Punta Paitilla Vacations from $547

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your Punta Paitilla Vacation

The easiest way to experience this exciting city is with a tailor-made Punta Paitilla vacation package. Base yourself in the neighborhood of Marbella, which is good for cafes, walking and dining or go someplace else — our package deals are all about you. Every trip to Punta Paitilla needs a well-planned itinerary. Fill yours with attractions like Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama. Expedia will help you escape your daily routine. Tailor your vacation to Punta Paitilla to suit your travel style, whatever that may be.

The Latest Punta Paitilla Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Villa Botero By Casa Mojito B&B

Villa Botero By Casa Mojito B&B

3 out of 5
Price was $857, price is now $547 per person
$547
per person
Apr 1 - Apr 5
found 1 day ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
9.8/10 Exceptional! (60 reviews)
We stayed one night and it exceeded our expectations. The owners were incredibly friendly and easy to contact, making us feel right at home. Everything was spotless, and the atmosphere was warm and inviting. The homemade breakfast was a highlight—absolutely delicious and full of flavor. We will stay again longer next time.

Reviewed on Jan 22, 2026

Mahogany Suites

Mahogany Suites

2 out of 5
Price was $1,591, price is now $690 per person
$690
per person
Apr 25 - May 2
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
10/10 Exceptional! (1 review)
Excellent apartment on a golf resort. 5 Star.

Reviewed on Jan 28, 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
Price was $2,224, price is now $1,303 per person
$1,303
per person
Apr 25 - May 2
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9/10 Wonderful! (1,002 reviews)
The employees were the best of all our hotels. They were so friendly. Super helpful booking reservations, guiding us where to go. The hotel is gorgeous. We felt like we were boarding the titanic with all the beautiful wooden stairs and piano playing! Loved all the live music. Every single employee was so friendly. Location is perfect for exploring the area. Didn’t eat the breakfast bc we were only here one day, but it looked and smelled delicious. Room was nice and clean, but one of the beds felt like the frame or box spring was broken bc my husband and I both rolled to the center! We ended up putting our kids in that bed and it was ok for them.

Reviewed on Feb 21, 2026

Playa Caracol Residences Vacation Rental

Playa Caracol Residences Vacation Rental

3.5 out of 5
Price was $926, price is now $636 per person
$636
per person
Mar 28 - Apr 2
found 2 hours ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
7.2/10 Good! (26 reviews)
Great, clean condo overlooking the pool and ocean. We didn't cook our meals, but used the restaurant on site. Staff was friendly and professional.

Reviewed on Dec 7, 2025

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was $1,382, price is now $1,044 per person
$1,044
per person
Apr 1 - Apr 5
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.4/10 Very Good! (1,204 reviews)
clean room, friendly staff, reasonably priced

Reviewed on Feb 20, 2026

Where to stay in Punta Paitilla

Find the best Punta Paitilla areas and neighborhoods for the activities you enjoy most. Learn more about Punta Paitilla
View of the Panama City Old Town

Casco Viejo

4.5/5(178 area reviews)

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

Punta Paitilla Hotel Deals

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
$166 nightly
The price is $183 total per night from Feb 25 to Feb 26
$183 total
Feb 25 - Feb 26
Total with taxes and fees
9/10 Wonderful! (1,043 reviews)
Good accommodations overall. Junior suite had no tv in living room. TV in bedroom had a tv barely hanging on the attachment. Message light on phone in bedroom and bathroom continually blinking red. Junior suite prices for a standard king quality room at best. Elevators took forever. Allot at least ...

Reviewed on Feb 21, 2026

Las Americas Golden Tower Panama
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro Panama City Panama
Fully refundableReserve now, pay when you stay
$116 nightly
The price is $128 total per night from Feb 22 to Feb 23
$128 total
Feb 22 - Feb 23
Total with taxes and fees
8.6/10 Excellent! (1,569 reviews)
Very good location. View of city is great. A little dated in the room but good.

Reviewed on Feb 21, 2026

Decapolis Hotel Panama City
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

3.5 out of 5
Italy Avenue, Punta Paitilla Panama City Panama
Fully refundableReserve now, pay when you stay
$92 nightly
The price is $102 total per night from Feb 23 to Feb 24
$102 total
Feb 23 - Feb 24
Total with taxes and fees
9.4/10 Exceptional! (2,148 reviews)
The room was clean, the automatic curtains worked, the AC cooled the room in short order, and the staff was gracious. The breakfast buffet was hot, replenished, and had plenty of selections. The omelet station was awesome!

Reviewed on Feb 21, 2026

Plaza Paitilla Inn Hotel
See all 1,548 properties in Punta Paitilla
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Punta Paitilla

Rainy day in Panama City but the charm of this city never ends. A beautiful rainbow over the city invites us to spend a bright day in paradise. #LifeAtExpedia

Multiplaza Pacific Mall

You can enjoy some retail therapy when you visit Multiplaza Pacific Mall, a popular shopping spot in Panama City. You can enjoy the restaurants while in the area.

Multiplaza Pacific Mall
Causeway, Amador, Panama

Amador Causeway

You can learn about the history of Ancon with a stop at Amador Causeway. Stroll along the seaside or visit the shops in this vibrant area.

Amador Causeway
Panama City night skyline

Avenida Balboa

You can find the perfect gifts to bring home at Avenida Balboa during your trip to Panama City. While you're in the area, wander around the natural setting.

Avenida Balboa

Things to do

Boat tour in the Panama Canal to Monkeys and sloths islands

Boat tour in the Panama Canal to Monkeys and sloths islands

$74
per adult
100% of travellers recommend
Boat tour in the Panama Canal to Monkeys and sloths islands
Panama City: Poin Full Package Experience

Panama City: Poin Full Package Experience

$155
per adult
98% of travellers recommend
Panama City: Poin Full Package Experience
Panama City: Poin Glass Observation Deck Ticket with VR Tour

Panama City: Poin Glass Observation Deck Ticket with VR Tour

$32
per adult
100% of travellers recommend
Panama City: Poin Glass Observation Deck Ticket with VR Tour
See all activities in Panama City
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.