$720 Cheap Flights from Manzanillo (ZLO) to Panama City (PTY)

View $720 flight on Fri, Jan 2, 2026Opens in a new window

Popular airlines from Manzanillo, Colima (ZLO-Playa de Oro Intl.) to Tocumen Intl. Airport (PTY)

  • notification illustration

    Be in the know

    Get alerts if flight prices drop or rise*
  • deals illustration

    Book smarter

    Save up to 30% on select hotels after you book a flight*
  • trophy illustration

    Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from Manzanillo to Panama City (ZLO-PTY)

Prices were available within the past 7 days and start at $720 for one-way flights and for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frequently asked questions

How much does a flight from Playa de Oro Intl. Airport (ZLO) to Tocumen Intl. Airport (PTY) cost?
Secure a cheap one-way flight from $720 or cheap return flight from Playa de Oro Intl. Airport (ZLO) to Tocumen Intl. Airport (PTY) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Playa de Oro Intl. Airport (ZLO) to Tocumen Intl. Airport (PTY)?
is the cheapest month to fly from ZLO to PTY. Traveling during quieter months is often the key to scoring lower fares.
What is the cheapest airline that flies from Playa de Oro Intl. Airport (ZLO) to Tocumen Intl. Airport (PTY)?
Use the filter tool on Expedia to compare airlines and find the most affordable carrier that'll take you from ZLO to PTY. Then, sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Playa de Oro Intl. Airport (ZLO) to Tocumen Intl. Airport (PTY)?
There are no daily nonstop flights from Playa de Oro Intl. Airport (ZLO) to Tocumen Intl. Airport (PTY). But you can book flights with layovers. Filter your search on Expedia to include one or two stops, and you'll be soaring above the clouds in no time.
What day of the week has the most flights from ZLO to PTY?
Typically you'll have the most choice when it comes to flights on a Friday. Tuesdays are often the quietest.* But this can change based on the season, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Playa de Oro Intl. Airport (ZLO) to Tocumen Intl. Airport (PTY)?
To land at Tocumen Intl. Airport (PTY) on time, choose a flight that leaves Playa de Oro Intl. Airport (ZLO) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Playa de Oro Intl. Airport (ZLO) to Tocumen Intl. Airport (PTY) last-minute?
Last-minute fares from ZLO to PTY are generally more expensive. For the lowest rates, start searching for flights early. That being said, if your travel plans are flexible, it's possible to find a cheap ticket right before you leave.
Is it cheaper to book a ZLO to PTY flight and hotel package?
Compared with arranging flights and hotels separately, booking a ZLO to PTY flight and hotel package with Expedia could result in significant savings. Better yet, having everything in one place will take the stress out of planning your trip. Just pick your flights and choose from our extensive range of hotels, then tailor your trip with extras like tours and car rentals.
Can I cancel or change the date of my flight from Playa de Oro Intl. Airport (ZLO) to Tocumen Intl. Airport (PTY)?
If you reserved your ZLO to PTY flight in the last 24 hours, you may be able to modify or cancel it without fees. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you want more information.

Travel information

Origin airport
Playa de Oro Intl.
Destination airport
Tocumen Intl.
Distance
1821 mi

Book with confidence

Manzanillo to Panama City Flights

The cheapest times to fly from Manzanillo to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Manzanillo to Panama City are during the month of . You can find some of the cheapest flights from Manzanillo to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Manzanillo to Panama City

Sunday is one of the best days to book for cheap flights from Manzanillo to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Manzanillo to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Manzanillo to Panama City in 2026. You can also book with separate airlines for your outbound and return journeys, from $720 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Manzanillo to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Manzanillo to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Manzanillo to Panama City Flights

Explore a world of travel with Expedia

*Available to One Key members.