Upstate South Carolina, SC

Travel Guide

Photo provided by South Carolina Department of Parks, Recreation & Tourism
Photo provided by Visit Greenville, South Carolina
Photo provided by South Carolina Department of Parks, Recreation & Tourism
Photo provided by Visit Greenville, South Carolina
Photo provided by Visit Greenville, South Carolina

Where to stay in Upstate South Carolina

Greenville featuring autumn leaves, a garden and a bridge

Greenville Downtown

5/5(654 area reviews)

The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.

Greenville Downtown
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Nicholtown

If you're spending some time in Nicholtown, Pleasantburg Shopping Center and Swamp Rabbit Trail are top sights worth seeing.

Nicholtown
Greenville - Spartanburg showing a sunset, tranquil scenes and mountains

Overbrook Historic District

While Overbrook Historic District might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Bon Secours Wellness Arena and Beattie House.

Overbrook Historic District
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West End

Arts and entertainment thrive in this Greenville neighborhood, with cultural events at the Peace Center and baseball games at Fluor Field at the West End. Don't miss Falls Park on the Reedy and the picturesque Liberty Bridge crossing the river.

West End
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Green Avenue

If you're looking for some top things to see and do in Green Avenue and surrounding area, you can visit Fluor Field at the West End and The Peace Center.

Green Avenue
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Pettigru Street Historic District

Tree-lined Pettigru Street Historic District boasts diverse architectural styles like Queen Anne, Colonial Revival, and Bungalow. Don't miss the Poinsett Club, Hayne School, and Pettigru Place Bed and Breakfast.

Pettigru Street Historic District
Hilton Greenville

Hilton Greenville

3.5 out of 5
45 W Orchard Park Dr Greenville SC
$100 nightly
The price is $110 total per night from Jan 25 to Jan 26
$110 total
Jan 25 - Jan 26
Total with taxes and fees
Book a stay at this business-friendly hotel in Greenville. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
8.2/10 Very Good! (1,001 reviews)
Convenient and clean

Reviewed on Jan 11, 2026

Hilton Greenville
Hyatt Regency Greenville

Hyatt Regency Greenville

3.5 out of 5
220 N Main St Greenville SC
$149 nightly
The price is $163 total per night from Jan 25 to Jan 26
$163 total
Jan 25 - Jan 26
Total with taxes and fees
Book a stay at this business-friendly hotel in Greenville. Enjoy free WiFi, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.6/10 Excellent! (1,004 reviews)
Great

Reviewed on Jan 7, 2026

Hyatt Regency Greenville
Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4 out of 5
44 EAST CAMPERDOWN WAY Greenville SC
$235 nightly
The price is $258 total per night from Jan 25 to Jan 26
$258 total
Jan 25 - Jan 26
Total with taxes and fees
Book a stay at this spa hotel in Greenville. Enjoy a full-service spa, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff ...
9.4/10 Exceptional! (435 reviews)
Great room and view if falls

Reviewed on Jan 11, 2026

Grand Bohemian Lodge Greenville, Autograph Collection
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
stayAPT Suites Greenville-Haywood Mall

stayAPT Suites Greenville-Haywood Mall

3 out of 5
85 Mall Connector Rd Greenville SC
Book a stay at this business-friendly aparthotel in Greenville. Enjoy free WiFi, free parking, and a 24-hour fitness center. Our guests praise the helpful staff ...
9/10 Wonderful! (200 reviews)
I didn’t stay for breakfast. But the rooms were clean and stocked. The apartment was closer than I expected to my meeting and I will definitely stay there again! Staff communication was excellent and professional.

Reviewed on Jan 11, 2026

stayAPT Suites Greenville-Haywood Mall
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

2 out of 5
299 Outpost Rd Seneca SC
Stay at this cabin in Seneca. Enjoy free parking, patios, and climate control. Popular attractions Friendship Recreaction Area and Cross Creek Plantation Golf ...
9.6/10 Exceptional! (54 reviews)
Excellent stay.

Reviewed on Dec 26, 2025

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Wooded Cottage - 3 Mi to Clemson University

Wooded Cottage - 3 Mi to Clemson University

3 out of 5
Clemson SC
Stay at this cottage in Clemson. Enjoy air conditioning. Popular attractions Clemson Area African American Museum and Larry W. Abernathy Waterfront Park are ...
Wooded Cottage - 3 Mi to Clemson University
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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