$109 Cheap American Airlines flights New Orleans (MSY) to Denver (DEN)

Landing cheap one-way American Airlines flights from MSY to DEN from $109 on Expedia couldn't be easier --- just filter by "Price (lowest to highest)." Alternatively, check out our affordable round-trip fares from $247 for your next getaway.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Look for affordable American Airlines flights from Louis Armstrong New Orleans Intl. Airport (MSY) to Denver Intl. Airport (DEN) one to three months prior to your departure. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. No matter the fare class and itinerary, the best day of the week to book a domestic flight is generally Sunday and the most expensive day is typically Monday. Passengers who book on a Sunday can save 6% on average compared to those who book on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Find American Airlines's earliest flights from MSY to DEN by selecting the "Early Morning" and "Morning" filters. Not only will you get to where you're going sooner, early departures also experience 20% fewer cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.