$159 Cheap American Airlines flights Chicago (ORD) to Tucson (TUS)

Finding cheap one-way American Airlines flights from ORD to TUS from $159 on Expedia is a breeze --- just filter by "Price (lowest to highest)." Or check out our affordable return fares from $321 for your next exciting vacation.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Look for cheap American Airlines flights from O'Hare Intl. Airport (ORD) to Tucson Intl. Airport (TUS) one to three months prior to your departure date. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. Regardless of fare type and itinerary, the best day of the week to book a domestic flight is usually Sunday and the most expensive day tends to be Monday. Passengers who book on a Sunday can save 6% on average compared to those who book their travel on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

The first flight from ORD to TUS with American Airlines leaves at 9:50AM UTC-6. You'll land at 12:56PM UTC-7. The final American Airlines flight of the day takes off at 8:45PM UTC-6 and arrives at 11:41PM UTC-7. With around 20% fewer cancellations for early and mid-morning departures, setting off early is often the smartest option.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.