$153 Cheap American Airlines flights Myrtle Beach (MYR) to Charlotte (CLT)

Finding cheap one-way American Airlines flights from MYR to CLT from $153 on Expedia is a breeze --- just filter by "Price (lowest to highest)." Alternatively, check out our budget-friendly round-trip fares from $281 for your next exciting getaway.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Search for cheap American Airlines flights from Myrtle Beach Intl. Airport (MYR) to Charlotte-Douglas Intl. Airport (CLT) one to three months prior to your departure day. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. Regardless of fare class and itinerary, the ideal day to book a domestic flight is generally Sunday and the most expensive is typically Monday. Passengers who book on a Sunday can save 6% on average compared to those who book their travel on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

The first flight from MYR to CLT with American Airlines departs at 5:05AM UTC-5. You'll land at 6:14AM UTC-5. The final American Airlines flight of the day leaves at 8:07PM UTC-5 and arrives at 9:24PM UTC-5. With approximately 20% fewer cancellations for departures before noon, beginning your travel day early is usually the best choice.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.