$159 Cheap American Airlines flights Denver (DEN) to Manchester (MHT)

Finding cheap one-way American Airlines flights from DEN to MHT from $159 on Expedia is a cinch — just filter by "Price (lowest to highest)." Alternatively, check out our affordable return fares from $297 for your next adventure.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

For cheap American Airlines fares from Denver Intl. Airport (DEN) to Manchester-Boston Regional Airport (MHT), start searching one to three months before your planned departure. Reserving domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also affect the overall cost. Sunday tends to be the most affordable, while Monday is often the most expensive for domestic flights. You can save 6% on average by booking your trip on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

To find the earliest departure from DEN to MHT with American Airlines, sort your results by "Early Morning" and "Morning." Booking an early flight usually means you're less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.