$232 Cheap Flights from Cleveland (CLE) to Panama City (PTY)

View $232 flight on Fri, Apr 24, 2026Opens in a new window

Popular airlines from Cleveland Hopkins International Airport (CLE) to Tocumen Intl. Airport (PTY)

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Cheap Flights from Cleveland to Panama City (CLE-PTY)

Prices were available within the past 7 days and start at $232 for one-way flights and $490 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Fri, Apr 24 - Tue, Apr 28
CLE
Cleveland
PTY
Panama City
$490 Roundtrip, found 2 hours ago
$490
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Fri, Apr 24 from Cleveland to Panama City, returning Tue, Apr 28, priced at $490 found 2 hours ago
Delta
Tue, Jan 13 - Wed, Jan 21
CLE
Cleveland
PTY
Panama City
$490 Roundtrip, found 12 hours ago
$490
Roundtrip
found 12 hours ago
Select Delta flight, departing Tue, Jan 13 from Cleveland to Panama City, returning Wed, Jan 21, priced at $490 found 12 hours ago
American Airlines
Fri, Dec 5 - Tue, Dec 9
CLE
Cleveland
PTY
Panama City
$494 Roundtrip, found 13 hours ago
$494
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Fri, Dec 5 from Cleveland to Panama City, returning Tue, Dec 9, priced at $494 found 13 hours ago
United
Sun, Dec 14 - Thu, Dec 18
CLE
Cleveland
PTY
Panama City
$497 Roundtrip, found 1 day ago
$497
Roundtrip
found 1 day ago
Select United flight, departing Sun, Dec 14 from Cleveland to Panama City, returning Thu, Dec 18, priced at $497 found 1 day ago
Delta
Sun, Mar 15 - Wed, Mar 25
CLE
Cleveland
PTY
Panama City
$498 Roundtrip, found 1 day ago
$498
Roundtrip
found 1 day ago
Select Delta flight, departing Sun, Mar 15 from Cleveland to Panama City, returning Wed, Mar 25, priced at $498 found 1 day ago
United
Thu, Mar 19 - Mon, Mar 23
CLE
Cleveland
PTY
Panama City
$500 Roundtrip, found 3 hours ago
$500
Roundtrip
found 3 hours ago
Select United flight, departing Thu, Mar 19 from Cleveland to Panama City, returning Mon, Mar 23, priced at $500 found 3 hours ago
American Airlines
Wed, Mar 11 - Wed, Mar 18
CLE
Cleveland
PTY
Panama City
$501 Roundtrip, found 4 hours ago
$501
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Wed, Mar 11 from Cleveland to Panama City, returning Wed, Mar 18, priced at $501 found 4 hours ago
American Airlines
Mon, Dec 15 - Fri, Dec 19
CLE
Cleveland
PTY
Panama City
$506 Roundtrip, found 17 hours ago
$506
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Mon, Dec 15 from Cleveland to Panama City, returning Fri, Dec 19, priced at $506 found 17 hours ago
Copa
Fri, Feb 13 - Sun, Mar 1
CLE
Cleveland
PTY
Panama City
$702 Roundtrip, found 1 hour ago
$702
Roundtrip
found 1 hour ago
Select Copa flight, departing Fri, Feb 13 from Cleveland to Panama City, returning Sun, Mar 1, priced at $702 found 1 hour ago
avianca
Wed, Oct 29 - Tue, Apr 14
CLE
Cleveland
PTY
Panama City
$1,330 Roundtrip, found 2 days ago
$1,330
Roundtrip
found 2 days ago
Select avianca flight, departing Wed, Oct 29 from Cleveland to Panama City, returning Tue, Apr 14, priced at $1,330 found 2 days ago

Find the cheapest month to fly from Cleveland (CLE) to Panama City (PTY)

April is typically the cheapest month to fly

From $437 - $1,241 per traveler.

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tocumen Intl. PTY. Cheapest option available. Average driving time to city center is 16 minutes. Flights from $1,578
PTY
Tocumen Intl.
Cheapest
Average driving time to city center16 min
Flights from $1,578
Flights from Cleveland (CLE) to Panama City (PTY)
Origin airport
Hopkins Intl.
Destination airport
Tocumen Intl.
Airlines serving
American Airlines, Copa, Delta, United, avianca
Roundtrip price
$489
Distance
2239 mi

Cleveland to Panama City Flights

The cheapest times to fly from Cleveland to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Cleveland to Panama City are during the month of April. You can find some of the cheapest flights from Cleveland to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Cleveland to Panama City

Sunday is one of the best days to book for cheap flights from Cleveland to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Cleveland to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Cleveland to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $232 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Cleveland to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Cleveland to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Hopkins Intl. Airport (CLE) to Tocumen Intl. Airport (PTY) cost?
Secure a cheap one-way flight from $232 or cheap return flight from $490 from Hopkins Intl. Airport (CLE) to Tocumen Intl. Airport (PTY) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Hopkins Intl. Airport (CLE) to Tocumen Intl. Airport (PTY)?
The cheapest month to fly from CLE to PTY is April, when demand is low. Off-peak months are generally when better flight deals are available between these airports.
What is the cheapest airline that flies from Hopkins Intl. Airport (CLE) to Tocumen Intl. Airport (PTY)?
Use the filters on Expedia to compare different airlines and find the most affordable carrier that'll fly you from CLE to PTY. Then, sort your results by "Price (lowest to highest)" to score a good deal.
How many flights per day from Hopkins Intl. Airport (CLE) to Tocumen Intl. Airport (PTY)?
There are no daily direct flights available from Hopkins Intl. Airport (CLE) to Tocumen Intl. Airport (PTY). But you can book flights with layovers. Filter your search on Expedia to include one or two stops, and you'll be cruising above the clouds before you know it.
What day of the week has the most flights from CLE to PTY?
You'll usually find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Hopkins Intl. Airport (CLE) to Tocumen Intl. Airport (PTY)?
Opt for a flight from Hopkins Intl. Airport (CLE) to Tocumen Intl. Airport (PTY) that leaves before 3 PM to reduce the likelihood of delays. Departures after this hour have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Hopkins Intl. Airport (CLE) to Tocumen Intl. Airport (PTY) last-minute?
Last-minute bookings from CLE to PTY are generally more expensive. To lock in the best rates, start looking for flights well in advance. That being said, if you're flexible with your travel plans, it's possible to land a cheap fare just before your departure.
Is it cheaper to book a CLE to PTY flight and hotel package?
Securing a CLE to PTY flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your trip all in one place. Choose from our wide range of hotels and then add activities, flights and car rentals to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Hopkins Intl. Airport (CLE) to Tocumen Intl. Airport (PTY)?
Typically, you can reschedule or cancel your CLE to PTY flight. However, additional charges may apply, especially if your booking was made more than 24 hours ago. Check your itinerary for the airline's policies and fees on flight changes, or if you need more details, go to our Customer Service portal.

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*Available to One Key members.