A bench, a bicycle, and a lake surrounded by trees.

Upstate South Carolina Vacation Rentals

  • Bundle & Save

    Get more, spend less whenever you see Bundle & Save deals

  • OneKeyCash

    Earn OneKeyCash on all your eligible bookings

  • Upfront pricing

    We are not like the others - we include taxes and fees

Check prices for these dates

In two weeks
Oct 9 - Oct 11
In two months
Nov 20 - Nov 22
In three months
Dec 18 - Dec 20
In four months
Jan 15 - Jan 17

Our top choices for Upstate South Carolina vacation rentals

A modern living room with a sofa, a coffee table, and a TV. There is a kitchen area with a microwave, stove, and refrigerator.

1. Adorable Upscale cottage in Downtown Fountain Inn.

Adorable Upscale cottage in Downtown Fountain Inn.
Fountain Inn
10.0 out of 10, Exceptional, (45 reviews)
"It was a great location for us as we're building in Fountain Inn. Very cute, very comfortable, close to everything we needed. Host was great. Will stay again"
United States
Valerie
$230 nightly
The price is $253
Sep 28 - Sep 29
Total with taxes and fees
Adorable Upscale cottage in Downtown Fountain Inn.
A cabin with a cozy interior, a wooden exterior, and a view of the forest.

2. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
Seneca
9.8 out of 10, Exceptional, (107 reviews)
"Me and my family had a great time"
United States
Nirumol
$133 nightly
The price is $146
Oct 4 - Oct 5
Total with taxes and fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
A swimming pool with lounge chairs and a covered area with tables and chairs.

3. Carolina Camp Cedar

Carolina Camp Cedar
3.5 star property
Pickens
10.0 out of 10, Exceptional, (3 reviews)
"The cottage was clean, staff was so friendly, our stay was quiet and peaceful… it was perfect! Definitely planning to stay there again!"
United States
Katlynn
$175 nightly
The price is $195
Oct 6 - Oct 7
Total with taxes and fees
Carolina Camp Cedar
A modern kitchen with white cabinetry, stainless steel appliances, and a wooden ladder.

4. Charming luxury cottage in the heart of Boiling Springs

Charming luxury cottage in the heart of Boiling Springs
Boiling Springs
9.0 out of 10, Wonderful, (18 reviews)
"Very nice guest house. Property was clean and the host was very responsive to our questions. Lots of natural shade in the deck area. Would stay here again."
United States
Pat L.
$190 nightly
The price is $211
Sep 28 - Sep 29
Total with taxes and fees
Charming luxury cottage in the heart of Boiling Springs
A modern kitchen with white cabinets, stainless steel appliances, a granite countertop, and a built-in oven.

5. The Blue Bungalow by Unity Park - Newly Renovated

The Blue Bungalow by Unity Park - Newly Renovated
Woodside Cotton Mill Village Historic District
9.8 out of 10, Exceptional, (108 reviews)
"Fully equipped, comfortable beds…everything to make for an enjoyable stay. "
United States
Ron E.
$199 nightly
The price is $219
Sep 28 - Sep 29
Total with taxes and fees
The Blue Bungalow by Unity Park - Newly Renovated
A rustic interior with a brick fireplace, wooden furniture, and a stone floor.

6. Whiffletree Farmhouse just 2 mins off I-26 & 8 mins from downtown Spartanburg!

Whiffletree Farmhouse just 2 mins off I-26 & 8 mins from downtown Spartanburg!
Roebuck
10.0 out of 10, Exceptional, (44 reviews)
"Awesome farmhouse, will stay here again on future trips!"
United States
Jeremy C.
$244 nightly
The price is $271
Sep 29 - Sep 30
Total with taxes and fees
Whiffletree Farmhouse just 2 mins off I-26 & 8 mins from downtown Spartanburg!
A house with a front yard and a paved driveway.

7. ~2 Bedroom Cozy Gem 💎 5 minutes from Downtown Spartanburg~

~2 Bedroom Cozy Gem 💎 5 minutes from Downtown Spartanburg~
Spartanburg
10.0 out of 10, Exceptional, (57 reviews)
"Nice property, well stocked and quiet."
United States
sarah p.
$190 nightly
The price is $211
Oct 4 - Oct 5
Total with taxes and fees
~2 Bedroom Cozy Gem 💎 5 minutes from Downtown Spartanburg~
A modern living room with a grey sofa, a round coffee table, and a dining area with a table and chairs.

8. Southern Charm Townhome

Southern Charm Townhome
Simpsonville
10.0 out of 10, Exceptional, (11 reviews)
"Very clean and safe location. Super cute interior decorations and comfortable. Also a great location for us to visit family who are local. Absolutely would stay again."
United States
Brianna F.
$331 nightly
The price is $376
Sep 28 - Sep 29
Total with taxes and fees
Southern Charm Townhome
A log cabin with a wooden door, two windows, and a chimney. There are two white metal chairs and a small table in front of the cabin.

9. Historic 19th Century Cabin in Greenville

Historic 19th Century Cabin in Greenville
Greenville
9.6 out of 10, Exceptional, (21 reviews)
"The cabin was beautiful."
United States
John A.
$142 nightly
The price is $156
Sep 28 - Sep 29
Total with taxes and fees
Historic 19th Century Cabin in Greenville
A house with a gravel driveway, a wooden fence, and a lawn.

10. Secluded Tiny Home in Exclusive Paris Mountain!

Secluded Tiny Home in Exclusive Paris Mountain!
Greenville
10.0 out of 10, Exceptional, (12 reviews)
"Great location, quiet and perfect for a couple stay. "
United States
craig d.
$122 nightly
The price is $134
Sep 28 - Sep 29
Total with taxes and fees
Secluded Tiny Home in Exclusive Paris Mountain!
A hotel entrance with glass doors, a caution sign, a potted plant, and a red mat.

11. 2 Queen Beds Non-Smoking

2 Queen Beds Non-Smoking
Greenville SC
10.0 out of 10, Exceptional, (86 reviews)
"Quiet atmosphere throughout the stay made it relaxing."
United States
Anonymous traveler
$66 nightly
The price is $72
Sep 28 - Sep 29
Total with taxes and fees
2 Queen Beds Non-Smoking

12. stayAPT Suites Greenville-Haywood Mall

stayAPT Suites Greenville-Haywood Mall
3.0 star property
Greenville
9.2 out of 10, Wonderful, (231 reviews)
"I was there for work and I was close to everything"
United States
Darius
$119 nightly
The price is $131
Sep 28 - Sep 29
Total with taxes and fees
stayAPT Suites Greenville-Haywood Mall
A living room with a sofa, coffee table, and a ceiling fan.

13. Cozy 1BR Close to Downtown & Greenville Drive Baseball

Cozy 1BR Close to Downtown & Greenville Drive Baseball
Greenville
9.2 out of 10, Wonderful, (32 reviews)
"Good location, great communication"
United States
isaiah
$139 nightly
The price is $152
Oct 4 - Oct 5
Total with taxes and fees
Cozy 1BR Close to Downtown & Greenville Drive Baseball
A modern kitchen with granite countertops, stainless steel appliances, and a dining area with a sofa and table.

14. 2BR Cedar Lane Road Retreat at Swamp Rabbit Trail!

2BR Cedar Lane Road Retreat at Swamp Rabbit Trail!
Greenville
9.4 out of 10, Exceptional, (41 reviews)
"We had a great stay- the location was close to everything & very clean "
United States
Anonymous traveler
$170 nightly
The price is $187
Sep 30 - Oct 1
Total with taxes and fees
2BR Cedar Lane Road Retreat at Swamp Rabbit Trail!
A modern kitchen with a stainless steel refrigerator, a microwave, and a sink. There is a wooden dining table with chairs and a laundry basket labeled "laundry" in the foreground.

15. 2BR 2Bath - Swamp Rabbit Trail Resort

2BR 2Bath - Swamp Rabbit Trail Resort
Greenville
9.2 out of 10, Wonderful, (43 reviews)
"Great place right by the swamp, rabbit, grocery and trail. The place was clean as a whistle, and we really appreciated the amenities. We would one hundred percent stay there again."
United States
Robyn L.
$170 nightly
The price is $187
Sep 30 - Oct 1
Total with taxes and fees
2BR 2Bath - Swamp Rabbit Trail Resort
A bunk bed with a leopard print bedspread, a ceiling fan, a window with blinds, and a carpeted floor.

16. Walk to Bridgeway Station! Home w/ Pool Access

Walk to Bridgeway Station! Home w/ Pool Access
3.0 star property
Greenville
$419 nightly
The price is $461
Sep 28 - Sep 29
Total with taxes and fees
Walk to Bridgeway Station! Home w/ Pool Access
A swimming pool with lounge chairs and umbrellas, surrounded by brick buildings with large windows.

17. Bright & Cozy 2BR Apt w/ Parking

Bright & Cozy 2BR Apt w/ Parking
Greenville
10.0 out of 10, Exceptional, (13 reviews)
"Excellent stay—spotless room, awesome staff, and great amenities."
United States
Crystal
$222 nightly
The price is $240
Sep 28 - Sep 29
Total with taxes and fees
Bright & Cozy 2BR Apt w/ Parking
A hallway with wooden flooring, a blue patterned rug, and a modern pendant light fixture.

18. GORGEOUS 1 BR on MAIN #2

GORGEOUS 1 BR on MAIN #2
Greenville Downtown
9.8 out of 10, Exceptional, (27 reviews)
"Looks better than the photos, great location. Comfy bed. We didn’t cook, but would have had all needed cookware. Appreciate the sound machine and extra clean linens. "
United States
Nikki P.
$220 nightly
The price is $242
Sep 30 - Oct 1
Total with taxes and fees
GORGEOUS 1 BR on MAIN #2
A kitchen with wooden cabinets, a granite countertop, a sink, and a window with a view of trees.

19. Chic Downtown 2BR Condo walk to The Well Arena

Chic Downtown 2BR Condo walk to The Well Arena
Greenville Downtown
9.8 out of 10, Exceptional, (10 reviews)
"We enjoyed our stay! "
United States
Finney G.
$252 nightly
The price is $277
Oct 20 - Oct 21
Total with taxes and fees
Chic Downtown 2BR Condo walk to The Well Arena
A spacious living room with two sofas, a coffee table, and a ceiling fan.

20. Peaceful Oasis Convenient to Greenville!

Peaceful Oasis Convenient to Greenville!
Simpsonville
10.0 out of 10, Exceptional, (115 reviews)
"Pet friendly"
United States
Debra C.
$278 nightly
The price is $293
Oct 18 - Oct 19
Total with taxes and fees
Peaceful Oasis Convenient to Greenville!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Upstate South Carolina Hotel Reviews

Comfort Inn Greenville - Haywood Mall

Comfort Inn Greenville - Haywood Mall

10/10 Excellent
"Great place to stay and very affordable"
Amy 4-night trip
Posted 7 hours ago
Comfort Inn Greenville - Haywood Mall

Find out more about Upstate South Carolina

Everything you need to know about Upstate South Carolina vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Upstate South Carolina vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Upstate South Carolina vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Upstate South Carolina vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Upstate South Carolina. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Upstate South Carolina in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $71 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Upstate South Carolina rentals

At Expedia, we put the best Upstate South Carolina vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Upstate South Carolina rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Upstate South Carolina vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Upstate South Carolina. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia