Title: The Best 5 Star Hotels in La Serena from $105 | Expedia.com

[La Serena Travel Guide](https://expedia.com/La-Serena.dx2139)[Hotels in La Serena](https://expedia.com/La-Serena-Hotels.d2139.Travel-Guide-Hotels)[Vacation Rentals in La Serena](https://expedia.com/La-Serena-Vacation-Rentals.d2139.Travel-Guide-VacationRentals)[Flights to La Serena](https://expedia.com/Cheap-Flights-To-La-Serena.d2139.Travel-Guide-Flights)[Things to do in La Serena](https://expedia.com/Things-To-Do-In-La-Serena.d2139.Travel-Guide-Activities)[Car Rentals in La Serena](https://expedia.com/Car-Rentals-In-La-Serena.d2139.Car-Rental-Guide)[La Serena Vacation Packages](https://expedia.com/La-Serena.d2139.Destination-Travel-Guides)

![Lighthouse at La Serena, Chile](https://images.trvl-media.com/place/2139/d4916bcd-6a4a-4c25-b665-93e13c32c0c5.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check availability on La Serena 5 Star Hotels

Tonight

[Feb 5 - Feb 6](https://www.expedia.com/Hotel-Search?regionId=2139&startDate=2026-02-05&endDate=2026-02-06&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Feb 6 - Feb 7](https://www.expedia.com/Hotel-Search?regionId=2139&startDate=2026-02-06&endDate=2026-02-07&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Feb 6 - Feb 8](https://www.expedia.com/Hotel-Search?regionId=2139&startDate=2026-02-06&endDate=2026-02-08&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Feb 13 - Feb 15](https://www.expedia.com/Hotel-Search?regionId=2139&startDate=2026-02-13&endDate=2026-02-15&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

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## Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in La Serena.

![Hotel y Cabañas Campanario](https://images.trvl-media.com/lodging/3000000/2140000/2133800/2133775/e8ace86b_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Hotel y Cabañas Campanario

Avenida del Mar 4600 La Serena 

$105 nightly

$105 total

Mar 1 - Mar 2

8.2/10 Very Good! (106 reviews)

[](https://expedia.com/La-Serena-Hotels-Hotel-Campanario-Del-Mar.h2133775.Hotel-Information)

![Enjoy Coquimbo](https://images.trvl-media.com/lodging/4000000/3830000/3826600/3826567/22924d69_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Enjoy Coquimbo

Avda. Penuelas Norte 56 Coquimbo 

[Get rates](https://expedia.com/Hotel-Search?startDate=2%2F19%2F2026&endDate=2%2F20%2F2026&selected=3826567&PinnedHotelID=3826567&HadPinnedHotel=true&regionId=2139)

8/10 Very Good! (270 reviews)

[](https://expedia.com/La-Serena-Hotels-Enjoy-Coquimbo.h3826567.Hotel-Information)

Still don't see what you're looking for?

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[Pool](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026&regionId=2139&star=50&star=50&amenities=POOL)[Spa](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026&regionId=2139&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026&regionId=2139&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026&regionId=2139&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026&regionId=2139&star=50&star=50&amenities=WATER_PARK)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## La Serena and related destinations

- La Serena
- Iquique
- Villarrica
- Asuncion
- João Pessoa

Elegant colonial architecture frames La Serena's Plaza de Armas, where you can visit the 19th-century cathedral and nearby archaeological museum. Spend evenings at Avenida del Mar beaches, then take day trips to Elqui Valley observatories or penguin colonies at Humboldt Penguin National Reserve.

[See all hotels in La Serena](https://www.expedia.com/Hotel-Search?startDate=2026-02-19&endDate=2026-02-20&adults=2&regionId=2139)

![Lighthouse at La Serena, Chile](https://images.trvl-media.com/place/2139/d4916bcd-6a4a-4c25-b665-93e13c32c0c5.jpg?impolicy=fcrop&w=900&h=597&p=1&q=high)

## Top La Serena Hotel Reviews

## Find out more about La Serena

There's nothing wrong with enjoying the finer things in life. Pamper yourself on your upcoming getaway. There's no reason to delay a getaway to La Serena any longer. You'll join the multitudes of vacationers who have made La Serena so fashionable recently. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Don't wait any longer. Our 5-star hotels in La Serena are the perfect places to relax in during your next chunk of time off.

### Get a Great Deal on 5-Star Hotels in La Serena

You'll have a wonderful time at one of these 5-star hotels. Top-notch customer care, granite-tiled bathrooms, and deeply relaxing spa offerings are waiting for you. You're sure to find exactly the accommodation you need. You can also expect excellent customer service from these hotels, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? 24-hour room service, so you can order that Turkish coffee in the wee hours of the morning? A mud wrap treatment that will leave you feeling like a million bucks? Butler services? Whatever it is your heart desires, you're bound to find it here. Want to see for yourself? Explore our listings and pick the perfect accommodation for your needs. 

Yearning for experiences outside your hotel room? We hear you. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what you end up doing, the 5-star hotels in La Serena are the perfect place to rest up after a busy day.

### Make Your Escape

The results are in, and La Serena 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Expedia can help you land a great deal on accommodation. It's time to plan your next great escape. Opt for one of our La Serena 5-star hotels today and soothe yourself in the lap of luxury tomorrow.

## Frequently asked questions

### How much does it cost to stay in a 5-star hotel in La Serena?

> - Search for the lowest price per night from $105

### What makes a hotel 5 stars in La Serena?

### Are there any 5-star all-inclusive resorts in La Serena?

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- [Flights from Santiago (SCL) to La Serena (LSC) ](https://www.expedia.com/lp/flights/scl/lsc/santiago-to-la-serena)
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- [Visit Coquimbo Region ](https://www.expedia.com/Coquimbo-Region.dx6236544)
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- [La Serena Archaeological Museum ](https://www.expedia.com/La-Serena-Archaeological-Museum-La-Serena.d6098424.Vacation-Attraction)
- [La Recova Market ](https://www.expedia.com/La-Recova-Market-La-Serena.d6293404.Vacation-Attraction)
- [Observatorio Turístico Collowara ](https://www.expedia.com/Observatorio-Turistico-Collowara-La-Serena.d553248621532374491.Vacation-Attraction)
- [Giliberto House ](https://www.expedia.com/Giliberto-House-La-Serena.d553248621563217376.Vacation-Attraction)
- [Casa Carmona ](https://www.expedia.com/Casa-Carmona-La-Serena.d6312008.Vacation-Attraction)
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- [La Serena Lighthouse ](https://www.expedia.com/La-Serena-Lighthouse-La-Serena.d6098434.Vacation-Attraction)
- [Sea Avenue ](https://www.expedia.com/Sea-Avenue-La-Serena.d6311984.Vacation-Attraction)
- [Elqui Valley ](https://www.expedia.com/Elqui-Valley-Coquimbo-Region.d6293291.Vacation-Attraction)

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