$561 Cheap Flights from Chicago (ORD) to La Serena (LSC)

View $561 flight on Wed, Jan 21, 2026Opens in a new window

Popular airlines from Chicago O'Hare Intl. Airport (ORD) to La Serena (LSC-La Florida)

Cheap Flights from Chicago to La Serena (ORD-LSC)

Prices were available within the past 7 days and start at $561 for one-way flights and $3,074 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

JetBlue Airways
Thu, Jan 1 - Sat, Jan 3
ORD
Chicago
LSC
La Serena
$3,074 Roundtrip, found 3 days ago
$3,074
Roundtrip
found 3 days ago
Select JetBlue Airways flight, departing Thu, Jan 1 from Chicago to La Serena, returning Sat, Jan 3, priced at $3,074 found 3 days ago
JetBlue Airways
Thu, Jan 1 - Sat, Jan 3
ORD
Chicago
LSC
La Serena
$3,179 Roundtrip, found 3 days ago
$3,179
Roundtrip
found 3 days ago
Select JetBlue Airways flight, departing Thu, Jan 1 from Chicago to La Serena, returning Sat, Jan 3, priced at $3,179 found 3 days ago
JetBlue Airways
Thu, Jan 1 - Sat, Jan 3
ORD
Chicago
LSC
La Serena
$3,269 Roundtrip, found 3 days ago
$3,269
Roundtrip
found 3 days ago
Select JetBlue Airways flight, departing Thu, Jan 1 from Chicago to La Serena, returning Sat, Jan 3, priced at $3,269 found 3 days ago
Delta
Thu, Jan 1 - Sat, Jan 3
ORD
Chicago
LSC
La Serena
$3,512 Roundtrip, found 3 days ago
$3,512
Roundtrip
found 3 days ago
Select Delta flight, departing Thu, Jan 1 from Chicago to La Serena, returning Sat, Jan 3, priced at $3,512 found 3 days ago
LATAM Airlines Group
Thu, Jan 1 - Sat, Jan 3
ORD
Chicago
LSC
La Serena
$3,522 Roundtrip, found 3 days ago
$3,522
Roundtrip
found 3 days ago
Select LATAM Airlines Group flight, departing Thu, Jan 1 from Chicago to La Serena, returning Sat, Jan 3, priced at $3,522 found 3 days ago
Delta
Thu, Jan 1 - Sat, Jan 3
ORD
Chicago
LSC
La Serena
$3,702 Roundtrip, found 3 days ago
$3,702
Roundtrip
found 3 days ago
Select Delta flight, departing Thu, Jan 1 from Chicago to La Serena, returning Sat, Jan 3, priced at $3,702 found 3 days ago
Delta
Thu, Jan 1 - Sat, Jan 3
ORD
Chicago
LSC
La Serena
$3,755 Roundtrip, found 3 days ago
$3,755
Roundtrip
found 3 days ago
Select Delta flight, departing Thu, Jan 1 from Chicago to La Serena, returning Sat, Jan 3, priced at $3,755 found 3 days ago
United
Thu, Jan 1 - Sat, Jan 3
ORD
Chicago
LSC
La Serena
$3,760 Roundtrip, found 3 days ago
$3,760
Roundtrip
found 3 days ago
Select United flight, departing Thu, Jan 1 from Chicago to La Serena, returning Sat, Jan 3, priced at $3,760 found 3 days ago
LATAM Airlines Group
Thu, Jan 1 - Sat, Jan 3
ORD
Chicago
LSC
La Serena
$3,765 Roundtrip, found 3 days ago
$3,765
Roundtrip
found 3 days ago
Select LATAM Airlines Group flight, departing Thu, Jan 1 from Chicago to La Serena, returning Sat, Jan 3, priced at $3,765 found 3 days ago
United
Thu, Jan 1 - Sat, Jan 3
ORD
Chicago
LSC
La Serena
$3,821 Roundtrip, found 3 days ago
$3,821
Roundtrip
found 3 days ago
Select United flight, departing Thu, Jan 1 from Chicago to La Serena, returning Sat, Jan 3, priced at $3,821 found 3 days ago

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Flights from Chicago (ORD) to La Serena (LSC)
Origin airport
O'Hare Intl.
Destination airport
La Florida
Roundtrip price
$3,073
Distance
5079 mi

Chicago to La Serena Flights

The cheapest times to fly from Chicago to La Serena

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Chicago to La Serena are during the month of January. You can find some of the cheapest flights from Chicago to La Serena with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Chicago to La Serena

Sunday is one of the best days to book for cheap flights from Chicago to La Serena: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Chicago to La Serena

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Chicago to La Serena in 2025. You can also book with separate airlines for your outbound and return journeys, from $561 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Chicago to La Serena flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Chicago to La Serena airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from O'Hare Intl. Airport (ORD) to La Florida Airport (LSC) cost?
Lock in a cheap one-way flight from $561 or cheap return flight from $3,074 from O'Hare Intl. Airport (ORD) to La Florida Airport (LSC) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from O'Hare Intl. Airport (ORD) to La Florida Airport (LSC)?
Planning your getaway for January can help you save, as it's the cheapest month for flights between ORD and LSC. You'll typically find the lowest prices during the off-season.
What is the cheapest airline that flies from O'Hare Intl. Airport (ORD) to La Florida Airport (LSC)?
Expedia's filter tool lets you easily compare different airlines, flight durations and fares all in one place. Customize the search to your preferences, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest ORD to LSC flight.
How many flights per day from O'Hare Intl. Airport (ORD) to La Florida Airport (LSC)?
There aren't any daily direct flights available from O'Hare Intl. Airport (ORD) to La Florida Airport (LSC). But you can choose flights with layovers. Filter your search results on Expedia to include one or more stops, and you'll be cruising above the clouds in no time.
What day of the week has the most flights from ORD to LSC?
Friday is generally the busiest day for flights, while Tuesday is often the quietest.* Keep in mind that flight schedules can change depending on a number of factors, such as the airline and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from O'Hare Intl. Airport (ORD) to La Florida Airport (LSC)?
To avoid possible delays on the O'Hare Intl. Airport (ORD) to La Florida Airport (LSC) route, aim to fly before 3 PM. Flights after this time are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from O'Hare Intl. Airport (ORD) to La Florida Airport (LSC) last-minute?
Last-minute bookings from ORD to LSC are generally more expensive. To lock in the cheapest rates, start looking for flights as soon as possible. That said, if you can play around with your travel dates, it's possible to find a cheap ticket just before your departure.
Is it cheaper to book an ORD to LSC flight and hotel package?
Compared with arranging hotels and flights separately, booking an ORD to LSC flight and hotel package with Expedia could lead to significant savings. Better still, having it all in one place takes the hassle out of planning your trip. Just pick your flights and choose from our wide range of stays, then personalize your trip with other add-ons like tours, activities and car rentals.
Can I cancel or change the date of my flight from O'Hare Intl. Airport (ORD) to La Florida Airport (LSC)?
In most instances, you're able to reschedule or cancel your ORD to LSC flight. However, there may be additional charges, especially if you booked more than 24 hours ago. Check your itinerary for the airline's fees and policies on flight changes, or if you want further details, head to our Customer Service portal.

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*Available to One Key members.