$143 Cheap Delta flights Des Moines (DSM) to Fort Myers (RSW)

Apply the “Price (lowest to highest)” filter on Expedia to find cheap Delta Air Lines round-trip flights from $285 from DSM to RSW. Affordable one-way tickets from $143 are also available.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Delta Air Lines flights to Fort Myers tend to be cheaper in the off-peak months of August and September. Whether you’re after a round-trip or one-way ticket, you could score a better deal then.

For cheap Delta Air Lines fares from Des Moines Intl. Airport (DSM) to Southwest Florida Intl. Airport (RSW), start searching one to three months before your intended departure. Securing domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also impact how much you pay. Sunday is usually the most affordable, while Monday is often the most expensive for domestic flights. You can save 6% on average by booking on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Enter your dates, click search and check the “Nonstop” filter on Expedia to find any direct flights from DSM to RSW with Delta Air Lines or another airline.

Search Delta Air Lines’s earliest flights from DSM to RSW by checking the “Morning” and “Early Morning” filters. Not only will you get to your destination sooner, early departures also have a 20% less chance of being canceled.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Southwest Florida Intl. Airport (RSW) is the primary Fort Myers hub for Delta Air Lines flights from Des Moines Intl. Airport (DSM).

Delta Air Lines makes traveling from DSM to RSW more comfortable with a rewarding loyalty program and an excellent in-flight experience. You may even earn points with Delta SkyMiles. Make sure you sign up to Expedia’s free One Key™ rewards program to earn OneKeyCash™*, which can be redeemed on future bookings.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.

Typically, you can change or cancel your flight, although there may be additional charges if you booked more than 24 hours ago. Want to keep your options open? Use Expedia’s “Changes included” and “No cancel fee” filters to find flights that won’t charge extra if you need to adjust your plans. To make changes, visit “Trips,” select your flight and click on “Manage Booking” for more details.