Upstate South Carolina Vacations from $273
Book a Hotel + Flight or Car together to unlock savings
Photo by Visit Greenville, South Carolina
- Plan, book, travel with confidence
Better together
Save up to $1,045 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
Your Upstate South Carolina Vacation
With a Upstate South Carolina vacation package, you can forget about the stress of planning and simply focus on experiencing what this thrilling destination has on offer. With so much to do and see on a trip to Upstate South Carolina, it can be hard to know where to begin. Kick off your travels in Greenville at Falls Park on the Reedy and Bon Secours Wellness Arena — two popular attractions here. Another top city worthy of a spot on your itinerary is Spartanburg. Don't miss WestGate Mall and Tyger River Park. Expedia is your one-stop shop for planning your Upstate South Carolina vacation. From hotels and flights, to car rentals and more, we're here to help you create a travel experience like no other.
The Latest Upstate South Carolina vacation packages
Price found within the past 48 hours. Click for updated prices.
The Westin Charlotte
Uptown Charlotte
Save 100% on your flight
Price was $999, price is now $657 per person
$657
per person
Dec 6 - Dec 9
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Charlotte (CLT)
9/10 Wonderful! (1,012 reviews)
This hotel was a very convenient location and provided excellent staff service. One of the best features was an easily accessed overnight menu and food selection that provided comfort for busy schedules and late travel. The lobby and lounge seating was comfortable, clean, and elegant. Will definitely stay here again.
Reviewed on Oct 16, 2025
Charlotte Marriott City Center
Uptown Charlotte
Price was $771, price is now $534 per person
$534
per person
Dec 7 - Dec 10
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Charlotte (CLT)
8.8/10 Excellent! (1,011 reviews)
Didn’t use their restaurants, but many available within a short walk. Staff very helpful. Rooms were nice-very clean. Great location for exploring Uptown Charlotte. Would stay there again.
Reviewed on Oct 27, 2025
The Windsor Boutique Hotel
Downtown Asheville
Save 100% on your flight
Price was $1,331, price is now $923 per person
$923
per person
Dec 29 - Jan 2
found 1 day ago
Roundtrip flight included
Miami (MIA) to Asheville (AVL)
9.8/10 Exceptional! (534 reviews)
Great staff - very comfortable accommodations, great location
Reviewed on Oct 25, 2025
Don't see what you're looking for?
See all available trips from Columbus to Upstate South Carolina
View all tripsWhere to stay in Upstate South Carolina
Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina
Greenville Downtown
3 out of top 10 points of interest in this area
5/5(654 area reviews)
The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.
Discover the most popular places to visit in Upstate South Carolina
Clemson University
5/5(410 reviews)
Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.
Falls Park on the Reedy
4.5/5(583 reviews)
Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.
Fred W. Symmes Chapel
5/5(12 reviews)
You can find out about the history of Cleveland when you stop by Fred W. Symmes Chapel. Wander the lakeside and forest in this relaxing area.
What to do in Upstate South Carolina
Small-Group Walking Tour in Greenville with Breakfast
$95
per adult
100% of travellers recommend
Epic City Scavenger Hunt in Garden Grove by Operation City Quest
$10
per adult
Upstate South Carolina Hotel Deals
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
851 Congaree Rd, Greenville, SC
Fully refundable
$95 nightly
The price is $105 total per night from Nov 9 to Nov 10
$105 total
Nov 9 - Nov 10
Total with taxes and fees
8.4/10 Very Good! (1,004 reviews)
Everything is just perfect
Reviewed on Oct 24, 2025
Hilton Greenville
45 W Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $117 total per night from Nov 2 to Nov 3
$117 total
Nov 2 - Nov 3
Total with taxes and fees
8/10 Very Good! (1,002 reviews)
Nice staff
Reviewed on Oct 21, 2025
Hyatt Regency Greenville
220 N Main St, Greenville, SC
$139 nightly
The price is $153 total per night from Nov 23 to Nov 24
$153 total
Nov 23 - Nov 24
Total with taxes and fees
8.6/10 Excellent! (1,004 reviews)
Extremely convenient for walking to restaurants and stores!
Reviewed on Oct 20, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Upstate South Carolina Vacation Packages
Upstate South Carolina Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Charleston Intl. Airport (CHS) |
More vacations you might like
Explore a world of travel with Expedia
- Woodruff Hotels
- Cabin Rentals in Woodruff
- Motels in Woodruff
- B&B in Woodruff
- Pet-friendly Hotels in Woodruff
- RV Parks in Woodruff
- Vacation Homes in Woodruff
- 3 Star Hotels in Woodruff
- Cottages in Woodruff
- 4 Star Hotels in Woodruff
- Hotels near Tyger-10 Nature Park
- Roebuck Hotels
- 4 Star Hotels in Roebuck
- Apartments in Roebuck
- Cabin Rentals in Roebuck
- B&B in Roebuck
- 5 Star Hotels in Roebuck
- Cottages in Roebuck
- Motels in Roebuck
- Vacation Homes in Roebuck
- RV Parks in Roebuck
- Moore Hotels
- Hotels near Walnut Grove Plantation
- Enoree Hotels
- Cottages in Enoree
- RV Parks in Enoree
- Cabin Rentals in Enoree
- Hotels near Willow Creek Golf Club
- Pauline Hotels
- Motels in Pauline
- 5 Star Hotels in Pauline
- B&B in Pauline
- Reidville Hotels
- Cabin Rentals in Reidville
- 4 Star Hotels in Reidville
- 3 Star Hotels in Reidville
- Hotels near Tyger River Park
- Hotels near River Falls Golf Course
- Hotels near Tyger River Park
- Anglewood Hotels
- Flights to Woodruff
- Flights from Woodruff
- Flights to Roebuck
- Flights from Roebuck
- Flights from Moore
- Flights from Enoree
- Flights from Pauline
- Flights from Reidville
- Flights from Charlotte (CLT) to Spartanburg (SPA)
- Flights from Spartanburg Downtown Memorial
- Flights from Asheville (AVL) to Spartanburg (SPA)
- Flights from Atlanta (ATL) to Spartanburg (SPA)
- Flights from New York (JFK) to Spartanburg (SPA)
- Flights from Columbia (CAE) to Spartanburg (SPA)
- Flights from Greenville (GSP) to Spartanburg (SPA)
- Flights from Raleigh (RDU) to Spartanburg (SPA)
- Flights from Miami (MIA) to Spartanburg (SPA)
- Flights from Seattle (SEA) to Spartanburg (SPA)
- Flights from Buffalo (BUF) to Spartanburg (SPA)
- Flights from Hickory (HKY) to Spartanburg (SPA)
- Flights from Richmond (RIC) to Spartanburg (SPA)
- Flights from Charleston (CHS) to Spartanburg (SPA)
- Flights from Los Angeles (LAX) to Spartanburg (SPA)
- Flights from Tampa (TPA) to Spartanburg (SPA)
- Flights from Trenton (TTN) to Spartanburg (SPA)
- Flights from Philadelphia (PHL) to Spartanburg (SPA)
- Flights from Punta Gorda Airport (PGD) to Spartanburg (SPA)
- Flights from Vero Beach (VRB) to Spartanburg (SPA)
- Flights from Chicago (ORD) to Spartanburg (SPA)
- Flights from Latrobe (LBE) to Spartanburg (SPA)
- Flights from Evansville (EVV) to Spartanburg (SPA)
- Flights from Washington (DCA) to Spartanburg (SPA)
- Flights from Cape Girardeau (CGI) to Spartanburg (SPA)
- Flights from Wilmington (ILM) to Spartanburg (SPA)
- Flights from Boston (BOS) to Spartanburg (SPA)
- Flights from Dallas (DFW) to Spartanburg (SPA)
- Flights from Fort Lauderdale (FLL) to Spartanburg (SPA)
- Flights from Syracuse (SYR) to Spartanburg (SPA)
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
