$269 Cheap Flights from Panama City (PTY) to Santo Domingo (SDQ)

View $269 flight on Fri, Nov 7, 2025Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ)

Cheap Flights from Panama City to Santo Domingo (PTY-SDQ)

Prices were available within the past 7 days and start at $269 for one-way flights and $445 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Aeromexico
Wed, Dec 31 - Sat, Jan 17
PTY
Panama City
SDQ
Santo Domingo
$445 Roundtrip, found 2 days ago
$445
Roundtrip
found 2 days ago
Select Aeromexico flight, departing Wed, Dec 31 from Panama City to Santo Domingo, returning Sat, Jan 17, priced at $445 found 2 days ago
Copa
Tue, Feb 24 - Tue, Mar 31
PTY
Panama City
SDQ
Santo Domingo
$453 Roundtrip, just found
$453
Roundtrip
just found
Select Copa flight, departing Tue, Feb 24 from Panama City to Santo Domingo, returning Tue, Mar 31, priced at $453 just found
Aeromexico
Tue, Feb 24 - Sat, Mar 28
PTY
Panama City
SDQ
Santo Domingo
$459 Roundtrip, found 1 day ago
$459
Roundtrip
found 1 day ago
Select Aeromexico flight, departing Tue, Feb 24 from Panama City to Santo Domingo, returning Sat, Mar 28, priced at $459 found 1 day ago
Copa
Sat, Nov 15 - Sun, Dec 7
PTY
Panama City
SDQ
Santo Domingo
$463 Roundtrip, found 2 hours ago
$463
Roundtrip
found 2 hours ago
Select Copa flight, departing Sat, Nov 15 from Panama City to Santo Domingo, returning Sun, Dec 7, priced at $463 found 2 hours ago
Copa
Sun, Dec 14 - Sun, Dec 21
PTY
Panama City
SDQ
Santo Domingo
$469 Roundtrip, found 2 hours ago
$469
Roundtrip
found 2 hours ago
Select Copa flight, departing Sun, Dec 14 from Panama City to Santo Domingo, returning Sun, Dec 21, priced at $469 found 2 hours ago
Copa
Sun, Dec 14 - Sun, Dec 21
PTY
Panama City
SDQ
Santo Domingo
$474 Roundtrip, found 2 hours ago
$474
Roundtrip
found 2 hours ago
Select Copa flight, departing Sun, Dec 14 from Panama City to Santo Domingo, returning Sun, Dec 21, priced at $474 found 2 hours ago
Copa
Sat, Nov 15 - Sun, Dec 7
PTY
Panama City
SDQ
Santo Domingo
$479 Roundtrip, found 2 hours ago
$479
Roundtrip
found 2 hours ago
Select Copa flight, departing Sat, Nov 15 from Panama City to Santo Domingo, returning Sun, Dec 7, priced at $479 found 2 hours ago
avianca
Wed, Dec 24 - Thu, Jan 1
PTY
Panama City
SDQ
Santo Domingo
$495 Roundtrip, just found
$495
Roundtrip
just found
Select avianca flight, departing Wed, Dec 24 from Panama City to Santo Domingo, returning Thu, Jan 1, priced at $495 just found
American Airlines
Sun, Dec 7 - Fri, Dec 26
PTY
Panama City
SDQ
Santo Domingo
$799 Roundtrip, found 7 hours ago
$799
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Sun, Dec 7 from Panama City to Santo Domingo, returning Fri, Dec 26, priced at $799 found 7 hours ago
United
Tue, Nov 4 - Fri, Nov 7
PTY
Panama City
SDQ
Santo Domingo
$1,408 Roundtrip, found 7 hours ago
$1,408
Roundtrip
found 7 hours ago
Select United flight, departing Tue, Nov 4 from Panama City to Santo Domingo, returning Fri, Nov 7, priced at $1,408 found 7 hours ago

Find the cheapest month to fly from Panama City (PTY) to Santo Domingo (SDQ)

May is typically the cheapest month to fly

From $335 - $495 per traveler.

Alternative airports near Santo Domingo

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Las Americas Intl. SDQ. Cheapest option available. Average driving time to city center is 22 minutes. Flights from $453
SDQ
Las Americas Intl.
Cheapest
Average driving time to city center22 min
Flights from $453

Frequently asked questions

How much does a flight from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ) cost?
Grab a cheap one-way flight from $269 or cheap return flight from $445 from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ)?
December is the least expensive month to fly from PTY to SDQ. Traveling outside of peak seasons is often the key to finding a great deal.
Which airlines fly direct from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ)?
When setting off from Tocumen Intl. Airport (PTY), you can get on a direct flight to Las Americas Intl. Airport (SDQ) with Copa Airlines.
What is the cheapest airline that flies from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ)?
Expedia's filter tool lets you easily compare airlines, flight times and baggage options all in one place. Tailor the search to your trip, then sort by "Price (lowest to highest)" to find the carrier with the cheapest PTY to SDQ flight.
How many flights per day from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ)?
When departing from Tocumen Intl. Airport (PTY), you'll have your pick from an average of 4 daily nonstop flights to Las Americas Intl. Airport (SDQ).
What are the most popular departure times for flights from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ)?
Flights between PTY and SDQ are their busiest at 6 PM. For a more relaxed atmosphere and potentially cheaper tickets, look for a time outside the usual busy windows.
What day of the week has the most flights from PTY to SDQ?
Wednesday has the most flights from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ). Consider taking off on this day and you'll have the best chance of finding a schedule that works for you.
What is the earliest flight from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ)?
Catch the earliest flight at around 7:18AM UTC-5, leaving from Tocumen Intl. Airport (PTY). You'll be in the air for about 2h 26m, touching down at Las Americas Intl. Airport (SDQ) at approximately 10:44AM UTC-4.
How long does it take to fly from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ)?
Flights from PTY to SDQ have an average travel time of 2 hours and 28 minutes. The total distance between the two is 920 mi.
What airline has the least delays from PTY to SDQ?
With 94% of flights typically arriving on schedule, Copa Airlines has the best on-time performance for direct flights from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ). To check your flight status and get notified about any changes, use the Expedia App.
What is the best time to fly from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ)?
Book a flight from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ) that takes off before 3 PM to reduce the risk of delays and cancellations. Departures later than this have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Santo Domingo from Tocumen Intl. Airport (PTY)?
Las Americas Intl. Airport (SDQ) is the only airport in Santo Domingo with direct flights from Tocumen Intl. Airport (PTY). Compare the options and find affordable fares on Expedia.
Is it cheaper to buy a plane ticket from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ) last-minute?
Booking your flight from PTY to SDQ right before your journey is usually more expensive. But if there's some wiggle room with your departure times and dates, you could grab a cheap last-minute fare.
Is it cheaper to book a PTY to SDQ flight and hotel package?
You can save money by securing a PTY to SDQ flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's simple to manage it all in one place. After selecting your preferred accommodations and flights, you can add extras such as activities, car rentals and tours.
Can I cancel or change the date of my flight from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ)?
If you booked your PTY to SDQ flight within the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the fare type you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal if you want more information.

Travel information

Origin airport
Tocumen Intl.
Destination airport
Las Americas Intl.
Airlines serving
Aeromexico, American Airlines, Copa, United, avianca
Roundtrip price
$445
Distance
917 mi
Average flight time
3 hours 30 mins

Book with confidence

Panama City to Santo Domingo Flights

The cheapest times to fly from Panama City to Santo Domingo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to Santo Domingo are during the month of December. You can find some of the cheapest flights from Panama City to Santo Domingo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Panama City to Santo Domingo

Sunday is one of the best days to book for cheap flights from Panama City to Santo Domingo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Panama City to Santo Domingo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to Santo Domingo in 2025. You can also book with separate airlines for your outbound and return journeys, from $269 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to Santo Domingo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to Santo Domingo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Panama City to Santo Domingo Flights

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*Available to One Key members.