$329 Cheap Flights from Lisbon (LIS) to Panama City (PTY)

View $329 flight on Wed, Apr 15, 2026Opens in a new window

Popular airlines from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY)

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Cheap Flights from Lisbon to Panama City (LIS-PTY)

Prices were available within the past 7 days and start at $329 for one-way flights and $650 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Air Europa
Sun, May 10 - Sun, May 24
LIS
Lisbon
PTY
Panama City
$650 Roundtrip, found 18 hours ago
$650
Roundtrip
found 18 hours ago
Select Air Europa flight, departing Sun, May 10 from Lisbon to Panama City, returning Sun, May 24, priced at $650 found 18 hours ago
Air Europa
Thu, May 7 - Tue, May 19
LIS
Lisbon
PTY
Panama City
$656 Roundtrip, found 1 day ago
$656
Roundtrip
found 1 day ago
Select Air Europa flight, departing Thu, May 7 from Lisbon to Panama City, returning Tue, May 19, priced at $656 found 1 day ago
Air Europa
Sun, May 10 - Sun, May 24
LIS
Lisbon
PTY
Panama City
$658 Roundtrip, found 18 hours ago
$658
Roundtrip
found 18 hours ago
Select Air Europa flight, departing Sun, May 10 from Lisbon to Panama City, returning Sun, May 24, priced at $658 found 18 hours ago
Air Europa
Thu, May 7 - Tue, May 19
LIS
Lisbon
PTY
Panama City
$664 Roundtrip, found 1 day ago
$664
Roundtrip
found 1 day ago
Select Air Europa flight, departing Thu, May 7 from Lisbon to Panama City, returning Tue, May 19, priced at $664 found 1 day ago
Air Europa
Thu, May 7 - Tue, May 19
LIS
Lisbon
PTY
Panama City
$667 Roundtrip, found 1 day ago
$667
Roundtrip
found 1 day ago
Select Air Europa flight, departing Thu, May 7 from Lisbon to Panama City, returning Tue, May 19, priced at $667 found 1 day ago
Air Europa
Thu, May 7 - Tue, May 19
LIS
Lisbon
PTY
Panama City
$675 Roundtrip, found 1 day ago
$675
Roundtrip
found 1 day ago
Select Air Europa flight, departing Thu, May 7 from Lisbon to Panama City, returning Tue, May 19, priced at $675 found 1 day ago
Iberia
Sun, Apr 26 - Sun, May 3
LIS
Lisbon
PTY
Panama City
$747 Roundtrip, found 6 days ago
$747
Roundtrip
found 6 days ago
Select Iberia flight, departing Sun, Apr 26 from Lisbon to Panama City, returning Sun, May 3, priced at $747 found 6 days ago
Turkish Airlines
Sun, May 10 - Sun, May 24
LIS
Lisbon
PTY
Panama City
$904 Roundtrip, found 18 hours ago
$904
Roundtrip
found 18 hours ago
Select Turkish Airlines flight, departing Sun, May 10 from Lisbon to Panama City, returning Sun, May 24, priced at $904 found 18 hours ago
United
Sun, May 17 - Sun, May 24
LIS
Lisbon
PTY
Panama City
$938 Roundtrip, found 6 days ago
$938
Roundtrip
found 6 days ago
Select United flight, departing Sun, May 17 from Lisbon to Panama City, returning Sun, May 24, priced at $938 found 6 days ago
Air France
Mon, Jul 20 - Sat, Sep 12
LIS
Lisbon
PTY
Panama City
$1,234 Roundtrip, found 22 hours ago
$1,234
Roundtrip
found 22 hours ago
Select Air France flight, departing Mon, Jul 20 from Lisbon to Panama City, returning Sat, Sep 12, priced at $1,234 found 22 hours ago

Frequently asked questions

How much does a flight from Lisbon (LIS-Humberto Delgado) to Panama City (PTY-Tocumen Intl.) cost?
You can find cheap one-way flights from $329 and cheap return flights from $650 Lisbon (LIS-Humberto Delgado) to Panama City (PTY-Tocumen Intl.) with Expedia. One-way flights usually range from $777 to $3058, and return flights typically cost between $1192 and $5431. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Lisbon (LIS-Humberto Delgado) to Panama City (PTY-Tocumen Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Lisbon (LIS-Humberto Delgado) to Panama City (PTY-Tocumen Intl.)?
The cheapest month to fly from LIS to PTY is May when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Lisbon (LIS-Humberto Delgado) to Panama City (PTY-Tocumen Intl.)?
Enter LIS to PTY and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Lisbon (LIS-Humberto Delgado) to Panama City (PTY-Tocumen Intl.)?
United is one of the cheapest airlines offering connecting flights from Lisbon (LIS) to Panama City (PTY) with return tickets starting from around $987 with a layover in Washington Dulles Intl. (IAD). Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Lisbon (LIS-Humberto Delgado) to Panama City (PTY-Tocumen Intl.)?
To find a cheap flight from Lisbon (LIS-Humberto Delgado) to Panama City (PTY-Tocumen Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Lisbon (LIS-Humberto Delgado) to Panama City (PTY-Tocumen Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Lisbon (LIS-Humberto Delgado) to Panama City (PTY-Tocumen Intl.)?
The earliest flight from Lisbon (LIS) to Panama City (PTY) usually leaves at around 5:00 AM, with KLM and Air France operating this route. An early departure can help you make the most of your time in Panama City. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Lisbon (LIS-Humberto Delgado) to Panama City (PTY-Tocumen Intl.)?
The most popular departure times for flights from Lisbon (LIS) to Panama City (PTY) are from 9am to 12pm. About 46% of passengers prefer this time window. Many major carriers, including United Airlines, Air Europa, and Copa Airlines, offer flights during this window. This timing is great for those looking to travel during the day.
How long does it take to fly from Lisbon (LIS-Humberto Delgado) to Panama City (PTY-Tocumen Intl.)?
Flying from LIS to PTY with a connection usually takes about 17 hours, traveling roughly 4,766 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Lisbon (LIS-Humberto Delgado) to Panama City (PTY-Tocumen Intl.)?
Business class is available on flights from LIS to PTY. Airlines that offer business class service on this route include:

  • Air Europa
  • Turkish Airlines
  • Swiss International Air Lines
  • United Airlines
  • Iberia
  • Lufthansa
  • British Airways
  • TAP Portugal
  • Air Canada
  • Brussels Airlines

How do I earn miles on a Lisbon (LIS-Humberto Delgado) to Panama City (PTY-Tocumen Intl.) flight with Expedia?
It's easy to earn miles on a Lisbon (LIS-Humberto Delgado) to Panama City (PTY-Tocumen Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Panama City from Humberto Delgado (LIS)?
From Humberto Delgado (LIS), you can fly into Tocumen Intl. (PTY) and Northwest Florida Beaches Intl. (ECP) in Panama City. Some flights may connect through major hubs like Adolfo Suarez Madrid-Barajas (MAD), Frankfurt Intl. (FRA), Washington Dulles Intl. (IAD) before reaching Panama City. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Lisbon (LIS-Humberto Delgado) to Panama City (PTY-Tocumen Intl.) at the last minute?
Typically, booking a last minute flight from Lisbon (LIS-Humberto Delgado) to Panama City (PTY-Tocumen Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Lisbon (LIS-Humberto Delgado) to Panama City (PTY-Tocumen Intl.) flight and hotel package?
Securing a Lisbon (LIS-Humberto Delgado) to Panama City (PTY-Tocumen Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Lisbon (LIS-Humberto Delgado) to Panama City (PTY-Tocumen Intl.)?
If you booked your Lisbon (LIS-Humberto Delgado) to Panama City (PTY-Tocumen Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Humberto Delgado
Destination airport
Tocumen Intl.
Airlines serving
Air Europa, Air France, American Airlines, Delta, Iberia, KLM, Lufthansa, Turkish Airlines, United, avianca
Roundtrip price
$649
Distance
4765 mi

Book with confidence

Lisbon to Panama City Flights

The cheapest times to fly from Lisbon to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Lisbon to Panama City are during the month of May. You can find some of the cheapest flights from Lisbon to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Lisbon to Panama City

Sunday is one of the best days to book for cheap flights from Lisbon to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Lisbon to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Lisbon to Panama City in 2026. You can also book with separate airlines for your outbound and return journeys, from $329 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Lisbon to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Lisbon to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Lisbon to Panama City Flights

*Flight schedules are subject to change.

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*Available to One Key members.