$159 Cheap American Airlines flights Melbourne (MLB) to New Orleans (MSY)

Finding cheap one-way American Airlines flights from MLB to MSY from $159 on Expedia is simple — just filter by "Price (lowest to highest)." Alternatively, check out our budget-friendly round-trip fares from $285 for your next exciting vacation.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

For cheap American Airlines fares from Orlando Melbourne Intl. Airport (MLB) to Louis Armstrong New Orleans Intl. Airport (MSY), start searching one to three months before your intended departure. Securing domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also impact what you pay. Sunday is usually the most affordable, while Monday is often the most expensive for domestic flights. You can save 6% on average by booking your trip on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Find American Airlines's earliest flights from MLB to MSY by using our "Morning" and "Early Morning" filters. Not only will you get to your destination sooner, early departures also have a 20% less chance of being canceled.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.