$222 Cheap Flights from Des Moines (DSM) to Greenville (PGV)

View $222 flight on Mon, Jan 12, 2026Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Greenville, NC (PGV-Pitt-Greenville)

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Cheap Flights from Des Moines to Greenville (DSM-PGV)

Prices were available within the past 7 days and start at $222 for one-way flights and $422 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Fri, Aug 7 - Tue, Aug 11
DSM
Des Moines
PGV
Greenville
$422 Roundtrip, found 1 day ago
$422
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Aug 7 from Des Moines to Greenville, returning Tue, Aug 11, priced at $422 found 1 day ago
American Airlines
Fri, Jul 17 - Tue, Jul 21
DSM
Des Moines
PGV
Greenville
$432 Roundtrip, found 1 day ago
$432
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Jul 17 from Des Moines to Greenville, returning Tue, Jul 21, priced at $432 found 1 day ago
American Airlines
Mon, Jan 12 - Thu, Jan 15
DSM
Des Moines
PGV
Greenville
$445 Roundtrip, found 1 day ago
$445
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Jan 12 from Des Moines to Greenville, returning Thu, Jan 15, priced at $445 found 1 day ago
American Airlines
Mon, Jan 12 - Thu, Jan 15
DSM
Des Moines
PGV
Greenville
$447 Roundtrip, found 1 day ago
$447
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Jan 12 from Des Moines to Greenville, returning Thu, Jan 15, priced at $447 found 1 day ago
American Airlines
Sun, Mar 1 - Mon, Mar 2
DSM
Des Moines
PGV
Greenville
$452 Roundtrip, found 1 day ago
$452
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sun, Mar 1 from Des Moines to Greenville, returning Mon, Mar 2, priced at $452 found 1 day ago
American Airlines
Fri, Aug 7 - Tue, Aug 11
DSM
Des Moines
PGV
Greenville
$457 Roundtrip, found 1 day ago
$457
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Aug 7 from Des Moines to Greenville, returning Tue, Aug 11, priced at $457 found 1 day ago
American Airlines
Fri, Jul 17 - Tue, Jul 21
DSM
Des Moines
PGV
Greenville
$467 Roundtrip, found 1 day ago
$467
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Jul 17 from Des Moines to Greenville, returning Tue, Jul 21, priced at $467 found 1 day ago
American Airlines
Tue, Jul 21 - Tue, Aug 4
DSM
Des Moines
PGV
Greenville
$472 Roundtrip, found 1 day ago
$472
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Jul 21 from Des Moines to Greenville, returning Tue, Aug 4, priced at $472 found 1 day ago
American Airlines
Fri, Mar 20 - Tue, Mar 24
DSM
Des Moines
PGV
Greenville
$477 Roundtrip, found 1 day ago
$477
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Mar 20 from Des Moines to Greenville, returning Tue, Mar 24, priced at $477 found 1 day ago
American Airlines
Sat, Jan 10 - Tue, Jan 13
DSM
Des Moines
PGV
Greenville
$479 Roundtrip, found 1 day ago
$479
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Jan 10 from Des Moines to Greenville, returning Tue, Jan 13, priced at $479 found 1 day ago
Flights from Des Moines (DSM) to Greenville (PGV)
Origin airport
Des Moines Intl.
Destination airport
Pitt-Greenville
Airlines serving
American Airlines
Roundtrip price
$421
Distance
966 mi

Des Moines to Greenville Flights

The cheapest times to fly from Des Moines to Greenville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Greenville are during the month of August. You can find some of the cheapest flights from Des Moines to Greenville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Greenville

Sunday is one of the best days to book for cheap flights from Des Moines to Greenville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Greenville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Greenville in 2026. You can also book with separate airlines for your outbound and return journeys, from $222 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Greenville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Greenville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Pitt-Greenville Airport (PGV) cost?
Snag a cheap one-way flight from $222 or cheap return flight from $422 from Des Moines Intl. Airport (DSM) to Pitt-Greenville Airport (PGV) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Pitt-Greenville Airport (PGV)?
Planning your trip for August may help you find better deals, as it's the cheapest month for flights between DSM and PGV. You'll usually find the lowest prices during off-peak months.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Pitt-Greenville Airport (PGV)?
To find the cheapest airline flying from DSM to PGV, use Expedia's filter tool. Tailor your search based on what matters most to you, such as preferred carriers and flight duration. You can then sort your results by "Price (lowest to highest)" to list the most affordable options first.
How many flights per day from Des Moines Intl. Airport (DSM) to Pitt-Greenville Airport (PGV)?
There are no daily direct flights available from Des Moines Intl. Airport (DSM) to Pitt-Greenville Airport (PGV). But you can book flights with layovers. Filter your search on Expedia to include one or more stops, and you'll be cruising above the clouds in no time at all.
What day of the week has the most flights from DSM to PGV?
Generally you'll find the most flight options available on a Friday. Tuesdays tend to be the quietest.* But this can vary depending on the time of year, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Pitt-Greenville Airport (PGV)?
To touch down at Pitt-Greenville Airport (PGV) without delays, opt for a flight that leaves Des Moines Intl. Airport (DSM) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Pitt-Greenville Airport (PGV) last-minute?
Holding off until just before your trip to book a ticket from DSM to PGV generally means paying more. While you might find some last-minute discounts, they're not always guaranteed. Keep your travel schedule open to maximize your chances of snagging a bargain.
Is it cheaper to book a DSM to PGV flight and hotel package?
Securing a DSM to PGV flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip all in one place. Pick from our wide range of accommodations and then add car rentals, flights and activities to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Pitt-Greenville Airport (PGV)?
If you reserved your DSM to PGV flight in the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the type of fare you have, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal if you want more information.

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*Available to One Key members.