$545 Cheap Flights from Denver (DEN) to Santander (SDR)

View $545 flight on Fri, Nov 28, 2025Opens in a new window

Popular airlines from Denver Intl. Airport (DEN) to Santander (SDR)

Cheap Flights from Denver to Santander (DEN-SDR)

Prices were available within the past 7 days and start at $545 for one-way flights and $724 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Iberia
Wed, Feb 18 - Thu, Mar 5
DEN
Denver
SDR
Santander
$724 Roundtrip, found 4 days ago
$724
Roundtrip
found 4 days ago
Select Iberia flight, departing Wed, Feb 18 from Denver to Santander, returning Thu, Mar 5, priced at $724 found 4 days ago
Iberia
Wed, Feb 18 - Thu, Mar 5
DEN
Denver
SDR
Santander
$730 Roundtrip, found 4 days ago
$730
Roundtrip
found 4 days ago
Select Iberia flight, departing Wed, Feb 18 from Denver to Santander, returning Thu, Mar 5, priced at $730 found 4 days ago
Iberia
Thu, Nov 13 - Thu, Nov 20
DEN
Denver
SDR
Santander
$743 Roundtrip, found 5 days ago
$743
Roundtrip
found 5 days ago
Select Iberia flight, departing Thu, Nov 13 from Denver to Santander, returning Thu, Nov 20, priced at $743 found 5 days ago
Iberia
Thu, Nov 13 - Thu, Nov 20
DEN
Denver
SDR
Santander
$753 Roundtrip, found 5 days ago
$753
Roundtrip
found 5 days ago
Select Iberia flight, departing Thu, Nov 13 from Denver to Santander, returning Thu, Nov 20, priced at $753 found 5 days ago
British Airways
Thu, Nov 13 - Thu, Nov 20
DEN
Denver
SDR
Santander
$763 Roundtrip, found 5 days ago
$763
Roundtrip
found 5 days ago
Select British Airways flight, departing Thu, Nov 13 from Denver to Santander, returning Thu, Nov 20, priced at $763 found 5 days ago
British Airways
Thu, Nov 13 - Thu, Nov 20
DEN
Denver
SDR
Santander
$771 Roundtrip, found 5 days ago
$771
Roundtrip
found 5 days ago
Select British Airways flight, departing Thu, Nov 13 from Denver to Santander, returning Thu, Nov 20, priced at $771 found 5 days ago
Iberia
Mon, Nov 17 - Mon, Nov 24
DEN
Denver
SDR
Santander
$785 Roundtrip, found 1 day ago
$785
Roundtrip
found 1 day ago
Select Iberia flight, departing Mon, Nov 17 from Denver to Santander, returning Mon, Nov 24, priced at $785 found 1 day ago
Iberia
Mon, Nov 17 - Mon, Nov 24
DEN
Denver
SDR
Santander
$793 Roundtrip, found 1 day ago
$793
Roundtrip
found 1 day ago
Select Iberia flight, departing Mon, Nov 17 from Denver to Santander, returning Mon, Nov 24, priced at $793 found 1 day ago
Iberia
Thu, Nov 13 - Thu, Nov 20
DEN
Denver
SDR
Santander
$801 Roundtrip, found 5 days ago
$801
Roundtrip
found 5 days ago
Select Iberia flight, departing Thu, Nov 13 from Denver to Santander, returning Thu, Nov 20, priced at $801 found 5 days ago
JetBlue Airways
Wed, Feb 18 - Thu, Mar 5
DEN
Denver
SDR
Santander
$844 Roundtrip, found 4 days ago
$844
Roundtrip
found 4 days ago
Select JetBlue Airways flight, departing Wed, Feb 18 from Denver to Santander, returning Thu, Mar 5, priced at $844 found 4 days ago
Flights from Denver (DEN) to Santander (SDR)
Origin airport
Denver Intl.
Destination airport
Santander
Airlines serving
Iberia
Roundtrip price
$723
Distance
4863 mi

Denver to Santander Flights

The cheapest times to fly from Denver to Santander

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Denver to Santander are during the month of February. You can find some of the cheapest flights from Denver to Santander with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Denver to Santander

Sunday is one of the best days to book for cheap flights from Denver to Santander: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Denver to Santander

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Denver to Santander in 2025. You can also book with separate airlines for your outbound and return journeys, from $545 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Denver to Santander flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Denver to Santander airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Denver Intl. Airport (DEN) to Santander Airport (SDR) cost?
Snag a cheap one-way flight from $545 or cheap return flight from $724 from Denver Intl. Airport (DEN) to Santander Airport (SDR) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Denver Intl. Airport (DEN) to Santander Airport (SDR)?
February is the most affordable month to fly from DEN to SDR. Traveling during quieter months is often the key to finding a great deal.
What is the cheapest airline that flies from Denver Intl. Airport (DEN) to Santander Airport (SDR)?
Expedia's filter tool lets you easily compare different airlines, travel time and fares all in one place. Customize the search to your preferences, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest DEN to SDR flight.
How many flights per day from Denver Intl. Airport (DEN) to Santander Airport (SDR)?
You'll need to catch a flight with a layover if you're traveling from Denver Intl. Airport (DEN) to Santander Airport (SDR). Direct flights don't operate daily on this route. However, just filter your search to include one or two stops to discover an option that works for you.
What day of the week has the most flights from DEN to SDR?
Typically you'll have the most choice when it comes to flights on a Friday. Tuesdays are often the quietest.* However, this can vary based on the season, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Denver Intl. Airport (DEN) to Santander Airport (SDR)?
To avoid potential delays on the Denver Intl. Airport (DEN) to Santander Airport (SDR) route, travel before 3 PM. Flights after this time have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Denver Intl. Airport (DEN) to Santander Airport (SDR) last-minute?
Last-minute fares from DEN to SDR are generally more expensive. To lock in the lowest rates, start looking for flights as early as possible. That said, if you're flexible with your travel plans, it's possible to land a cheap ticket right before your trip.
Is it cheaper to book a DEN to SDR flight and hotel package?
Booking a DEN to SDR flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels in one place. Select from our extensive range of hotels and then add car rentals, activities and flights to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Denver Intl. Airport (DEN) to Santander Airport (SDR)?
If you reserved your DEN to SDR flight in the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the fare type you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for further details.

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*Available to One Key members.