$182 Cheap Flights from Medellín (MDE) to Columbus (CMH)

View $182 flight on Wed, Sep 24, 2025Opens in a new window

Popular airlines from Jose Maria Cordova Intl. Airport (MDE) to John Glenn Columbus Intl. Airport (CMH)

  • Plan, book, fly with confidence

  • trending down icon

    Be in the know

    Get alerts if flight prices drop or rise*
  • bex rewards loyalty icon

    Book smarter

    Save up to 30% on select hotels after you book a flight*
  • one key icon

    Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from Medellín to Columbus (MDE-CMH)

Prices were available within the past 7 days and start at $182 for one-way flights and $276 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Spirit Airlines
Fri, Sep 5 - Tue, Sep 9
MDE
Medellin
CMH
Columbus
$276 Roundtrip, found 4 days ago
$276
Roundtrip
found 4 days ago
Select Spirit Airlines flight, departing Fri, Sep 5 from Medellin to Columbus, returning Tue, Sep 9, priced at $276 found 4 days ago
Spirit Airlines
Tue, Oct 28 - Mon, Nov 3
MDE
Medellin
CMH
Columbus
$288 Roundtrip, found 6 days ago
$288
Roundtrip
found 6 days ago
Select Spirit Airlines flight, departing Tue, Oct 28 from Medellin to Columbus, returning Mon, Nov 3, priced at $288 found 6 days ago
Spirit Airlines
Thu, Sep 18 - Sat, Sep 27
MDE
Medellin
CMH
Columbus
$297 Roundtrip, found 2 days ago
$297
Roundtrip
found 2 days ago
Select Spirit Airlines flight, departing Thu, Sep 18 from Medellin to Columbus, returning Sat, Sep 27, priced at $297 found 2 days ago
Spirit Airlines
Thu, Sep 18 - Sat, Sep 27
MDE
Medellin
CMH
Columbus
$302 Roundtrip, found 2 days ago
$302
Roundtrip
found 2 days ago
Select Spirit Airlines flight, departing Thu, Sep 18 from Medellin to Columbus, returning Sat, Sep 27, priced at $302 found 2 days ago
Spirit Airlines
Thu, Sep 25 - Mon, Sep 29
MDE
Medellin
CMH
Columbus
$311 Roundtrip, found 3 days ago
$311
Roundtrip
found 3 days ago
Select Spirit Airlines flight, departing Thu, Sep 25 from Medellin to Columbus, returning Mon, Sep 29, priced at $311 found 3 days ago
Spirit Airlines
Sat, Dec 6 - Sun, Dec 7
MDE
Medellin
CMH
Columbus
$334 Roundtrip, found 6 days ago
$334
Roundtrip
found 6 days ago
Select Spirit Airlines flight, departing Sat, Dec 6 from Medellin to Columbus, returning Sun, Dec 7, priced at $334 found 6 days ago
Copa
Thu, Sep 25 - Mon, Sep 29
MDE
Medellin
CMH
Columbus
$491 Roundtrip, found 3 days ago
$491
Roundtrip
found 3 days ago
Select Copa flight, departing Thu, Sep 25 from Medellin to Columbus, returning Mon, Sep 29, priced at $491 found 3 days ago
United
Thu, Oct 9 - Thu, Oct 23
MDE
Medellin
CMH
Columbus
$610 Roundtrip, found 5 days ago
$610
Roundtrip
found 5 days ago
Select United flight, departing Thu, Oct 9 from Medellin to Columbus, returning Thu, Oct 23, priced at $610 found 5 days ago
American Airlines
Thu, Oct 16 - Sun, Nov 2
MDE
Medellin
CMH
Columbus
$621 Roundtrip, found 6 days ago
$621
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Oct 16 from Medellin to Columbus, returning Sun, Nov 2, priced at $621 found 6 days ago
LATAM Airlines Group
Tue, Sep 2 - Sun, Nov 9
MDE
Medellin
CMH
Columbus
$925 Roundtrip, found 1 day ago
$925
Roundtrip
found 1 day ago
Select LATAM Airlines Group flight, departing Tue, Sep 2 from Medellin to Columbus, returning Sun, Nov 9, priced at $925 found 1 day ago
Flights from Medellín (MDE) to Columbus (CMH)
Origin airport
José María Córdova Intl.
Destination airport
John Glenn Columbus Intl.
Airlines serving
LATAM Airlines Group, Spirit Airlines, avianca
Roundtrip price
$276
Distance
2382 mi

Medellín to Columbus Flights

The cheapest times to fly from Medellín to Columbus

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medellín to Columbus are during the month of September. You can find some of the cheapest flights from Medellín to Columbus with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medellín to Columbus

Sunday is one of the best days to book for cheap flights from Medellín to Columbus: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medellín to Columbus

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medellín to Columbus in 2025. You can also book with separate airlines for your outbound and return journeys, from $182 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medellín to Columbus flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medellín to Columbus airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Jose Maria Cordova Intl. Airport (MDE) to John Glenn Columbus Intl. Airport (CMH) cost?
Get a cheap one-way flight from $182 or cheap return flight from $276 from Jose Maria Cordova Intl. Airport (MDE) to John Glenn Columbus Intl. Airport (CMH) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Jose Maria Cordova Intl. Airport (MDE) to John Glenn Columbus Intl. Airport (CMH)?
Flying in September is a great way to save, as it's the cheapest month for flights between MDE and CMH. You'll typically find the lowest prices during off-peak months.
What is the cheapest airline that flies from Jose Maria Cordova Intl. Airport (MDE) to John Glenn Columbus Intl. Airport (CMH)?
To find the cheapest airline flying from MDE to CMH, use Expedia's filter tool. Customize your search based on what's important to you, such as preferred carriers and number of stops. You can then sort your results by "Price (lowest to highest)" to see the cheapest fares upfront.
How many flights per day from Jose Maria Cordova Intl. Airport (MDE) to John Glenn Columbus Intl. Airport (CMH)?
Nonstop flights from Jose Maria Cordova Intl. Airport (MDE) to John Glenn Columbus Intl. Airport (CMH) aren't available daily, so you'll have to take a flight with a layover. Explore your options with our filter tool. Enter your travel dates and select either "1 Stop" or "2+ Stops."
What day of the week has the most flights from MDE to CMH?
Usually you'll find the greatest selection of flight options on a Friday. Tuesdays tend to be the quietest.* However, this can vary depending on the time of year, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Jose Maria Cordova Intl. Airport (MDE) to John Glenn Columbus Intl. Airport (CMH)?
To arrive at John Glenn Columbus Intl. Airport (CMH) on time, book a flight that leaves from Jose Maria Cordova Intl. Airport (MDE) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Jose Maria Cordova Intl. Airport (MDE) to John Glenn Columbus Intl. Airport (CMH) last-minute?
Waiting until just before your departure to book a flight from MDE to CMH generally means paying more. While it's possible to find some last-minute deals, they're not always guaranteed. Keep your travel plans flexible to maximize your chances of scoring a bargain.
Is it cheaper to book a MDE to CMH flight and hotel package?
You'll generally save money by booking a MDE to CMH flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's easy to manage it all in one convenient place. Once you've selected your preferred flights and accommodations, consider other add-ons like activities, car rentals and tours.
Can I cancel or change the date of my flight from Jose Maria Cordova Intl. Airport (MDE) to John Glenn Columbus Intl. Airport (CMH)?
In most instances, you can cancel or reschedule your MDE to CMH flight. However, there may be additional fees, especially if you booked over 24 hours ago. Check your itinerary for the airline's guidelines and fees on flight changes, or if you'd like further details, visit our Customer Service portal.

Explore a world of travel with Expedia

*Available to One Key members.