$124 Cheap American Airlines flights Chicago (ORD) to Greenville (GSP)

You can discover cheap round-trip American Airlines flights from $195 from ORD to GSP by organizing your results from "Price (lowest to highest)" on Expedia. Or look for deals from $124 for a one-way trip.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Look for affordable American Airlines flights from O'Hare Intl. Airport (ORD) to Greenville-Spartanburg Intl. Airport (GSP) one to three months prior to your departure. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. Regardless of fare type and journey, the best day to book a domestic flight is generally Sunday and the most expensive day tends to be Monday. Passengers who book on a Sunday can save 6% on average compared to those who book on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Taking off from ORD at 5:30PM UTC-6, the earliest American Airlines flight to GSP arrives at 8:24PM UTC-5. Traveling early means you'll be less likely to experience cancellations.* Prefer a later start? The last American Airlines flight from ORD to GSP departs at 5:30PM UTC-6 and touches down at 8:24PM UTC-5.*Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.