$277 Cheap Flights from Santiago (SCL) to Panama City (PTY)

View $277 flight on Wed, Nov 12, 2025Opens in a new window

Popular airlines from Santiago Intl. Airport (SCL) to Tocumen Intl. Airport (PTY)

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Cheap Flights from Santiago to Panama City (SCL-PTY)

Prices were available within the past 7 days and start at $277 for one-way flights and $450 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Thu, Nov 13 - Thu, Nov 20
SCL
Santiago
PTY
Panama City
$450 Roundtrip, found 4 days ago
$450
Roundtrip
found 4 days ago
Select Copa flight, departing Thu, Nov 13 from Santiago to Panama City, returning Thu, Nov 20, priced at $450 found 4 days ago
Copa
Sat, Dec 27 - Sat, Jan 3
SCL
Santiago
PTY
Panama City
$471 Roundtrip, found 2 hours ago
$471
Roundtrip
found 2 hours ago
Select Copa flight, departing Sat, Dec 27 from Santiago to Panama City, returning Sat, Jan 3, priced at $471 found 2 hours ago
Copa
Sat, Dec 27 - Sat, Jan 3
SCL
Santiago
PTY
Panama City
$486 Roundtrip, found 2 hours ago
$486
Roundtrip
found 2 hours ago
Select Copa flight, departing Sat, Dec 27 from Santiago to Panama City, returning Sat, Jan 3, priced at $486 found 2 hours ago
Copa
Thu, Nov 20 - Tue, Nov 25
SCL
Santiago
PTY
Panama City
$498 Roundtrip, found 3 days ago
$498
Roundtrip
found 3 days ago
Select Copa flight, departing Thu, Nov 20 from Santiago to Panama City, returning Tue, Nov 25, priced at $498 found 3 days ago
Copa
Tue, Dec 2 - Fri, Dec 5
SCL
Santiago
PTY
Panama City
$501 Roundtrip, found 6 hours ago
$501
Roundtrip
found 6 hours ago
Select Copa flight, departing Tue, Dec 2 from Santiago to Panama City, returning Fri, Dec 5, priced at $501 found 6 hours ago
Copa
Sat, Dec 27 - Sat, Jan 3
SCL
Santiago
PTY
Panama City
$505 Roundtrip, found 2 hours ago
$505
Roundtrip
found 2 hours ago
Select Copa flight, departing Sat, Dec 27 from Santiago to Panama City, returning Sat, Jan 3, priced at $505 found 2 hours ago
Copa
Sat, Nov 22 - Mon, Dec 1
SCL
Santiago
PTY
Panama City
$509 Roundtrip, found 4 days ago
$509
Roundtrip
found 4 days ago
Select Copa flight, departing Sat, Nov 22 from Santiago to Panama City, returning Mon, Dec 1, priced at $509 found 4 days ago
avianca
Wed, Dec 3 - Mon, Dec 8
SCL
Santiago
PTY
Panama City
$580 Roundtrip, found 3 hours ago
$580
Roundtrip
found 3 hours ago
Select avianca flight, departing Wed, Dec 3 from Santiago to Panama City, returning Mon, Dec 8, priced at $580 found 3 hours ago
Aeromexico
Tue, Dec 2 - Fri, Dec 5
SCL
Santiago
PTY
Panama City
$905 Roundtrip, found 6 hours ago
$905
Roundtrip
found 6 hours ago
Select Aeromexico flight, departing Tue, Dec 2 from Santiago to Panama City, returning Fri, Dec 5, priced at $905 found 6 hours ago
American Airlines
Fri, Jan 23 - Mon, Feb 9
SCL
Santiago
PTY
Panama City
$1,459 Roundtrip, found 4 hours ago
$1,459
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Fri, Jan 23 from Santiago to Panama City, returning Mon, Feb 9, priced at $1,459 found 4 hours ago

Find the cheapest month to fly from Santiago (SCL) to Panama City (PTY)

November is typically the cheapest month to fly

From $407 - $720 per traveler.

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tocumen Intl. PTY. Cheapest option available. Average driving time to city center is 16 minutes. Flights from $450
PTY
Tocumen Intl.
Cheapest
Average driving time to city center16 min
Flights from $450
Flights from Santiago (SCL) to Panama City (PTY)
Origin airport
Arturo Merino Benitez
Destination airport
Tocumen Intl.
Airlines serving
Aeromexico, American Airlines, Copa, avianca
Roundtrip price
$450
Distance
2987 mi
Average flight time
4 hours 52 mins

Santiago to Panama City Flights

The cheapest times to fly from Santiago to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Santiago to Panama City are during the month of November. You can find some of the cheapest flights from Santiago to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Santiago to Panama City

Sunday is one of the best days to book for cheap flights from Santiago to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Santiago to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Santiago to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $277 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Santiago to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Santiago to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Arturo Merino Benitez Airport (SCL) to Tocumen Intl. Airport (PTY) cost?
Grab a cheap one-way flight from $277 or cheap return flight from $450 from Arturo Merino Benitez Airport (SCL) to Tocumen Intl. Airport (PTY) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Arturo Merino Benitez Airport (SCL) to Tocumen Intl. Airport (PTY)?
November is the most affordable month to fly from SCL to PTY. Traveling during quieter months is often the key to better flight prices.
Which airlines fly direct from Arturo Merino Benitez Airport (SCL) to Tocumen Intl. Airport (PTY)?
When flying out of Arturo Merino Benitez Airport (SCL), you can take a direct flight to Tocumen Intl. Airport (PTY) with Copa Airlines.
What is the cheapest airline that flies from Arturo Merino Benitez Airport (SCL) to Tocumen Intl. Airport (PTY)?
Expedia's filter tool lets you easily compare different airlines, travel time and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest SCL to PTY flight.
How many flights per day from Arturo Merino Benitez Airport (SCL) to Tocumen Intl. Airport (PTY)?
With an average of 5 nonstop flights departing from Arturo Merino Benitez Airport (SCL) to Tocumen Intl. Airport (PTY) daily, you'll be taking off on vacation soon enough.
What are the most popular departure times for flights from Arturo Merino Benitez Airport (SCL) to Tocumen Intl. Airport (PTY)?
More people fly between SCL and PTY at 1 AM than at any other point in the day. Rather go when it's quieter? Consider flying outside peak hours and it's possible you'll save on your ticket as well.
What day of the week has the most flights from SCL to PTY?
Fly on a Thursday if you're after the biggest selection of flights from Arturo Merino Benitez Airport (SCL) to Tocumen Intl. Airport (PTY).
What is the earliest flight from Arturo Merino Benitez Airport (SCL) to Tocumen Intl. Airport (PTY)?
The earliest flight out of Arturo Merino Benitez Airport (SCL) is at around 1:18AM UTC-3. Board this flight and you'll touch down at Tocumen Intl. Airport (PTY) at approximately 6:03AM UTC-5. The entire trip takes 6h 45m.
How long does it take to fly from Arturo Merino Benitez Airport (SCL) to Tocumen Intl. Airport (PTY)?
Typically, it takes 6 hours and 46 minutes to fly the 3,000 mi from SCL to PTY.
What is the best time to fly from Arturo Merino Benitez Airport (SCL) to Tocumen Intl. Airport (PTY)?
To avoid possible delays on the Arturo Merino Benitez Airport (SCL) to Tocumen Intl. Airport (PTY) route, travel before 3 PM. Departures after this time are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Panama City from Arturo Merino Benitez Airport (SCL)?
Tocumen Intl. Airport (PTY) is the only airport in Panama City with direct flights from Arturo Merino Benitez Airport (SCL). Check out your options and find cheap fares on Expedia.
Is it cheaper to buy a plane ticket from Arturo Merino Benitez Airport (SCL) to Tocumen Intl. Airport (PTY) last-minute?
Last-minute fares from SCL to PTY are typically more expensive. For the lowest rates, start searching for flights as early as possible. That being said, if you can play around with your travel dates, it's possible to find a cheap ticket right before your journey.
Is it cheaper to book a SCL to PTY flight and hotel package?
You can save money by securing a SCL to PTY flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one place. After selecting your ideal flights and accommodations, consider adding extras including activities, tours and car rentals.
Can I cancel or change the date of my flight from Arturo Merino Benitez Airport (SCL) to Tocumen Intl. Airport (PTY)?
In most instances, you're able to cancel or reschedule your SCL to PTY flight. However, there may be additional fees, especially if you made your booking more than 24 hours ago. Check your itinerary for the airline's fees and policies on flight changes, or if you need more details, go to our Customer Service portal.

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*Available to One Key members.