Title: Upstate South Carolina Vacation Rentals from $106: Search Short-Term Rentals | Expedia.com [Upstate South Carolina Travel Guide](https://expedia.com/Upstate-South-Carolina.dx553248635975748552)[Hotels in Upstate South Carolina](https://expedia.com/Upstate-South-Carolina-Hotels.d553248635975748552.Travel-Guide-Hotels)[Flights to Upstate South Carolina](https://expedia.com/Cheap-Flights-To-Upstate-South-Carolina.d553248635975748552.Travel-Guide-Flights)[Things to do in Upstate South Carolina](https://expedia.com/Things-To-Do-In-Upstate-South-Carolina.d553248635975748552.Travel-Guide-Activities)[Car Rentals in Upstate South Carolina](https://expedia.com/Car-Rentals-In-Upstate-South-Carolina.d553248635975748552.Car-Rental-Guide)[Upstate South Carolina Vacation Packages](https://expedia.com/Upstate-South-Carolina.d553248635975748552.Destination-Travel-Guides) ![](https://images.trvl-media.com/place/6122927/69b8ebaa-53a3-428e-ba53-37ac2de11862.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Ryan Watts ![](https://images.trvl-media.com/place/6122927/69b8ebaa-53a3-428e-ba53-37ac2de11862.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_bundle_and_save.svg) ### Bundle & Save Get more, spend less whenever you see Bundle & Save deals - ![](https://a.travel-assets.com/travel-assets-manager/pictograms-expedia/light__onekey.svg) ### OneKeyCash Earn OneKeyCash on all your eligible bookings - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_ftc.svg) ### Upfront pricing We are not like the others - we include taxes and fees ## Check prices for these dates In two weeks [Apr 17 - Apr 19](https://www.expedia.com/Hotel-Search?regionId=553248635975748552&startDate=2026-04-17&endDate=2026-04-19&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [May 29 - May 31](https://www.expedia.com/Hotel-Search?regionId=553248635975748552&startDate=2026-05-29&endDate=2026-05-31&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In three months [Jun 26 - Jun 28](https://www.expedia.com/Hotel-Search?regionId=553248635975748552&startDate=2026-06-26&endDate=2026-06-28&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In four months [Jul 24 - Jul 26](https://www.expedia.com/Hotel-Search?regionId=553248635975748552&startDate=2026-07-24&endDate=2026-07-26&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Upstate South Carolina vacation rentals ![View from property](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/d7c06df6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin, 1 Queen Bed (View) | Private kitchen | Mini-fridge, stovetop, cookware/dishes/utensils, paper towels](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/e935ccb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, laptop workspace, bed sheets](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/f29b16c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, towels, soap, shampoo](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/cf119645.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy [](https://www.expedia.com/Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information) Seneca 9.8/10 Exceptional (66 reviews) "Excellent stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Beonca $139 nightly $153 total Apr 2 - Apr 3 Total with taxes and fees [](https://www.expedia.com/Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information) ![Premium bedding, in-room safe, individually furnished, laptop workspace](https://images.trvl-media.com/lodging/123000000/122100000/122099800/122099740/afe0f510.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin, 1 Bedroom, Courtyard View | Living area | 55-inch Smart TV with digital channels, streaming services](https://images.trvl-media.com/lodging/123000000/122100000/122099800/122099740/3f2de599.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, individually furnished, laptop workspace](https://images.trvl-media.com/lodging/123000000/122100000/122099800/122099740/4d5d913d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool, open 7:00 AM to 10:00 PM, pool umbrellas](https://images.trvl-media.com/lodging/123000000/122100000/122099800/122099740/b26b87ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Carolina Camp Cedar [](https://www.expedia.com/Pickens-Hotels-Carolina-Camp-Cedar.h122099740.Hotel-Information) Pickens 10/10 Exceptional (3 reviews) "The cottage was clean, staff was so friendly, our stay was quiet and peaceful… it was perfect! Definitely planning to stay there again!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Katlynn $242 nightly $269 total Apr 2 - Apr 3 Total with taxes and fees [](https://www.expedia.com/Pickens-Hotels-Carolina-Camp-Cedar.h122099740.Hotel-Information) ![Signature Cottage, 2 Bedrooms | Living room | 43-inch Smart TV with cable channels, TV, Netflix](https://images.trvl-media.com/lodging/90000000/89510000/89502700/89502605/a4df93b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature Cottage, 2 Bedrooms | 2 bedrooms, individually decorated, individually furnished](https://images.trvl-media.com/lodging/90000000/89510000/89502700/89502605/9cd5859a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature Cottage, 2 Bedrooms | Private kitchen | Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/90000000/89510000/89502700/89502605/0d77f138.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature Cottage, 2 Bedrooms | Private kitchen | Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/90000000/89510000/89502700/89502605/w775h924x3y0-5b08ac43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Clemson Memorabilia House [](https://www.expedia.com/Clemson-Hotels-Clemson-Memorabilia-House.h89502605.Hotel-Information) Clemson 9.8/10 Exceptional (9 reviews) "We enjoyed our stay, it was the perfect size for our family of four. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ashley $214 nightly $238 total Apr 2 - Apr 3 Total with taxes and fees [](https://www.expedia.com/Clemson-Hotels-Clemson-Memorabilia-House.h89502605.Hotel-Information) ![Exterior detail](https://images.trvl-media.com/lodging/119000000/118950000/118940800/118940757/b352fd91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/119000000/118950000/118940800/118940757/ab14146e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/119000000/118950000/118940800/118940757/2365af8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/119000000/118950000/118940800/118940757/0ae5a686.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cozy A-frame cabin just 1/4 mile from Lake Hartwell - perfect for anglers [](https://www.expedia.com/Townville-Hotels-Cozy-A-Frame-Cabin-Just-14-Mile-From-Lake-Hartwell-Perfect-For-Anglers.h118940757.Hotel-Information) Townville 10/10 Exceptional (3 reviews) "Everything was excellent. Perfect place my husband and I for a Clemson football weekend!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joyce P. $170 nightly $189 total Apr 2 - Apr 3 Total with taxes and fees [](https://www.expedia.com/Townville-Hotels-Cozy-A-Frame-Cabin-Just-14-Mile-From-Lake-Hartwell-Perfect-For-Anglers.h118940757.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/118000000/117970000/117968000/117967992/6856c3ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/118000000/117970000/117968000/117967992/c148f208.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace](https://images.trvl-media.com/lodging/118000000/117970000/117968000/117967992/04ddac11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace](https://images.trvl-media.com/lodging/118000000/117970000/117968000/117967992/5fe9e2fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Historic 19th Century Cabin in Greenville [](https://www.expedia.com/Greenville-Hotels-Historic-19th-Century-Cabin-In-Greenville.h117967992.Hotel-Information) Greenville 9.8/10 Exceptional (8 reviews) "unique ,cozy cabin!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Martha G. $146 nightly $161 total Apr 6 - Apr 7 Total with taxes and fees [](https://www.expedia.com/Greenville-Hotels-Historic-19th-Century-Cabin-In-Greenville.h117967992.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/88000000/87340000/87337600/87337581/83fe6802.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/88000000/87340000/87337600/87337581/4c9b67dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/88000000/87340000/87337600/87337581/94af1b49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/88000000/87340000/87337600/87337581/7c7b67a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Gnome Hill Cottage - A Rustic Pet-Friendly Cottage In The Woods [](https://www.expedia.com/Cleveland-Hotels-Gnome-Hill-Cottage.h87337581.Hotel-Information) Cleveland 9.8/10 Exceptional (112 reviews) "Fun for a remote get away. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) April $130 nightly $144 total Apr 2 - Apr 3 Total with taxes and fees [](https://www.expedia.com/Cleveland-Hotels-Gnome-Hill-Cottage.h87337581.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/79000000/78140000/78137300/78137271/ff8281c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/79000000/78140000/78137300/78137271/88b08b4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/79000000/78140000/78137300/78137271/245dc985.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/79000000/78140000/78137300/78137271/ec7d22d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Blue Bungalow by Unity Park - Newly Renovated [](https://www.expedia.com/Greenville-Hotels-The-Blue-Bungalow-By-Unity-Park-Newly-Renovated.h78137271.Hotel-Information) Woodside Cotton Mill Village Historic District 9.8/10 Exceptional (90 reviews) "The Bungalow was so clean, tidy, and full of all the amenities you need to enjoy an extended stay in Greenville. It was in a perfect location and our host promptly responded to any inquiries. We loved our stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Evan T. $200 nightly $220 total Apr 7 - Apr 8 Total with taxes and fees [](https://www.expedia.com/Greenville-Hotels-The-Blue-Bungalow-By-Unity-Park-Newly-Renovated.h78137271.Hotel-Information) ![Outdoor spa tub](https://images.trvl-media.com/lodging/77000000/76930000/76929000/76928997/de87b393.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/77000000/76930000/76929000/76928997/w945h710x0y32-a770d4e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/77000000/76930000/76929000/76928997/1a9df087.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, free WiFi, bed sheets](https://images.trvl-media.com/lodging/77000000/76930000/76929000/76928997/394f1525.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lazy Bear Retreat by the Creek [](https://www.expedia.com/Pickens-Hotels-Lazy-Bear-Retreat-By-The-Creek.h76928997.Hotel-Information) Pickens 10/10 Exceptional (54 reviews) "What a beautiful little getaway! Great communication with owner, easy to find the location and entry. Everything was very clean and working as it should. Loved the hot tub." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Molly $166 nightly $184 total Apr 13 - Apr 14 Total with taxes and fees [](https://www.expedia.com/Pickens-Hotels-Lazy-Bear-Retreat-By-The-Creek.h76928997.Hotel-Information) ![1 bedroom, free WiFi, bed sheets](https://images.trvl-media.com/lodging/81000000/80940000/80930400/80930381/9a8d8ddd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/81000000/80940000/80930400/80930381/8bccb626.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/81000000/80940000/80930400/80930381/a6933580.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/81000000/80940000/80930400/80930381/53855e39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Modern cabin near Table Rock/Pretty Place [](https://www.expedia.com/Cleveland-Hotels-Modern-Cabin-Near-Table-RockPretty-Place.h80930381.Hotel-Information) Cleveland 10/10 Exceptional (71 reviews) "This was our third time staying here! It's just perfect for two people! Everything was super clean and cozy. Can't wait to stay again!!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Grace H. $200 nightly $220 total Apr 2 - Apr 3 Total with taxes and fees [](https://www.expedia.com/Cleveland-Hotels-Modern-Cabin-Near-Table-RockPretty-Place.h80930381.Hotel-Information) ![Sauna](https://images.trvl-media.com/lodging/115000000/114810000/114805200/114805191/w1284h1856x0y1-5421e5b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, in-room safe, WiFi, bed sheets](https://images.trvl-media.com/lodging/115000000/114810000/114805200/114805191/8c57b2cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/115000000/114810000/114805200/114805191/78a8b7f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/115000000/114810000/114805200/114805191/02b206f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Field Trip Unit 9 Small Bell Tent [](https://www.expedia.com/Travelers-Rest-Hotels-Unit-9-Beautiful-Bell-Tent-With-AC-And-WiFi-In-Travelers-Rest.h114805191.Hotel-Information) Travelers Rest 10/10 Exceptional (3 reviews) "Hot tub, sauna and cold plunge are really nice. Bathrooms are clean and nice. I was able to work remotely in their clubhouse with fast internet. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dustin W. $182 nightly $200 total Apr 2 - Apr 3 Total with taxes and fees [](https://www.expedia.com/Travelers-Rest-Hotels-Unit-9-Beautiful-Bell-Tent-With-AC-And-WiFi-In-Travelers-Rest.h114805191.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/96000000/95310000/95305700/95305698/51159ba6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, DVD player](https://images.trvl-media.com/lodging/96000000/95310000/95305700/95305698/07362c17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, DVD player](https://images.trvl-media.com/lodging/96000000/95310000/95305700/95305698/02ce48d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/96000000/95310000/95305700/95305698/a4ea3c70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Private Apartment on Beautiful Grounds, Walking Distance to Landrum SC [](https://www.expedia.com/Landrum-Hotels-Private-Apartment-On-Beautiful-Grounds.h95305698.Hotel-Information) Landrum 9.8/10 Exceptional (35 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jahaun A. $140 nightly $156 total Apr 30 - May 1 Total with taxes and fees [](https://www.expedia.com/Landrum-Hotels-Private-Apartment-On-Beautiful-Grounds.h95305698.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/108000000/107780000/107773400/107773310/7a59f7da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/108000000/107780000/107773400/107773310/dae7e187.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, bed sheets](https://images.trvl-media.com/lodging/108000000/107780000/107773400/107773310/2d362c1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/108000000/107780000/107773400/107773310/74e49b03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Romantic Cottage Getaway, tucked peacefully in the woods [](https://www.expedia.com/Pickens-Hotels-Romantic-Cottage-Getaway.h107773310.Hotel-Information) Pickens 10/10 Exceptional (17 reviews) "Amazing secluded retreat!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stephen N. $181 nightly $201 total Apr 2 - Apr 3 Total with taxes and fees [](https://www.expedia.com/Pickens-Hotels-Romantic-Cottage-Getaway.h107773310.Hotel-Information) ![1 bedroom, WiFi](https://images.trvl-media.com/lodging/97000000/96850000/96841100/96841079/w917h683x47y0-d230f19b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchen](https://images.trvl-media.com/lodging/97000000/96850000/96841100/96841079/w506h683x259y0-d852d25a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/97000000/96850000/96841100/96841079/w507h683x258y0-049ffbf3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/97000000/96850000/96841100/96841079/w507h683x258y0-53bf1731.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Patriot Point A [](https://www.expedia.com/Roebuck-Hotels-Patriot-Point-A.h96841079.Hotel-Information) Roebuck 10/10 Exceptional (23 reviews) "Excellent place to stay! We’ve stayed in both units and have not been disappointed." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nancy K. $145 nightly $161 total Apr 17 - Apr 18 Total with taxes and fees [](https://www.expedia.com/Roebuck-Hotels-Patriot-Point-A.h96841079.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/101000000/100840000/100837400/100837392/12f9ef68.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Game room](https://images.trvl-media.com/lodging/101000000/100840000/100837400/100837392/w1024h681x0y2-2fb5b1c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/101000000/100840000/100837400/100837392/w1024h680x0y3-8b0d38e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/101000000/100840000/100837400/100837392/w1024h680x0y3-c6d3b0e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cozy A-frame Tiny Home with Game room 3 Minutes to Lake Hartwell! [](https://www.expedia.com/Fair-Play-Hotels-Cozy-A-Frame-Tiny-Home-With-Game-Room-3-Minutes-To-Lake-Hartwell.h100837392.Hotel-Information) Fair Play 9.4/10 Exceptional (14 reviews) "It was a quiet and beautiful site. Hopefully we can stay longer next time!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kelley B. $199 nightly $219 total Apr 2 - Apr 3 Total with taxes and fees [](https://www.expedia.com/Fair-Play-Hotels-Cozy-A-Frame-Tiny-Home-With-Game-Room-3-Minutes-To-Lake-Hartwell.h100837392.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/67000000/66030000/66026900/66026894/efec02d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/67000000/66030000/66026900/66026894/fc94d8c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/67000000/66030000/66026900/66026894/69fcdbfb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, table tennis](https://images.trvl-media.com/lodging/67000000/66030000/66026900/66026894/ad2b1b86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Luxury Vacation Mountain Home [](https://www.expedia.com/Pickens-Hotels-Luxury-Vacation-Mtn-Home.h66026894.Hotel-Information) Pickens 9.8/10 Exceptional (26 reviews) "Everything was perfect from the hot tub to the comfort of the beds!!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kelly C. $291 nightly $323 total Apr 14 - Apr 15 Total with taxes and fees [](https://www.expedia.com/Pickens-Hotels-Luxury-Vacation-Mtn-Home.h66026894.Hotel-Information) ![Trailside Wedge Cottage | Terrace/patio](https://images.trvl-media.com/lodging/89000000/88370000/88362000/88361952/346fcb37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/89000000/88370000/88362000/88361952/87440d66.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Trailside Wedge Cottage | Terrace/patio](https://images.trvl-media.com/lodging/89000000/88370000/88362000/88361952/fa38c3ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vista Wedge Cottage | Private kitchen | Full-size fridge, microwave, dishwasher, coffee/tea maker](https://images.trvl-media.com/lodging/89000000/88370000/88362000/88361952/9304eefe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Station by Compo Hotels [](https://www.expedia.com/Travelers-Rest-Hotels-The-Station-By-Compo-Hotels.h88361952.Hotel-Information) Travelers Rest 10/10 Exceptional (18 reviews) "great place perfect for more privacy vs. a standard hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John $279 nightly $307 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Travelers-Rest-Hotels-The-Station-By-Compo-Hotels.h88361952.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/79000000/78600000/78594300/78594240/119c9e7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/79000000/78600000/78594300/78594240/414e1929.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/79000000/78600000/78594300/78594240/63923b8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/79000000/78600000/78594300/78594240/42257081.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Residences on Main- Yellow Branch Suite [](https://www.expedia.com/Walhalla-Hotels-Residences-On-Main-Yellow-Branch-Suite.h78594240.Hotel-Information) Walhalla 10/10 Exceptional (19 reviews) "Great stay! It was clean, cute, and very comfortable. Will definitely be back for a getaway!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Meredith A. $267 nightly $281 total Apr 2 - Apr 3 Total with taxes and fees [](https://www.expedia.com/Walhalla-Hotels-Residences-On-Main-Yellow-Branch-Suite.h78594240.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/39000000/38200000/38191100/38191009/w1015h757x6y0-8c36a621.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/39000000/38200000/38191100/38191009/e3a10a02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, free WiFi, bed sheets](https://images.trvl-media.com/lodging/39000000/38200000/38191100/38191009/7f9e5481.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker, blender](https://images.trvl-media.com/lodging/39000000/38200000/38191100/38191009/b5050b0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cozy Cabin 2/LAKE HARTWELL/Green Pond & Broyles Lndgs/Lockable Boat Shelters [](https://www.expedia.com/Townville-Hotels-Tiny-House-Min-From-Lake-Hartwellclemson.h38191009.Hotel-Information) Townville 10/10 Exceptional (88 reviews) "Beautiful and clean cabin and wonderful scenery!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael F. $205 nightly $228 total Apr 2 - Apr 3 Total with taxes and fees [](https://www.expedia.com/Townville-Hotels-Tiny-House-Min-From-Lake-Hartwellclemson.h38191009.Hotel-Information) ![Private kitchen](https://images.trvl-media.com/lodging/99000000/98530000/98527500/98527491/w715h535x173y8-4b719005.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/99000000/98530000/98527500/98527491/0bea6995.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/99000000/98530000/98527500/98527491/dc9366b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/99000000/98530000/98527500/98527491/5ce41bd7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 2BR Cedar Lane Road Retreat at Swamp Rabbit Trail! [](https://www.expedia.com/Greenville-Hotels-2BR-Cedar-Lane-Road-Retreat-At-Swamp-Rabbit-Trail.h98527491.Hotel-Information) Greenville 9.6/10 Exceptional (27 reviews) "Good little place, comfortable. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jonathan P. $177 nightly $195 total Apr 12 - Apr 13 Total with taxes and fees [](https://www.expedia.com/Greenville-Hotels-2BR-Cedar-Lane-Road-Retreat-At-Swamp-Rabbit-Trail.h98527491.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/110000000/109870000/109860500/109860449/bba31fff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchen](https://images.trvl-media.com/lodging/110000000/109870000/109860500/109860449/43a7c7ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/110000000/109870000/109860500/109860449/8a1c1825.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchen](https://images.trvl-media.com/lodging/110000000/109870000/109860500/109860449/8fb1165b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Secluded Yurt Hideaway 10 min to Table Rock [](https://www.expedia.com/Cleveland-Hotels-Secluded-Yurt-Hideaway-10-Min-To-Table-Rock.h109860449.Hotel-Information) cleveland 9.6/10 Exceptional (7 reviews) "The place is awesome! I don’t usually leave comments but this place is worth the visit." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael $294 nightly $323 total Apr 16 - Apr 17 Total with taxes and fees [](https://www.expedia.com/Cleveland-Hotels-Secluded-Yurt-Hideaway-10-Min-To-Table-Rock.h109860449.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-15&endDate=2026-04-16®ionId=553248635975748552&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ## Find vacation rentals that suit your style Cabins [](https://www.expedia.com/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-06-30&d1=2026-06-30&endDate=2026-07-03&d2=2026-07-03&lodging=CABIN) Cottages [](https://www.expedia.com/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-06-30&d1=2026-06-30&endDate=2026-07-03&d2=2026-07-03&lodging=COTTAGE) Private vacation homes [](https://www.expedia.com/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-06-30&d1=2026-06-30&endDate=2026-07-03&d2=2026-07-03&lodging=VACATION_HOME) Condos [](https://www.expedia.com/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-06-30&d1=2026-06-30&endDate=2026-07-03&d2=2026-07-03&lodging=CONDO) Houseboats [](https://www.expedia.com/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-06-30&d1=2026-06-30&endDate=2026-07-03&d2=2026-07-03&lodging=HOUSE_BOAT) Villas [](https://www.expedia.com/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-06-30&d1=2026-06-30&endDate=2026-07-03&d2=2026-07-03&lodging=VILLA) Aparthotels [](https://www.expedia.com/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-06-30&d1=2026-06-30&endDate=2026-07-03&d2=2026-07-03&lodging=APART_HOTEL) Apartments [](https://www.expedia.com/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-06-30&d1=2026-06-30&endDate=2026-07-03&d2=2026-07-03&lodging=APARTMENT) Chalets [](https://www.expedia.com/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-06-30&d1=2026-06-30&endDate=2026-07-03&d2=2026-07-03&lodging=CHALET) Residences [](https://www.expedia.com/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-06-30&d1=2026-06-30&endDate=2026-07-03&d2=2026-07-03&lodging=RESIDENCE) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FUpstate-South-Carolina-Vacation-Rentals.d553248635975748552.Travel-Guide-VacationRentals)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FUpstate-South-Carolina-Vacation-Rentals.d553248635975748552.Travel-Guide-VacationRentals) ## Top Upstate South Carolina Hotel Reviews ![Best Western Plus Greenville I-385 Inn & Suites](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/f09ffe86_y.jpg) ### Best Western Plus Greenville I-385 Inn & Suites 10/10 Excellent "Very clean and lots of great touches like hot chocolate. Fantastic breakfast and great location. " [](https://expedia.com/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) ![Best Western Plus Clemson Hotel & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/1400/1370/w3837h2558x3y3-4efd29d6_y.jpg) ### Best Western Plus Clemson Hotel & Conference Center 6/10 Okay "Dirty hallways; terrible gym facilities." [](https://expedia.com/Anderson-Hotels-Best-Western-Plus-University-Inn-Conference-Center.h1370.Hotel-Information) ![Comfort Inn Greenville - Haywood Mall](https://images.trvl-media.com/lodging/1000000/30000/25000/24994/840ecd1b_y.jpg) ### Comfort Inn Greenville - Haywood Mall 6/10 Okay "Not very clean Old facilities" [](https://expedia.com/Greenville-Hotels-Comfort-Inn-Greenville-Haywood-Mall.h24994.Hotel-Information) ![Aloft Greenville Downtown](https://images.trvl-media.com/lodging/12000000/11960000/11959000/11958914/d91c1d51_y.jpg) ### Aloft Greenville Downtown 10/10 Excellent "We love the friendly staff. Parking garage is attached to the hotel Great location." [](https://expedia.com/Greenville-Hotels-Aloft-Greenville-Downtown.h11958914.Hotel-Information) ![Hyatt Place Greenville/Haywood](https://images.trvl-media.com/lodging/1000000/70000/64600/64570/w3840h2556x0y3-09ad394d_y.jpg) ### Hyatt Place Greenville/Haywood 4/10 Poor "Old building " [](https://expedia.com/Greenville-Hotels-Hyatt-Place-GreenvilleHaywood.h64570.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/5971f25f_y.jpg) ### La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd. 10/10 Excellent "No breakfast " [](https://expedia.com/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Woodruff-Rd.h22513453.Hotel-Information) ![Embassy Suites Greenville Golf Resort & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/b0e15e12_y.jpg) ### Embassy Suites Greenville Golf Resort & Conference Center 8/10 Good "The food was great but the room was to cold for me and my wife comfort. I tried many times to rise the temperature but it only went to 72.When I stay again for more than one night I will call the front desk to send maintenance to repair the issue." [](https://expedia.com/Greenville-Hotels-Embassy-Suites-Greenville-Golf-Resort-Conference-Center.h3223.Hotel-Information) ![Lakeside Lodge Clemson](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/db449d90_y.jpg) ### Lakeside Lodge Clemson 2/10 Terrible "I must have gotten the absolute worst room here. The last time I stayed I had a great room with a balcony. This time, I got a "patio," that I even paid extra for that connected to the parking lot overlooking the highway on the fist floor. The room smelled AWFUL. Then I realized it must have been a pet room. Smelled like dog urine and the front desk said they couldn't move me because I had booked through Expedia. They offered to spray the room. With what, I have no idea. Probably some kind of dog urine spray reducer. Gross. Very disappointed. " [](https://expedia.com/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information) ![Homewood Suites by Hilton Greenville Downtown](https://images.trvl-media.com/lodging/30000000/29060000/29050100/29050020/88b33cc2_y.jpg) ### Homewood Suites by Hilton Greenville Downtown 10/10 Excellent "The staff all were perhaps the nicest of any hotel I’ve stayed at. From the reception to the maintenance to the breakfast service, without exception. Quiet, large room. Nice covered parking. Good breakfast selection. Great location. " [](https://expedia.com/Greenville-Hotels-Homewood-Suites-By-Hilton-Greenville-Downtown.h29050020.Hotel-Information) ## Find out more about Upstate South Carolina **Everything you need to know about Upstate South Carolina vacation rentals** Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Upstate South Carolina vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on. There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Upstate South Carolina vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. **Upstate South Carolina vacation rentals: An excellent choice for every season** Whenever you want to travel, a warm welcome awaits you in Upstate South Carolina. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Upstate South Carolina in high season. Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $106 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals! **How to find incredible deals on Upstate South Carolina rentals** At Expedia, we put the best Upstate South Carolina vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. To find some top Upstate South Carolina rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Upstate South Carolina vacation. If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Upstate South Carolina. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. ## Explore a world of travel with Expedia - Trending destinations on Expedia.com - All accommodation types in Upstate South Carolina ### Trending destinations on Expedia.com - [Destin Vacation Rentals ](https://www.expedia.com/Destin-Vacation-Rentals.d6906.Travel-Guide-VacationRentals) - [Panama City Vacation Rentals ](https://www.expedia.com/Panama-City-Beach-Vacation-Rentals.d8021.Travel-Guide-VacationRentals) - [Hilton Head Vacation Rentals ](https://www.expedia.com/Hilton-Head-Island-Vacation-Rentals.d601684.Travel-Guide-VacationRentals) - [Gulf Shores Vacation Rentals ](https://www.expedia.com/Gulf-Shores-Vacation-Rentals.d603078.Travel-Guide-VacationRentals) - [Key West Vacation Rentals ](https://www.expedia.com/Key-West-Vacation-Rentals.d1187.Travel-Guide-VacationRentals) - [Gatlinburg Vacation Rentals ](https://www.expedia.com/Gatlinburg-Vacation-Rentals.d7474.Travel-Guide-VacationRentals) - 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[Resorts in Upstate South Carolina ](https://expedia.com/Upstate-South-Carolina-Resorts.d553248635975748552-aaResorts.Travel-Guide-Accommodation) ### Expedia's Latest Trends Hotels - [Hotels with Early Check-in in Greenville - Spartanburg](https://expedia.com/Greenville-Spartanburg-Hotels-Hotel-With-Early-Check-In.0-0-d6035267-thotelwithearlycheckin.Travel-Guide-Filter-Hotels) - [Coastal South Carolina Hotels with a Swim-up Bar](https://expedia.com/Coastal-South-Carolina-Hotels-Hotels-With-Swimup-Bar.0-0-d6057937-tHotelswithSwimupBar.Travel-Guide-Filter-Hotels) - [Hyatt Hotels Hotels in Greenville - Spartanburg](https://expedia.com/Greenville-Spartanburg-Hotels-Hyatt-Hotels.0-0-d6035267--bHyattHotels.Travel-Guide-Filter-Hotels) - [Greenville - Spartanburg Golf Hotels](https://expedia.com/Greenville-Spartanburg-Hotels-Golf-Hotel.0-0-d6035267-tGolfHotel.Travel-Guide-Filter-Hotels) - [Extended Stay Hotels in Greenville - Spartanburg](https://expedia.com/Greenville-Spartanburg-Hotels-Extended-Stay-Hotels.0-0-d6035267-tExtendedStayHotels.Travel-Guide-Filter-Hotels) - 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