Island

Panama City: All-Inclusive Catamaran Cruise to Taboga Island

$99
per adult
94% of travellers recommend
Panama City: All-Inclusive Catamaran Cruise to Taboga Island
From Panama City: San Blas Island Hopping Day Tour

From Panama City: San Blas Island Hopping Day Tour

$145
per adult
98% of travellers recommend
From Panama City: San Blas Island Hopping Day Tour
See all activities in Panama City
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.