An aerial view of a town with industrial buildings, roads, and green areas.

St. Charles Vacation Rentals

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Check prices for these dates

In two weeks
Sep 4 - Sep 6
In two months
Oct 16 - Oct 18
In three months
Nov 13 - Nov 15
In four months
Dec 11 - Dec 13

Our top choices for St. Charles vacation rentals

A wooden cabin with a porch, two chairs, and a door.

1. Tiny Treehouse Cabin | Bluff Woodlands #2

Tiny Treehouse Cabin | Bluff Woodlands #2
Elba
9.8 out of 10, Exceptional, (16 reviews)
"Beautiful area enjoyed our stay immensely"
United Kingdom
I.M l.
$178 nightly
The price is $191
Aug 24 - Aug 25
Total with taxes and fees
Tiny Treehouse Cabin | Bluff Woodlands #2
A covered deck with outdoor seating, surrounded by a forested area.

2. Tiny Treehouse Cabin | Bluff Woodlands #3

Tiny Treehouse Cabin | Bluff Woodlands #3
Elba
10.0 out of 10, Exceptional, (13 reviews)
"My family of 4 had a wonderful stay!"
United States
Josh S.
$193 nightly
The price is $207
Aug 24 - Aug 25
Total with taxes and fees
Tiny Treehouse Cabin | Bluff Woodlands #3
Two wooden cabins elevated on stilts in a forest, with outdoor seating and hammocks.

3. Tiny Treehouse Cabin | Bluff Woodlands #1

Tiny Treehouse Cabin | Bluff Woodlands #1
Elba
9.6 out of 10, Exceptional, (9 reviews)
"Great area a place to stay. "
United States
Paul T.
$193 nightly
The price is $207
Aug 24 - Aug 25
Total with taxes and fees
Tiny Treehouse Cabin | Bluff Woodlands #1
A spacious living area with a wooden dining table, a sofa, and a TV mounted on the wall.

4. Hygge House | A Cozy Guesthouse

Hygge House | A Cozy Guesthouse
Rochester
10.0 out of 10, Exceptional, (20 reviews)
"Very clean and cozy spot. Stayed here to take my husband to Mayo and the drive was really easy!"
United States
Mady F.
$190 nightly
The price is $204
Aug 30 - Aug 31
Total with taxes and fees
Hygge House | A Cozy Guesthouse
A compact RV kitchen with wooden cabinets, a stove, and a dining area with a bench.

5. Big River Escape Coyote Camper #1

Big River Escape Coyote Camper #1
Buffalo City
10.0 out of 10, Exceptional, (1 review)
"Awesome as usual "
United States
Matthew B.
$138 nightly
The price is $146
Aug 24 - Aug 25
Total with taxes and fees
Big River Escape Coyote Camper #1
A wooden cabin with a porch, two chairs, and a door.

6. Three Treehouse Cabins in the Bluff Woodlands

Three Treehouse Cabins in the Bluff Woodlands
Elba
$525 nightly
The price is $565
Aug 24 - Aug 25
Total with taxes and fees
Three Treehouse Cabins in the Bluff Woodlands
A living room with a television, sofa, coffee table, and shelves with decorative items.

7. Vintage Lustron Home Piece of History

Vintage Lustron Home Piece of History
Minnesota City
10.0 out of 10, Exceptional, (34 reviews)
"I loved staying here! The interior was comfortable, cozy, and fascinating! "
United States
melanie
$233 nightly
The price is $251
Aug 31 - Sep 1
Total with taxes and fees
Vintage Lustron Home Piece of History
A wooden cabin interior with a sofa, dining table, chairs, kitchen area, and a ceiling fan.

8. Turtle Cabin Near Mississippi River

Turtle Cabin Near Mississippi River
Buffalo City
10.0 out of 10, Exceptional, (2 reviews)
"Beautiful area, friendly locals. Perfect place to stay for aome family time! We can't wait to come back!"
United States
Sarah M.
$144 nightly
The price is $152
Sep 1 - Sep 2
Total with taxes and fees
Turtle Cabin Near Mississippi River
A two-story house with a covered patio and a pathway leading to the entrance.

9. Magical Nest Hideaway

Magical Nest Hideaway
Rochester
10.0 out of 10, Exceptional, (160 reviews)
"An excellent place to stay! Clean, private, safe and beautiful neighborhood. "
United States
Brandi B.
$119 nightly
The price is $137
Sep 6 - Sep 7
Total with taxes and fees
Magical Nest Hideaway

10. Riverfront Cabin with Private Dock

Riverfront Cabin with Private Dock
Buffalo City
10.0 out of 10, Exceptional, (5 reviews)
"Great place!!!"
United States
Cynthia B.
$171 nightly
The price is $180
Sep 8 - Sep 9
Total with taxes and fees
Riverfront Cabin with Private Dock

11. Farmhouse Apartment - River Road Historic Home

Farmhouse Apartment - River Road Historic Home
Fountain City
9.8 out of 10, Exceptional, (24 reviews)
"Beautiful property with views of the Mississippi. Host checked in on us often and was very accommodating. We really enjoyed reading about the history of the home. There were so many cute details including a framed print of the original house plans. Nice place to stay."
United States
Heather O.
$223 nightly
The price is $235
Aug 24 - Aug 25
Total with taxes and fees
Farmhouse Apartment - River Road Historic Home
A wooden cabin interior with a dining table, chairs, a refrigerator, a stove, and a ladder leading to a loft.

12. Badger Cabin w/ Lofts, Fireplace & WiFi

Badger Cabin w/ Lofts, Fireplace & WiFi
Buffalo City
10.0 out of 10, Exceptional, (1 review)
"The cabin was adorable. Greg was great! The cabin was spotless. Great water pressure. It rained and it was lovely with the tin roof:) The tv reception was good and the wi - fi was great. Loved it!"
United States
Sharon M.
$175 nightly
The price is $185
Aug 24 - Aug 25
Total with taxes and fees
Badger Cabin w/ Lofts, Fireplace & WiFi

13. 2.5 miles to Mayo, 4 steps entry Covered By Faith

2.5 miles to Mayo, 4 steps entry Covered By Faith
Rochester
10.0 out of 10, Exceptional, (1 review)
$293 nightly
The price is $355
Aug 25 - Aug 26
Total with taxes and fees
2.5 miles to Mayo, 4 steps entry Covered By Faith
A living room with a yellow armchair, a blue sofa, a patterned rug, a small white table, and a TV mounted on a brick wall.

14. The Little House | 1 mi from downtown, Love Pets!

The Little House | 1 mi from downtown, Love Pets!
Slatterly Park
10.0 out of 10, Exceptional, (21 reviews)
"Beautiful little house and comfortable stay."
United States
Cheryl P.
$229 nightly
The price is $263
Aug 24 - Aug 25
Total with taxes and fees
The Little House | 1 mi from downtown, Love Pets!
A modern living room with a flat-screen TV, a sofa, a coffee table, and a fireplace.

15. Discounted Oasis! 5 Star-3 Bedroom Showstopping Duplex 4 Minutes to Mayo Clinic!

Discounted Oasis! 5 Star-3 Bedroom Showstopping Duplex 4 Minutes to Mayo Clinic!
East Side Pioneers
9.0 out of 10, Wonderful, (35 reviews)
"Great place to stay! "
United States
Melissa H.
$268 nightly
The price is $309
Aug 29 - Aug 30
Total with taxes and fees
Discounted Oasis! 5 Star-3 Bedroom Showstopping Duplex 4 Minutes to Mayo Clinic!
A living room with a sectional sofa, a dining area with a table and chairs, and a kitchen in the background.

16. Meet Bev, a charming 2-bedroom, pet-friendly home in Rochester

Meet Bev, a charming 2-bedroom, pet-friendly home in Rochester
Washington
10.0 out of 10, Exceptional, (45 reviews)
"Wonderful place to stay. Caring hosts and great yard for dogs"
United States
Ashley A.
$182 nightly
The price is $209
Aug 31 - Sep 1
Total with taxes and fees
Meet Bev, a charming 2-bedroom, pet-friendly home in Rochester
A spacious living room with a fireplace, a television mounted on the wall, and a dining area with a table and chairs.

17. The Gwen | 2BR Apt, Fenced Yard, Pets, <3mi Mayo

The Gwen | 2BR Apt, Fenced Yard, Pets, <3mi Mayo
Rochester
9.8 out of 10, Exceptional, (7 reviews)
"This is a very nice property to stay at with a fenced in yard for the dogs. Plenty of room, good condition, close to everything you need and nice host. We would definitely stay there again!"
United States
Shanda H.
The Gwen | 2BR Apt, Fenced Yard, Pets, <3mi Mayo
A modern kitchen with a central island, bar stools, and a view of the backyard through large sliding doors.

18. Meet Don - A Modern, Zero-step, Pet-friendly home in Rochester

Meet Don - A Modern, Zero-step, Pet-friendly home in Rochester
Slatterly Park
10.0 out of 10, Exceptional, (37 reviews)
"Great host, great property!"
United States
Ashley T.
$207 nightly
The price is $238
Aug 24 - Aug 25
Total with taxes and fees
Meet Don - A Modern, Zero-step, Pet-friendly home in Rochester
A living room with a television displaying a scenic view, a dark armchair, a sofa, and a wooden coffee table.

19. 2 steps entry 1mile to Mayo CoveredByFaith Inspire

2 steps entry 1mile to Mayo CoveredByFaith Inspire
Parkway
10.0 out of 10, Exceptional, (2 reviews)
" Wet comfortable place to stay. "
United States
Brad T.
$255 nightly
The price is $293
Sep 7 - Sep 8
Total with taxes and fees
2 steps entry 1mile to Mayo CoveredByFaith Inspire
A two-story house with a wooden staircase leading to a yellow door, a brick wall, and a window with a white frame.

20. Charming 1BR house with WiFi, AC, Private Patio + Cruiser Bikes & Grill Add-Ons

Charming 1BR house with WiFi, AC, Private Patio + Cruiser Bikes & Grill Add-Ons
Historic Downtown Winona
10.0 out of 10, Exceptional, (28 reviews)
"Very clean, great hosts, fully equipped we everything we needed. "
United States
Amy B.
$172 nightly
The price is $191
Sep 22 - Sep 23
Total with taxes and fees
Charming 1BR house with WiFi, AC, Private Patio + Cruiser Bikes & Grill Add-Ons
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top St. Charles Hotel Reviews

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

8/10 Good
"the pool deck was very slippery."
Jerry 3-night trip
Posted 4 hours ago
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Find out more about St. Charles

Everything you need to know about St. Charles vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the St. Charles vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect St. Charles vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

St. Charles vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in St. Charles. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit St. Charles in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $123 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on St. Charles rentals

At Expedia, we put the best St. Charles vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top St. Charles rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream St. Charles vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around St. Charles. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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Frequently asked questions

Can I find vacation rentals in St. Charles?

Yes, we offer vacation rentals close to the most popular attractions in St. Charles, or you can go with a more remote option if you want a relaxing place to stay. St. Charles is known for its parks.

What are some of the best vacation rentals that St. Charles has to offer?

The Hen House Retreat - A Comfortable Place to Roost: Visitors like this St. Charles vacation home rental. It is located in a rural location and has a fireplace, a patio, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You can relax into your vacation with a garden and a selection of games.

What can I see and do in St. Charles?

While you're exploring the area, Whitewater River and Root River are a couple of picturesque spots to get outside and enjoy nature. Whitewater State Park and St. Mary's University of Minnesota are a couple of places you'll find in the larger area.

What are vacation rentals like in St. Charles?

Vacation rentals are privately owned properties you can book for short or long periods in St. Charles. Vacation rentals feature amenities such as patios, hot tubs, and fire pits so your stay will be comfortable. If you're concerned about a clean environment, a vacation rental can offer a sense of seclusion away from public hotel elevators and lobbies bustling with people while still allowing you to travel. You'll also find more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is an attractive choice for families.