$302 Cheap Flights from Lisbon (LIS) to Panama City (PTY)

View $302 flight on Sat, Sep 6, 2025Opens in a new window

Popular airlines from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY)

Cheap Flights from Lisbon to Panama City (LIS-PTY)

Prices were available within the past 7 days and start at $302 for one-way flights and $567 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Air Europa
Fri, Nov 7 - Sat, Nov 22
LIS
Lisbon
PTY
Panama City
$567 Roundtrip, found 12 hours ago
$567
Roundtrip
found 12 hours ago
Select Air Europa flight, departing Fri, Nov 7 from Lisbon to Panama City, returning Sat, Nov 22, priced at $567 found 12 hours ago
Air Europa
Fri, Nov 7 - Sat, Nov 22
LIS
Lisbon
PTY
Panama City
$575 Roundtrip, found 12 hours ago
$575
Roundtrip
found 12 hours ago
Select Air Europa flight, departing Fri, Nov 7 from Lisbon to Panama City, returning Sat, Nov 22, priced at $575 found 12 hours ago
Iberia
Sun, Sep 7 - Mon, Oct 6
LIS
Lisbon
PTY
Panama City
$577 Roundtrip, found 5 days ago
$577
Roundtrip
found 5 days ago
Select Iberia flight, departing Sun, Sep 7 from Lisbon to Panama City, returning Mon, Oct 6, priced at $577 found 5 days ago
Iberia
Sun, Sep 7 - Mon, Oct 6
LIS
Lisbon
PTY
Panama City
$585 Roundtrip, found 5 days ago
$585
Roundtrip
found 5 days ago
Select Iberia flight, departing Sun, Sep 7 from Lisbon to Panama City, returning Mon, Oct 6, priced at $585 found 5 days ago
Iberia
Sun, Sep 7 - Mon, Oct 6
LIS
Lisbon
PTY
Panama City
$612 Roundtrip, found 5 days ago
$612
Roundtrip
found 5 days ago
Select Iberia flight, departing Sun, Sep 7 from Lisbon to Panama City, returning Mon, Oct 6, priced at $612 found 5 days ago
Air Europa
Fri, Nov 7 - Sat, Nov 22
LIS
Lisbon
PTY
Panama City
$613 Roundtrip, found 12 hours ago
$613
Roundtrip
found 12 hours ago
Select Air Europa flight, departing Fri, Nov 7 from Lisbon to Panama City, returning Sat, Nov 22, priced at $613 found 12 hours ago
Iberia
Sun, Sep 7 - Mon, Oct 6
LIS
Lisbon
PTY
Panama City
$620 Roundtrip, found 5 days ago
$620
Roundtrip
found 5 days ago
Select Iberia flight, departing Sun, Sep 7 from Lisbon to Panama City, returning Mon, Oct 6, priced at $620 found 5 days ago
Air France
Tue, Sep 9 - Thu, Sep 18
LIS
Lisbon
PTY
Panama City
$648 Roundtrip, found 5 days ago
$648
Roundtrip
found 5 days ago
Select Air France flight, departing Tue, Sep 9 from Lisbon to Panama City, returning Thu, Sep 18, priced at $648 found 5 days ago
Turkish Airlines
Wed, Oct 1 - Sun, Oct 12
LIS
Lisbon
PTY
Panama City
$920 Roundtrip, found 10 hours ago
$920
Roundtrip
found 10 hours ago
Select Turkish Airlines flight, departing Wed, Oct 1 from Lisbon to Panama City, returning Sun, Oct 12, priced at $920 found 10 hours ago
KLM
Mon, Sep 8 - Mon, Sep 15
LIS
Lisbon
PTY
Panama City
$937 Roundtrip, found 5 days ago
$937
Roundtrip
found 5 days ago
Select KLM flight, departing Mon, Sep 8 from Lisbon to Panama City, returning Mon, Sep 15, priced at $937 found 5 days ago
Flights from Lisbon (LIS) to Panama City (PTY)
Origin airport
Humberto Delgado
Destination airport
Tocumen Intl.
Airlines serving
Air Europa, Air France, British Airways, Delta, Iberia, KLM, Turkish Airlines, United
Roundtrip price
$567
Distance
4765 mi

Lisbon to Panama City Flights

The cheapest times to fly from Lisbon to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Lisbon to Panama City are during the month of November. You can find some of the cheapest flights from Lisbon to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Lisbon to Panama City

Sunday is one of the best days to book for cheap flights from Lisbon to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Lisbon to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Lisbon to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $302 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Lisbon to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Lisbon to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY) cost?
Grab a cheap one-way flight from $302 or cheap return flight from $567 from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY)?
Planning your getaway for November is a great way to save, as it's the cheapest month for flights between LIS and PTY. You'll often find the lowest fares during off-peak months.
What is the cheapest airline that flies from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY)?
To find the cheapest airline flying from LIS to PTY, use Expedia's filter tool. Customize your search based on what's important to you, such as preferred carriers and seat class. You can then sort your results by "Price (lowest to highest)" to discover the cheapest flight right away.
How many flights per day from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY)?
There are no daily direct flights departing from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY). But you can opt for flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be soaring above the clouds before you know it.
What day of the week has the most flights from LIS to PTY?
Typically you'll find the greatest selection of flight options on a Friday. Tuesdays tend to be the quietest.* However, this can vary based on the airline, season and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY)?
To avoid potential delays on the Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY) route, aim to travel before 3 PM. Departures after this time have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY) last-minute?
Last-minute fares from LIS to PTY are typically more expensive. To secure the best rates, start searching for flights well in advance. That said, if your travel plans are flexible, you may land a cheap ticket right before your trip.
Is it cheaper to book a LIS to PTY flight and hotel package?
Compared with arranging hotels and flights separately, booking a LIS to PTY flight and hotel package with Expedia could result in significant savings. Better still, having it all in one place will take the stress out of planning your trip. Simply secure your flights and select from our extensive range of hotels, then customize your trip with other add-ons like tours and car rentals.
Can I cancel or change the date of my flight from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY)?
If you booked your LIS to PTY flight in the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you want more information.

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*Available to One Key members.