$62 Cheap Flights from Myrtle Beach (MYR) to Louisville (SDF)

View $62 flight on Wed, Oct 22, 2025Opens in a new window

Popular airlines from Myrtle Beach Intl. Airport (MYR) to Louisville Intl. Airport (SDF)

Cheap Flights from Myrtle Beach to Louisville (MYR-SDF)

Prices were available within the past 7 days and start at $62 for one-way flights and $124 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Spirit Airlines
Sat, Nov 1 - Sat, Nov 8
MYR
Myrtle Beach
SDF
Louisville
$124 Roundtrip, found 2 hours ago
$124
Roundtrip
found 2 hours ago
Select Spirit Airlines flight, departing Sat, Nov 1 from Myrtle Beach to Louisville, returning Sat, Nov 8, priced at $124 found 2 hours ago
American Airlines
Wed, Oct 1 - Fri, Oct 3
MYR
Myrtle Beach
SDF
Louisville
$156 Roundtrip, found 6 days ago
$156
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Oct 1 from Myrtle Beach to Louisville, returning Fri, Oct 3, priced at $156 found 6 days ago
Delta
Wed, Oct 1 - Fri, Oct 3
MYR
Myrtle Beach
SDF
Louisville
$160 Roundtrip, found 6 days ago
$160
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, Oct 1 from Myrtle Beach to Louisville, returning Fri, Oct 3, priced at $160 found 6 days ago
Spirit Airlines
Sat, Nov 1 - Mon, Nov 3
MYR
Myrtle Beach
SDF
Louisville
$169 Roundtrip, found 1 day ago
$169
Roundtrip
found 1 day ago
Select Spirit Airlines flight, departing Sat, Nov 1 from Myrtle Beach to Louisville, returning Mon, Nov 3, priced at $169 found 1 day ago
Delta
Thu, Nov 13 - Sat, Nov 15
MYR
Myrtle Beach
SDF
Louisville
$171 Roundtrip, found 6 days ago
$171
Roundtrip
found 6 days ago
Select Delta flight, departing Thu, Nov 13 from Myrtle Beach to Louisville, returning Sat, Nov 15, priced at $171 found 6 days ago
American Airlines
Thu, Nov 13 - Sat, Nov 15
MYR
Myrtle Beach
SDF
Louisville
$174 Roundtrip, found 6 days ago
$174
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Nov 13 from Myrtle Beach to Louisville, returning Sat, Nov 15, priced at $174 found 6 days ago
Southwest Airlines
Wed, Oct 1 - Fri, Oct 3
MYR
Myrtle Beach
SDF
Louisville
$176 Roundtrip, found 6 days ago
$176
Roundtrip
found 6 days ago
Select Southwest Airlines flight, departing Wed, Oct 1 from Myrtle Beach to Louisville, returning Fri, Oct 3, priced at $176 found 6 days ago
Southwest Airlines
Tue, Oct 28 - Fri, Oct 31
MYR
Myrtle Beach
SDF
Louisville
$178 Roundtrip, found 2 days ago
$178
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Tue, Oct 28 from Myrtle Beach to Louisville, returning Fri, Oct 31, priced at $178 found 2 days ago
Southwest Airlines
Wed, Oct 1 - Fri, Oct 3
MYR
Myrtle Beach
SDF
Louisville
$179 Roundtrip, found 6 days ago
$179
Roundtrip
found 6 days ago
Select Southwest Airlines flight, departing Wed, Oct 1 from Myrtle Beach to Louisville, returning Fri, Oct 3, priced at $179 found 6 days ago
United
Wed, Oct 1 - Fri, Oct 3
MYR
Myrtle Beach
SDF
Louisville
$190 Roundtrip, found 6 days ago
$190
Roundtrip
found 6 days ago
Select United flight, departing Wed, Oct 1 from Myrtle Beach to Louisville, returning Fri, Oct 3, priced at $190 found 6 days ago

Find the cheapest month to fly from Myrtle Beach (MYR) to Louisville (SDF)

May is typically the cheapest month to fly

From $82 - $356 per traveler.

Frequently asked questions

How much does a flight from Myrtle Beach Intl. Airport (MYR) to Louisville Intl. Airport (SDF) cost?
Lock in a cheap one-way flight from $62 or cheap return flight from $124 from Myrtle Beach Intl. Airport (MYR) to Louisville Intl. Airport (SDF) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Myrtle Beach Intl. Airport (MYR) to Louisville Intl. Airport (SDF)?
The cheapest month to fly from MYR to SDF is November, when there's less demand. Off-peak season is often when you'll find lower airfares between these airports.
What is the cheapest airline that flies from Myrtle Beach Intl. Airport (MYR) to Louisville Intl. Airport (SDF)?
To find the cheapest airline that'll fly you from MYR to SDF, use Expedia's filter tool. Customize your search based on your travel needs, such as preferred carriers and ideal departure window. You can then sort your results by "Price (lowest to highest)" to see the most affordable options first.
How many flights per day from Myrtle Beach Intl. Airport (MYR) to Louisville Intl. Airport (SDF)?
You'll need to book a flight with a layover if you're traveling from Myrtle Beach Intl. Airport (MYR) to Louisville Intl. Airport (SDF). Direct flights don't operate daily on this route. However, simply filter your search to include one or two stops to discover the best option for your trip.
What day of the week has the most flights from MYR to SDF?
You'll usually find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Myrtle Beach Intl. Airport (MYR) to Louisville Intl. Airport (SDF)?
To land at Louisville Intl. Airport (SDF) on schedule, book a flight that leaves Myrtle Beach Intl. Airport (MYR) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Myrtle Beach Intl. Airport (MYR) to Louisville Intl. Airport (SDF) last-minute?
Last-minute fares from MYR to SDF are generally more expensive. For the lowest rates, start searching for flights ahead of time. That being said, if your travel plans are flexible, you may find a cheap fare just before your departure.
Is it cheaper to book a MYR to SDF flight and hotel package?
You'll generally save money by booking a MYR to SDF flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one convenient place. After choosing your ideal accommodations and flights, consider adding extras including tours, activities and car rentals.
Can I cancel or change the date of my flight from Myrtle Beach Intl. Airport (MYR) to Louisville Intl. Airport (SDF)?
Usually, it's possible to cancel or reschedule your MYR to SDF flight. However, if the booking was made more than 24 hours ago, additional fees may apply. Check your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find further details on our Customer Service portal.

Travel information

Travel information

Origin airport
Myrtle Beach Intl.
Destination airport
Louisville Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, Spirit Airlines, United
Roundtrip price
$123
Distance
492 mi

Book with confidence

Book with confidence

Myrtle Beach to Louisville Flights

The cheapest times to fly from Myrtle Beach to Louisville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Myrtle Beach to Louisville are during the month of November. You can find some of the cheapest flights from Myrtle Beach to Louisville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Myrtle Beach to Louisville

Sunday is one of the best days to book for cheap flights from Myrtle Beach to Louisville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Myrtle Beach to Louisville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Myrtle Beach to Louisville in 2025. You can also book with separate airlines for your outbound and return journeys, from $62 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Myrtle Beach to Louisville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Myrtle Beach to Louisville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Myrtle Beach to Louisville Flights

Explore a world of travel with Expedia

Explore a world of travel with Expedia

*Available to One Key members.