$443 Cheap Flights from Medellín (MDE) to Reynosa (REX)

View $443 flight on Thu, Nov 13, 2025Opens in a new window

Popular airlines from Jose Maria Cordova Intl. Airport (MDE) to Reynosa, Tamaulipas (REX-General Lucio Blanco Intl.)

Cheap Flights from Medellín to Reynosa (MDE-REX)

Prices were available within the past 7 days and start at $443 for one-way flights and $582 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Aeromexico
Thu, Dec 4 - Thu, Dec 11
MDE
Medellin
REX
Reynosa
$582 Roundtrip, found 6 days ago
$582
Roundtrip
found 6 days ago
Select Aeromexico flight, departing Thu, Dec 4 from Medellin to Reynosa, returning Thu, Dec 11, priced at $582 found 6 days ago
Aeromexico
Thu, Dec 4 - Thu, Dec 11
MDE
Medellin
REX
Reynosa
$714 Roundtrip, found 6 days ago
$714
Roundtrip
found 6 days ago
Select Aeromexico flight, departing Thu, Dec 4 from Medellin to Reynosa, returning Thu, Dec 11, priced at $714 found 6 days ago
Aeromexico
Thu, Dec 4 - Thu, Dec 11
MDE
Medellin
REX
Reynosa
$801 Roundtrip, found 6 days ago
$801
Roundtrip
found 6 days ago
Select Aeromexico flight, departing Thu, Dec 4 from Medellin to Reynosa, returning Thu, Dec 11, priced at $801 found 6 days ago
Aeromexico
Sat, Dec 27 - Fri, Jan 2
MDE
Medellin
REX
Reynosa
$1,108 Roundtrip, found 1 day ago
$1,108
Roundtrip
found 1 day ago
Select Aeromexico flight, departing Sat, Dec 27 from Medellin to Reynosa, returning Fri, Jan 2, priced at $1,108 found 1 day ago
Aeromexico
Sat, Dec 27 - Fri, Jan 2
MDE
Medellin
REX
Reynosa
$1,269 Roundtrip, found 1 day ago
$1,269
Roundtrip
found 1 day ago
Select Aeromexico flight, departing Sat, Dec 27 from Medellin to Reynosa, returning Fri, Jan 2, priced at $1,269 found 1 day ago

Frequently asked questions

How much does a flight from Jose Maria Cordova Intl. Airport (MDE) to General Lucio Blanco Intl. Airport (REX) cost?
Grab a cheap one-way flight from $443 or cheap return flight from $582 from Jose Maria Cordova Intl. Airport (MDE) to General Lucio Blanco Intl. Airport (REX) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Jose Maria Cordova Intl. Airport (MDE) to General Lucio Blanco Intl. Airport (REX)?
December is the cheapest month to fly from MDE to REX. Timing your trip outside of the busy season is often the key to better flight prices.
What is the cheapest airline that flies from Jose Maria Cordova Intl. Airport (MDE) to General Lucio Blanco Intl. Airport (REX)?
Expedia's filter tool lets you easily compare different airlines, travel time and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest MDE to REX flight.
How many flights per day from Jose Maria Cordova Intl. Airport (MDE) to General Lucio Blanco Intl. Airport (REX)?
There are no daily nonstop flights from Jose Maria Cordova Intl. Airport (MDE) to General Lucio Blanco Intl. Airport (REX). But you can opt for flights with layovers. Filter your search on Expedia to include one or two stops, and you'll be on your way before you know it.
What day of the week has the most flights from MDE to REX?
You'll typically find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can change from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Jose Maria Cordova Intl. Airport (MDE) to General Lucio Blanco Intl. Airport (REX)?
To land at General Lucio Blanco Intl. Airport (REX) without delays, choose a flight that leaves from Jose Maria Cordova Intl. Airport (MDE) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Jose Maria Cordova Intl. Airport (MDE) to General Lucio Blanco Intl. Airport (REX) last-minute?
Booking your flight from MDE to REX right before your getaway is typically more expensive. However, if there's some wiggle room with your departure times and dates, you could bag a cheap last-minute fare.
Is it cheaper to book a MDE to REX flight and hotel package?
Opting for a MDE to REX flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels all in one place. Choose from our extensive range of accommodations and then add car rentals, flights and activities to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Jose Maria Cordova Intl. Airport (MDE) to General Lucio Blanco Intl. Airport (REX)?
If you reserved your MDE to REX flight in the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the fare type you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for more information.

Travel information

Origin airport
José María Córdova Intl.
Destination airport
General Lucio Blanco Intl.
Airlines serving
Aeromexico
Roundtrip price
$582
Distance
2034 mi

Book with confidence

Medellín to Reynosa Flights

The cheapest times to fly from Medellín to Reynosa

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medellín to Reynosa are during the month of December. You can find some of the cheapest flights from Medellín to Reynosa with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medellín to Reynosa

Sunday is one of the best days to book for cheap flights from Medellín to Reynosa: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medellín to Reynosa

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medellín to Reynosa in 2025. You can also book with separate airlines for your outbound and return journeys, from $443 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medellín to Reynosa flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medellín to Reynosa airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Medellín to Reynosa Flights

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*Available to One Key members.