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Top South San Diego Luxury Hotels

The Rambler

3.0 star property
9.0 out of 10, Wonderful, (1909)
"Great stay"
$106 nightly
The price is $123
Oct 1 - Oct 2
Total with taxes and fees
The Rambler

Hercor Hotel - Urban Boutique

3.0 star property
8.6 out of 10, Excellent, (1245)
"We enjoyed our stay and staff was fantastic "
$107 nightly
The price is $118
Sep 28 - Sep 29
Total with taxes and fees
Hercor Hotel - Urban Boutique

Howard Johnson Suites by Wyndham San Diego Chula Vista/BayFt

2.0 star property
6.6 out of 10, (1003)
"Cool place to stay"
$111 nightly
The price is $122
Sep 7 - Sep 8
Total with taxes and fees
Howard Johnson Suites by Wyndham San Diego Chula Vista/BayFt

Hotel Palmeras Chula Vista

2.0 star property
7.0 out of 10, Good, (1857)
"Great stay"
$76 nightly
The price is $84
Sep 2 - Sep 3
Total with taxes and fees
Hotel Palmeras Chula Vista

El Primero Hotel

2.5 star property
9.2 out of 10, Wonderful, (1002)
"Favorite Hotel in Chula Vista"
$91 nightly
The price is $100
Sep 2 - Sep 3
Total with taxes and fees
El Primero Hotel

La Quinta Inn by Wyndham San Diego Chula Vista

3.0 star property
8.6 out of 10, Excellent, (1397)
"Great place to stay at , along with a good breakfast variety. Overall I'll stay here again"
$104 nightly
The price is $114
Sep 7 - Sep 8
Total with taxes and fees
La Quinta Inn by Wyndham San Diego Chula Vista

Best Western Americana Inn

2.5 star property
9.0 out of 10, Wonderful, (1145)
"Breakfast was amazing! "
$116 nightly
The price is $132
Sep 30 - Oct 1
Total with taxes and fees
Best Western Americana Inn

Comfort Inn Chula Vista San Diego South

2.5 star property
8.2 out of 10, Very Good, (1063)
"Good place to stay when in the area."
$108 nightly
The price is $119
Sep 8 - Sep 9
Total with taxes and fees
Comfort Inn Chula Vista San Diego South

Quality Suites San Diego Otay Mesa

2.5 star property
7.2 out of 10, Good, (1011)
"Nice place. Clean and quiet. "
$107 nightly
The price is $122
Sep 21 - Sep 22
Total with taxes and fees
Quality Suites San Diego Otay Mesa

Big 7 Motel Chula Vista I-5

2.5 star property
6.2 out of 10, (933)
"The hotel is suitable for a one-night stay or a short visit. The staff is friendly, and the place was clean, which is the most important thing."
$89 nightly
The price is $97
Sep 7 - Sep 8
Total with taxes and fees
Big 7 Motel Chula Vista I-5
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about South San Diego

Find out more about South San Diego

How to find luxury hotels in South San Diego on Expedia

Finding some of the best South San Diego luxury hotels is a breeze on Expedia thanks to the wide selections of properties available and easy-to-use search wizard. Select your travel dates and, within seconds, it'll show you some of the best luxury hotels in South San Diego. You can then customize the results using the search filters, such as “star rating”. 5-star hotels in South San Diego are renowned for their exceptional hospitality that'll make you feel like royalty. There are also top-rated 4-star hotels in South San Diego that are worth adding to your wish list.  

Expedia's range of high-end properties will place you in some of South San Diego most upscale areas. The “popular locations” and “neighborhood” search filter let you pinpoint hotels in the most exclusive parts of town. If you're planning on a dip in the pool or chilling out with a glass of bubbly in the hot tub, the amenities filters are especially helpful. Once you've found your ideal South San Diego luxury hotel, you can book a room in just a few easy clicks.  

Plan your South San Diego luxury stay

When weighing up your options for your getaway, it's a good idea to think about what kind of room you'd like to stay in. From sprawling executive suites to state-of-the-art penthouse rooms, you'll find it all on Expedia. Keep an eye out for the size of the room, as well as the type of bedding and views it has. All this information, as well as the cancellation policy, is clearly displayed on Expedia. Luxury hotels with breakfast included in South San Diego are a popular option where you can, for example, expect artisan breads, gourmet egg dishes, and the finest coffee. Use the “breakfast included” filter to pin down these properties. 

Popular luxurious hotels

Most upscale stays in South San Diego in 2025

Some of the most popular luxurious hotels in South San Diego boast indulgent spas and wellness centers. Enjoy a restorative facial, pamper your senses with a therapeutic massage, and rejuvenate body and mind with holistic treatments. Be sure to select the “spa” search filter on Expedia to view these types of properties. Many upscale hotels offer concierge services and curated local experiences, allowing you to uncover South San Diego's hidden gems and get off the beaten path.  

You'll also want to consider the dining options on offer at different South San Diego luxury hotels. The most prestigious properties typically boast opulent restaurants with spectacular views where you can dine on exquisite cuisine. A glass of champagne or after-dinner cocktails are a delightful treat while on vacation, so consider choosing somewhere with an on-site bar. The “bar” and “restaurant” search filters can help locate these. 

Why plan your South San Diego luxury stay on Expedia

From prestigious international brands to high-end local boutiques, you'll find a wide selection of South San Diego luxury hotels on Expedia. The varied search filters give you total control over your search, making it a breeze to find your ideal place to stay. Whether you're seeking a personalized concierge service that caters to your every whim or chic design and elegant interiors, Expedia's detailed hotel descriptions mean you'll know exactly what to expect when you arrive. 

The most upscale stays in South San Diego in 2025 tend to get booked up in advance. Fortunately, many properties on Expedia allow for free cancellation, so might be able to book your first choice of hotel even if your plans aren't 100% certain. Make sure to read the terms and conditions before booking. 

Top South San Diego Hotel Reviews

Explore a world of travel with Expedia

Explore a world of travel with Expedia