An aerial view of a town with industrial buildings, roads, and green areas.

St. Charles Vacation Rentals

  • Bundle & Save

    Get more, spend less whenever you see Bundle & Save deals

  • OneKeyCash

    Earn OneKeyCash on all your eligible bookings

  • Upfront pricing

    We are not like the others - we include taxes and fees

Check prices for these dates

In two weeks
Aug 7 - Aug 9
In two months
Sep 18 - Sep 20
In three months
Oct 16 - Oct 18
In four months
Nov 13 - Nov 15

Our top choices for St. Charles vacation rentals

Terrace/patio

Treehouse Cabin in the Bluff Woodlands

Treehouse Cabin in the Bluff Woodlands
Elba
9.8 out of 10, Exceptional, (16 reviews)
"Beautiful area enjoyed our stay immensely"
United Kingdom
I.M l.
$172 nightly
The price is $185
Aug 7 - Aug 8
Total with taxes and fees
Treehouse Cabin in the Bluff Woodlands
Property grounds

Treehouse Cabin in the Bluff Woodlands South

Treehouse Cabin in the Bluff Woodlands South
Elba
10.0 out of 10, Exceptional, (13 reviews)
"My family of 4 had a wonderful stay!"
United States
Josh S.
$191 nightly
The price is $205
Jul 28 - Jul 29
Total with taxes and fees
Treehouse Cabin in the Bluff Woodlands South
Terrace/patio

Treehouse Cabin in the Bluff Woodlands North

Treehouse Cabin in the Bluff Woodlands North
Elba
9.6 out of 10, Exceptional, (9 reviews)
"Great area a place to stay. "
United States
Paul T.
$190 nightly
The price is $204
Jul 27 - Jul 28
Total with taxes and fees
Treehouse Cabin in the Bluff Woodlands North
Interior

Valley Cabin

Valley Cabin
Spring Valley
9.2 out of 10, Wonderful, (7 reviews)
"Great property with plenty of outdoor activities. Had fun fishing the stream and exploring the area. Dan is a great host and I will be visiting again."
United States
JAKE I.
$106 nightly
The price is $114
Jul 27 - Jul 28
Total with taxes and fees
Valley Cabin
Terrace/patio

Three Treehouse Cabins in the Bluff Woodlands

Three Treehouse Cabins in the Bluff Woodlands
Elba
$526 nightly
The price is $566
Jul 28 - Jul 29
Total with taxes and fees
Three Treehouse Cabins in the Bluff Woodlands
Exterior

Magical Nest Hideaway

Magical Nest Hideaway
Rochester
10.0 out of 10, Exceptional, (159 reviews)
"An excellent place to stay! Clean, private, safe and beautiful neighborhood. "
United States
Brandi B.
$119 nightly
The price is $137
Jul 29 - Jul 30
Total with taxes and fees
Magical Nest Hideaway
Smart TV, books

Vintage Lustron Home Piece of History

Vintage Lustron Home Piece of History
Minnesota City
10.0 out of 10, Exceptional, (33 reviews)
"I loved staying here! The interior was comfortable, cozy, and fascinating! "
United States
melanie
$225 nightly
The price is $242
Aug 3 - Aug 4
Total with taxes and fees
Vintage Lustron Home Piece of History
Dining

Discounted Charming 2-bedroom main-level TRIPLEX in Rochester

Discounted Charming 2-bedroom main-level TRIPLEX in Rochester
East Side Pioneers
9.2 out of 10, Wonderful, (17 reviews)
"The place was great"
United States
Michelle L.
$182 nightly
The price is $210
Aug 2 - Aug 3
Total with taxes and fees
Discounted Charming 2-bedroom main-level TRIPLEX in Rochester
Smart TV, fireplace, books

Discounted Oasis! 5 Star-3 Bedroom Showstopping Duplex 4 Minutes to Mayo Clinic!

Discounted Oasis! 5 Star-3 Bedroom Showstopping Duplex 4 Minutes to Mayo Clinic!
East Side Pioneers
9.0 out of 10, Wonderful, (35 reviews)
"Great place to stay! "
United States
Melissa H.
$240 nightly
The price is $276
Aug 3 - Aug 4
Total with taxes and fees
Discounted Oasis! 5 Star-3 Bedroom Showstopping Duplex 4 Minutes to Mayo Clinic!
Smart TV, DVD player, foosball, books

2 steps entry 1mile to Mayo CoveredByFaith Inspire

2 steps entry 1mile to Mayo CoveredByFaith Inspire
Parkway
10.0 out of 10, Exceptional, (2 reviews)
" Wet comfortable place to stay. "
United States
Brad T.
$225 nightly
The price is $259
Jul 28 - Jul 29
Total with taxes and fees
2 steps entry 1mile to Mayo CoveredByFaith Inspire
Smart TV

ColorHouse | 1 mi to Mayo Clinic, No Stairs Entry

ColorHouse | 1 mi to Mayo Clinic, No Stairs Entry
East Side Pioneers
9.0 out of 10, Wonderful, (14 reviews)
"Great place!"
United States
Jeremiah E.
$261 nightly
The price is $300
Jul 27 - Jul 28
Total with taxes and fees
ColorHouse | 1 mi to Mayo Clinic, No Stairs Entry
Coffee/tea maker, fridge, microwave, oven

Big River Escape Coyote Camper #1

Big River Escape Coyote Camper #1
Buffalo City
10.0 out of 10, Exceptional, (1 review)
"Awesome as usual "
United States
Matthew B.
$138 nightly
The price is $146
Aug 4 - Aug 5
Total with taxes and fees
Big River Escape Coyote Camper #1
Exterior detail

Charming 1-bedroom house in delightful Winona with WiFi, AC and PRIVATE PATIO

Charming 1-bedroom house in delightful Winona with WiFi, AC and PRIVATE PATIO
Historic Downtown Winona
10.0 out of 10, Exceptional, (27 reviews)
"Very clean, great hosts, fully equipped we everything we needed. "
United States
Amy B.
$171 nightly
The price is $190
Jul 27 - Jul 28
Total with taxes and fees
Charming 1-bedroom house in delightful Winona with WiFi, AC and PRIVATE PATIO
Interior

Apple Blossom Cottage | 2 Mi from Mayo Clinic

Apple Blossom Cottage | 2 Mi from Mayo Clinic
Rochester
9.8 out of 10, Exceptional, (12 reviews)
"Very comfortable home away from home"
United States
ROBERT B.
Apple Blossom Cottage | 2 Mi from Mayo Clinic
Living area

Farmhouse Apartment - River Road Historic Home

Farmhouse Apartment - River Road Historic Home
Fountain City
10.0 out of 10, Exceptional, (22 reviews)
"We enjoyed watching the river. We especially liked watching the migrating birds and the tug boats. The property was clean and the owner was responsive when we had a question. Check out was easy and the only cleaning requirements were to wash any dishes and clean up any messes."
United States
Linda S.
$220 nightly
The price is $232
Aug 4 - Aug 5
Total with taxes and fees
Farmhouse Apartment - River Road Historic Home
Exterior

Turtle Cabin Near Mississippi River

Turtle Cabin Near Mississippi River
Buffalo City
10.0 out of 10, Exceptional, (2 reviews)
"Beautiful area, friendly locals. Perfect place to stay for aome family time! We can't wait to come back!"
United States
Sarah M.
$172 nightly
The price is $182
Aug 4 - Aug 5
Total with taxes and fees
Turtle Cabin Near Mississippi River
Exterior

Riverfront Cabin with Private Dock

Riverfront Cabin with Private Dock
Buffalo City
10.0 out of 10, Exceptional, (4 reviews)
"Great place!!!"
United States
Cynthia B.
$174 nightly
The price is $184
Aug 4 - Aug 5
Total with taxes and fees
Riverfront Cabin with Private Dock
Coffee/tea maker, fridge, microwave, oven

Discounted Oasis, 2 Bedroom Lower-Level Duplex 5 Minutes to Mayo Clinic!

Discounted Oasis, 2 Bedroom Lower-Level Duplex 5 Minutes to Mayo Clinic!
Rochester
9.4 out of 10, Exceptional, (31 reviews)
"This was a very clean and cozy property."
United States
Angela O.
$188 nightly
The price is $216
Jul 28 - Jul 29
Total with taxes and fees
Discounted Oasis, 2 Bedroom Lower-Level Duplex 5 Minutes to Mayo Clinic!
3 bedrooms, desk, iron/ironing board, travel crib

Cozy 3BR near Mayo and downtown. Charming, spotless, and designed for comfort with restful bedrooms, a stocked kitchen, and two welcoming living spaces. Perfect for Mayo visits, business trips, or family stays. Dogs allowed, too.

Cozy 3BR near Mayo and downtown. Charming, spotless, and designed for comfort with restful bedrooms, a stocked kitchen, and two welcoming living spaces. Perfect for Mayo visits, business trips, or family stays. Dogs allowed, too.
Rochester
9.8 out of 10, Exceptional, (8 reviews)
"This house is adorable and comfortable! The back yard is beautiful and location is central and quiet. The kitchen is fully stocked with anything you would need and plus some more. The house is thoughtfully planned out and clean. The bedrooms are very nice and the pillows and mattresses are very comfortable! Highly recommend."
United States
Nicolle D
$408 nightly
The price is $467
Jul 28 - Jul 29
Total with taxes and fees
Cozy 3BR near Mayo and downtown. Charming, spotless, and designed for comfort with restful bedrooms, a stocked kitchen, and two welcoming living spaces. Perfect for Mayo visits, business trips, or family stays. Dogs allowed, too.
Coffee/tea maker, fridge, microwave, oven

Meet Don - A Modern, Zero-step, Pet-friendly home in Rochester

Meet Don - A Modern, Zero-step, Pet-friendly home in Rochester
Slatterly Park
10.0 out of 10, Exceptional, (32 reviews)
"Great host, great property!"
United States
Ashley T.
$206 nightly
The price is $237
Aug 3 - Aug 4
Total with taxes and fees
Meet Don - A Modern, Zero-step, Pet-friendly home in Rochester
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top St. Charles Hotel Reviews

Hampton Inn Rochester-South

Hampton Inn Rochester-South

10/10 Excellent
"Everything good as you would expect at a Hampton Inn"
Tim 1-night trip
Posted 1 hour ago
Hampton Inn Rochester-South

Find out more about St. Charles

Everything you need to know about St. Charles vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the St. Charles vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect St. Charles vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

St. Charles vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in St. Charles. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit St. Charles in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $137 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on St. Charles rentals

At Expedia, we put the best St. Charles vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top St. Charles rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream St. Charles vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around St. Charles. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Can I find vacation rentals in St. Charles?

Yes, we offer vacation rentals close to the most popular attractions in St. Charles, or you can go with a more remote option if you want a relaxing place to stay. St. Charles is known for its parks.

What are some of the best vacation rentals that St. Charles has to offer?

Clean, fun, comfy ranch home near parks, 2.5 mi to Mayo w Pingpong and Playroom: Visitors like this St. Charles vacation home rental. It offers a patio, a garden, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Make the most of the selection of games in this rental home to help you unwind.

What can I see and do in St. Charles?

While you're exploring the area, Whitewater River and Root River are a couple of picturesque spots to get outside and enjoy nature. Whitewater State Park and St. Mary's University of Minnesota are a couple of places you'll find in the larger area.

What are vacation rentals like in St. Charles?

Vacation rentals are privately owned properties you can book for short or long periods in St. Charles. Vacation rentals feature amenities such as patios, hot tubs, and fire pits so your stay will be comfortable. If you're concerned about a clean environment, a vacation rental can offer a sense of seclusion away from public hotel elevators and lobbies bustling with people while still allowing you to travel. You'll also find more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is an attractive choice for families.