$306 Cheap Flights from McAllen (MFE) to Santo Domingo (SDQ)

View $306 flight on Thu, Oct 30, 2025Opens in a new window

Popular airlines from Miller Intl. Airport (MFE) to Las Americas Intl. Airport (SDQ)

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Cheap Flights from McAllen to Santo Domingo (MFE-SDQ)

Prices were available within the past 7 days and start at $306 for one-way flights and $521 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Oct 28 - Wed, Nov 5
MFE
McAllen
SDQ
Santo Domingo
$521 Roundtrip, found 3 hours ago
$521
Roundtrip
found 3 hours ago
Select Delta flight, departing Tue, Oct 28 from McAllen to Santo Domingo, returning Wed, Nov 5, priced at $521 found 3 hours ago
American Airlines
Wed, Jan 21 - Thu, Feb 12
MFE
McAllen
SDQ
Santo Domingo
$522 Roundtrip, found 4 days ago
$522
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Jan 21 from McAllen to Santo Domingo, returning Thu, Feb 12, priced at $522 found 4 days ago
Delta
Tue, Oct 28 - Mon, Nov 10
MFE
McAllen
SDQ
Santo Domingo
$531 Roundtrip, found 3 hours ago
$531
Roundtrip
found 3 hours ago
Select Delta flight, departing Tue, Oct 28 from McAllen to Santo Domingo, returning Mon, Nov 10, priced at $531 found 3 hours ago
American Airlines
Tue, Dec 2 - Mon, Dec 8
MFE
McAllen
SDQ
Santo Domingo
$532 Roundtrip, just found
$532
Roundtrip
just found
Select American Airlines flight, departing Tue, Dec 2 from McAllen to Santo Domingo, returning Mon, Dec 8, priced at $532 just found
American Airlines
Tue, Feb 3 - Sun, Feb 8
MFE
McAllen
SDQ
Santo Domingo
$537 Roundtrip, found 3 days ago
$537
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Feb 3 from McAllen to Santo Domingo, returning Sun, Feb 8, priced at $537 found 3 days ago
American Airlines
Tue, Oct 28 - Tue, Nov 11
MFE
McAllen
SDQ
Santo Domingo
$539 Roundtrip, found 2 days ago
$539
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Oct 28 from McAllen to Santo Domingo, returning Tue, Nov 11, priced at $539 found 2 days ago
American Airlines
Tue, Dec 2 - Mon, Dec 8
MFE
McAllen
SDQ
Santo Domingo
$539 Roundtrip, just found
$539
Roundtrip
just found
Select American Airlines flight, departing Tue, Dec 2 from McAllen to Santo Domingo, returning Mon, Dec 8, priced at $539 just found
American Airlines
Thu, Oct 30 - Sat, Nov 8
MFE
McAllen
SDQ
Santo Domingo
$541 Roundtrip, found 3 hours ago
$541
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Thu, Oct 30 from McAllen to Santo Domingo, returning Sat, Nov 8, priced at $541 found 3 hours ago
Delta
Sat, Nov 1 - Mon, Nov 10
MFE
McAllen
SDQ
Santo Domingo
$542 Roundtrip, found 3 hours ago
$542
Roundtrip
found 3 hours ago
Select Delta flight, departing Sat, Nov 1 from McAllen to Santo Domingo, returning Mon, Nov 10, priced at $542 found 3 hours ago
United
Tue, Oct 28 - Tue, Nov 11
MFE
McAllen
SDQ
Santo Domingo
$586 Roundtrip, found 2 days ago
$586
Roundtrip
found 2 days ago
Select United flight, departing Tue, Oct 28 from McAllen to Santo Domingo, returning Tue, Nov 11, priced at $586 found 2 days ago

Alternative airports near Santo Domingo

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Las Americas Intl. SDQ. Cheapest option available. Average driving time to city center is 22 minutes. Flights from $654
SDQ
Las Americas Intl.
Cheapest
Average driving time to city center22 min
Flights from $654
Flights from McAllen (MFE) to Santo Domingo (SDQ)
Origin airport
Miller Intl.
Destination airport
Las Americas Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$520
Distance
1898 mi

McAllen to Santo Domingo Flights

The cheapest times to fly from McAllen to Santo Domingo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from McAllen to Santo Domingo are during the month of October. You can find some of the cheapest flights from McAllen to Santo Domingo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from McAllen to Santo Domingo

Sunday is one of the best days to book for cheap flights from McAllen to Santo Domingo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from McAllen to Santo Domingo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from McAllen to Santo Domingo in 2025. You can also book with separate airlines for your outbound and return journeys, from $306 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap McAllen to Santo Domingo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your McAllen to Santo Domingo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Miller Intl. Airport (MFE) to Las Americas Intl. Airport (SDQ) cost?
Secure a cheap one-way flight from $306 or cheap return flight from $521 from Miller Intl. Airport (MFE) to Las Americas Intl. Airport (SDQ) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Miller Intl. Airport (MFE) to Las Americas Intl. Airport (SDQ)?
Planning your trip for October is a good way to save, as it's the cheapest month for flights between MFE and SDQ. You'll usually find the lowest prices during off-peak months.
What is the cheapest airline that flies from Miller Intl. Airport (MFE) to Las Americas Intl. Airport (SDQ)?
To find the cheapest airline that'll fly you from MFE to SDQ, use Expedia's filter tool. Tailor your search based on your travel style, such as preferred carriers and seat class. You can then sort your results by "Price (lowest to highest)" to see the cheapest flights first.
How many flights per day from Miller Intl. Airport (MFE) to Las Americas Intl. Airport (SDQ)?
Nonstop flights from Miller Intl. Airport (MFE) to Las Americas Intl. Airport (SDQ) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filters. Enter your dates and select either "1 Stop" or "2+ Stops."
What day of the week has the most flights from MFE to SDQ?
Typically you'll have the most choice when it comes to flights on a Friday. Tuesdays tend to be the quietest.* However, this can change based on the airline, season and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Miller Intl. Airport (MFE) to Las Americas Intl. Airport (SDQ)?
To avoid potential delays on the Miller Intl. Airport (MFE) to Las Americas Intl. Airport (SDQ) route, aim to travel before 3 PM. Departures after this time are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Miller Intl. Airport (MFE) to Las Americas Intl. Airport (SDQ) last-minute?
Holding off until right before your break to book a flight from MFE to SDQ generally means paying more. While you may come across some last-minute deals, they aren't always guaranteed. Be flexible with your travel plans to boost your chances of landing a bargain.
Is it cheaper to book a MFE to SDQ flight and hotel package?
Compared with arranging hotels and flights separately, booking a MFE to SDQ flight and hotel package with Expedia could lead to significant savings. Better yet, having everything in one place will take the stress out of travel planning. Just pick your flights and choose from our wide range of stays, then personalize your trip with extras like activities, tours and car rentals.
Can I cancel or change the date of my flight from Miller Intl. Airport (MFE) to Las Americas Intl. Airport (SDQ)?
Generally, it's possible to cancel or reschedule your MFE to SDQ flight. However, if it's been more than 24 hours since booking, additional charges may apply. Check your airline's policies in your itinerary to see what changes are possible and whether any costs are involved. You'll also find more details on our Customer Service portal.

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*Available to One Key members.