$539 Cheap Flights from Lisbon (LIS) to Panama City (PTY)

View $539 flight on Tue, Apr 14, 2026Opens in a new window

Popular airlines from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY)

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Cheap Flights from Lisbon to Panama City (LIS-PTY)

Prices were available within the past 7 days and start at $539 for one-way flights and $691 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Air Europa
Sun, Nov 2 - Tue, Nov 11
LIS
Lisbon
PTY
Panama City
$691 Roundtrip, found 1 day ago
$691
Roundtrip
found 1 day ago
Select Air Europa flight, departing Sun, Nov 2 from Lisbon to Panama City, returning Tue, Nov 11, priced at $691 found 1 day ago
Air Europa
Sat, Nov 1 - Tue, Nov 11
LIS
Lisbon
PTY
Panama City
$702 Roundtrip, found 1 day ago
$702
Roundtrip
found 1 day ago
Select Air Europa flight, departing Sat, Nov 1 from Lisbon to Panama City, returning Tue, Nov 11, priced at $702 found 1 day ago
Air Europa
Tue, Sep 9 - Tue, Sep 23
LIS
Lisbon
PTY
Panama City
$726 Roundtrip, found 1 day ago
$726
Roundtrip
found 1 day ago
Select Air Europa flight, departing Tue, Sep 9 from Lisbon to Panama City, returning Tue, Sep 23, priced at $726 found 1 day ago
Air France
Tue, Sep 9 - Mon, Sep 29
LIS
Lisbon
PTY
Panama City
$727 Roundtrip, found 1 day ago
$727
Roundtrip
found 1 day ago
Select Air France flight, departing Tue, Sep 9 from Lisbon to Panama City, returning Mon, Sep 29, priced at $727 found 1 day ago
KLM
Mon, Sep 15 - Sun, Oct 5
LIS
Lisbon
PTY
Panama City
$727 Roundtrip, found 1 day ago
$727
Roundtrip
found 1 day ago
Select KLM flight, departing Mon, Sep 15 from Lisbon to Panama City, returning Sun, Oct 5, priced at $727 found 1 day ago
KLM
Mon, Sep 8 - Thu, Sep 25
LIS
Lisbon
PTY
Panama City
$729 Roundtrip, found 1 day ago
$729
Roundtrip
found 1 day ago
Select KLM flight, departing Mon, Sep 8 from Lisbon to Panama City, returning Thu, Sep 25, priced at $729 found 1 day ago
Air Europa
Mon, Sep 8 - Tue, Sep 23
LIS
Lisbon
PTY
Panama City
$737 Roundtrip, found 1 day ago
$737
Roundtrip
found 1 day ago
Select Air Europa flight, departing Mon, Sep 8 from Lisbon to Panama City, returning Tue, Sep 23, priced at $737 found 1 day ago
Air France
Fri, Sep 5 - Sun, Sep 21
LIS
Lisbon
PTY
Panama City
$740 Roundtrip, found 1 day ago
$740
Roundtrip
found 1 day ago
Select Air France flight, departing Fri, Sep 5 from Lisbon to Panama City, returning Sun, Sep 21, priced at $740 found 1 day ago
Iberia
Sat, Nov 29 - Wed, Dec 3
LIS
Lisbon
PTY
Panama City
$907 Roundtrip, found 4 days ago
$907
Roundtrip
found 4 days ago
Select Iberia flight, departing Sat, Nov 29 from Lisbon to Panama City, returning Wed, Dec 3, priced at $907 found 4 days ago
Turkish Airlines
Wed, Oct 15 - Sat, Nov 1
LIS
Lisbon
PTY
Panama City
$929 Roundtrip, found 1 day ago
$929
Roundtrip
found 1 day ago
Select Turkish Airlines flight, departing Wed, Oct 15 from Lisbon to Panama City, returning Sat, Nov 1, priced at $929 found 1 day ago

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tocumen Intl. PTY. Cheapest option available. Average driving time to city center is 16 minutes. Flights from $1,185
PTY
Tocumen Intl.
Cheapest
Average driving time to city center16 min
Flights from $1,185
Flights from Lisbon (LIS) to Panama City (PTY)
Origin airport
Humberto Delgado
Destination airport
Tocumen Intl.
Airlines serving
Air Europa, Delta, Iberia, KLM
Roundtrip price
$691
Distance
4765 mi

Lisbon to Panama City Flights

The cheapest times to fly from Lisbon to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Lisbon to Panama City are during the month of November. You can find some of the cheapest flights from Lisbon to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Lisbon to Panama City

Sunday is one of the best days to book for cheap flights from Lisbon to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Lisbon to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Lisbon to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $539 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Lisbon to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Lisbon to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY) cost?
Discover the latest flight deals from LIS to PTY by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from LIS to PTY?
The cheapest flights from LIS to PTY are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from LIS to PTY?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from LIS to PTY. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY)?
There are no daily direct flights departing from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY). But you can opt for flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be soaring above the clouds before you know it.
What day of the week has the most flights from LIS to PTY?
Typically you'll find the greatest selection of flight options on a Friday. Tuesdays tend to be the quietest.* However, this can vary based on the airline, season and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY)?
To avoid potential delays on the Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY) route, aim to travel before 3 PM. Departures after this time have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY) last-minute?
Last-minute fares from LIS to PTY are typically more expensive. To secure the best rates, start searching for flights well in advance. That said, if your travel plans are flexible, you may land a cheap ticket right before your trip.
Is it cheaper to book a LIS to PTY flight and hotel package?
Compared with arranging hotels and flights separately, booking a LIS to PTY flight and hotel package with Expedia could result in significant savings. Better still, having it all in one place will take the stress out of planning your trip. Simply secure your flights and select from our extensive range of hotels, then customize your trip with other add-ons like tours and car rentals.
Can I cancel or change the date of my flight from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY)?
If you booked your LIS to PTY flight in the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you want more information.

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*Available to One Key members.